Clinical Trials on Severe Combined Immunodeficiency in Germany

Total 387 results

CureVac
Coalition for Epidemic Preparedness Innovations

Completed

A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Vaccine CVnCoV in Healthy Adults for COVID-19

Severe Acute Respiratory Syndrome | COVID-19 | SARS-CoV-2 | Coronavirus

Belgium, Germany
University Hospital, Saarland

Unknown

Infranodal Conduction Time During TAVR as Predictor of HAVB (HOM-TAVI)

Left Bundle-Branch Block | Severe Aortic Valve Stenosis | High-degree AV Block

Germany
CSL Behring

Completed

A Study to Evaluate the Safety and Pharmacokinetics of Two Formulations of C1-esterase Inhibitor

Hereditary Angioedema Types I and II

Germany
ViiV Healthcare
GlaxoSmithKline

Terminated

Dose-finding Study of BMS-955176 to Treat HIV-1 Infected Treatment-naive Adults

Infection, Human Immunodeficiency Virus

United States, France, Germany, Canada, Spain, United Kingdom, Mexico, Italy, Argentina, Chile, South Africa, Poland
ViiV Healthcare
GlaxoSmithKline

Completed

Dolutegravir Compared to Darunavir/Ritonavir , Each in Combination With Dual Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in ART-naive Subjects (FLAMINGO)

Infection, Human Immunodeficiency Virus

Spain, France, Germany, United States, Italy, Romania, Russian Federation, Switzerland, Puerto Rico
Technische Universität Dresden

Recruiting

TREATgermany: German National Clinical Registry for Patients With Moderate-to-severe Atopic Dermatitis (TREATgermany)

Moderate-to-severe Atopic Dermatitis

Germany
Basilea Pharmaceutica

Completed

Derazantinib in Subjects With FGFR2 Gene Fusion-, Mutation- or Amplification- Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma (FIDES-01)

Intrahepatic Cholangiocarcinoma | Combined Hepatocellular and Cholangiocarcinoma

Canada, United States, Spain, Belgium, Italy, Korea, Republic of, Germany, Switzerland, France, United Kingdom, Ireland
Goethe University
Nationwide Network of University Medicine (NUM) on Covid-19

Recruiting

Intersectoral Platform (SÜP) of the National Pandemic Cohort Network (NAPKON) (SUEP-NAPKON)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Germany
Kompetenznetz Sepsis
Biosyn; Brahms AG

Completed

Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis (SISPCT)

Septic Shock | Severe Sepsis

Germany
Australian and New Zealand Intensive Care Research...
The Alfred

Completed

The REDEEM Pilot Study: A Feasibility RCT of Early ECMO in Severe Acute Respiratory Infection, Including COVID-19, WHO (REDEEM)

Covid19 | Mechanical Ventilation Complication | Severe Acute Respiratory Infection

Australia, Germany
Schön Klinik Berchtesgadener Land

Completed

Short and Medium-term Effects of Pulmonary Rehabilitation in Mild to Critical Post-acute COVID-19 (STEPCO)

Quality of Life | Covid19 | Pulmonary Rehabilitation | SARS-CoV Infection

Germany
Sphingotec GmbH
Cliniques universitaires Saint-Luc- Université Catholique de Louvain; Hopital... and other collaborators

Completed

Adrenomedullin and Outcome in Severe Sepsis and Septic Shock (AdrenOSS)

Septic Shock | Severe Sepsis

France, Belgium, Germany, Italy, Netherlands
Universitätsklinikum Hamburg-Eppendorf

Terminated

Piecemeal Versus En Bloc Resection of Large Rectal Adenomas (PERLA)

Colorectal Adenomatous Polyp | Colorectal Adenoma With Mild Dysplasia | Colorectal Adenoma With Severe Dysplasia | Colorectal Low Grade Intraepithelial Neoplasia | Colorectal High Grade Intraepithelial Neoplasia

Germany, United Kingdom
Nestlé

Completed

Effect of Starter Formula on Infection Prevention

Gastro-intestinal Infections | Infections With Fever

France, Germany, Netherlands
Charite University, Berlin, Germany

Unknown

Exercise for Patients With HIV Infections

HIV Infections | Inflammation | Lipodystrophy

Germany
ViiV Healthcare

Terminated

GW873140 In Combination With Combivir In HIV Infected Subjects

HIV Infection | Infection, Human Immunodeficiency Virus I

United States, France, Canada, Germany, Italy, Belgium, United Kingdom, Portugal, Spain
Universität Duisburg-Essen
Bavarian State Ministry of Health and Care

Recruiting

Mild Water-filtered Infrared-A Whole-body Hyperthermia in Patients With Post-COVID Syndrome (HyPoCo) (HyPoCo)

Post-COVID Syndrome

Germany
LMU Klinikum
University of Leipzig; Heart Center Leipzig - University Hospital; Deutsches... and other collaborators

Recruiting

TRICuspid Intervention in Heart Failure Trial (TRICI-HF)

Heart Failure Attributable to Severe Tricuspid Regurgitation

Germany
Radboud University Medical Center

Completed

Pharmacokinetic and Safety Study of Raltegravir and Atazanavir in a Once Daily Dose Regimen in HIV-1 Infected Patients (PRADA)

HIV Infections | HIV Infection

Germany, Netherlands
GlaxoSmithKline

Completed

KIVEXA Vs TRUVADA, Both Administered With Efavirenz, In ART-Naive Subjects (ASSERT)

HIV Infection | Infection, Human Immunodeficiency Virus I

Germany, Belgium, United Kingdom, Spain, Ireland, Italy, France, Austria, Denmark, Netherlands, Switzerland, Portugal, Latvia
ViiV Healthcare
GlaxoSmithKline; Shionogi

Completed

A Trial Comparing GSK1349572 50mg Once Daily to Raltegravir 400mg Twice Daily (SPRING-2)

Infection, Human Immunodeficiency Virus I

Germany, Spain, France, Australia, United States, Canada, United Kingdom, Italy, Russian Federation
AstraZeneca

Completed

Quality of Life in Daxas-treated Patients Older Than 18 Years With Severe COPD (DINO)

Severe COPD

Germany
medac GmbH
Syneos Health; Celerion; Venn Life Sciences

Completed

Treosulfan-based Versus Busulfan-based Conditioning in Paediatric Patients With Non-malignant Diseases

Bone Marrow Failure Syndromes | Inborn Errors of Metabolism | Primary Immunodeficiencies | Haemoglobinopathies

Poland, Czechia, Germany, Italy
ViiV Healthcare
GlaxoSmithKline

Completed

HIV-1 Infection Study of Once a Day Versus Twice a Day Protease Inhibitor in Antiretroviral Treatment Naive Adults

HIV-1 Infection | Infection, Human Immunodeficiency Virus I

Germany, Spain, France, Belgium, United Kingdom, Italy, Romania, Russian Federation, Switzerland
Johann Wolfgang Goethe University Hospital

Unknown

Neurofilament Light- Chain in Ataxia Telangiectasia

Ataxia Telangiectasia

Germany
Advanced Bionics AG

Not yet recruiting

Hearing and Structure Preservation Via ECochG (PRESERVE)

Hearing Loss, Sensorineural | Severe-to-profound Hearing Loss

Belgium, United Kingdom, France, Germany, Italy, Poland
University Hospital Schleswig-Holstein
Universitätsklinikum Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany and other collaborators

Completed

Hemodynamics During the Soccer Championship 2012

Myocardial Infarction | Angina, Stable | Angina, Unstable | Severe Cardiomyopathy

Germany
Chiesi Farmaceutici S.p.A.

Completed

Phase II Study to Evaluate the Cardiac Safety of 2 Doses of CHF5993 Both Combined With CHF1535 BID Versus CHF1535 BID in Patients With Moderate to Severe COPD (CARSAF)

Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Bulgaria, Germany, Hungary, Poland, Russian Federation, United Kingdom
ViiV Healthcare
GlaxoSmithKline

Completed

Dolutegravir Expanded Access Study (DEAP)

HIV Infections | Infection, Human Immunodeficiency Virus

France, Germany, United States, Canada, Belgium, Austria, Brazil, Italy, Poland
ViiV Healthcare
GlaxoSmithKline; Shionogi

Completed

A Trial Comparing GSK1349572 50mg Plus Abacavir/Lamivudine Once Daily to Atripla (Also Called The SINGLE Trial)

Infection, Human Immunodeficiency Virus I

United States, Spain, Germany, Australia, Canada, Belgium, Denmark, Netherlands, United Kingdom, France, Italy, Romania
Center for Sepsis Control and Care, Germany
Center for Clinical Studies, University Hospital Jena, Germany; Dept. of Microbiology... and other collaborators

Completed

(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis (CandiSep)

Septic Shock | Severe Sepsis

Germany
ViiV Healthcare

Completed

New Tablet Containing Two FDA Approved Anti-HIV Drugs For Antiretroviral Therapy Experienced HIV-1 Infected Subjects

HIV Infection | Infection, Human Immunodeficiency Virus I

United States, Spain, Germany, Canada, Belgium, Portugal, Italy, France, United Kingdom
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of Canakinumab in Patients With Hereditary Periodic Fevers

Hereditary Periodic Fevers

Belgium, Italy, Japan, Russian Federation, Turkey, Spain, Germany, United Kingdom, France, United States, Ireland, Israel, Canada, Hungary, Netherlands, Switzerland
Novartis Pharmaceuticals

Completed

A Dose Finding Study of AEB071 Assessing Psoriasis Area and Severity Index in Patients With Plaque Psoriasis

Moderate and Severe Plaque Psoriasis

United States, Argentina, Germany, Belgium, Italy, United Kingdom, Turkey, Guatemala, Australia
Universität Duisburg-Essen

Completed

Whole-body Hyperthermia for Mild to Moderate Depressive Disorder (HYPE1)

Depression, Unipolar

Germany
Johann Wolfgang Goethe University Hospital

Completed

Oxidative Stress, Low Grade Inflammation, Tissue Breakdown and Biomarkers in Cerebrospinal Fluid of A-T

Ataxia Telangiectasia

Germany
Universität Duisburg-Essen

Completed

Whole-body Hyperthermia for Moderate to Severe Depressive Disorder (HYPE2)

Depression, Unipolar

Germany
Kompetenznetz Sepsis
Bayer; AstraZeneca

Completed

Comparison of Two Antibiotic Regimen (Meropenem Versus Meropenem+Moxifloxacin)in the Treatment of Severe Sepsis and Septic Shock (MaxSep)

Septic Shock | Severe Sepsis

Germany
University of Ulm

Recruiting

Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis (MIPSA)

Sepsis | Critically Ill | Pseudomonas Infections | Sepsis, Severe | Pseudomonas Septicemia | Pseudomonas; Pneumonia | Pseudomonal Bacteraemia | Pseudomonas Urinary Tract Infection | Pseudomonas Gastrointestinal Tract Infection

Germany
ViiV Healthcare

Terminated

A Dose Ranging Study Of GW640385 Boosted With Ritonavir (Rtv) In Comparison To A RTV-Boosted Protease Inhibitor (PI) In HIV-1 Infected PI-Experienced Adults

HIV-1 Infection | Infection, Human Immunodeficiency Virus I

United States, France, Germany, Canada, Italy, Australia, Belgium, Portugal, Puerto Rico, Romania, United Kingdom
JenaValve Technology, Inc.

Not yet recruiting

TAVIS Registry - Trilogy Heart Valve System for Management of Patients With Aortic Valve Disease (TAVIS)

Aortic Valve Stenosis | Aortic Valve Disease | Heart Valve Diseases | Ventricular Outflow Obstruction | Constriction, Pathologic | Aortic Valve Stenosis With Insufficiency | Cardiovascular Diseases in Old Age | Aortic Stenosis, Severe | Aortic Valve Regurgitation

Germany
GlaxoSmithKline

Completed

KALETRA Or LEXIVA With Ritonavir Combined With EPIVIR And Abacavir In Naive Subjects Over 48 Weeks

HIV Infection | Infection, Human Immunodeficiency Virus

United States, Belgium, France, Germany, Spain, Canada, Italy, Portugal, Romania, Austria, Switzerland, Poland, Latvia, Luxembourg
Agennix

Completed

Safety and Efficacy Study of Recombinant Human Lactoferrin to Treat Severe Sepsis

Severe Sepsis

United States, Canada, France, Germany, Spain
ViiV Healthcare
GlaxoSmithKline

Completed

An Efficacy, Safety, and Tolerability Study Comparing Dolutegravir (DTG) Plus Lamivudine (3TC) With Dolutegravir Plus Tenofovir/Emtricitabine in Treatment naïve HIV Infected Participants (Gemini 2)

HIV Infections | Infection, Human Immunodeficiency Virus

United States, Argentina, Spain, Germany, Belgium, Australia, Canada, United Kingdom, Italy, Romania, Taiwan, Russian Federation, Mexico, France, Switzerland, Peru, Poland, Portugal
ViiV Healthcare

Terminated

GW873140 In Combination With Kaletra In HIV Infected Subjects

HIV Infection | Infection, Human Immunodeficiency Virus I

United States, Germany, France, Canada, Spain, Italy, Portugal, United Kingdom, Denmark, Netherlands
Regeneron Pharmaceuticals
Sanofi

Completed

A Study to Evaluate the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Moderate-to-Severe Atopic Hand and Foot Dermatitis (Liberty-AD-HAFT)

Moderate to Severe Atopic Hand and Foot Dermatitis

United States, Germany, Japan, Poland
Johann Wolfgang Goethe University Hospital

Unknown

Susceptibility to Infections, Tumor Risk and Liver Disease in Patients With Ataxia Telangiectasia

Ataxia Telangiectasia

Germany
MeMed Diagnostics Ltd.
Heidelberg University; European Commission; University of Parma

Completed

Diagnostic Accuracy of a Host-response Based Diagnostic Tool for Distinguishing Between Bacterial and Viral Etiologies in Pediatric Patients (AutoPilot)

Respiratory Tract Infections | Fever

Germany, Italy
Novartis Pharmaceuticals

Completed

Study of Safety, Tolerability, and Efficacy of Secukinumab in Subjects With Moderate to Severe Nail Psoriasis (TRANSFIGURE)

Moderate to Severe Nail Psoriasis

Germany, Belgium, Spain, United States, Australia, United Kingdom, Denmark, Czechia, Greece
Janssen R&D Ireland

Completed

A Study to Assess the Safety, Tolerability and Efficacy of TMC435 Along With Pegylated Interferon Alpha-2a (Pegasys) and Ribavirin (Copegus) Triple Therapy in Chronic Hepatitis C Genotype-1 Infected Patients Co-infected With Human Immunodeficiency Virus-Type 1

Hepatitis C Virus Genotype-1

United States, France, United Kingdom, Germany, Spain, Portugal, Canada, Puerto Rico

Clinical Trials on Severe Combined Immunodeficiency in Germany

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