Clinical Trials on De Novo Mutation

Total 1880 results

National Cancer Institute (NCI)

Completed

A Phase II Study Of The Farnesyltransferase Inhibitor ZANESTRA (R115777, NSC #702818, IND #58,359) In Complete Remission Following Induction And/Or Consolidation Chemotherapy In Adults With Poor-Risk Acute Myelogenous Leukemia (AML) And High-Risk Myelodysplasia (MDS)

Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) | Adult Acute Myeloid Leukemia... and other conditions

United States
Indiana University
United States Department of Defense; University of Notre Dame

Completed

Limb Health and Socket Pressure in Response to Powered Ankle Protheses (OPORP)

Amputation | Prosthesis User | Mobility Limitation | Pressure Ulcer, Ankle | Prosthesis Durability | Skin Wound | Amputation; Traumatic, Foot | Limb Deficiencies

United States
VA Office of Research and Development
University of Washington

Completed

Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amputees While They Are Walking

Leg Injuries | Diabetes Complications | Amputation | Traumatic Amputation

United States
Blokhin's Russian Cancer Research Center

Recruiting

Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer (GENCONCOR-1)

Colorectal Cancer Metastatic | Brain Metastases, Adult | HER2 Gene Mutation | MSI | BRAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation

Russian Federation
Henan Cancer Hospital

Unknown

S-1 Plus Gefitinib Versus Gefitinib Monotherapy in Patients With EGFR-sensitive Mutation Advanced Non-squamous NSCLC

Advanced NSCLC With EGFR Mutation

China
Assistance Publique - Hôpitaux de Paris

Unknown

Screening of Pulmonary Veino Occlusive Disease in Heterozygous EIF2AK4 Mutation Carriers (DELPHI-4)

Genetic Syndrome | Mutation

France
Nantes University Hospital

Terminated

Analysis of Oculo-motor Deficiencies Associated With FMR1 Gene Expression (Genetic Abnormality Predisposing to a Neurodegenerative Disease)

Pre-mutation on FMR1 Gene

France
University of Washington

Not yet recruiting

E-Socket, Diagnostic Monitoring

Trans-Tibial Amputation
University of Florida

Not yet recruiting

Clinical Trial to Compare Clear Aligners' Auxiliaries on Rotational Accuracy

Rotation of Tooth
Centre Hospitalier Universitaire de Nīmes

Not yet recruiting

Identification of Limiting Factors in the Locomotor Activity of Individuals With Lower Limb Amputation: (AMPUTEEFACT)

Lower Limb Amputation
Assiut University

Not yet recruiting

Consequences of Female Genital Mutilation on Married Women.

Female Genital Mutilation
VA Office of Research and Development

Recruiting

Improving Prosthetic Provision in Rural Communities: Limb Scanning With Caregiver Assistance

Lower Extremity Amputation

United States
YourResearchProject Pty Ltd
Össur Ehf

Recruiting

Biomechanical Assessment of Load Applied on Residuum of Individuals With Limb Loss Fitted With a Prosthetic Limb

Amputation | Prosthesis User

Australia
FondationbHopale
Lille Catholic University

Recruiting

Walking Strategies in Usual Locomotion of Lower Limb Amputees (STRAAL)

Lower Limb Amputation

France
Duke University

Recruiting

Hyperbaric Oxygen and Outcome After Below Knee Amputations

Amputation; Postoperative, Sequelae

United States
Seattle Institute for Biomedical and Clinical Research
United States Department of Defense

Active, not recruiting

Adherence and Perspiration While Wearing Lower Limb Prostheses

Lower Extremity Amputation

United States
University of Washington
WillowWood Global LLC

Completed

Community Walking Trials: Comparing Prosthetic Feet

Lower Extremity Amputation

United States
Indiana University
United States Department of Defense

Completed

Development of Adaptive Vacuum Suspension to Improve Prosthetic Fit and Residual Limb Health (DoD)

Lower Limb Amputation

United States
Infinite Biomedical Technologies

Completed

RESCU System for Robust Upper Limb Prosthesis Control (RESCU)

Amputation | Upper Limb

United States
Tan Tock Seng Hospital
Prosfit Technologies JSC; Centre for Allied Health and Pharmacy Excellence...

Completed

Evaluating User Satisfaction and Feasibility of a Remote Model for 3d Scanned and Printed Transtibial Prosthetic Sockets

Amputation | Prosthesis User

Singapore
George Mason University
National Institute for Biomedical Imaging and Bioengineering (NIBIB); Infinite...

Enrolling by invitation

Sonomyographic Upper Limb Prosthetics: A New Paradigm

Amputation | Prosthesis User

United States
Darlington-Peter Chibuzor Ugoji

Completed

Does Oral Propranolol Accelerate Labor Induction/Augmentation With Oxytocin in Nulliparous Women in Abakaliki?

Duration of Labor

Nigeria
University Rehabilitation Institute, Republic of...

Completed

Metric Charcteristics of Sit-to-stand Tests in Patients After Lower-limb Amputation (STST)

Lower Limb Amputation

Slovenia
University of California, San Francisco

Completed

Impact of a Lower Extremity Amputation Pathway Protocol in Dysvascular Patients

Lower Extremity Amputation

United States
Mayo Clinic

Completed

Comparative Performance of Dynamic Elastic Response Feet

Transtibial Amputation - Unilateral

United States
Queen Margaret University

Completed

Outcome Measures for Lower Limb Amputees - A Repeatability Study

Lower Limb Amputation

United Kingdom
Queen Margaret University

Completed

Outcome Measures for Lower Limb Amputees - A Rehabilitation Study

Lower Limb Amputation

United Kingdom
Heidelberg University

Unknown

Relevance of Biomarkers in the Process of Weaning

Duration of Weaning

Germany
Dokuz Eylul University

Not yet recruiting

Comparison of The Effects of Different Stretching Techniques in Overhead Athletes

Glenohumeral Internal Rotation Deficit
Orthocare Innovations, LLC
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Withdrawn

Energy-Harvesting Mesofluidic Impulse Prosthesis: e-MIP

Transtibial Amputation | Artificial Limbs

United States
Liberating Technologies, Inc.

Completed

Myoelectric Game Training and Outcomes

Amputation | Prosthesis | Prosthesis User

United States
Montreal General Hospital

Completed

Intravenous and Perineural Dexamethasone for Ultrasound-Guided Axillary Blocks

Brachial Plexus Block Duration

Canada, Thailand
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Fludarabine Phosphate, Cytarabine, Filgrastim-sndz, Gemtuzumab Ozogamicin, and Idarubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Untreated Adult Acute Myeloid Leukemia | Myelodysplastic Syndrome With Excess Blasts | High Risk Myelodysplastic Syndrome | de Novo Myelodysplastic Syndrome | Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1 | Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 | Acute Myeloid... and other conditions

United States
Shanghai Jiatan Pharmatech Co., Ltd

Recruiting

A Study of WX390 Combined With Toripalimab in Patients With Advanced Gastric-type Endocervical Adenocarcinoma With STK11 Mutations

Gastric Type Adenocarcinoma (GAS) With STK11 Mutation

China
Novartis Pharmaceuticals

Active, not recruiting

Study of Efficacy and Safety of Voretigene Neparvovec in Japanese Patients With Biallelic RPE65 Mutation-associated Retinal Dystrophy

Biallelic RPE65 Mutation-associated Retinal Dystrophy

Japan
Eloxx Pharmaceuticals, Inc.
SGS Life Sciences, a division of SGS Belgium NV

Completed

Phase 1 Study of ELX-02 in Healthy Adults

Genetic Disease | Nonsense Mutation

Belgium
European Institute of Oncology

Recruiting

LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients (LobularCard)

BRCA1 Mutation | BRCA2 Mutation | Lobular Breast Carcinoma | Lobular in Situ Breast Carcinoma

Italy
Aarhus University Hospital

Completed

Reconstruction of the Medial Patellofemoral Ligament - A Randomised Controlled Trial Comparing Two Surgery Technics

Knee Stability | Patella Luxation

Denmark
Sensorion

Recruiting

Natural History in Children up to 10 Years With Moderate to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes (Otoconex)

Sensorineural Hearing Loss, Bilateral | Congenital Deafness | AUNB1 | DFNB1A | DFNB9 | OTOF Gene Mutation | GJB2 Gene Mutation

France
Bayer

Recruiting

First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)

Advanced Non-small Cell Lung Cancer | EGFR Mutation | HER2 Mutation

Hong Kong, United States, Taiwan, Spain, Belgium, China, Japan, France, Korea, Republic of, Singapore, Poland, Israel, Italy, Netherlands, Portugal, Brazil
Bayer

Completed

A Study to Learn About How Itraconazole and Carbamazepine Affect the Level of BAY2927088 in the Blood When These Drugs Are Taken Together by Healthy Participants

Healthy Volunteers | Advanced Non-small Cell Lung Cancer | EGFR Mutation | HER2 Mutation

United States
GenoSaber
Sun Yat-sen University; Shanghai Chest Hospital; Shanghai Pulmonary Hospital,...

Unknown

Human EGFR Mutations Quantitative Detection Kit (Real-time Fluorescent PCR Method)

Non Small Cell Lung Cancer | EGFR-TKI Resistant Mutation | EGFR-TKI Sensitizing Mutation
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Cycling in Preventing Colorectal Cancer in Participants With Lynch Syndrome

High-Frequency Microsatellite Instability | Mismatch Repair Gene Mutation | Mutation-Negative Lynch Syndrome | Mutation-Positive Lynch Syndrome

United States
Centre Hospitalier Universitaire de Nīmes

Completed

Asymmetry of the Center of Pressure During Gait After Amputation of Lower Limbs (ASCOPALL)

Lower Limb Amputation Below Knee (Injury) | Lower Limb Amputation Above Knee (Injury)

France
Minneapolis Veterans Affairs Medical Center
United States Department of Defense

Completed

Women's-Specific Footwear With Prosthetic Feet (WSF)

Lower Limb Amputation Below Knee (Injury) | Lower Limb Amputation Above Knee (Injury)

United States
Istituti Clinici Scientifici Maugeri SpA

Recruiting

Clinical and Psychological Adjustment of Patients With LLA: a Multidisciplinary Rehabilitative Intervention Project (AMPADinRehab)

Prosthesis User | Lower Limb Amputation

Italy
University of Zurich
ETH Zurich

Recruiting

CNS Changes Following Amputation

Amputation, Congenital | Upper Limb; Amelia

Switzerland
Sunnybrook Health Sciences Centre

Recruiting

Psychosocial Transitional Group Pragmatic Trial

Amputation | Mental Health | Psychotherapy, Group

Canada
University of Wisconsin, Madison
United States Department of Defense

Recruiting

Evaluating Mobility Interventions in the Real World

Lower Limb Amputation | Drop Foot

United States
Hospices Civils de Lyon

Recruiting

Double Upper Limb Allograft: Intervention and Clinical Evaluation. A Pilot Study of 5 Cases (DAMIE)

Bilateral Amputation of Upper Limb

France

Clinical Trials on De Novo Mutation

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Uruguay

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations