Clinical Trials on Critical Aortic Stenosis

Total 7998 results

Meshalkin Research Institute of Pathology of Circulation

Recruiting

Esmolol for Myocardial Protection in Hypertrophic Obstructive Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Russian Federation
Tau Pnu Medical Co., Ltd.

Recruiting

First-in-Man Early Feasibility Study for Transcatheter HOCM Septal Ablation

Hypertrophic Obstructive Cardiomyopathy

Korea, Republic of
Bristol-Myers Squibb

Active, not recruiting

A Study of Mavacamten in Obstructive Hypertrophic Cardiomyopathy (HORIZON-HCM)

Cardiomyopathy, Hypertrophic Obstructive

Japan
Xijing Hospital

Active, not recruiting

The Safety and Influencing Factors of Liwen Procedure in The Treatment of Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

China
Assiut University

Unknown

Hyp Obst Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy
Rabin Medical Center

Unknown

Evaluate the Efficacy of Disopyramide Therapy in Hypertrophic Obstructive Cardiomyopathy Patients

Cardiomyopathy
Celltrion

Terminated

A Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CT-G20 in Subjects With Obstructive Hypertrophic Cardiomyopathy

Cardiomyopathy, Hypertrophic Obstructive

Korea, Republic of, United States, Poland
Ottawa Heart Institute Research Corporation

Terminated

Mobilization of Endothelial Progenitor Cells and Aspirin (TROPHIC 3)

Hypertrophic Obstructive Cardiomyopathy

Canada
University Hospital, Bordeaux
Amicus Therapeutics; Fédération Française de Cardiologie; Fondation Bordeaux...

Completed

Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies (HCM-Vein)

Endothelial Dysfunction | Hypertrophic Cardiomyopathy

France
Xijing Hospital
Hangzhou Nuo Cheng Medical Instrument Co.,Ltd

Unknown

The Clinical Research of the Safety and Effectiveness Evaluation for Using Echocardiography-guided Liwen RF Radiofrequency Ablation System to Treat Hypertrophic Obstructive Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

China
Meshalkin Research Institute of Pathology of Circulation

Completed

Mitral Valve Management During Septal Myectomy (MVMSM)

Hypertrophic Cardiomyopathy

Russian Federation
Xinhua Hospital, Shanghai Jiao Tong University...
RenJi Hospital; Ruijin Hospital; Shanghai Jiao Tong University Affiliated Sixth...

Unknown

Evaluating the Effect of Spironolactone on Hypertrophic Cardiomyopathy

Fibrosis | Hypertrophic Cardiomyopathy

China
Xijing Hospital

Unknown

Echocardiography-guided Transthoracic Radio Frequency/Laser Ablation for Ventricular Septum of Hypertrophic Obstructive Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

China
Nantes University Hospital

Completed

Burden Comorbidities and Transcatheter Aortic Valve Implantation (TAVIQUAL)

Symptomatic Severe Aortic Valve Stenosis in Older Patients

France
Shanghai MicroPort Medical (Group) Co., Ltd.

Unknown

Safety and Efficacy Study of MicroPort's Transcatheter Aortic Valve and Delivery System for TAVI

Aortic Valve Stenosis | Aortic Valve Disease | Aortic Valve Calcification

China
University of Pennsylvania
National Heart, Lung, and Blood Institute (NHLBI)

Not yet recruiting

Sodium Glucose Co-transporter (SGLT) Inhibitors in Nonobstructive Hypertrophic Cardiomyopathy (SOTA-CROSS HCM)

Hypertrophic Cardiomyopathy Without Obstruction
Hangzhou Valgen Medtech Co., Ltd

Not yet recruiting

Feasibility Study of the DragonFire for Hypertrophic Obstructive Cardiomyopathy

Obstructive Hypertrophic Cardiomyopathy

China
China National Center for Cardiovascular Diseases

Recruiting

Percutaneous Endocardial Septal Radiofrequency Ablation in Obstructive Hypertrophic Cardiomyopathy

Obstructive Hypertrophic Cardiomyopathy

China
Second Xiangya Hospital of Central South University

Recruiting

Safety and Efficacy of Stereotactic Body Radiotherapy in the Treatment of Hypertrophic Obstructive Cardiomyopathy (SAFECARE)

Hypertrophic Obstructive Cardiomyopathy | Stereotactic Body Radiotherapy

China
Bristol-Myers Squibb

Not yet recruiting

A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Obstructive Hypertrophic Cardiomyopathy

Korea, Republic of
Ji Xing Pharmaceuticals (Shanghai) Co., Ltd.

Recruiting

An Open-Label Study of Aficamten for Chinese Patients With Symptomatic oHCM

Obstructive Hypertrophic Cardiomyopathy

China
Xiang Wei

Recruiting

Transapical Beating-Heart Septal Myectomy in Patients With Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

Nonobstructive Hypertrophic Cardiomyopathy

China
Istituto Auxologico Italiano

Recruiting

Permanent Pacing for Drug-refractory Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy. (PACE-OHCM)

Obstructive Hypertrophic Cardiomyopathy

Italy
Cytokinetics

Recruiting

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM (MAPLE-HCM)

Obstructive Hypertrophic Cardiomyopathy (oHCM)

United States, Denmark, Spain, Netherlands, United Kingdom, Germany, France, China, Israel, Italy, Hungary, Canada
Bristol-Myers Squibb

Recruiting

A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive HCM) (DISCOVER-HCM)

Obstructive Hypertrophic Cardiomyopathy

United States, Puerto Rico
Cytokinetics

Enrolling by invitation

Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM (FOREST-HCM)

Symptomatic Hypertrophic Cardiomyopathy (HCM)

United States, France, Israel, Spain, United Kingdom, Italy, Portugal, Poland, Hungary, Denmark, Netherlands, Germany, Czechia
Bristol-Myers Squibb

Active, not recruiting

COLLIGO-HCM: A Multinational Observational Study of the Real-World Effectiveness of Mavacamten Among Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM) (COLLIGO-HCM)

Hypertrophic Cardiomyopathy (HCM)

United States
Cytokinetics
Ji Xing Pharmaceuticals (Shanghai) Co., Ltd.

Completed

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM (SEQUOIA-HCM) (SEQUOIA-HCM)

Obstructive Hypertrophic Cardiomyopathy (oHCM)

United States, France, Spain, Portugal, Germany, China, United Kingdom, Israel, Netherlands, Denmark, Czechia, Hungary, Italy, Poland
University of Texas Southwestern Medical Center
American Heart Association; Biotronik SE & Co. KG; American College of Sports...

Completed

High Intensity Exercise for Increasing Fitness in Patients With Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy

United States
MyoKardia, Inc.

Completed

A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) (MAVERICK-HCM)

Non-obstructive Hypertrophic Cardiomyopathy

United States
University Hospital, Bordeaux

Completed

Hyper-synchronicity in Hypertrophic Cardiomyopathy (HCM) : Description, Mechanism and Origin With a Multi-imaging Approach to Predict Dual Chamber Pacing Response (HSYNC)

Hypertrophic Cardiomyopathy | Mechanical Hyper-synchronicity

France
University Hospital, Montpellier

Withdrawn

Depression and Major Adverse Events in Older Patients Who Undergo a Transcatheter Aortic Valve Implantation (TAVIDEP)

Depression | Aortic Stenosis
NYU Langone Health

Completed

Aortic Valve and Root Measurements Under Real-Time 3-Dimensional Visualization During Angiography

Coronary Artery Disease | Aortic Stenosis

United States
David C. Rotzinger

Recruiting

Impact of Fast-rotation Coronary CT in Patients Undergoing Aortic Stenosis Workup (FAST-CCT)

Cardiovascular Diseases | Aortic Valve Stenosis | Coronary Stenosis

Switzerland
Medical University of Graz

Terminated

Effect of TF-TAVR on Emotional Status, Quality of Life, Frailty and Inflammation

Depression | Inflammation | Aortic Valve Stenosis | Frail Elderly Syndrome | Clinical Trial

Austria
Jordan Collaborating Cardiology Group

Not yet recruiting

Prevalence of ATTR Cardiac Amyloidosis in Patients Undergoing TAVR

Aortic Valve Stenosis | Severe Aortic Stenosis | ATTR Amyloidosis Wild Type | Middle East Studies
REDNVIA Co., Ltd.

Recruiting

A Study to Evaluate the Efficacy and Safety of DA-1229 (Evogliptin) in Patient's Calcific Aortic Valve Disease With Mild to Moderate Aortic Stenosis (EVOID-AS)

Calcific Aortic Valve Disease

United States
Case Western Reserve University

Completed

Intensive Communication for Chronically Critically Ill

Critical Care

United States
University Hospital, Strasbourg, France

Not yet recruiting

Expression of Sodium-glucose Co-transporter 2 in Human Heart (SGLT2-MICRA)

Aortic Valve Stenosis

France
University of Virginia

Recruiting

Platelet Adhesion in the Pathobiology of Aortic Stenosis

Aortic Valve Stenosis

United States
University Hospital, Lille
Ministry of Health, France

Recruiting

Balloon-Expandable Versus Self-expanding Transcatheter Heart Valve for Treatment of Symptomatic Native Aortic Valve Stenosis (BEST) (BEST)

Aortic Valve Stenosis

France
Radboud University Medical Center

Recruiting

Myeloid Cells in Aortic Valve Stenosis (MIRACLE)

Aortic Valve Stenosis | Aortic Valve Disease

Netherlands
Meril Life Sciences Pvt. Ltd.

Recruiting

Myval Global Study of Myval™ THV Series Implanted in Patients With Native Severe Aortic Valve Stenosis.

Aortic Valve Stenosis

Slovenia, Spain, Turkey, Italy, Netherlands, Estonia, Poland
University Hospital, Rouen
University Hospital, Caen

Recruiting

Measurement of Myocardial Stiffness Using Elastometry in Patients With Aortic Stenosis (ELASTOP-AS)

Aortic Valve Stenosis

France
Biotronik AG
Medstar Health Research Institute

Completed

BIOVALVE - I / II Clincial Investigation (BIOVALVE)

Aortic Valve Stenosis | Heart Valve Diseases

Belgium, Germany, Switzerland, Netherlands
Catharina Ziekenhuis Eindhoven

Active, not recruiting

Stress Aortic Valve Index for Assessing Risk in Aortic Valve Stenosis Patients (SAVI-AoS)

Aortic Valve Stenosis

Denmark, Netherlands, United States
Cardiawave SA

Completed

Valvosoft First-In-Man Study in Severe Symptomatic Aortic Stenosis

Aortic Valve Stenosis

France, Netherlands
Cardiawave SA

Active, not recruiting

Valvosoft First-In-Human Study in Severe Symptomatic Aortic Stenosis

Aortic Valve Stenosis

Serbia
Aarhus University Hospital Skejby

Completed

Pressure Gradient vs. Flow Relationships in Patients With Symptomatic Valvular Aortic Stenosis (PREFLOW)

Aortic Valve Stenosis

Denmark
Edwards Lifesciences

Active, not recruiting

ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis

Aortic Valve Stenosis

United States

Clinical Trials on Critical Aortic Stenosis

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