Search clinical trials for: Glycine Transporter-1 inhibitor

Total 11861 results

GlaxoSmithKline

Terminated

A Repeat Dose Study With GSK1018921 to Assess Safety, Tolerability, Pharmacokinetics, Pharmacodynamics in Healthy Volunteers and Patients With Schizophrenia and to Evaluate Its Effect on PK of Midazolam. (GT1110791)

Schizophrenia

United States
Medical University of Lodz

Completed

Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia (PULSAR)

Schizophrenia

Poland
Massachusetts General Hospital
National Institute on Drug Abuse (NIDA)

Completed

A Study of the Effects of Sarcosine on Symptoms and Brain Glycine Levels in People With Schizophrenia (Sarc)

Schizophrenia

United States
Chroma Therapeutics

Completed

Safety and Anti-Disease Activity of CHR-2797 (Tosedostat) in Elderly and/or Treatment Refractory Patients With Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM)

Acute Myeloid Leukemia | Multiple Myeloma | Myelodysplastic Syndrome

United Kingdom
Mayo Clinic
Takeda

Completed

The Effect of Ixazomib on the Latent HIV Reservoir

Human Immunodeficiency Virus (HIV)

United States
University of Florida
National Institutes of Health (NIH)

Completed

Vitamin B6 Dependence of One-Carbon Metabolism

Vitamin B6 Deficiency

United States
Ono Pharmaceutical Co. Ltd

Completed

Controlled Study of ONO-5046Na in Patients With Acute Respiratory Failure Associated With Community-Acquired Pneumonia

Community-acquired Pneumonia

Japan
GlaxoSmithKline

Completed

Phase III Study of GSK1278863 in Japanese Non-dialysis (ND) and Peritoneal Dialysis (PD) Subjects With Renal Anemia

Anaemia

Japan
Peking Union Medical College Hospital

Completed

Analyse of Diagnosis Value of Keloid on 68Ga- FAPI-04 PET-CT

Keloid

China
CTI BioPharma
Chroma Therapeutics

Completed

Crossover Trial of the Effect of a High-Fat Meal on the PK of Oral CHR 2797 in Healthy Male Subjects (8265134)

Healthy

United States
Ono Pharmaceutical Co. Ltd

Completed

Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan

Systemic Inflammatory Response Syndrome | Acute Lung Injury

Japan
The Hospital for Sick Children

Completed

Uptake and Utilization of Amino Acids by Splanchnic Bed

Healthy Males

Canada
PrECOG, LLC.
Takeda

Completed

A Study of Ixazomib and Ibrutinib in Relapsed/Refractory Mantle Cell Lymphoma (PrE0404)

Mantle-Cell Lymphoma

United States
Onconova Therapeutics, Inc.

Completed

Efficacy and Safety of ON 01910.Na in Myelodysplastic Syndrome (MDS) Patients With Trisomy 8 or Classified as Intermediate-1, -2 or High Risk

Myelodysplastic Syndrome

United States
Second Affiliated Hospital, School of Medicine,...
Shaoxing People's Hospital; Shaoxing Second Hospital; Huizhou Municipal Central... and other collaborators

Recruiting

Ixazomib Plus Low-dose Lenalidomide Versus Ixazomib Alone for Maintenance Treatment of High Risk Multiple Myeloma

Multiple Myeloma

China
Mayo Clinic
Patient-Centered Outcomes Research Institute

Active, not recruiting

Second-line Therapies for Patients With Type 2 Diabetes and Moderate Cardiovascular Disease Risk

Type 2 Diabetes | Cardiac Disease

United States
Servier Bio-Innovation LLC
Institut de Recherches Internationales Servier

Recruiting

Ivosidenib, Nivolumab, and Ipilimumab Combination in Previously Treated Subjects With Nonresectable or Metastatic IDH1 Mutant Cholangiocarcinoma

IDH1-mutant Cholangiocarcinoma

United States, United Kingdom
Jeil Pharmaceutical Co., Ltd.

Not yet recruiting

Evaluation of Efficacy and Safety When Administered JP-2266 in Type 2 Diabetes Patients

Type 2 Diabetes Mellitus

Korea, Republic of
National Cancer Institute (NCI)

Completed

Ixazomib and Pevonedistat in Treating Patients With Multiple Myeloma That Has Come Back or Does Not Respond to Treatment

Refractory Multiple Myeloma | Recurrent Multiple Myeloma

United States
Stichting Hemato-Oncologie voor Volwassenen Nederland
Deutsch-Österreichische Studiengruppe Akute Myeloische Leukämie (AMLSG)

Recruiting

A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy (HOVON150AML)

Acute Myeloid Leukemia | Myelodysplastic Syndrome With Excess Blasts-2

Australia, Austria, Belgium, Estonia, Finland, France, Germany, Ireland, Lithuania, Luxembourg, Netherlands, Norway, Spain, Sweden, Switzerland
Xiaotong Hou

Not yet recruiting

A Pilot Study of Sivelestat Sodium to Shorten Mechanical Ventilation in Acute Aortic Dissection

Acute Aortic Dissection

China
GlaxoSmithKline
Octagon Research Solutions, Incoporated

Completed

Study to Assess the Pharmacokinetics of GSK1278863A Coadministered With a High Fat Meal or an Inhibitor of CYP2C8 (Gemfibrozil) (DDI)

Anaemia

India
University Hospital, Basel, Switzerland

Active, not recruiting

Effects of MDMA-like Substances in Healthy Subjects (MDMA-like)

Healthy

Switzerland
University of Chicago
National Cancer Institute (NCI); Multiple Myeloma Research Foundation

Active, not recruiting

Lenalidomide With or Without Ixazomib Citrate and Dexamethasone in Treating Patients With Residual Multiple Myeloma After Donor Stem Cell Transplant

Plasma Cell Myeloma | Residual Disease

United States
Queen's University, Belfast
Belfast Health and Social Care Trust

Recruiting

Investigation of Biomarker Response to SGLT2 Inhibition in Heart Failure (SiN-HF)

Heart Failure

United Kingdom
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Ibrutinib and Ixazomib Citrate in Treating Newly Diagnosed, Relapsed or Refractory Waldenstrom Macroglobulinemia

Waldenstrom Macroglobulinemia | Recurrent Waldenstrom Macroglobulinemia | Refractory Waldenstrom Macroglobulinemia

United States
Akebia Therapeutics

Completed

Effect of AKB-6548 on Cardiac Repolarization Intervals in Healthy Volunteers

Healthy Volunteers

United States
GlaxoSmithKline

Completed

A Study to Demonstrate the Efficacy and Tolerability of Ferrous Bisglycinate Chelate in Iron Deficiency Anaemia and to Compare These With Those of Ferrous Ascorbate.

Haematopoiesis

India
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Ixazomib Citrate and Lenalidomide After Stem Cell Transplant in Treating Patients With Newly Diagnosed Multiple Myeloma

Plasma Cell Myeloma | Hematopoietic Cell Transplantation Recipient

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI)

Recruiting

Trial of Ixazomib for Kaposi Sarcoma

Kaposi Sarcoma | Skin

United States
Assiut University

Not yet recruiting

Effect of Sodium Glucose Cotransporter 2 Inhibitiors on Left Ventricular Remodeling Among Diabetic and Non Diabetic Patients With Chronic Heart Failure

Chronic Heart Disease | SGLT2 Inhibitiors Remodeling Effect
Brigham and Women's Hospital
Novo Nordisk A/S via Research Grant to Brigham and Women's Hospital

Completed

Diabetes Remote Intervention to improVe Use of Evidence-based Medications (DRIVE)

Cardiovascular Diseases | Diabetes

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Ixazomib Citrate in Treating Patients With Chronic Graft-versus-Host Disease

Chronic Graft Versus Host Disease

United States
Fred Hutchinson Cancer Center

Active, not recruiting

Alternating Ixazomib Citrate and Lenalidomide as Maintenance Therapy After Stem Cell Transplant in Treating Patients With Multiple Myeloma

Plasma Cell Myeloma | Transplant-Related Carcinoma

United States
Brigham and Women's Hospital
Patient-Centered Outcomes Research Institute

Recruiting

PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes (PRECIDENTD)

Type2Diabetes | ASCVD

United States
Boston University
American Heart Association

Recruiting

Assessment of Dapagliflozin on Vascular Health in Patients With Type 2 Diabetes (SFRNDM2)

Diabetes Mellitus, Type 2 | Endothelial Dysfunction

United States
Kamada, Ltd.

Completed

Phase II Study to Evaluate the Efficacy and Safety of Glassia® in Type-1 Diabetes

New Onset Type-1 Diabetes

Israel
University of Tartu

Completed

Effects of Diabetes Medications on Adrenal Function and Intestinal Microbiota

Type 2 Diabetes

Estonia
University of Dundee

Recruiting

Bronchiectasis Alpha-1 Augmentation Trial- Modulating Airway Neutrophil Function (BATMAN)

Bronchiectasis Adult

United Kingdom
University of Palermo

Not yet recruiting

SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF (DAPA-TONIC)

Heart Failure With Reduced Ejection Fraction | Heart Failure With Preserved Ejection Fraction | Diabetes Type 2 | Heart Failure Acute
Boehringer Ingelheim

Completed

DIA_CENTRAL:T2D Treatment Pattern in Central Europe

Diabetes Mellitus, Type 2

Bulgaria, Czechia, Hungary, Poland, Russian Federation
University of Padova

Completed

Cardiovascular Outcomes SGLT-2 Inhibitors Versus GLP-1 Receptor Agonists

Type 2 Diabetes

Italy
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Alpha 1 Anti-Trypsin (AAT) in Treating Patients With Acute Graft-Versus-Host Disease GVHD)

Graft-Versus-Host Disease (GVHD) Acute on Chronic

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Tosedostat and Cytarabine or Azacitidine in Treating Older Participants With Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

Acute Myeloid Leukemia | High Risk Myelodysplastic Syndrome

United States
CSL Behring

Recruiting

The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft-Versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant (MODULAATE)

Acute-graft-versus-host Disease

United States, Korea, Republic of, Spain, Australia, Germany, Italy, Turkey, Japan
Dong Wang

Not yet recruiting

TC Plus PD-1 Inhibitors Combined With Anlotinib for Advanced Advanced Esophageal Cancer (TC)

ESCC

China
Michael Campos, MD
CSL Behring

Completed

Effect of Double Dose of Alpha 1-antitrypsin Augmentation Therapy on Lung Inflammation.

Alpha 1 Antitrypsin Deficiency

United States
Boehringer Ingelheim

Completed

Evaluating Comparative Effectiveness of Empagliflozin in Type 2 Diabetes Population With and Without Chronic Kidney Disease

Diabetes Mellitus, Type 2

United States
Samsung Medical Center

Recruiting

Peri-treatment of SGLT-2 Inhibitor on Myocardial Infarct Size and Remodeling Index in Patients With Acute Myocardial Infarction and High Risk of Heart Failure Undergoing Percutaneous Coronary Intervention (PRESTIGE-AMI)

Heart Failure | Acute Myocardial Infarction

Korea, Republic of
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Tosedostat in Combination With Cytarabine or Decitabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Secondary Acute Myeloid Leukemia | Untreated Adult Acute Myeloid Leukemia | Previously Treated Myelodysplastic Syndromes | Secondary Myelodysplastic Syndromes | Adult Acute Myeloid Leukemia... and other conditions

United States

Search clinical trials for: Glycine Transporter-1 inhibitor

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