Search clinical trials for: Dornase Alfa Inhalation Solution [Pulmozyme]

Total 530 results

University College, London

Completed

Nebulised Dornase Alfa for Treatment of COVID-19 (COVASE)

Hypoxia | COVID19

United Kingdom
University of Missouri-Columbia

Completed

Dornase Alfa for ARDS in Patients With Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) (DORNASESARS2)

SARS-CoV 2 | ARDS

United States
Fondation Ophtalmologique Adolphe de Rothschild
University Hospital, Strasbourg, France; Centre Hospitalier Régional Metz-Thionville

Terminated

Efficacy and Safety of aerosolizedDornase Alfa Administration in Patients With COVID19 Induced ARDS (COVIDORNASE) (COVIDORNASE)

COVID-19 | Acute Respiratory Distress Syndrome

France
Northwestern University
Genentech, Inc.

Unknown

Pilot Study of Pulmozyme (rhDNase) in Patients With Head and Neck Cancers Treated With Radiation Therapy + Chemotherapy

Head and Neck Cancer

United States
University of Vermont
Genentech, Inc.

Completed

Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis

Sinusitis | Cystic Fibrosis

United States
University of Melbourne

Recruiting

Improving Early Reperfusion With Adjuvant Dornase Alfa in Large Vessel Ischemic Stroke (EXTEND-IA DNase)

Ischemic Stroke

Australia
Nicole Hamblett
University of Washington; Dartmouth-Hitchcock Medical Center; Cystic Fibrosis...

Completed

Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy (SIMPLIFY)

Cystic Fibrosis

United States
Boston Children's Hospital
Brigham and Women's Hospital; South Shore Hospital

Recruiting

Pulmozyme to Improve COVID-19 ARDS Outcomes

COVID

United States
Genentech, Inc.

Terminated

A Study of Pulmozyme® (Dornase Alpha) in 3- to 5-Year-Old Patients With Cystic Fibrosis

Cystic Fibrosis
University of Colorado, Denver
Genentech, Inc.

Completed

Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®)

Otitis Media

United States
Genentech, Inc.

Terminated

A Trial of Pulmozyme Withdrawal on Exercise Tolerance in Cystic Fibrosis Subjects With Severe Lung Disease (TOPIC)

Cystic Fibrosis

United States
Genentech, Inc.

Completed

A Study of the Comparable Efficacy and Safety of Pulmozyme (Dornase Alfa) Delivered by the eRapid Nebulizer System in Patients With Cystic Fibrosis

Cystic Fibrosis

United States
University of Medicine and Dentistry of New Jersey

Completed

Impact of Nebulized Dornase Alpha on Mechanically Ventilated Patients

Atelectasis | Ventilation, Mechanical

United States
University of Jena

Completed

Nasal Inhalation of Pulmozyme in Patients With Cystic Fibrosis and Chronic Rhinosinusitis

Cystic Fibrosis | Rhinosinusitis

Germany
Ludwig-Maximilians - University of Munich
University Hospital Erlangen; University Hospital Regensburg

Not yet recruiting

Reduction of SystemiC Inflammation After Ischemic Stroke by Intravenous DNase Administration (ReSCInD) (ReSCInD)

Ischemic Stroke | Inflammatory Response

Germany
AO GENERIUM

Completed

Efficacy and Safety of Tigerase® vs. Pulmozyme® in Patients With Cystic Fibrosis

Fibrosis | Cystic Fibrosis

Russian Federation
UConn Health

Withdrawn

Pulmozyme for Sjogren's Associated Cough

Cough | Sjogren's Syndrome

United States
Georgetown University
Genentech, Inc.

Completed

Dornase Alfa Therapy for Ventilator Associated Lung Infections in the Neonatal Intensive Care Unit (NICU) (PVAIN)

Pulmonary Infections

United States
Nicole Hamblett
University of Washington; Dartmouth-Hitchcock Medical Center; Cystic Fibrosis...

Completed

Impact of Discontinuing Dornase Alfa in People With CF on Highly Effective CFTR Modulator Therapy-A SIMPLIFY Sub-Study (SIMPLIFY-DN)

Cystic Fibrosis

United States
The Alfred
The Alfred Research Trusts Small Project Grant.; Dr Carey Denholm and Laura...

Completed

Preliminary Study of Dornase Alfa to Treat Chest Infections Post Lung Transplant.

Lower Respiratory Tract Infection | Lung Transplant Infection

Australia
University Hospital, Strasbourg, France

Recruiting

Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma (TRAUMADORNASE)

Multiple Trauma | Respiratory Distress Syndrome, Adult

France
Milton S. Hershey Medical Center
Genentech, Inc.

Withdrawn

Pulmozyme in Cystic Fibrosis With Sinusitis

Sinusitis | Cystic Fibrosis

United States
University Hospital Tuebingen
Joachim Riethmueller, Dr. med.

Unknown

Time of Ventilation and Lung Function of Ventilated Patients Under Therapy With Dornase Alfa

Long Term Ventilation

Germany
AO GENERIUM

Completed

Tigerase® Efficacy and Safety as Part of Complex Therapy in Patients With COVID-19

COVID-19 | Coronavirus Disease 2019

Russian Federation
Nationwide Children's Hospital
Genentech, Inc.

Completed

Effectiveness of Pulmozyme in Infants With Cystic Fibrosis

Cystic Fibrosis

United States
The Hospital for Sick Children
Canadian Institutes of Health Research (CIHR); Unity Health Toronto; Children... and other collaborators

Completed

Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial)

Pleural Empyema

Canada
JHL Biotech, Inc.

Completed

A Comparative Safety and Pharmacokinetic Study of JHL1922 and Pulmozyme® in Healthy Subjects

Healthy Subjects

Netherlands
University of Illinois at Chicago
Genentech, Inc.; Research to Prevent Blindness

Terminated

DNase Treatment for Dry Eyes

Dry Eye

United States
Pharmaxis

Completed

Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis

Cystic Fibrosis

United Kingdom
Azienda Ospedaliera di Padova
Hoffmann-La Roche

Unknown

Dornase Alfa and Urokinase for Kids With Pleural Empyema (DUKE)

Pleural Empyema

Italy
Fondation Ophtalmologique Adolphe de Rothschild

Recruiting

Efficacy of Pulmozyme® on Arterial Recanalization in Post-thrombectomy Patients Managed for Ischemic Stroke (NETs-target) (NETs-target)

Ischemic Stroke

France
University Medical Centre Ljubljana

Terminated

Usefulness of DORNASE in COVID-19 on HFNO

COVID-19 Pneumonia

Slovenia
Jon Simmons
University of South Alabama

Recruiting

Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure (DAMPENCOVID)

Covid19

United States
Eastern Regional Medical Center

Recruiting

Combination Tissue Plasminogen Activator (Tpa) and Dornase Alfa (Dnase) Administration Through Intrapleural Catheters for the Treatment of Loculated or Non-Draining Malignant Pleural Effusions

Loculated or Non-draining Malignant Pleural Effusions

United States
Kexing Biopharm Co., Ltd.
The Third Hospital of Changsha; Guoxin Pharmaceutical Technology (Beijing)... and other collaborators

Active, not recruiting

A Phase I Study of Human Interferon Alfa 1b Inhalation Solution in Healthy Participants

Healthy Participants

China
Aires Pharmaceuticals, Inc.

Completed

Dose-Finding, Safety, Pharmacodynamic Effect Study of Sodium Nitrite Inhalation Solution in Normal, Healthy Volunteers (AIR001-CS02)

Pulmonary Arterial Hypertension

United States
National University of Malaysia

Completed

Short Duration High Intensity Intrapleural Alteplase With Pulmozyme in Pleural Infection Management

Loculated Empyema

Malaysia
Pharmosa Biopharm Inc.
PPD

Completed

Single Ascending Dose Study for Evaluation of Safety, Tolerability and Pharmacokinetics of L606

Pulmonary Arterial Hypertension

United States
Aires Pharmaceuticals, Inc.

Completed

Safety, Tolerability, and PK Parameters of Sodium Nitrite Inhalation Solution in Healthy Subjects

Pulmonary Arterial Hypertension | Pulmonary Hypertension

United States
Pharmosa Biopharm Inc.
Novotech (Australia) Pty Limited

Recruiting

Safety, Tolerability and Pharmacokinetics of L608 in Healthy Adults

Pulmonary Arterial Hypertension

Australia
Mylan Pharma UK Ltd.

Completed

Revefenacin in Chinese Subjects With Moderate to Very Severe Chronic Obstructive Pulmonary Disease(COPD)

COPD

China
Aires Pharmaceuticals, Inc.

Terminated

A Phase 2 Study to Determine the Safety and Efficacy of AIR001 in Subjects With Pulmonary Arterial Hypertension (PAH)

Pulmonary Arterial Hypertension

United States, Australia, Hungary
University of Illinois at Chicago
National Eye Institute (NEI); Genentech, Inc.

Terminated

rhDNase Eye Drops in Patients With Ocular Graft-Vs.-Host Disease

Dry Eye | Ocular Graft vs Host Disease

United States
National Jewish Health

Unknown

Use of DNAse in Neutrophilic Asthma

Neutrophilic Asthma

United States
Meiji Seika Pharma Co., Ltd.

Completed

Pharmacokinetics and Safety Study of ME1100 in Healthy Volunteers

Healthy

United States
Erik Allen Jensen
University of Florida

Active, not recruiting

Inhaled Tobramycin in BPD

Bronchopulmonary Dysplasia

United States
Sunovion Respiratory Development Inc.

Completed

Assessment of the Safety and Ability of a Once-a-day Dose of an Orally Inhaled Medicine [ie, Glycopyrrolate Inhalation Solution = GIS] to Improve Airflow in the Lungs When Delivered With an Electronic eFlow Nebulizer System in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease
Gerard Turino

Completed

Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency

Emphysema | Alpha 1-Antitrypsin Deficiency

United States, Canada
Bitop AG

Active, not recruiting

Multicentre Post-market Study of Ectoin® Inhalation Solution in Treatment of Asthma. (EIL-AST)

Asthma

Poland
Bitop AG

Completed

Efficacy and Feasibility of Ectoin® Inhalation Solution in Inflammatory Obstruction and Ageing of the Lung (EFECT)

COPD | Particulate Matter Induced Inflammation of the Lung

Germany

Search clinical trials for: Dornase Alfa Inhalation Solution [Pulmozyme]

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