Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome

Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome: Study Conducted in the Hauts-de-France

Sponsors

Lead Sponsor: University Hospital, Lille

Source University Hospital, Lille
Brief Summary

Lynch Syndrome increases Endometrial Cancer Occurrence in women due to failure in MisMatch Repair System. Lifetime Cumulative risk of developing endometrial Cancer is approximatively 40% in women with Lynch Syndrome.

Endometrial cancer is the third women cancer in France. Many risk factors are known in general population. Lots of factors are related to over exposure to estrogen.

Data about influence of general risk factors in Women with Lynch Syndrome are poor. Recently, a cohort study appears to have shown a significant decrease in the risk of endometrial cancer with multiparity, the use of hormonal contraception and late menopause in Lynch women. The impact of weight and certain metabolic parameters on the occurrence of endometrial cancers remains poorly known to this day.

Overall Status Not yet recruiting
Start Date July 2020
Completion Date December 2020
Primary Completion Date December 2020
Study Type Observational
Primary Outcome
Measure Time Frame
Correlation between endometrial cancer and predictif factors Baseline
Secondary Outcome
Measure Time Frame
Correlation between endometrial cancer and predictif factors in post menopausal woman Baseline
Enrollment 150
Condition
Intervention

Intervention Type: Other

Intervention Name: questionnaire assesment

Description: Each patient will to answer questions about their medical history.

Eligibility

Sampling Method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- Lynch Syndrome Diagnosis at University Hospital

- Alive at study time

- Age over 30 at endometrial cancer or Lynch Syndrome Diagnosis

Case group :

- No cancer before endometrial cancer diagnosis

Control group :

- No endometrial cancer developped

- Free cancer women at Lynch Syndrome diagnosis

Exclusion Criteria:

- Refusing to participate

- Poor understanding of the French language

- Other cancer diagnosed before endometrial cancer

- Hysterectomy before lynch diagnosis for free cancer women

Gender: Female

Gender Based: Yes

Gender Description: woman

Minimum Age: 30 Years

Maximum Age: N/A

Healthy Volunteers: Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Solveig MENU-HESPEL, MD Principal Investigator University Hospital, Lille
Overall Contact

Last Name: Solveig MENU-HESPEL, MD

Phone: 0320445962

Phone Ext.: +33

Email: [email protected]

Verification Date

June 2020

Responsible Party

Type: Sponsor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: case group

Description: Women with Lynch Syndrome and endometrial Cancer matched on age of endometrial cancer diagnosis

Label: control group

Description: Women with Lynch Syndrome, without Cancer at Lynch Syndrome Diagnostic matched on their age at Lynch Diagnostic

Acronym PrediLynch
Patient Data No
Study Design Info

Observational Model: Case-Control

Time Perspective: Retrospective

Source: ClinicalTrials.gov