Clinical Trials on Therapy Failure in Australia

Total 408 results

Novo Nordisk A/S

Recruiting

A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation (ATHENA)

Heart Failure | Systemic Inflammation

United States, Greece, France, Australia, Czechia, Spain, India, Canada, Turkey, Portugal, Malaysia, Poland, United Kingdom, Germany, Bulgaria, Argentina
Boehringer Ingelheim
Eli Lilly and Company

Completed

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)

Heart Failure

United States, Spain, Canada, Korea, Republic of, China, Germany, Belgium, Australia, Italy, United Kingdom, Argentina, Hungary, Czechia, Poland, Netherlands, Japan, Mexico, India, Brazil, France
Paragonix Technologies

Enrolling by invitation

Global Utilization And Registry Database for Improved heArt preservatioN (GUARDIAN)

Heart Diseases | Heart Failure | Heart Defects, Congenital

United States, Spain, Austria, United Kingdom
Abbott Medical Devices

Completed

Physiologic Pacing Registry

Heart Failure | Heart Block | Bradycardia | Syncope | Cardiomyopathies | Ventricular Tachycardia | Sinus Node Dysfunction

United States, Australia, Netherlands, South Africa, Switzerland, Spain, Germany, Singapore, Canada, Austria, Czechia, France, Hong Kong, India, Italy, Poland
AstraZeneca

Completed

AURORA: Crestor 10mg Versus Placebo in Subjects With End-stage Renal Disease (ESRD)

Renal Failure

Sweden, Bulgaria, Czech Republic, France, Poland, United Kingdom, Germany, Hungary, Finland, Netherlands, Norway, Canada, Mexico, Australia, Austria, Belgium, Denmark, Greece, Italy, Iceland, Brazil, Switzerland, Ireland, Korea, Republic... and more
Ole Frobert, MD, PhD
Uppsala University; Sanofi Pasteur, a Sanofi Company; Swedish Heart Lung Foundation and other collaborators

Completed

Study on the Effect of Influenza Vaccination After Heart Attack on Future Cardiovascular Prognosis (IAMI)

Myocardial Infarction | Heart Failure | Stroke | Influenza, Human | Influenza Vaccines

Denmark, United Kingdom, Sweden, Australia, Bangladesh, Czechia, Latvia, Norway
Population Health Research Institute
Canadian Institutes of Health Research (CIHR)

Recruiting

Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease (ACHIEVE)

Endstage Renal Disease

Canada, Australia, United Kingdom, New Zealand, Malaysia, Brazil, India, Philippines, Uruguay, Ecuador
Biogen

Completed

Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency (TRIDENT-1)

Renal Insufficiency | Congestive Heart Failure

Israel, Italy, United States, Finland, Canada, Australia, France, Netherlands, Poland, Bulgaria, Russian Federation, India, Brazil, Sweden, Romania, Czechia, Argentina, Germany
Boston Scientific Corporation

Completed

Ingenio Device Algorithm Study (IVORY)

Heart Failure | AV Block | Sinus Node Disease

Denmark, United Kingdom, Spain, Hong Kong, Netherlands, Sweden, Malaysia, Austria, Belgium, France, Germany, Italy
University Hospital Freiburg

Completed

Assessing Immune Function in Young Patients With Cytopenia That Did Not Respond to Treatment

Myelodysplastic Syndromes | Fanconi Anemia | Dyskeratosis Congenita | Pearson Marrow-pancreas Syndrome | Shwachman-diamond Syndrome

Spain, Germany, Switzerland, Austria, Netherlands, Italy, Czech Republic, Belgium, Denmark, Ireland
Bayer

Active, not recruiting

A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer (OASIS-4)

Hot Flashes | Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer

Spain, France, Belgium, United Kingdom, Hungary, Israel, Italy, Ireland, Germany, Portugal, Finland, Poland, Romania, Canada, Austria, Kazakhstan
Edwards Lifesciences

Active, not recruiting

Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol

Coronary Artery Disease | Heart Failure | Mitral Valve Regurgitation | Mitral Valve Incompetence

Canada, United States, Austria, Germany
Novo Nordisk A/S

Recruiting

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation (HERMES)

Heart Failure

Korea, Republic of, Belgium, United States, Australia, Italy, China, Latvia, United Kingdom, Croatia, Spain, Netherlands, Serbia, Malaysia, Israel, Austria, Singapore, Thailand, Hungary, Argentina, Japan, Taiwan, Turkey, Germany, South... and more
Bayer

Active, not recruiting

Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40% (FINEARTS-HF)

Heart Failure

United States, Spain, Denmark, Korea, Republic of, Taiwan, Australia, Hong Kong, Russian Federation, Israel, Canada, Malaysia, United Kingdom, Latvia, Netherlands, Japan, Brazil, China, Lithuania, Poland, Turkey, Italy, Austria, Bul... and more
Amgen

Completed

Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Multiple Myeloma and Renal Disease

End-stage Renal Disease | Relapsed Multiple Myeloma

United States, Australia, Canada
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Comparison Of Outcomes In Patients In New York Heart Association (NYHA) Class II Heart Failure When Treated With Eplerenone Or Placebo In Addition To Standard Heart Failure Medicines (EMPHASIS-HF)

Heart Failure

United States, Canada, Spain, United Kingdom, France, Greece, Germany, Ireland, Italy, Poland, Portugal, Slovakia, India, Russian Federation, South Africa, Belgium, Hong Kong, Hungary, Sweden, Ukraine, Australia, Netherlands, United... and more
Boston Scientific Corporation
Guidant Corporation

Completed

Feature Assessment Study for Indications Based Programming (FASt-IBP)

Heart Failure | Ventricular Fibrillation | Ventricular Tachycardia | Ventricular Flutter

Germany, Spain, Switzerland, China, Austria, Belgium, France, Greece, Latvia, Netherlands, Slovakia
Bausch Health Americas, Inc.

Active, not recruiting

Study to Assess Rifaximin Soluble Solid Dispersion (SSD) for the Delay of Encephalopathy Decompensation in Cirrhosis (RED-C-3131)

Hepatic Encephalopathy

United States, Australia, Canada, Puerto Rico
AstraZeneca

Recruiting

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen (TILIA)

Viral Lung Infection and Acute Respiratory Failure

United States, China, Australia, Czechia, Denmark, Hungary, Israel, Spain, United Kingdom, Canada, Germany, Italy, Argentina, Bulgaria, India, Turkey, Vietnam, Japan, France, Egypt, Malaysia, Taiwan, Thailand, Brazil, Greece, Belgium, Hong... and more
Medtronic Cardiac Rhythm and Heart Failure

Completed

REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE)

Heart Failure

United States, France, Spain, Germany, Denmark, Canada, Czech Republic, Belgium, Hungary, Italy, Ireland, Sweden, United Kingdom, Austria, Norway
Vifor (International) Inc.

Active, not recruiting

Cardiovascular and Renal Treatment in Heart Failure Patients With Hyperkalaemia or at High Risk of Hyperkalaemia (CARE-HK)

Heart Failure | Hyperkalemia

Spain, United States, United Kingdom, Italy, Switzerland, Belgium, Austria
Ocera Therapeutics, Inc.

Completed

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE) (STOP-HE)

Hepatic Encephalopathy | Acute Episode of Overt Hepatic Encephalopathy

Belgium, Germany, Italy, Spain, United States, France, Austria, Russian Federation, Czechia, Australia, Hungary, Israel, Netherlands, Bulgaria, Estonia, Denmark, New Zealand
Novo Nordisk A/S

Completed

Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes (STEP HFpEF DM)

Heart Failure With Preserved Ejection Fraction (HFpEF) and Diabetes Mellitus, Type 2

United States, Spain, Hungary, United Kingdom, India, Netherlands, Germany, Japan, Canada, Czechia, Argentina, Austria, Israel, Italy, Poland, Sweden
Shire

Terminated

Dynepo Infrequent Dosing Study

Anemia | Kidney Failure

Spain, United Kingdom, Austria, Belgium, France, Germany, Italy
Novartis Pharmaceuticals

Terminated

A Dose Finding Study to Assess the Effect of LIK066 Compared to Placebo or Empagliflozin in Patients With Type 2 Diabetes Mellitus and Heart Failure

Diabetes Mellitus and Heart Failure

United States, Belgium, Austria, Croatia, Czechia, Netherlands, Canada, Korea, Republic of, Taiwan, Hungary, United Kingdom, Italy, Bulgaria, Germany, Argentina, Ireland, Norway, Spain, Denmark, Singapore, South Africa, Mexico, Poland, Puerto Rico
LLS PedAL Initiative, LLC
National Cancer Institute (NCI); Children's Oncology Group

Recruiting

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome | Myeloid Leukemia Associated With Down Syndrome | Mixed Phenotype Acute Leukemia | Acute Myeloid Leukemia Post Cytotoxic Therapy | Myelodysplastic Syndrome Post Cytotoxic Therapy

United States, Canada, Australia, Puerto Rico, New Zealand
Sanford Health
National Ataxia Foundation; Beyond Batten Disease Foundation; Pitt Hopkins Research... and other collaborators

Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

Mitochondrial Diseases | Retinitis Pigmentosa | Myasthenia Gravis | Eosinophilic Gastroenteritis | Multiple System Atrophy | Leiomyosarcoma | Leukodystrophy | Anal Fistula | Spinocerebellar Ataxia Type 3 | Friedreich Ataxia | Kennedy Disease | Lyme Disease | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia... and other conditions

United States, Australia
Edwards Lifesciences

Completed

Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX

Coronary Artery Disease | Heart Failure | Aortic Valve Stenosis | Aortic Valve Insufficiency | Aortic Valve Disorder

Canada, United States, Austria, Germany, Spain, United Kingdom
Merck Sharp & Dohme LLC

Active, not recruiting

Global Study of MK-2060 (Anti-Factor XI Monoclonal Antibody) in Participants With End Stage Renal Disease Receiving Hemodialysis (FXI Hemodialysis Study) (MK-2060-007)

Kidney Failure, Chronic | End-Stage Renal Disease | End-Stage Kidney Disease

United States, Argentina, Australia, Brazil, Bulgaria, Canada, Czechia, Germany, Greece, Italy, Portugal, Puerto Rico, Romania, Russian Federation, Sweden
Medtronic Cardiac Rhythm and Heart Failure

Completed

AdaptResponse Clinical Trial

Heart Failure With Left Bundle Branch Block

Korea, Republic of, Spain, United States, Netherlands, Taiwan, France, Denmark, Italy, Sweden, Switzerland, Germany, Belgium, Finland, Japan, Poland, United Kingdom, Canada, Australia, Saudi Arabia, Hungary, India, Norway, Slovakia, A... and more
Cytokinetics

Completed

Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)

Heart Failure

United States, Canada, Germany, Italy, Netherlands, Belgium, France, Czechia, Australia, Russian Federation, Hungary, Poland, Bulgaria, Slovakia, United Kingdom, Finland, Greece, Lithuania, Norway
Bayer

Completed

BAY94-8862 Dose Finding Trial in Subjects With Chronic Heart Failure and Mild (Part A) or Moderate (Part B) Chronic Kidney Disease (ARTS)

Heart Failure

Denmark, Germany, Belgium, Austria, Czechia, Israel, Norway, Sweden, Poland, Finland
Medtronic Cardiac Rhythm and Heart Failure

Completed

Safety and Clinical Performance of the Protecta ICD and CRT-D

Heart Failure | Ventricular Dysfunction | Tachyarrhythmias

United States, Netherlands, Colombia, South Africa, Japan, Israel, Spain, Canada, United Kingdom, Germany, Slovenia, Sweden, Saudi Arabia, Switzerland, Malaysia, Austria, Czechia, Denmark, India, Italy, United Arab Emirates
Scios, Inc.

Completed

A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure

Heart Decompensation

United States, Australia, France, Poland, China, Germany, Taiwan, Argentina, Colombia, Israel, Mexico, Bulgaria, India, Malaysia, Ukraine, Canada, Greece, Korea, Republic of, Chile, New Zealand, Singapore, Brazil, Russian Federation, ... and more
AstraZeneca
Parexel

Recruiting

A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2 (Re-PHIRE)

Heart Failure | Pulmonary Hypertension (World Health Organization Group 2)

Netherlands, Spain, Japan, Germany, Austria, Italy, China, Sweden, United Kingdom, United States, Poland, Czechia, Denmark, Canada
UCB BIOSCIENCES GmbH

Completed

A Sleep Laboratory Study to Investigate the Safety and Efficacy of the Rotigotine Skin Patch in Subjects With Restless Legs Syndrome and End-Stage Renal Disease Requiring Hemodialysis

Restless Legs Syndrome | End-Stage Renal Disease

United States, Austria, Finland, France, Germany, Italy
ResMed
CRI-The Clinical Research Institute GmbH

Completed

Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure (Serve-HF)

Heart Failure | Sleep Disordered Breathing

Germany, Netherlands, Australia, Denmark, France, United Kingdom, Switzerland, Norway, Finland, Sweden, Czechia
Medtronic

Recruiting

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products (PPR)

Heart Failure | Bradycardia | Arrhythmia | Sinus Tachycardia

China, France, United States, Australia, Belgium, Canada, Czechia, Denmark, Germany, Greece, Hungary, Israel, Italy, Japan, Korea, Republic of, Malaysia, Netherlands, Norway, Poland, Portugal, Saudi Arabia, Serbia, Spain, Sweden, Switze... and more
Boehringer Ingelheim
Eli Lilly and Company

Completed

EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction)

Myocardial Infarction

United States, Spain, Australia, Denmark, Netherlands, Canada, China, Germany, Korea, Republic of, Israel, Hungary, Japan, Argentina, France, Romania, Russian Federation, Serbia, Ukraine, Poland, India, Brazil, Bulgaria
Hoffmann-La Roche

Completed

HELPS Study - A Study of Peginterferon Alfa-2a (Pegasys) in Patients With Chronic Hepatitis C (CHC) and End-Stage Renal Disease (ESRD)

Hepatitis C, Chronic

France, Greece, Austria, Turkey, United Arab Emirates, Brazil, Italy, Indonesia
American Regent, Inc.
Duke Clinical Research Institute

Completed

Randomized Placebo-controlled Trial of FCM as Treatment for Heart Failure With Iron Deficiency (HEART-FID)

Heart Failure | Iron-deficiency

United States, Canada, Australia, Bulgaria, Georgia, New Zealand, Latvia, Hungary, Poland, Czechia, Lithuania, Russian Federation, Ukraine
Novartis Pharmaceuticals

Completed

Efficacy, Safety and Tolerability of Everolimus in Preventing End-stage Renal Disease in Patients With Autosomal Dominant Polycystic Kidney Disease

Autosomal Dominant Polycystic Kidney Disease

Germany, Austria, France
Bausch Health Americas, Inc.

Active, not recruiting

Study to Assess Rifaximin Soluble Solid Dispersion (SSD) for the Delay of Encephalopathy Decompensation in Cirrhosis (RED-C-3132)

Hepatic Encephalopathy

United States, Australia, Belgium, Bulgaria, Canada, France, Germany, Hungary, India, Italy, Korea, Republic of, Mongolia, New Zealand, Poland, Puerto Rico, Spain, United Kingdom
AbbVie (prior sponsor, Abbott)
Massachusetts General Hospital

Completed

The PRIMO Study: Paricalcitol Capsules Benefits Renal Failure Induced Cardiac Morbidity in Subjects With Chronic Kidney Disease Stage 3/4 (PRIMO)

Chronic Kidney Disease | Left Ventricular Hypertrophy

United States, Australia, Czech Republic, Germany, Italy, Poland, Puerto Rico, Romania, Russian Federation, Spain, Taiwan, United Kingdom
Bayer

Completed

Phase IIb Safety and Efficacy Study of Different Oral Doses of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Chronic Kidney Disease Alone (ARTS-HF)

Heart Failure

France, Taiwan, United States, Turkey, Spain, Greece, Portugal, Germany, Canada, Austria, Czechia, Denmark, Israel, Korea, Republic of, Poland, South Africa, Sweden, Bulgaria, Italy, Finland, Hungary, Lithuania, Netherlands, Australia, ...
Sandoz
Hexal AG

Completed

MONITOR-CKD5 - Multi-level Evaluation of Anaemia Treatment, Outcomes, and Determinants in Chronic Kidney Disease Stage 5 (MONITOR-CKD5)

Chronic Kidney Disease | End-stage Renal Disease | Anaemia

Austria, France, Germany, Italy, Poland, Romania, Slovenia, Spain, Switzerland, United Kingdom
Gesellschaft fur Padiatrische Onkologie und Hamatologie...

Completed

Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma

Brain and Central Nervous System Tumors | Perioperative/Postoperative Complications | Long-term Effects Secondary to Cancer Therapy in Children | Psychosocial Effects of Cancer and Its Treatment | Weight Changes

Switzerland, Germany, Austria, Sweden
Abbott
Massachusetts General Hospital; Harvard University

Terminated

The PRIMO II Study: Paricalcitol Injection Benefits in Renal Failure Induced Cardiac Morbidity in Subjects With Chronic Kidney Disease (CKD) Stage 5 (PRIMO II)

Hypertrophy, Left Ventricular | Chronic Kidney Disease (CKD) Stage 5

Italy, United States, Taiwan, Poland, United Kingdom, Greece, Germany, Russian Federation, Spain, Australia, Czech Republic, Puerto Rico, Romania
Zambon SpA

Active, not recruiting

Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-2) (BOSTON-2)

Bronchiolitis Obliterans | Lung Transplant Rejection | Lung Transplant; Complications | Lung Transplant Failure and Rejection | Chronic Rejection of Lung Transplant | Chronic Lung Allograft Dysfunction

France, United States, Spain, Israel, Belgium, Denmark, Germany, United Kingdom, Austria
Lexicon Pharmaceuticals
Sanofi

Terminated

Effect of Sotagliflozin on Cardiovascular Events in Participants With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial)

Heart Failure | Type 2 Diabetes Mellitus

Belgium, Canada, Israel, Spain, Germany, Argentina, Chile, Hungary, Korea, Republic of, Latvia, Lithuania, Russian Federation, Sweden, Romania, Poland, Brazil, Denmark, United States, Australia, Austria, Czechia, Finland, France, Greece, Ita... and more

Clinical Trials on Therapy Failure in Australia

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