Clinical Trials on MEN1 Gene Mutation in United States

Total 930 results

Escape Bio, Inc.
Momentum Pharma; Science 37

Terminated

A Natural History Study of Patients With G2019S LRRK2 Parkinson's Disease

Patients With Parkinson's Disease (PD) Caused by the p.Gly2019Ser (G2019S) Pathogenic Mutation of the Leucine-Rich Repeat Kinase 2 (LRRK2) Gene

United States
NYU Langone Health

Withdrawn

3.0 Tesla Magnetic Resonance Imaging for Breast Cancer Detection in High Risk Women

Breast Cancer | BRCA1 Mutation | BRCA2 Mutation

United States
Hoffmann-La Roche

No longer available

Expanded Access to Entrectinib for Cancers With NTRK1/2/3, ROS1, or ALK Gene Fusions

Cancers With NTRK, ROS1, or ALK Gene Fusions

United States
RWJ Barnabas Health at Jersey City Medical Center

Unknown

Lynch Syndrome Can be Diagnosed Just From Somatic Mismatch Repair Mutation

Lynch Syndrome | Endometrial Cancer | Somatic Mutation | Cancer Gene Mutation

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
Merck Sharp & Dohme LLC

Active, not recruiting

Study of MK-3475 (Pembrolizumab) in Patients With Microsatellite Unstable (MSI) Tumors (Cohort D)

High Tumor Mutation Burden | High TMB (Tumor Mutation Burden) | MSS (Microsatellite Stable)

United States
Faeth Therapeutics

Active, not recruiting

Combination of Serabelisib and Insulin Suppressing Diet With or Without Nab-paclitaxel in Subjects With Advanced Solid Tumors With PIK3CA Mutations

Advanced Solid Tumor | PIK3CA Mutation | PTEN Loss of Function Mutation

United States
Massachusetts General Hospital

Completed

Depression and Body Image Distress Following Mastectomy With Reconstruction

Breast Cancer | BRCA1 Mutation | BRCA2 Mutation

United States
M.D. Anderson Cancer Center
Syndax Pharmaceuticals

Not yet recruiting

A Phase II Study of the Menin Inhibitor Revumenib in Leukemia Associated With Upregulation of HOX Genes

Leukemia | HOX Gene

United States
Gynecologic Oncology Group
National Cancer Institute (NCI)

Unknown

Studying Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers

Breast Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United States
Shirley Ryan AbilityLab
University of Alberta

Recruiting

GaMA Metric to Quantify Functional Importance of Various Upper Limb Prosthetic Devices

Amputation | Amputation; Traumatic, Hand | Amputation, Traumatic | Amputation; Traumatic, Limb

United States
Boehringer Ingelheim

Active, not recruiting

A Study to Test Different Doses of BI 1823911 Alone and Combined With Other Medicines in People With Different Types of Advanced Cancer With KRAS Mutation

Solid Tumors, KRAS Mutation

Spain, United Kingdom, United States, Belgium
Roswell Park Cancer Institute
Celgene

Withdrawn

Enasidenib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia With an IDH2 Gene Mutation

Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | IDH2 Gene Mutation | Blasts Under 5 Percent of Peripheral Blood White Cells | Bone Marrow Blasts Decreased by 50 Percent or More Compared to Pretreatment Level

United States
Georgetown University
Immune System Key Ltd

Recruiting

NEROFE and Doxorubicin in KRAS-mutated ST2-positive Solid Tumors

Solid Tumor | KRAS Mutation-Related Tumors

United States
Memorial Sloan Kettering Cancer Center
Memorial Health University Medical Center

Completed

BRCA1 Haploinsufficiency and Gene Expression

BRCA1 Mutations

United States
Merrimack Pharmaceuticals

Completed

A Study of MM-111 in Combination With Multiple Treatments in Patients With HER2 Positive Cancer

HER-2 Gene Amplification

United States
Blueprint Medicines Corporation

Active, not recruiting

(SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC

Neoplasms | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Carcinoma, Non-Small-Cell Lung | Lung Neoplasms | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Bronchial Neoplasms | Neoplasms, Nerve Tissue | EGF-R Positive Non-Small Cell Lung... and other conditions

United States, Canada, Taiwan, Korea, Republic of, Singapore, Japan, United Kingdom, France, Netherlands, Spain
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Genentech, Inc.

Recruiting

AZA + Venetoclax as Maintenance Therapy in Patients With AML in Remission

Acute Myeloid Leukemia | Therapy-Related Acute Myeloid Leukemia | Hematologic and Lymphocytic Disorder | Acute Myeloid Leukemia in Remission | FLT3 Gene Mutation | Minimal Residual Disease Persistence

United States
Iambic Therapeutics, Inc

Recruiting

A Phase 1/1b Study of IAM1363 in HER2 Cancers

HER2 Mutation-Related Tumors

United States
Massachusetts General Hospital
Agios Pharmaceuticals, Inc.

Completed

IDH1 Inhibition Using Ivosidenib as Maintenance Therapy for IDH1-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation

IDH1 Mutation Myeloid Neoplasms

United States
Kymera Therapeutics, Inc.

Suspended

Safety, PK/PD, and Clinical Activity of KT-413 in Adult Patients With Relapsed or Refractory B-cell NHL

Non Hodgkin Lymphoma | Diffuse Large B Cell Lymphoma | DLBCL | MYD88 Gene Mutation

United States, United Kingdom
Blueprint Medicines Corporation

Terminated

(HARMONY) Study of BLU-701 in EGFR-mutant NSCLC

Neoplasms | Respiratory Tract Diseases | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Carcinoma, Non-Small-Cell Lung | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Bronchial Neoplasms | Neoplasms, Nerve Tissue | Non Small Cell Lung... and other conditions

United States
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Active, not recruiting

Regorafenib, With Cetuximab or Panitumumab, for the Treatment of Unresectable, Locally Advanced, or Metastatic Colorectal Cancer

Metastatic Colorectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Stage III Colorectal Cancer AJCC v8 | Stage IIIA Colorectal Cancer AJCC v8 | Stage IIIB Colorectal Cancer AJCC... and other conditions

United States
Liberating Technologies, Inc.
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

EMG-Based Hand-Wrist Control: Study B Mirrored (PSICON-B)

Amputation | Prosthesis User | Amputation; Traumatic, Hand | Amputation, Congenital

United States
Shirley Ryan AbilityLab
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Active, not recruiting

Functional Importance of a Powered Multifunction Wrist Protocol

Amputation | Amputation; Traumatic, Limb | Upper Limb Amputation at the Hand | Upper Limb Amputation at the Wrist

United States
Shirley Ryan AbilityLab

Recruiting

Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait

Amputation | Amputation, Traumatic | Amputation; Traumatic, Limb | Amputation of Knee

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Deslorelin Combined With Low-Dose Add-Back Estradiol and Testosterone in Preventing Breast Cancer in Premenopausal Women Who Are at High Risk for This Disease

Breast Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United States
Penn State University

Completed

Temporal Genomics Mechanisms Underlying Disease and Aging

Gene Expression in Response to Acute Stress

United States
General Oncology, Inc.
Myriad Genetics, Inc.

Recruiting

SHARON: A Clinical Trial for Metastatic Cancer With a BRCA or PALB2 Mutation Using Chemotherapy and Patients' Own Stem Cells

Pancreatic Cancer | Pancreatic Ductal Adenocarcinoma | Pancreatic Cancer Stage IV | Breast Cancer Stage IV | BRCA1 Mutation | BRCA2 Mutation | Pancreatic Acinar Cell Carcinoma | Metastatic Pancreatic Cancer | Breast Cancer Metastatic | HER2-negative Breast Cancer | Metastatic Pancreatic Ductal Adenocarcinoma and other conditions

United States
Gynecologic Oncology Group
National Cancer Institute (NCI)

Withdrawn

Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers

Breast Carcinoma | BRCA1 Mutation Carrier | BRCA2 Mutation Carrier

United States
Rutgers, The State University of New Jersey
National Cancer Institute (NCI)

Terminated

Irradiated Donor Cells Following Stem Cell Transplant in Controlling Cancer in Patients With Hematologic Malignancies

Acute Lymphoblastic Leukemia | Mantle Cell Lymphoma | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Plasma Cell Myeloma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Minimal Residual Disease | Therapy-Related Acute Myeloid Leukemia | Therapy-Related Myelodysplastic... and other conditions

United States
Coapt, LLC
Congressionally Directed Medical Research Programs

Completed

Pattern Recognition Prosthetic Control (Adaptation)

Prosthesis User | Congenital Amputation of Upper Limb | Amputation; Traumatic, Limb

United States
Southern Illinois University
Memorial Medical Center; Memorial Medical Center Foundation

Completed

Vascularized Composite Allotransplantation of the Hand and Upper Extremity (Hand Transplant)

Traumatic Amputation of Arm | Traumatic Amputation of Hand

United States
SwanBio Therapeutics, Inc.

Active, not recruiting

Study of Disease Progression in Adults With Inherited Forms of Spastic Paraplegia (CYGNET)

AMN | AMN Gene Mutation | X-ALD

United States, Netherlands, Germany
Brigham and Women's Hospital

Recruiting

Vascularized Composite Allotransplantation for Multiple Extremity Amputations

Limb Amputation | Extremity Amputation

United States
Henry M. Jackson Foundation for the Advancement...
University of Miami; Walter Reed National Military Medical Center; Uniformed... and other collaborators

Unknown

Mobile Device Outcomes-based Rehabilitation Program (MDORP)

Transtibial Amputation | Transfemoral Amputation

United States
Columbia University
American Cancer Society, Inc.

Completed

Decision Support for BRCA Testing in Ethnically Diverse Women

Breast Cancer | Ovarian Cancer | BRCA1 Mutation | BRCA2 Mutation

United States
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Oral Erdafitinib in People With Recurrent Non-Invasive Bladder Cancer

Bladder Cancer | Recurrent Bladder Cancer | FGFR3 Gene Mutation

United States
Boninger, Michael, MD
National Institute of Neurological Disorders and Stroke (NINDS); Ripple Therapeutics...

Recruiting

Evaluation of Myoelectric Implantable Recording Array (MIRA) in Participants With Transradial Amputation (MIRA)

Amputation | Amputation; Traumatic, Hand

United States
Liberating Technologies, Inc.
Vivonics, Inc.

Completed

Socket Cooling Effectiveness Take Home Study

Lower Limb Amputation Below Knee (Injury) | Amputation | Prosthesis User | Amputation; Traumatic, Leg, Lower | Limb; Absence, Congenital, Lower | Amputation Stump

United States
National Institute of Environmental Health Sciences...

Completed

Estrogen Receptor Gene Mutations

Hormones | Mutations

United States
Shirley Ryan AbilityLab
United States Department of Defense

Completed

Comparison of Pattern Recognition Control and Direct Control in TMR

Amputation | Amputation; Traumatic, Arm, Upper

United States
Yale University
National Institute on Drug Abuse (NIDA)

Completed

Pharmacogenetics of Cannabinoid Response

COMT Gene Polymorphism

United States
Shirley Ryan AbilityLab
Otto Bock Healthcare

Completed

Functional Outcomes in Dysvascular Transfemoral Amputees (CLEG)

Transfemoral Amputation | Unilateral Traumatic Amputation of Leg at or Above Knee

United States
Point Designs
University of Colorado, Boulder

Completed

Teleoperation Experimental Comparison With Able-bodied Subjects

Amputation; Traumatic, Arm, Upper

United States
Georgetown University
George Washington University

Enrolling by invitation

Genetic Education in BRCA Families

BRCA1 Mutation | BRCA2 Mutation

United States
Point Designs
University of Colorado, Denver

Completed

Validation of User Needs of the Point Digit With Partial Hand Amputees

Amputation; Traumatic, Hand

United States
University of Michigan

Completed

No Power Bionic Lower Extremity Prosthesis

Amputation | Amputation, Traumatic | Amputation; Traumatic, Leg, Lower

United States
Point Designs
University of Colorado, Denver

Completed

Validation of Point Partial User Needs With Partial Finger Amputees

Amputation; Traumatic, Hand

United States
ABM Therapeutics Corporation

Recruiting

Safety and Effectiveness of ABM-168 in Adults With Advanced Solid Tumors.

Advanced Solid Tumor | RAS Mutation | NF1 Mutation | RAF Mutation

United States
Brigham and Women's Hospital

Enrolling by invitation

Kinematics of Ewing Amputees

Lower Extremity Amputation | Trans-Tibial Amputation | Traumatic Lower Extremity Amputation | Agonist-Antagonist Myoneural Interface

United States

Clinical Trials on MEN1 Gene Mutation in United States

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