Clinical Trials on Neoplastic Syndromes, Hereditary

Total 39564 results

UCSF Benioff Children's Hospital Oakland
National Cancer Institute (NCI)

Completed

Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Face

Neoplastic Syndrome

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Weight Management and Health Behavior Intervention in Lowering Cancer Risk for BRCA Positive and Lynch Syndrome Families

Lynch Syndrome | Hereditary Breast Carcinoma | Hereditary Ovarian Carcinoma

United States
National Cancer Institute (NCI)

Completed

Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and Carriers

Colorectal Neoplasm | Hereditary Nonpolyposis

United States
Sun Yat-sen University
Guangdong Provincial Hospital of Traditional Chinese Medicine; Fujian Cancer... and other collaborators

Recruiting

PD-1 Antibody for The Prevention of Adenomatous Polyps and Second Primary Tumors in Lynch Syndrome Patients

Lynch Syndrome

China
Tampere University Hospital
Tampere University

Recruiting

Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)

Lynch Syndrome | Urothelial Carcinoma

Canada, Finland
Sydney Children's Hospitals Network
Children's Cancer Institute Australia

Recruiting

Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With Newly Diagnosed Cancer (PREDICT)

Cancer | Neoplastic Syndromes, Hereditary | Genetic Predisposition to Disease

Australia
National Institute of Diabetes and Digestive and...

Completed

Studies of Elevated Parathyroid Activity

Hyperparathyroidism | Multiple Endocrine Neoplasia | Hypercalcemia | MEN1 | Parathyroid Neoplasm

United States
San Raffaele University
Unita' di Gastroenterologia - Policlinico Universitario di Bari; Unita' di... and other collaborators

Recruiting

Videocapsule Endoscopy in Lynch Syndrome

Lynch Syndrome | MLH1 Gene Mutation | MSH2 Gene Mutation | MSH6 Gene Mutation | PMS2 Gene Mutation | Lynch Syndrome II | Small Bowel Adenocarcinoma | Lynch Syndrome I

Italy
Jazz Pharmaceuticals

Active, not recruiting

Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution

Tuberous Sclerosis Complex | Dravet Syndrome | Lennox Gastaut Syndrome

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
Johns Hopkins University; National Cancer Institute (NCI)

Completed

Using High Resolution Function Imaging To Detect Melanoma and Dysplastic Nevi

Melanoma

United States
John Kirkwood

Completed

Pilot Study Evaluating Sulforaphane in Atypical Nevi-Precursor Lesions

Melanoma | Atypical Nevi

United States
Prof. Evelien Dekker, MD, PhD
Dutch Digestive Diseases Foundation

Completed

Identifying Patients With Hereditary and Familial Colorectal Cancer by Using an Online Risk Tool (FR-QUENT)

Colorectal Cancer | Lynch Syndrome | Familial Colorectal Cancer
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Completed

Tretinoin With or Without Fenretinide in Treating Patients With Dysplastic Nevus Syndrome

Melanoma (Skin)

United States
National University Health System, Singapore

Completed

Routine Transcervical Thymectomy in MEN-1 Patients

Thymic Carcinoid | Multiple Endocrine Neoplasia Type 1 (MEN-1)

Singapore
Barretos Cancer Hospital

Completed

Neoadjuvant Carboplatin in Triple Negative Breast Cancer

BRCA1 Hereditary Breast and Ovarian Cancer Syndrome

Brazil
Lei Li

Unknown

MSI in Circulatory DNA of Endometrial Cancer

Lynch Syndrome | Endometrial Cancer | Microsatellite Instability | Circulating Tumor Cell

China
Yale University
National Cancer Institute (NCI)

Completed

Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants

Non-melanomatous Skin Cancer | Neoplastic Syndrome
National Cancer Institute (NCI)

Completed

Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of Samples

Urologic Neoplasms | Neoplastic Syndromes, Hereditary

United States
National Health Research Institutes, Taiwan
Chang Gung Memorial Hospital

Unknown

Hereditary Nonpolyposis Colorectal Cancer in Taiwan-Related Genetic Study and Clinical Applications

Hereditary Nonpolyposis Colorectal Cancer

Taiwan
Rabin Medical Center

Unknown

Prostate Cancer Screening Among Men With High Risk Genetic Predisposition

Lynch Syndrome | BRCA1 Syndrome | BRCA2 Syndrome

Israel
NYU Langone Health

Withdrawn

Turmeric as Treatment in Epilepsy

Epilepsy | Tuberous Sclerosis | Dravet Syndrome | Focal Seizures | Lennox-Gastaut Syndrome

United States
Radboud University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Unknown

Implementation of a New Strategy to Identify HNPCC Patients

Colorectal Neoplasms | Hereditary Nonpolyposis Colorectal Cancer

Netherlands
Georgetown University
Virginia Commonwealth University; Cornell University

Completed

Testing an Intelligent Tutoring System to Enhance Genetic Risk Assessment

Hereditary Breast and Ovarian Cancer

United States
University of Southern California
Stanford University

Completed

Cancer Genetics Hereditary Cancer Panel Testing (HCP)

Hereditary Breast and Ovarian Cancer

United States
Acibadem University
Boston Children's Hospital; Ege University

Recruiting

PTEN Hamartoma Tumor Syndrome Pediatric Patient Registry

PTEN Hamartoma Tumor Syndrome | Macrocephaly Autism Syndrome

Turkey
Royal Marsden NHS Foundation Trust

Recruiting

Inherited Cancer Early Diagnosis (ICED) Study (ICED)

Lynch Syndrome | Familial Adenomatous Polyposis | Hereditary Diffuse Gastric Cancer | Peutz-Jeghers Syndrome | Cowden Syndrome | Li Fraumeni Syndrome | MutYH-associated Polyposis | SMAD4 Gene Mutation

United Kingdom
Neuromed IRCCS

Recruiting

Epidemiology of Pituitary Tumours: Prevalence of Associated Neoplasia (EpidemioPIT)

Hyperparathyroidism | Solid Tumor | Pituitary Tumor | Endocrine Neoplasia | Familial Tumor Syndrome

Italy
Haramaya Unversity

Completed

Poorly Differentiated Adenocarcinoma of the Jejunum in a Patient With Peutz-Jeghers Syndrome: A Case Report

Peutz-Jeghers Syndrome

Ethiopia
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome

Cancer | Muscle Weakness | Skin Fibroblasts

United States
National Cancer Institute (NCI)

Completed

Family Study of Melanoma in Italy

Melanoma | Dysplastic Nevi | Melanocytic Nevi

Spain, Italy
John Hays
Bristol-Myers Squibb

Terminated

Nivolumab in Preventing Colon Adenomas in Participants With Lynch Syndrome and a History of Partial Colectomy

Lynch Syndrome | Colon Adenoma | Colon Carcinoma | MLH1 Gene Mutation | MSH2 Gene Mutation

United States
University Hospital, Lille

Completed

Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome (PrediLynch)

Lynch Syndrome

France
University of British Columbia
Children's & Women's Health Centre of British Columbia; Vancouver Foundation; Circle of Care

Terminated

Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC

Exostoses, Multiple Hereditary

Canada
University of Pennsylvania
Epigenomics, Inc

Completed

Preliminary Evaluation of Septin9 in Patients With Hereditary Colon Cancer Syndromes (Septin9)

Colorectal Cancer | Lynch Syndrome | Familial Adenomatous Polyposis | Map Syndrome | Hnpcc

United States
Istituto Ortopedico Rizzoli

Completed

Height, Ulnar Length and Forearm Function in Multiple Hereditary Exostoses

Exostoses, Multiple Hereditary

Italy
London North West Healthcare NHS Trust

Completed

Magnification Narrow Band Imaging Colonoscopy for Hereditary Non-Polyposis Colorectal Cancer Surveillance

Colorectal Neoplasms, Hereditary Nonpolyposis

United Kingdom
Fundació Institut de Recerca de l'Hospital de la...

Recruiting

Study of Quality of Life Post Salpingo-oophorectomy in BRCA1/2 & PALB2 Mutation Carriers (BRCA-HRT) (BRCA-HRT)

Hereditary Breast and Ovarian Cancer

Spain
University of British Columbia

Suspended

Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project

Exostoses, Multiple Hereditary

Canada
National Human Genome Research Institute (NHGRI)

Completed

Psychosocial Aspects of Genetic Testing for Hereditary Nonpolyposis Colon Cancer

HNPCC | Hereditary Nonpolyposis Colon Cancer

United States
National Cancer Institute (NCI)

Completed

Study of Molecular Pathways in Medullary Thyroid Carcinoma and Correlation of Molecular Data With Clinical Behavior of the MTC in Individuals Patients

Multiple Endocrine Neoplasia Type 2 | Medullary Thyroid Carcinoma

United States
National Cancer Institute (NCI)

Completed

Vandetanib to Treat Children and Adolescents With Medullary Thyroid Cancer

Multiple Endocrine Neoplasia Type 2A | Multiple Endocrine Neoplasia Type 2B | Medullary Thyroid Carcinoma

United States
Umeå University
Karolinska Institutet; Lund University; Göteborg University

Enrolling by invitation

Direct Information to At-risk Relatives (DIRECT)

Lynch Syndrome | Hereditary Breast and Ovarian Cancer Syndrome | Familial Breast Cancer | Hereditary Breast Cancer | Familial Colorectal Cancer

Sweden
National Cancer Institute (NCI)

Active, not recruiting

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

Lynch Syndrome | Stage III Colon Cancer AJCC v8 | Colon Adenocarcinoma | DNA Repair Disorder

United States, Puerto Rico, Germany
Georgetown University
Virginia Commonwealth University; Basser Center for BRCA; Nueva Vida, Inc.; Capital... and other collaborators

Completed

Enhance the Use of Genetic Counseling and Testing in Latinas

Hereditary Breast and Ovarian Cancer Syndrome

United States
University of California, San Francisco
National Cancer Institute (NCI); Cancer Prevention Institute of California

Completed

Statewide Communication to Reach Diverse Low Income Women

Hereditary Breast and Ovarian Cancer Syndrome
Sheba Medical Center

Unknown

Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers

Hereditary Breast and Ovarian Cancer Syndrome

Israel
Sheba Medical Center

Completed

Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers

Hereditary Breast and Ovarian Cancer Syndrome

Israel
Johns Hopkins University
National Human Genome Research Institute (NHGRI)

Completed

Genetic Risk: Whether, When, and How to Tell Adolescents

Huntington Disease | Hereditary Cancer | Hereditary Breast and Ovarian Cancer | Hereditary Non-polyposis Colon Cancer | Hereditary Non-Polyposis Colorectal Cancer Syndrome

United States
Institut Cancerologie de l'Ouest

Recruiting

Women at Risk of Breast Cancer and OLFM4

Hereditary Breast and Ovarian Cancer Syndrome

France
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Lenvatinib and Everolimus in Treating Patients With Advanced, Unresectable Carcinoid Tumors

Neuroendocrine Neoplasm | Multiple Endocrine Neoplasia Type 1 | Advanced Carcinoid Tumor | Digestive System Neuroendocrine Neoplasm | Unresectable Carcinoid Tumor

United States

Clinical Trials on Neoplastic Syndromes, Hereditary

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