Clinical Trials on Immune Reconstitution Inflammatory Syndrome in South Africa

Total 771 results

Janssen Research & Development, LLC

Completed

A Study to Assess the Acceptability of the Darunavir/Cobicistat (DRV/COBI) Fixed-dose Combination (FDC) Tablet in Human Immunodeficiency Virus (HIV)-1 Infected Children

Human Immunodeficiency Virus (HIV)

United States, Spain, South Africa
Wellcome Trust Liverpool Glasgow Centre for Global...
Professor David Lalloo; Professor Hamish Simpson; Professor William J Harrison; Professor Sithombo Maqungo

Unknown

HIV in Orthopaedic Skeletal Trauma Study (HOST)

Fracture Healing in HIV-positive Patients

South Africa
National Institute of Allergy and Infectious Diseases...
GlaxoSmithKline; Bill and Melinda Gates Foundation; Medical Research Council; Sanofi... and other collaborators

Completed

A Safety and Immune Response Study of 2 Experimental HIV Vaccines

HIV Infection

South Africa
ANRS, Emerging Infectious Diseases
University of KwaZulu; Africa Centre For Health and Population Studies

Completed

Impact of Immediate Versus South African Recommendations Guided ART Initiation on HIV Incidence (TasP)

HIV Infection

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Acceptability, Safety, and Use of Daily Truvada Pre-Exposure Prophylaxis in Adolescents

HIV Infections

South Africa
Walter Sisulu University
Medical University of Graz; Nelson Mandela Academic Hospital; Umtata General...

Not yet recruiting

Cardiometabolic Health of Children Exposed to Anti-retroviral Therapy (ART) in Utero (ARTMOMSBABES)

In Utero Drug Exposure

South Africa
Africa Health Research Institute

Recruiting

Long-Acting HIV Pre-Exposure Prophylaxis Integrated With Sexual and Reproductive Health - cRCT (LAPIS)

HIV Infections

South Africa
University of Sussex
University of Cape Town; Africa Health Research Institute

Not yet recruiting

Optimised Electronic Patient Records to Improve Clinical Monitoring of HIV-positive Patients in Rural South Africa (MONART)

HIV Infections

South Africa
London School of Hygiene and Tropical Medicine
Department for International Development, United Kingdom; University of Witwatersrand... and other collaborators

Completed

The Intervention With Microfinance for AIDS and Gender Equity (IMAGE) Study

HIV Infections | Gender Based Violence

South Africa
University of Washington
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Point-of-care Viral Load Testing to Enable Streamlined Care and Task Shifting for Chronic HIV Care (STREAM)

Chronic HIV Infection

South Africa
International Partnership for Microbicides, Inc.

Completed

Observational Study of HIV Infection in Participants of Seroconvert During Dapivirine Vaginal Ring Trials

HIV Infections

South Africa, Rwanda
University of Witwatersrand, South Africa

Unknown

A Comparison of Immediate Treatment of CIN1 With Cryotherapy and 12 Month Cytology Follow up in HIV Seropositive Women

Cervical Dysplasia

South Africa
Duke University
The Emmes Company, LLC

Recruiting

Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana (BMS02)

HIV Infections | Lactating Women on Select DOI | Breastmilk Fed Infants of Mothers on Select DOI

South Africa
Johns Hopkins Bloomberg School of Public Health
National Institute of Mental Health (NIMH); Unity Health Toronto; TB/HIV Care

Recruiting

Project Phakama: Testing Support Strategies to Empower Young Women on PrEP in South Africa

HIV Infections | Pre-exposure Prophylaxis

South Africa
Massachusetts General Hospital
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure on TLD in Sub-Saharan Africa (RESOLVE)

HIV Infections | AIDS | Virologic Failure

South Africa, Uganda
Imperial College London
University of Cape Town

Completed

Male Partner Involvement in the Prevention of MTCT of HIV

HIV Infections

South Africa
Elizabeth Glaser Pediatric AIDS Foundation
Harvard School of Public Health (HSPH); Centre for Infectious Disease Research... and other collaborators

Completed

Elizabeth Glaser Pediatric AIDS Foundation Maternal Events and Pregnancy Outcomes (MEP Project)A Multi-site Protocol (MEPProject)

HIV Infections | Pregnant Women | HIV Positive

South Africa, Zambia
University of Cape Town
Wellcome Trust; Médecins Sans Frontières, Belgium

Completed

Tenofovir-lamivudine-dolutegravir Combination as Second-line ART: a Randomised Controlled Trial (ARTIST)

HIV Infections

South Africa
University of Cape Town
Desmond Tutu HIV Centre; Wits Reproductive Health and HIV Institute

Terminated

Clinical Evaluation of Adjusted Doses of Darunavir/Ritonavir With Rifampicin in HIV-infected Volunteers (Darifi)

HIV Infections

South Africa
University of Washington
National Institute of Mental Health (NIMH)

Completed

Lotto to Link Study: A Prospective, Interventional, Randomized Study of Conditional Incentives

HIV Infections | Incentives | ART

South Africa
Boston University
National Institute of Mental Health (NIMH); Africa Health Research Institute

Completed

Life Plans Intervention Study

HIV/AIDS | Health Knowledge, Attitudes, Practice | Chronic HIV Infection

South Africa
University of Miami
National Institute of Mental Health (NIMH); Massachusetts General Hospital; University...

Completed

Effectiveness of Nurse-delivered Care for Adherence/Mood in HIV in South Africa

Depressive Symptoms | Immunodeficiency Virus, Human

South Africa, United States
Centre for Health Systems Research & Development...
World Bank; Bank-Netherlands Partnership Programme (BNPP)

Unknown

Effective Aids Treatment and Support in the Free State (FEATS) (FEATS)

HIV Infections | HIV/AIDS | Food Insecurity

South Africa
University College, London
London School of Hygiene and Tropical Medicine; MRC/UVRI and LSHTM Uganda Research... and other collaborators

Active, not recruiting

Long-Acting Treatment in Adolescents (LATA) (LATA)

HIV Infections | Hiv | HIV-1-infection | Paediatric Human Immunodeficiency Virus Infection

Uganda, Zimbabwe, Kenya, South Africa
Gilead Sciences

Active, not recruiting

Study to Evaluate the Pharmacokinetics, Safety, and Antiviral Activity of the Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) Single Tablet Regimen (STR) in HIV-1 Infected Antiretroviral Treatment-Naive Adolescents and Virologically Suppressed Children

HIV Infections | Acquired Immune Deficiency Syndrome (AIDS)

United States, Thailand, Uganda, South Africa, Zimbabwe
Henry M. Jackson Foundation for the Advancement...
Johns Hopkins University; Karolinska Institutet; University of Miami; Chulalongkorn... and other collaborators

Active, not recruiting

Safety and Effects of Using Prime-boost HIVIS DNA and MVA-CMDR Vaccine Regimens With or Without Toll-like Receptor 4 Agonist on HIV Reservoirs in Perinatally HIV Infected Children and Youth (HVRRICANE)

HIV Infections

South Africa
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); University of Cape Town

Completed

Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in South Africa

Alcohol-Related Disorders | Drug Use | Human Immunodeficiency Virus

United States, South Africa
HIV Vaccine Trials Network
National Institute of Allergy and Infectious Diseases (NIAID); AIDS Clinical... and other collaborators

Recruiting

Analytical Treatment Interruption (ATI) to Assess the Immune System's Ability to Control HIV in Participants Who Became HIV-infected During the HVTN 703/HPTN 081 AMP Study

HIV Infection

Malawi, Botswana, South Africa, Zimbabwe
National Institutes of Health Clinical Center (CC)

Completed

Antiretroviral Therapy for Advanced HIV Disease in South Africa

HIV

South Africa
University of Stellenbosch
Columbia University; McMaster University

Active, not recruiting

Mobile Phone Text Messaging Plus Motivational Interviewing: Effects on Breastfeeding, Child Health Outcomes (MTM-MI)

HIV Infections | Breastfeeding, Exclusive

South Africa
University of Stellenbosch
University of British Columbia; McMaster University

Completed

Text Messaging Plus Motivational Interviewing in Promotion of Breastfeeding Among HIV-infected Women

HIV Infections | Breast Feeding

South Africa
Harriet Shezi Children's Clinic

Unknown

Dosing, Safety and Pharmacokinetic Profile of Rifabutin in Children Receiving Concomitant Treatment With Kaletra (RBT)

Children With Confirmed HIV Infection | Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose | Successfully Completed TB Treatment in the Past 2 to 6 Weeks of Enrollment

South Africa
Boston University
National Institute of Mental Health (NIMH); Massachusetts General Hospital; New... and other collaborators

Active, not recruiting

Supporting Sustained HIV Treatment Adherence After Initiation (SUSTAIN)

HIV Infections | Adherence, Medication

South Africa
University of Stellenbosch
Thrasher Research Fund

Unknown

The Effect of Bacille Calmette Guerin (BCG) Vaccination on Immune Responses in HIV-Exposed and Unexposed Infants

HIV Infections

South Africa
Foundation for Professional Development (Pty) Ltd
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes

HIV/AIDS | Pregnancy | Cost-effectiveness | Antenatal Care | Chlamydia Trachomatis | Vaginal Microbiome | Birth Outcomes | Sexually Transmitted Infection | Neisseria Gonorrhoeae | Trichomonas Vaginalis

South Africa
University of California, San Francisco
National Institute of Allergy and Infectious Diseases (NIAID); University Hospital... and other collaborators

Not yet recruiting

Pragmatic Use of Next-generation Sequencing for Management of Drug-resistant Tuberculosis (TSELiOT)

Drug-resistant Tuberculosis | Cost-Benefit Analysis | HIV Coinfection

South Africa
University of Witwatersrand, South Africa

Completed

Validation of Implementation of Cervical Dysplasia Treatment Modalities in HIV-Seropositive Women (VICAR2)

Cervical Intraepithelial Neoplasia

South Africa
Johns Hopkins Bloomberg School of Public Health
National Institute of Mental Health (NIMH); TB/HIV Care; Community Media Trust

Completed

Le Kip Kip: A Campaign to Change Social Norms and Build Sustainable Demand for PrEP Among Women in South Africa

HIV Infections | Pre-exposure Prophylaxis

South Africa
Boehringer Ingelheim

Completed

Trial to Evaluate Steady State Pharmacokinetic Parameters, Efficacy and Safety of Nevirapine in Antiretroviral Drug naïve Pediatric Patients

HIV Infections

South Africa
ApoPharma

Completed

Evaluation of the Safety, Efficacy, and Pharmacokinetics of Intravenous Deferiprone in HIV-Positive Subjects

Asymptomatic HIV Infection

South Africa
Desmond Tutu HIV Foundation
Karolinska Institutet; University of North Carolina, Chapel Hill; ViiV Healthcare and other collaborators

Completed

Bidirectional, Upbeat Communication and Differentiated, Distanced Care for Young People (BUDDY)

HIV Infections | Covid19 | Health Care Utilization | Gender-based Violence

South Africa
Barbara Ensoli, MD
Italian Ministry of Foreign Affairs - Dir. Gen. for Cooperation and Development

Completed

Study to Assess the Seroprevalence of Anti-Tat Antibodies in HIV-infected Patients (ISS OBS T-004)

HIV Infection

South Africa
University of California, San Francisco
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Phase 2 Trial of LACTIN-V in Women at High Risk of HIV Acquisition

HIV Infections | Bacterial Vaginosis

South Africa
PATH
National Institute of Allergy and Infectious Diseases (NIAID); National Institutes... and other collaborators

Completed

Phase II Safety and Acceptability of an Investigational Injectable Product, TMC278LA, for Pre-Exposure Prophylaxis (TMC278LA)

Human Immunodeficiency Virus (HIV)

United States, South Africa, Zimbabwe
HIV Vaccine Trials Network

Completed

Safety of and Immune Response to Vaccination With 2 Experimental HIV Vaccines in Healthy Adults (HVTN 097)

HIV Infection

South Africa
Population Council
United States Agency for International Development (USAID); Bill and Melinda...

Completed

Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission

HIV Infections | Sexually Transmitted Diseases | AIDS | HIV Seroconversion

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Safety, Tolerability and Acceptability of Long-Acting Cabotegravir (CAB LA) for the Prevention of HIV Among Adolescent Females - A Sub-study of HPTN 084

HIV Infections

Zimbabwe, South Africa, Uganda
FHI 360
United States Agency for International Development (USAID); Makerere University and other collaborators

Completed

Interactions Between Antiretrovirals (ARVs) and Combined Oral Contraceptives (COCs)

HIV Infections | HIV/AIDS

South Africa, Uganda
Merck Sharp & Dohme LLC

Completed

MK-8527 Single-Dose Trial in HIV-1 Infected Participants (MK-8527-004)

Human Immunodeficiency Virus

Romania, South Africa
FHI 360
University of Cape Town; City University of New York, School of Public Health

Completed

Comparison of Two Intrauterine Devices (IUDs) Among Cape Town HIV-positive Women

HIV

South Africa

Clinical Trials on Immune Reconstitution Inflammatory Syndrome in South Africa

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Burkina Faso

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations