- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03497585
Developing an Activity Pacing Framework: Feasibility and Acceptability
Developing an Activity Pacing Framework for the Management of Chronic Pain/Fatigue. Stage III: Feasibility and Acceptability Studies
Study Overview
Status
Intervention / Treatment
Detailed Description
Activity pacing is frequently advised in the management of chronic pain/fatigue, including chronic low back pain, chronic widespread pain/fibromyalgia and chronic fatigue syndrome/myalgic encephalomyelitis. However, there is no agreed definition of 'activity pacing' and it is instructed in various ways. For some, pacing involves adapting/limiting activities (for example, breaking down tasks/having rests); while for others, pacing involves having consistent activities/gradually increasing activities. Furthermore, pacing has been associated with both improved symptoms (decreased fatigue/anxiety/depression) and worsened symptoms (increased pain/disability).
Due to the high prevalence and cost (personal and financial) of chronic pain/fatigue, it is imperative that coping strategies such as pacing are clearly defined and evidence-based. This study involves Stage III in the development of an activity pacing framework to standardise how pacing is instructed by healthcare professionals. Stage I: Online Survey of pacing involved 92 healthcare professionals (doctors/nurses/physiotherapists/occupational therapists/clinical psychologists). The survey findings, together with existing research were used to develop the pacing framework. The framework was further developed in Stage II: Nominal Group Technique (consensus meeting), involving four patients and six healthcare professionals.
Stage III will test the feasibility of implementing the pacing framework clinically, by using it to underpin existing rehabilitation programmes for chronic pain/fatigue. Patients will attend rehabilitation programmes at the study sites as per usual practice. Patients' participation in this study involves their completion of a booklet of questionnaires. The aim of this feasibility study is to explore whether the activity pacing framework is usable in the clinical setting, to explore recruitment/retention rates, together with changes in symptoms between the start and end of treatment, and at 3-months follow-up. Stage III will also explore the acceptability of the framework by undertaking interviews with the patients and healthcare professionals involved in the rehabilitation programmes. Stage III is expected to last 22 months.
Future study will test the framework in a clinical trial to assess the effects of pacing on patients' symptoms. The pacing framework has the potential to improve treatments by providing guidance on the components of pacing found to have benefits for patients.
This study is funded by a Health Education England/National Institute for Health Research (HEE/NIHR) Integrated Clinical Academic (ICA) Clinical Lectureship.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Lancashire
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Bury, Lancashire, United Kingdom, BL9 7TD
- The Pennine Acute Hospitals NHS Trust
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Feasibility Study Inclusion Criteria:
- Patients with an initial General Practitioner (GP)/hospital consultant referral to The Pennine Acute Hospitals NHS Trust with diagnoses of chronic low back pain, chronic widespread pain, fibromyalgia or CFS/ME, with a minimum symptom duration of 3 months.
- Patients referred to a rehabilitation programme for chronic pain/fatigue
- Patients aged ≥18 years
- Patients able to read/write in English
Exclusion Criteria:
- Patients with evidence of a serious underlying pathology, such as a current diagnosis of cancer
- Patients with severe mental health/cognitive functioning issues
Acceptability Study (qualitative interviews) Inclusion Criteria:
- Patients with an initial GP/hospital consultant referral to The Pennine Acute Hospitals National Health Service (NHS) Trust with diagnoses of chronic low back pain, chronic widespread pain, fibromyalgia or CFS/ME, with a minimum symptom duration of 3 months (as per the feasibility study).
- Patients who attended a minimum of one session of the rehabilitation programme, who consented to the study and completed the first questionnaire booklet. Patients do not need to have completed the programme, since the interviews will include patients who both completed and did not complete the programme.
- Qualified healthcare professionals delivering the rehabilitation programmes who received training in using the activity pacing framework: physiotherapists and psychological wellbeing practitioners employed by The Pennine Acute Hospitals NHS Trust and Pennine Care NHS Foundation Trust.
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Activity Pacing Framework
Adult patients attending rehabilitation programmes underpinned by the activity pacing framework.
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The activity pacing framework will be used to structure and standardise the instructions of pacing in existing rehabilitation programmes for adult patients with chronic pain/fatigue.
The activity pacing framework has been developed in Stages I and II of this research.
Stage I involved an online survey of activity pacing across healthcare professionals in England.
The survey findings, together with existing research were used to develop the first draft of the framework.
The framework was refined in Stage II: Nominal group technique (consensus method).
The activity pacing framework describes the aims, facets and stages of pacing, together with how pacing relates to different behavioural typologies and other pain management strategies.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Activity Pacing Questionnaire (APQ-28) From Baseline to the End of the 6-week's Programme
Time Frame: Change in activity pacing from baseline (pre-treatment: up to one week before the programme) to the end of the 6-week's programme
|
The Activity Pacing Questionnaire (APQ) was developed to measure different themes of activity pacing. The APQ was initially validated among a sample of patients with chronic pain/fatigue and contained 26 items. Factor analysis identified five themes of pacing contained within the APQ-26: Activity adjustment, Activity consistency, Activity planning, Activity acceptance and Activity progression. The APQ-26 has been modified for the purpose of this study with the addition of two items to correspond to important aspects of pacing that were not included in the APQ-26. The APQ-28 reflects the content of the activity pacing framework. The APQ-28 will be used to assess the changes in activity pacing from baseline (pre-treatment: up to one week before the programme) to end of the programme (6-week's programme). Each of the five themes of pacing is calculated as a mean score (0-4), where higher scores indicated more implementation of pacing strategies. |
Change in activity pacing from baseline (pre-treatment: up to one week before the programme) to the end of the 6-week's programme
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Activity Pacing at Baseline: Activity Pacing Questionnaire (APQ-28)
Time Frame: Baseline (pre-treatment: up to one week before the programme)
|
The Activity Pacing Questionnaire (APQ) was developed to measure different themes of activity pacing. The APQ was initially validated among a sample of patients with chronic pain/fatigue and contained 26 items. Factor analysis identified five themes of pacing contained within the APQ-26: Activity adjustment, Activity consistency, Activity planning, Activity acceptance and Activity progression. The APQ-26 has been modified for the purpose of this study with the addition of two items to correspond to important aspects of pacing that were not included in the APQ-26. The APQ-28 reflects the content of the activity pacing framework. The APQ-28 will be used to measure activity pacing at baseline (pre-treatment: up to one week before the programme). Each of the five themes of pacing is calculated as a mean score (0-4), where higher scores indicated more implementation of pacing strategies. |
Baseline (pre-treatment: up to one week before the programme)
|
Activity Pacing at the End of Treatment: Activity Pacing Questionnaire (APQ-28)
Time Frame: 6-weeks (end of the programme)
|
The Activity Pacing Questionnaire (APQ) was developed to measure different themes of activity pacing. The APQ was initially validated among a sample of patients with chronic pain/fatigue and contained 26 items. Factor analysis identified five themes of pacing contained within the APQ-26: Activity adjustment, Activity consistency, Activity planning, Activity acceptance and Activity progression. The APQ-26 has been modified for the purpose of this study with the addition of two items to correspond to important aspects of pacing that were not included in the APQ-26. The APQ-28 reflects the content of the activity pacing framework. The APQ-28 will be used to measure activity pacing at the end of the 6-week's programme. Each of the five themes of pacing is calculated as a mean score (0-4), where higher scores indicated more implementation of pacing strategies. |
6-weeks (end of the programme)
|
Activity Pacing at 3-months Follow up: Activity Pacing Questionnaire (APQ-28)
Time Frame: 3-months follow-up (after the end of the 6-week's programme)
|
The Activity Pacing Questionnaire (APQ) was developed to measure different themes of activity pacing. The APQ was initially validated among a sample of patients with chronic pain/fatigue and contained 26 items. Factor analysis identified five themes of pacing contained within the APQ-26: Activity adjustment, Activity consistency, Activity planning, Activity acceptance and Activity progression. The APQ-26 has been modified for the purpose of this study with the addition of two items to correspond to important aspects of pacing that were not included in the APQ-26. The APQ-28 reflects the content of the activity pacing framework. The APQ-28 will be used to measure activity pacing at 3-months follow up after the end of the 6-week's programme. Each of the five themes of pacing is calculated as a mean score (0-4), where higher scores indicated more implementation of pacing strategies. |
3-months follow-up (after the end of the 6-week's programme)
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Pain at Baseline: 11-point Numerical Rating Scale (NRS) of Pain
Time Frame: Baseline (pre-treatment: up to one week before the programme)
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Two 11-point Numerical Rating Scales (NRS) will assess current pain and usual pain, where 0='no pain' and 10='worst possible pain' at baseline (pre-treatment: up to one week before the programme)
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Baseline (pre-treatment: up to one week before the programme)
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Pain at the End of Treatment (6-weeks): 11-point Numerical Rating Scale (NRS) of Pain
Time Frame: 6-weeks (end of the programme)
|
Two 11-point Numerical Rating Scales (NRS) will assess current pain and usual pain, where 0='no pain' and 10='worst possible pain' at the end of the 6-week's programme.
|
6-weeks (end of the programme)
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Pain at 3-months Follow up: 11-point Numerical Rating Scale (NRS) of Pain
Time Frame: 3-months follow-up (after the end of the 6-week's programme)
|
Two 11-point Numerical Rating Scales (NRS) will assess current pain and usual pain, where 0='no pain' and 10='worst possible pain' at 3-months follow up after the end of the 6-week's programme
|
3-months follow-up (after the end of the 6-week's programme)
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Depression at Baseline: Patient Health Questionnaire-9 (PHQ-9)
Time Frame: Baseline (pre-treatment: up to one week before the programme)
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The Patient Health Questionnaire (PHQ-9) contains nine items that screen for and measure the severity of depression in the clinical setting.
Items are developed based on the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV).
This will be measured at baseline (pre-treatment: up to one week before the programme).
The total range of scores is 0-27, where 1-4=minimal depression, 5-9=mild depression, 10-14=moderate depression and ≥15=severe depression.
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Baseline (pre-treatment: up to one week before the programme)
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Depression at the End of Treatment (6-weeks): Patient Health Questionnaire-9 (PHQ-9)
Time Frame: 6-weeks (end of the programme)
|
The Patient Health Questionnaire (PHQ-9) contains nine items that screen for and measure the severity of depression in the clinical setting.
Items are developed based on the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV).
This will be measured at the end of the 6-week's programme.
The total range of scores is 0-27, where 1-4=minimal depression, 5-9=mild depression, 10-14=moderate depression and ≥15=severe depression.
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6-weeks (end of the programme)
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Depression at 3-months Follow-up: Patient Health Questionnaire-9
Time Frame: 3-months follow-up (after the end of the 6-week's programme)
|
The Patient Health Questionnaire (PHQ-9) contains nine items that screen for and measure the severity of depression in the clinical setting.
Items are developed based on the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV).
This will be measured at 3-months follow up after the end of the 6-week's programme.
The total range of scores is 0-27, where 1-4=minimal depression, 5-9=mild depression, 10-14=moderate depression and ≥15=severe depression.
|
3-months follow-up (after the end of the 6-week's programme)
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Anxiety at Baseline: Generalised Anxiety Disorder Assessment (GAD-7)
Time Frame: Baseline (pre-treatment: up to one week before the programme)
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The Generalised Anxiety Disorder Assessment (GAD-7) contains seven items that screen for and measure the severity of anxiety in the clinical setting.
The items are based on the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV).
This will be measured at baseline (pre-treatment: up to one week before the programme).
The total range of scores is 0-21, where 5-9=mild anxiety, 10-14=moderate anxiety and ≥15=severe anxiety.
|
Baseline (pre-treatment: up to one week before the programme)
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Anxiety at the End of Treatment (6-weeks): Generalised Anxiety Disorder Assessment (GAD-7)
Time Frame: 6-weeks (end of the programme)
|
The Generalised Anxiety Disorder Assessment (GAD-7) contains seven items that screen for and measure the severity of anxiety in the clinical setting.
The items are based on the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV).
This will be measured at the end of the 6-week's programme.
The total range of scores is 0-21, where 5-9=mild anxiety, 10-14=moderate anxiety and ≥15=severe anxiety.
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6-weeks (end of the programme)
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Anxiety at 3-months Follow up: Generalised Anxiety Disorder Assessment (GAD-7)
Time Frame: 3-months follow-up (after the end of the 6-week's programme)
|
The Generalised Anxiety Disorder Assessment (GAD-7) contains seven items that screen for and measure the severity of anxiety in the clinical setting.
The items are based on the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV).
This will be measured at 3-months follow up after the end of the 6-week's programme.
The total range of scores is 0-21, where 5-9=mild anxiety, 10-14=moderate anxiety and ≥15=severe anxiety.
|
3-months follow-up (after the end of the 6-week's programme)
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Self-efficacy at Baseline: Pain Self Efficacy Questionnaire (PSEQ)
Time Frame: Baseline (pre-treatment: up to one week before the programme)
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The Pain Self-Efficacy Questionnaire (PSEQ) contains 10 items that assess a persons' confidence in their ability to do things despite their pain.
This will be measured at baseline (pre-treatment: up to one week before the programme).
The range of total scores is 0-60 where PSEQ≥40 indicate those patients who are more likely to continue implementing coping strategies and PSEQ≤16 are considered low.
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Baseline (pre-treatment: up to one week before the programme)
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Self-efficacy at the End of Treatment: Pain Self Efficacy Questionnaire (PSEQ)
Time Frame: 6-weeks (end of the programme)
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The Pain Self-Efficacy Questionnaire (PSEQ) contains 10 items that assess a persons' confidence in their ability to do things despite their pain.
This will be measured at the end of the 6-week's programme.
The range of total scores is 0-60 where PSEQ≥40 indicate those patients who are more likely to continue implementing coping strategies and PSEQ≤16 are considered low.
|
6-weeks (end of the programme)
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Self-efficacy at 3-months Follow up: Pain Self Efficacy Questionnaire (PSEQ)
Time Frame: 3-months follow-up (after the end of the 6-week's programme)
|
The Pain Self-Efficacy Questionnaire (PSEQ) contains 10 items that assess a persons' confidence in their ability to do things despite their pain.
This will be measured at 3-months follow up after the end of the 6-week's programme.
The range of total scores is 0-60 where PSEQ≥40 indicate those patients who are more likely to continue implementing coping strategies and PSEQ≤16 are considered low.
|
3-months follow-up (after the end of the 6-week's programme)
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Fatigue at Baseline: Chalder Fatigue Questionnaire (CFQ)
Time Frame: Baseline (pre-treatment: up to one week before the programme)
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The Chalder Fatigue Questionnaire (CFQ) contains two subscales: physical fatigue (seven items) and mental fatigue (four items).
This will be measured at baseline (pre-treatment: up to one week before the programme).
The total range for physical fatigue is 7-28 and the range for mental fatigue is 4-16, where higher scores indicated less fatigue.
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Baseline (pre-treatment: up to one week before the programme)
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Fatigue at the End of Treatment: Chalder Fatigue Questionnaire (CFQ)
Time Frame: 6-weeks (end of the programme)
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The Chalder Fatigue Questionnaire (CFQ) contains two subscales: physical fatigue (seven items) and mental fatigue (four items).
This will be measured at the end of the 6-week's programme.
The total range for physical fatigue is 7-28 and the range for mental fatigue is 4-16, where higher scores indicated less fatigue.
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6-weeks (end of the programme)
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Fatigue at 3-months Follow up: Chalder Fatigue Questionnaire (CFQ)
Time Frame: 3-months follow-up (after the end of the 6-week's programme)
|
The Chalder Fatigue Questionnaire (CFQ) contains two subscales: physical fatigue (seven items) and mental fatigue (four items).
This will be measured at 3-months follow up after the end of the 6-week's programme.
The total range for physical fatigue is 7-28 and the range for mental fatigue is 4-16, where higher scores indicated less fatigue.
|
3-months follow-up (after the end of the 6-week's programme)
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Pain-related Anxiety, Fear and Avoidance at Baseline: Pain Anxiety Symptoms Scale-short Version (PASS-20)
Time Frame: Baseline (pre-treatment: up to one week before the programme)
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The Pain Anxiety Symptoms Scale-short version (PASS-20) measures pain-related fear, anxiety and avoidance and it contains four subscales: cognitive anxiety, escape/avoidance, fearful thoughts and physiological anxiety.
This will be measured at baseline (pre-treatment: up to one week before the programme).
Only the Escape/avoidance subscale data were analysed to provide an measure of avoidance.
The total score of this 5 item subscale ranges from 0-25 where higher scores indicated greater avoidance.
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Baseline (pre-treatment: up to one week before the programme)
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Pain-related Anxiety, Fear and Avoidance at the End of Treatment: Pain Anxiety Symptoms Scale-short Version (PASS-20)
Time Frame: 6-weeks (end of the programme)
|
The Pain Anxiety Symptoms Scale-short version (PASS-20) measures pain-related fear, anxiety and avoidance and it contains four subscales: cognitive anxiety, escape/avoidance, fearful thoughts and physiological anxiety.
This will be measured at the end of the 6-week's programme.
Only the Escape/avoidance subscale data were analysed to provide an measure of avoidance.
The total score of this 5 item subscale ranges from 0-25 where higher scores indicated greater avoidance.
|
6-weeks (end of the programme)
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Pain-related Anxiety, Fear and Avoidance at 3-months Follow up: Pain Anxiety Symptoms Scale-short Version (PASS-20)
Time Frame: 3-months follow-up (after the end of the 6-week's programme)
|
The Pain Anxiety Symptoms Scale-short version (PASS-20) measures pain-related fear, anxiety and avoidance and it contains four subscales: cognitive anxiety, escape/avoidance, fearful thoughts and physiological anxiety.
This will be measured at 3-months follow up after the end of the 6-week's programme.
Only the Escape/avoidance subscale data were analysed to provide an measure of avoidance.
The total score of this 5 item subscale ranges from 0-25 where higher scores indicated greater avoidance.
|
3-months follow-up (after the end of the 6-week's programme)
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Physical and Mental Function at Baseline: 12-Item Short-Form Health Survey (SF-12)
Time Frame: Baseline (pre-treatment: up to one week before the programme)
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The 12-Item Short-Form Health Survey (SF-12) is a generic health survey that assesses physical and mental function.
This will be measured at baseline (pre-treatment: up to one week before the programme).
The two subscale scores have a maximum score of 100, where higher scores indicated better function.
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Baseline (pre-treatment: up to one week before the programme)
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Physical and Mental Function at the End of Treatment: 12-Item Short-Form Health Survey (SF-12)
Time Frame: 6-weeks (end of the programme)
|
The 12-Item Short-Form Health Survey (SF-12) is a generic health survey that assesses physical and mental function.
This will be measured at the end of the 6-week's programme.
The two subscale scores have a maximum score of 100, where higher scores indicated better function.
|
6-weeks (end of the programme)
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Physical and Mental Function at 3-months Follow up: 12-Item Short-Form Health Survey (SF-12)
Time Frame: 3-months follow-up (after the end of the 6-week's programme)
|
The 12-Item Short-Form Health Survey (SF-12) is a generic health survey that assesses physical and mental function.
This will be measured at 3-months follow up after the end of the 6-week's programme.
The two subscale scores have a maximum score of 100, where higher scores indicated better function.
|
3-months follow-up (after the end of the 6-week's programme)
|
General Health Status and Quality of Life at Baseline: EuroQol (EQ-5D-5L)
Time Frame: Baseline (pre-treatment: up to one week before the programme)
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The EuroQol (EQ-5D-5L) is a generic measure of health status that is widely used to assess both clinical and economic efficacy; and to compare health status across diseases.
This will be measured at baseline (pre-treatment: up to one week before the programme).
The EQ-5D-5L was calculated as an index score (0-1) where higher scores indicate better health-related quality of life.
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Baseline (pre-treatment: up to one week before the programme)
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General Health Status and Quality of Life at the End of Treatment: EuroQol (EQ-5D-5L)
Time Frame: 6-weeks (end of the programme)
|
The EuroQol (EQ-5D-5L) is a generic measure of health status that is widely used to assess both clinical and economic efficacy; and to compare health status across diseases.
This will be measured at the end of the 6-week's programme.
The EQ-5D-5L was calculated as an index score (0-1) where higher scores indicate better health-related quality of life.
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6-weeks (end of the programme)
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General Health Status and Quality of Life at 3-months Follow up: EuroQol (EQ-5D-5L)
Time Frame: 3-months follow-up (after the end of the 6-week's programme)
|
The EuroQol (EQ-5D-5L) is a generic measure of health status that is widely used to assess both clinical and economic efficacy; and to compare health status across diseases.
This will be measured at 3-months follow up after the end of the 6-week's programme.
The EQ-5D-5L was calculated as an index score (0-1) where higher scores indicate better health-related quality of life.
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3-months follow-up (after the end of the 6-week's programme)
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Collaborators and Investigators
Investigators
- Principal Investigator: Deborah Antcliff, PhD, BSc, Pennine Acute Hospitals NHS Trust
Publications and helpful links
General Publications
- Antcliff D, Campbell M, Woby S, Keeley P. Activity Pacing is Associated With Better and Worse Symptoms for Patients With Long-term Conditions. Clin J Pain. 2017 Mar;33(3):205-214. doi: 10.1097/AJP.0000000000000401.
- Antcliff D, Keenan AM, Keeley P, Woby S, McGowan L. Testing a newly developed activity pacing framework for chronic pain/fatigue: a feasibility study. BMJ Open. 2021 Dec 8;11(12):e045398. doi: 10.1136/bmjopen-2020-045398.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- IRAS:242203, V2.1, 27.04.18
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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