Search clinical trials for: 2: Placebo Comparator

Total 67492 results

Johns Hopkins University
The Cleveland Clinic; University of Toledo Health Science Campus

Completed

Ictal and Interictal Inflammatory Markers in Migraine

Migraine

United States
Pfizer
GlaxoSmithKline

Completed

Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders (EAGLES)

Smoking Cessation

United States, Spain, Germany, Canada, South Africa, Finland, Denmark, Australia, Brazil, Bulgaria, Chile, Mexico, New Zealand, Russian Federation, Slovakia, Argentina
Chinese PLA General Hospital
309th Hospital of Chinese People's Liberation Army; Beijing Naval General Hospital and other collaborators

Unknown

Study of Busulfan and FLAG Conditioning Regimen for Allogeneic Peripheral Blood Stem Cell Transplantation

Leukemia
Yale University

Completed

Naltrexone & SSRI in Alcoholics With Depression/PTSD

Depression | PTSD | Alcoholism

United States
University Hospital, Basel, Switzerland

Completed

Influence of Bupropion on the Effects of MDMA

Healthy | Substance-related Disorders

Switzerland
Bristol-Myers Squibb

Completed

Abatacept and Infliximab in Combination With Methotrexate in Subjects With Rheumatoid Arthritis

Rheumatoid Arthritis

Spain, United States, Argentina, Brazil, Canada, Mexico, Peru, Korea, Republic of, Sweden, Australia, Russian Federation, Poland, Puerto Rico, Czech Republic, Denmark, South Africa, Switzerland
Takeda

Completed

Efficacy of Lu AA21004 on Cognitive Dysfunction in Major Depressive Disorder

Depressive Disorder, Major

United States, Ukraine, Germany, Poland, Bulgaria, Finland, Russian Federation
Nantes University Hospital
Sanofi

Terminated

Hydroquinidine Versus Placebo in Patients With Brugada Syndrome (Quidam)

Brugada Syndrome

France
Orexigen Therapeutics, Inc

Completed

A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 Diabetes

Obesity | Diabetes Mellitus, Type 2 | Overweight

United States
Technische Universität Dresden

Completed

Comparison of Skin Thickness Under Treatment With Pimecrolimus 1% Cream, Hydrocortisonacetat 1% Cream, Betamethasonvalerat 0,1% Cream and Clobetasol-17-propionat 0,05% Cream Assessed by Optical Coherence Tomography (OCT) and 20-MHZ Ultrasound (OCT)

Healthy

Germany
H. Lundbeck A/S

Completed

Randomised Placebo-controlled Duloxetine-referenced Study of Efficacy and Safety of 5 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder in Elderly Patients

Major Depressive Disorder
Takeda

Completed

Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder

Depressive Disorder, Major

United States
Takeda
H. Lundbeck A/S

Completed

Efficacy and Safety of Vortioxetine (Lu AA21004) in the Treatment of Patients With Major Depressive Disorder

Major Depressive Disorder

United States
Emory University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Daiichi... and other collaborators

Completed

Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance

Prediabetic State | Impaired Glucose Tolerance

United States
National Cancer Institute (NCI)

Completed

Gemcitabine With or Without Bevacizumab in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer

Adenocarcinoma of the Pancreas | Recurrent Pancreatic Cancer | Stage III Pancreatic Cancer | Stage IV Pancreatic Cancer | Stage II Pancreatic Cancer

United States
Ryerson University

Unknown

Behavioral Insomnia Therapy For Those With Insomnia and Depression

Insomnia | Major Depressive Disorder

Canada
King Faisal Specialist Hospital & Research Center

Completed

The Placebo Effect May Involve Modulating Drug Bioavailability

Pharmacokinetics | Placebo Effect | Drug Half Life

Saudi Arabia
Medical University of Vienna

Completed

Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation During Isometric Exercise in Healthy Humans

Healthy

Austria
Instituto Nacional de Ciencias Medicas y Nutricion...
University of Pennsylvania; University of Witwatersrand, South Africa; Case Western... and other collaborators

Unknown

Maraviroc (CCR5) Antagonism to Decrease the Incidence of the Immune Reconstitution Inflammatory Syndrome in HIV-Infected Patients (CADIRIS)

HIV Infections | HIV | Immune Reconstitution Inflammatory Syndrome

Mexico, United States, South Africa
GlaxoSmithKline
Shionogi

Completed

Study to Assess Cardiac Conduction of GSK1349572

Healthy Subjects

United States
Cardresearch

Recruiting

A Multicenter, Adaptive, Randomized, doublE-blinded, Placebo-controlled Study in Participants With Long COVID-19: The REVIVE Trial (REVIVE)

Chronic Fatigue Syndrome | Long COVID-19 Syndrome

Brazil
Beijing Tiantan Hospital

Not yet recruiting

Esketamine Combined With Pregabalin on CPSP in Spinal Patients.

Chronic Post Operative Pain | Esketamine | Pregabaline

China
Tanta University

Recruiting

Cilostazol and Methotrexate in Rheumatoid Arthritis

Rheumatoid Arthritis

Egypt
Daniel Merenstein
Patient-Centered Outcomes Research Institute; University of California, Los... and other collaborators

Active, not recruiting

Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis (NOSES)

Sinus Infection | Acute Sinusitis

United States
Merck Sharp & Dohme LLC

Active, not recruiting

Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)

Gastric Cancer | Gastroesophageal Junction Cancer

United States, Belgium, Brazil, Canada, Chile, China, Estonia, France, Germany, Guatemala, Israel, Italy, Japan, Korea, Republic of, Latvia, Lithuania, Malaysia, Philippines, Poland, Russian Federation, Singapore, Taiwan, Ukraine, United...
SFJ Pharmaceuticals, Inc.

Completed

Phase 2B Study to Evaluate the Efficacy of Bentracimab (PB2452) in Reversal of Ticagrelor in Subjects Aged 50-80 Years Old

Healthy

United States, Canada
Yale University
National Center for Complementary and Integrative Health (NCCIH); Brain & Behavior...

Completed

Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD

ADHD

United States
Guang'anmen Hospital of China Academy of Chinese...
China Academy of Chinese Medical Sciences

Active, not recruiting

Treatment Effects of Chinese Medicine (Yi-Qi-Qing-Jie Herbal Compound) Combined With Immunosuppression Therapies in IgA Nephropathy Patients With High-risk of ESRD (TCMWINE)

IgA Nephropathy at High Risk of Developing ESRD

China
Janssen Research & Development, LLC
Pharmacyclics LLC.

Completed

A Study of PCI-32765 (Ibrutinib) in Combination With Either Bendamustine and Rituximab or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Participants With Previously Treated Indolent Non-Hodgkin Lymphoma (SELENE)

Lymphoma

United States, France, Ukraine, United Kingdom, China, Germany, Spain, Argentina, Belgium, Israel, Russian Federation, Turkey, Japan, Australia, Sweden, Korea, Republic of, Brazil, Puerto Rico, Poland
Chipscreen Biosciences, Ltd.

Active, not recruiting

Phase III Study of Tucidinostat in Combination With R-CHOP in Patients With Newly Diagnosed Double-Expressor DLBCL (DEB)

Diffuse Large B-cell Lymphoma

China
Ohio State University Comprehensive Cancer Center
Cancer and Leukemia Group B

Completed

Omega-3 Fatty Acids in Preventing Joint Symptoms in Patients With Stage I-III Breast Cancer Receiving Anastrozole, Exemestane, or Letrozole

Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer

United States
Federal Research Institute of Pediatric Hematology...

Active, not recruiting

CD19 T-CAR for Treatment of Children and Young Adults With r/r B-ALL

B-cell Acute Lymphoblastic Leukemia | Acute Lymphocytic Leukemia, Pediatric

Russian Federation
Sound Pharmaceuticals, Incorporated
Medical University of South Carolina; Cystic Fibrosis Foundation

Enrolling by invitation

SPI-1005 for Prevention and Treatment of Tobramycin Induced Ototoxicity

Ototoxicity

United States
Sanofi
Regeneron Pharmaceuticals

Completed

Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

Ukraine, Argentina, Chile, Poland, Russian Federation, Turkey, United States, Australia, Canada, Germany
Boston Medical Center

Withdrawn

Duloxetine Tibial Plateau

Pain, Postoperative | Tibial Plateau Fracture

United States
Sadat City University

Completed

The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder.

Major Depressive Disorder

Egypt
Baylor College of Medicine

Completed

Complementary Combination Therapy for Cocaine Dependence

Cocaine Dependence

United States
University of Texas at Austin

Completed

Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine (DCS/PSRT)

Panic Attack | Nicotine Addiction

United States
University of Roma La Sapienza

Completed

Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery

To Control Pain After Third Molar Surgery

Italy
Amgen

Completed

Efficacy and Safety Study of Apremilast (CC-10004) in Subjects With Moderate-to-Severe Plaque-Type Psoriasis (Core Study)

Psoriasis | Plaque-type Psoriasis

United States, Canada
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression (TRANSFORM-1)

Treatment-resistant Depression

United States, France, Belgium, Mexico, Canada, Brazil, Estonia, Hungary, Slovakia
University College, London
University of Leeds; University of Sheffield; Medical Research Council; Queen Mary... and other collaborators

Completed

MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART)

Secondary Progressive Multiple Sclerosis

United Kingdom
Grünenthal GmbH
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Terminated

A Study to Evaluate the Effectiveness and Safety of CG5503 (Tapentadol) in the Treatment of Chronic Tumor Related Pain Compared With Placebo and Morphine

Pain | Cancer | Neoplasm

United States, Argentina, Chile, France, Latvia, Ukraine
Arrowhead Pharmaceuticals

Terminated

Study of ARC-520 in Participants With Hepatitis B Virus e Antigen (HBeAg) Positive Chronic Hepatitis B Virus

Chronic Hepatitis B

United States
Tehran University of Medical Sciences

Completed

Reducing Ketamine-Induced Agitation, by Midazolam or Haloperidol Premedication After Adult Procedural Sedation

Ketamine Induced Agitation

Iran, Islamic Republic of
Emory University
National Institute of Mental Health (NIMH); John Templeton Foundation

Completed

Biological Basis of Individual Variation in Social Cooperation

Healthy

United States
Helsinki University Central Hospital

Completed

A Study on Molecular Genetics of Drug Responsiveness in Essential Hypertension (GENRES)

Hypertension | Pharmacogenetics

Finland
The Scripps Research Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Duloxetine Versus Pregabalin for Alcohol Dependence

Alcohol Dependence

United States
H. Lundbeck A/S

Completed

Efficacy of Vortioxetine on Cognitive Dysfunction in Working Patients With Major Depressive Disorder

Major Depressive Disorder

Finland, Germany, Estonia, Lithuania
St. Louis University
Janssen Services, LLC

Withdrawn

Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis

Sickle Cell Disease | Hb-SS Disease With Vasoocclusive Pain | Hemoglobin SS Disease With Vasoocclusive Crisis | Other Sickle Cell Disease With Vaso-Occlusive Pain | Hemoglobin SS Disease With Crisis

United States

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