Search clinical trials for: Bradykinin B2 Receptor Antagonists

Total 9270 results

Shire

Completed

A Study of Icatibant for Acute Attacks of Hereditary Angioedema in Japanese Participants

Hereditary Angioedema (HAE)

Japan
Massachusetts General Hospital
Shire Human Genetic Therapies, Inc.

Completed

Efficacy, Safety and Tolerability of Icatibant for the Treatment of HAE (IHA)

Hereditary Angioedema

United States
Shire

Completed

A Study of Icatibant in Patients With Acute Attacks of Hereditary Angioedema (FAST-3)

Hereditary Angioedema

United States, Australia, Israel, Canada, Hungary, Romania, Russian Federation, South Africa, Ukraine
Shire

Completed

A Pharmacokinetic, Tolerability and Safety Study of Icatibant in Children and Adolescents With Hereditary Angioedema

Hereditary Angioedema (HAE)

United States, Canada, Australia, Austria, Colombia, Germany, Hungary, Israel, Italy, Spain
Sanofi

Completed

Efficacy and Safety Study of Intra-articular Multiple Doses of Icatibant in Patients With Painful Knee Osteoarthritis

Joint Disease

United States, Austria, Czech Republic, Germany, Poland
Shire
Takeda

Completed

FIRAZYR General Drug Use-Results Survey (Japan)

Hereditary Angioedema (HAE)

Japan
Shire
PPD

Completed

Blinded Safety & Efficacy Placebo Controlled Study of Icatibant for Angiotensin Converting Enzyme Inhibitor Induced Angioedema

Angiotensin Converting Enzyme Inhibitor Induced Angioedema

United States, Canada, United Kingdom, Israel
Takeda

Completed

A Study of Icatibant (TAK-667) in Japanese Children and Teenagers With Acute Attacks of Hereditary Angioedema

Hereditary Angioedema

Japan
Vanderbilt University
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Bradykinin Receptor Blocker in ACE Inhibitor-associated Angioedema

Angioneurotic Edema

United States
Vanderbilt University Medical Center
Renal Research Institute; Pharvaris Netherlands B.V.

Recruiting

Prevention of Intradialytic Hypotension by Inhibiting Bradykinin B2 Receptor

Intradialytic Hypotension

United States
Shire
Jerini AG

Completed

EASSI - Evaluation of the Safety of Self-Administration With Icatibant (EASSI)

Hereditary Angioedema

Spain, Argentina, Austria, Denmark, France, Germany, Israel, Italy, Switzerland, United Kingdom
Takeda

Recruiting

A Survey of Icatibant in Pediatric Participants With Hereditary Angioedema

Hereditary Angioedema (HAE)

Japan
Shire

Completed

Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers

Hereditary Angioedema (HAE)

United States
Vanderbilt University Medical Center

Completed

Mitochondria and Chronic Kidney Disease (MitoCKD)

Mitochondrial Diseases | Hemodialysis-Induced Symptom

United States
Vanderbilt University Medical Center
Shire

Terminated

Effect of Bradykinin Receptor Antagonism on ACE Inhibitor-associated Angioedema

ACE Inhibitor-associated Angioedema

United States
University of Edinburgh
University of Aarhus; University of Oxford

Completed

The Effect of Ischaemic-Reperfusion and Remote Ischaemic Preconditioning in Man - A Bradykinin Dependent Pathway

Ischaemic Heart Diseases

United Kingdom
Shire

Completed

Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema

Angioedema

United States
University of Edinburgh
University of Aarhus; University of Oxford

Completed

The Effect of Ischaemic-Reperfusion in Man - A Bradykinin Dependent Pathway

Ischaemic Heart Diseases

United Kingdom
Menarini Group

Completed

Fasitibant Intra-articular Injection in Patients With Symptomatic Osteoarthritis of the Knee (ALBATROSS-3)

Knee Osteoarthritis

United States, Italy, Germany, Czech Republic
Belfast Health and Social Care Trust
Queen's University, Belfast

Completed

Inhibition of Bradykinin in COVID-19 Infection With Icatibant (ICASARS)

SARS CoV 2 Infection

United Kingdom
GCS Ramsay Santé pour l'Enseignement et la Recherche

Completed

Evaluation of the Effects of Bradykinin Antagonists on Pulmonary Manifestations of COVID-19 Infections (AntagoBrad-Cov Study). (AntagoBrad)

Covid19

France
Sebastian Videla

Completed

Investigating the Efficacy and Safety ICATIBANT For The Treatment of Patients With SARS-CoV-2 (COVID-19) Infection (ICAT·COVID)

COVID-19 Pneumonia

Spain
Technical University of Munich

Completed

AMelioration of Angiotensin Converting Enzyme Inhibitor Induced Angioedema Study

Angioedema

Germany
Vanderbilt University Medical Center

Recruiting

Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 2

Heart Failure

United States
Vanderbilt University

Completed

Bradykinin Receptor Antagonism During Cardiopulmonary Bypass (BRAC)

Inflammation | Surgery | Cardiopulmonary Bypass | Fibrinolysis

United States
Menarini Group

Completed

A Locally Injected Bradykinin Antagonist for TReatment of OSteoarthritiS (ALBATROSS)

Osteoarthritis, Knee

Germany, France, Italy, Spain
Shire

Completed

Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema (HAE) (FAST2)

Hereditary Angioedema

Italy
Vanderbilt University Medical Center

Withdrawn

Mechanism(s) Underlying Cardiovascular Effects of ARB/NEP Inhibition - Aim 2

Heart Failure NYHA Class II | Heart Failure NYHA Class III | Heart Failure NYHA Class I

United States
University Potiguar
Universidade Federal de Sergipe

Completed

TRANSDERMAL HRT RELIEVING POSTMENOPAUSAL SYMPTOMS (THRT)

Menopause

Brazil
Boehringer Ingelheim

Completed

The Use of Angiotensin Receptor Blockers and the Risk of Cancer

Neoplasm
University Potiguar
Universidade Federal do Ceará; Federal Institute of Science and Technology...

Completed

Safety Study of Transdermal Testosterone for Low Libido in Pre and Postmenopausal Women (TESTOSTERONE)

Sex Behavior

Brazil
QuantumLeap Healthcare Collaborative
M.D. Anderson Cancer Center; University of Colorado, Denver; University of Pennsylvania and other collaborators

Recruiting

I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients (I-SPY_COVID)

COVID-19

United States
The George Institute

Not yet recruiting

The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect (CAPTIVATE)

Chronic Kidney Diseases
Actelion

Withdrawn

Correlation of LONGterm Wrist ACTigraphy Recorded Physical Performance & 6-minute Walk Distance in Patients With Pulmonary Arterial Hypertension (LONGACT)

Pulmonary Arterial Hypertension
Suzhou Kintor Pharmaceutical Inc,

Completed

The Safety and Tolerability of GT0918 in Subjects With mHSPC and mCRPC

Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) | Metastatic Castrate Resistant Prostate Cancer (mCRPC)

United States
Suzhou Kintor Pharmaceutical Inc,

Completed

Safety, Tolerability, and PK of GT0918 (Proxalutamide) in Subjects With Metastatic Castrate Prostate Cancer

Metastatic Castrate Resistant Prostate Cancer (mCRPC)

United States
Biogen

Terminated

Oral Tonapofylline (BG9928) in Patients With Heart Failure and Renal Insufficiency (POSEIDON)

Heart Failure | Renal Insufficiency

United States
Tracon Pharmaceuticals Inc.
Janssen Pharmaceutica N.V., Belgium

Completed

Phase 1/2A Study of TRC253, an Androgen Receptor Antagonist, in Metastatic Castration-resistant Prostate Cancer Patients

Metastatic Castrate-resistant Prostate Cancer | Adenocarcinoma, Prostate

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effects of Miconazole on Blood Flow

Healthy

United States
Hospices Civils de Lyon

Completed

[11C]Yohimbine PET Study of alpha2-AR ([11C]Yohimbine)

Healthy Controls

France
Bristol-Myers Squibb

Completed

A Phase I Dose-Escalation Study of BMS-641988 in Patients With Castration-Resistant Prostate Cancer

Prostate Cancer

United States
The Affiliated Hospital of Qingdao University

Not yet recruiting

A Retrospective Real-world Study of Abemaciclib Tablets Based on HIS System in HR+ Breast Cancer Patients

Neoplasms | Breast Cancer | Breast Diseases

China
Actelion

Completed

A Study of Two Different Test Formulations Compared to the Reference Formulation of Macitentan in Healthy Adult Participants

Healthy

Belgium
Actelion

Terminated

A Pulmonary Arterial Hypertension Study With Macitentan to Validate the PAH-SYMPACT™ in France, Italy and Spain (ORCHESTRA)

Pulmonary Arterial Hypertension

Spain, France, Italy
KBP Biosciences

Completed

Safety, Tolerability and Pharmacokinetics of KBP-5074 in Healthy Subjects and Subjects With Renal Impairment

Healthy | Renal Insufficiency

United States
Actelion

Withdrawn

Safety and Tolerability Study of Macitentan in Patients With Idiopathic Pulmonary Fibrosis (MUSIC OL)

Idiopathic Pulmonary Fibrosis
University of California, Los Angeles
American Heart Association; Janssen, LP

Completed

Endothelin-1 and Cardiac Allograft Vasculopathy (CAV)

Cardiac Allograft Vasculopathy

United States
Boston University
Actelion

Terminated

Macitentan in Pulmonary Hypertension of Sickle Cell Disease (MENSCH)

Sickle Cell Disease | Pulmonary Hypertension

United States
Actelion

Completed

REPAIR: Right vEntricular Remodeling in Pulmonary ArterIal hypeRtension (REPAIR)

Pulmonary Arterial Hypertension

United States, Israel, France, Netherlands, Malaysia, Germany, Australia, United Kingdom, Hong Kong, Italy, Russian Federation, Singapore
Actelion

Terminated

Clinical Study of Macitentan in Patients With PAH to Psychometrically Validate PAH-SYMPACT Instrument (SYMPHONYext)

Pulmonary Arterial Hypertension

United States

Search clinical trials for: Bradykinin B2 Receptor Antagonists

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