Search clinical trials for: TTI-621 radiation

Total 8243 results

Pfizer

Terminated

A Trial of PF-07901800 (TTI-621) for Patients With Hematologic Malignancies and Selected Solid Tumors

Solid Tumor | Hematologic Malignancies

United States, Canada
Pfizer

Terminated

Trial of Intratumoral Injections of TTI-621 in Subjects With Relapsed and Refractory Solid Tumors and Mycosis Fungoides

Melanoma | Soft Tissue Sarcoma | Mycosis Fungoides | Breast Carcinoma | Solid Tumors | Squamous Cell Carcinoma | Human Papillomavirus-Related Malignant Neoplasm | Merkel-cell Carcinoma

United States
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

TTI-622 and TTI-621 in Combination With Pembrolizumab for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Recurrent B-Cell Non-Hodgkin Lymphoma | Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma | Recurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements | Refractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements | Recurrent Diffuse Large B-Cell... and other conditions

United States
Pfizer

Recruiting

A Study to Learn About the Study Medicine (Maplirpacept) in People With Advanced Non-Hodgkin Lymphoma or Multiple Myeloma in China

Multiple Myeloma | Non-Hodgkin Lymphoma

China
Oregon Research Institute

Completed

Transitional Treatment of Adolescents in Family Therapy (Transitions)

Substance Abuse

United States
Pfizer

Active, not recruiting

A Study to Learn About the Study Medicine (Called Maplirpacept (PF-07901801)) in Japanese With Hematologic Malignancies

Lymphoma | Multiple Myeloma

Japan
Cancer Institute and Hospital, Chinese Academy...

Unknown

Real-world Treatment Patterns and Clinical Outcomes in EGFR-mutant Unresectable Locally Advanced NSCLC

Non Small Cell Lung Cancer | Stage III Non-small-cell Lung Cancer | EGFR Mutation-Related Tumors
Universitätsklinikum Hamburg-Eppendorf

Recruiting

Nasotracheal Intubation in Critically Ill. (NaTra-P)

Critical Care | Tracheal Intubation Morbidity

Germany
Edward Via Virginia College of Osteopathic Medicine
National Center for Complementary and Integrative Health (NCCIH); The University...

Recruiting

Effect of Tai Chi Exercise on Mechanical Joint Loading in Knee Osteoarthritis

Knee Osteoarthritis

United States
Tata Memorial Hospital

Recruiting

Local Consolidative Radiation Therapy Plus TKI Versus TKI Alone in Driver Mutated OM-NSCLC (TARGET-01)

Non-small Cell Lung Cancer | Oligometastatic Disease | Driver Mutation

India
Memorial Sloan Kettering Cancer Center
Trillium Therapeutics Inc.

Active, not recruiting

A Study of TTI-622 in Combination With Daratumumab Hyaluronidase-fihj in People With Multiple Myeloma

Multiple Myeloma

United States
Vertex Pharmaceuticals Incorporated

Active, not recruiting

Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age

Cystic Fibrosis

United States, Australia, Germany, Sweden, Switzerland, France, Netherlands, United Kingdom
Vertex Pharmaceuticals Incorporated

Active, not recruiting

A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy

Cystic Fibrosis

United States, Spain, United Kingdom, Belgium, Netherlands, Denmark, Israel, New Zealand, France, Australia, Ireland, Germany, Sweden, Canada, Czechia, Switzerland, Portugal, Italy, Austria, Hungary, Norway, Poland, Greece
Vertex Pharmaceuticals Incorporated

Completed

Pharmacokinetics and Safety Assessment of VX-121/Tezacaftor/Deutivacaftor in Participants With Moderate Hepatic Impairment

Cystic Fibrosis

United States
Vertex Pharmaceuticals Incorporated

Completed

A Study to Evaluate the Relative Bioavailability of a Fixed-dose Combination Tablet of VX-121/Tezacaftor/Deutivacaftor

Cystic Fibrosis

United States
Vertex Pharmaceuticals Incorporated

Enrolling by invitation

Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in Cystic Fibrosis Participants 1 Year of Age and Older

Cystic Fibrosis

United States, Australia, Germany, Sweden, Switzerland, France, Netherlands, United Kingdom
Vertex Pharmaceuticals Incorporated

Enrolling by invitation

A Study of Vanzacaftor/Tezacaftor/Deutivacaftor (VNZ/TEZ/D-IVA) in Healthy Adult Panelists

Cystic Fibrosis

United States
Vertex Pharmaceuticals Incorporated

Recruiting

A Study To Evaluate the Relative Bioavailability, Food Effect, and Dose Proportionality of a Granule Formulation of Vanzacaftor/Tezacaftor/Deutivacaftor(VNZ/TEZ/D-IVA)

Cystic Fibrosis

United States
Ottawa Hospital Research Institute

Recruiting

Total Marrow Irradiation & Autologous Stem Cell Transplantation for Relapsed or Refractory Myeloma (TMI-ASCT)

Multiple Myeloma

Canada
IRCCS Azienda Ospedaliera Universitaria San Martino...

Completed

Exclusive Intraoperative Radiation Therapy for Breast Cancer

Breast Neoplasms | Toxicity

Italy
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

TBI Using IMRT (VMAT or Tomotherapy) for the Prevention of Pul Toxicities in Patients Undergoing Donor SCT

Acute Leukemia | Myelodysplastic Syndrome

United States
NCIC Clinical Trials Group
National Cancer Institute (NCI); Radiation Therapy Oncology Group; North Central... and other collaborators

Completed

Radiation Therapy in Treating Women Who Have Undergone Surgery for Early-Stage Invasive Breast Cancer

Breast Cancer

Canada
The Netherlands Cancer Institute
Dutch Cancer Society

Completed

Hippocampus Avoidance PCI vs PCI (HA-PCI)

Small Cell Lung Cancer | Lung Cancer

Netherlands, Belgium
Hamamatsu University
Japan Agency for Medical Research and Development

Unknown

A Trial of TTA-121 on Autism Spectrum Disorder

Autism Spectrum Disorder

Japan
Tvardi Therapeutics, Incorporated
M.D. Anderson Cancer Center

Active, not recruiting

Oral STAT3 Inhibitor, TTI-101, in Patients With Advanced Cancers

Melanoma | Breast Cancer | Colorectal Cancer | Gastric Adenocarcinoma | Non Small Cell Lung Cancer | Advanced Cancer | Head and Neck Squamous Cell Carcinoma | Hepatocellular Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Radiation Therapy Alone for the Treatment of Stage 1 and 2 Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma

Ann Arbor Stage II Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue | Ann Arbor Stage I Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue | Extranodal Marginal Zone Lymphoma

United States
Emory University
National Cancer Institute (NCI)

Recruiting

Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer

Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Oropharyngeal HPV-Positive Squamous Cell Carcinoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Ultra Low-Dose Radiation Therapy in Treating Patients With Stage I-IV Stomach MALT Lymphoma

Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

United States
Pfizer

Recruiting

A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma (MagnetisMM-20)

Multiple Myeloma

United States, Israel
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Terminated

Low-Dose Total Lymphoid Irradiation in Treating Patients With Refractory Chronic Graft-versus-Host Disease After Donor Stem Cell Transplant

Graft Versus Host Disease

United States
Medical College of Wisconsin

Not yet recruiting

Radiation Prior to TKI to Delay Progression in Advanced Driver-Mutated Non-small Cell Lung Cancers (RadiaNCe Lung X)

Non Small Cell Lung Cancer

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Terminated

Study Evaluating TTI-237 in Advanced Malignant Solid Tumors

Neoplasms

United States
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

Intracranial Meningioma | Grade II Meningioma

Canada, United States, Japan, Saudi Arabia, India
University of California, San Francisco
Varian Medical Systems

Recruiting

Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers

Stage IV Anal Cancer AJCC v8 | Metastatic Gastroesophageal Junction Adenocarcinoma | Metastatic Colorectal Carcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Postneoadjuvant Therapy Stage... and other conditions

United States
Brynn Chappell
The Christie NHS Foundation Trust

Terminated

PIT: Prophylactic Irradiation of Tracts in Patients With Malignant Pleural Mesothelioma (PIT)

Mesothelioma

United Kingdom
University of Colorado, Denver
Tvardi Therapeutics, Incorporated

Recruiting

Trial of Radiotherapy in Combination With TTI-101 in Patients With Borderline Resectable Pancreatic Cancer

Pancreatic Cancer

United States
Trillium Therapeutics Inc.

Completed

Safety Study of Single Intravesical Doses of TTI-1612 in Women With Interstitial Cystitis/Bladder Pain Syndrome

Interstitial Cystitis

Canada
Wyeth is now a wholly owned subsidiary of Pfizer

Terminated

Study Evaluating TTI-237 in Advanced Malignant Solid Tumors.

Neoplasms | Tumors

United States
M.D. Anderson Cancer Center
National Institutes of Health (NIH); Tvardi Therapeutics, Inc

Not yet recruiting

Randomized Pre-surgical Window-of-Opportunity Trial of TTI-101 in Patients With Stage II-IV Resectable HPV-negative Squamous Cell Carcinoma of the Head and Neck

Squamous Cell Carcinoma of Head and Neck

United States
Tvardi Therapeutics, Incorporated

Recruiting

Study of TTI-101 in Participants With Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis

United States
University of Florida
Florida Department of Health

Active, not recruiting

Breast Cancer Lung Late Effects (BELLE)

Breast Cancer | Radiation Injury

United States
British Columbia Cancer Agency
Canadian Institutes of Health Research (CIHR)

Unknown

Long Term Outcomes of Breast Intensity-Modulated Radiation Therapy (BIMRT)

Breast Cancer

Canada
University of Colorado, Denver
University of California, Los Angeles; H. Lee Moffitt Cancer Center and Research... and other collaborators

Recruiting

TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus)

Esophageal Cancer | Barrett's Esophagus

United States
UNICANCER

Active, not recruiting

Standard or Hypofractionated Radiotherapy Versus Accelerated Partial Breast Irradiation (APBI) for Breast Cancer (SHARE)

Breast Cancer | Lumpectomy

France
Pfizer

Terminated

A Study to Learn About the Study Medicine (Called Ontorpacept or TTI-621) Given Alone and in Combination With Doxorubicin in People With Leiomyosarcoma (TTI-621-03)

Leiomyosarcoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

NBTXR3 Activated by Radiation Therapy for the Treatment of Locally Advanced or Borderline-Resectable Pancreatic Cancer

Stage III Pancreatic Cancer AJCC v8 | Borderline Resectable Pancreatic Adenocarcinoma | Resectable Pancreatic Ductal Adenocarcinoma | Locally Advanced Pancreatic Ductal Adenocarcinoma

United States
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Radiation Therapy With Protons or Photons in Treating Patients With Liver Cancer

Unrectable or Locally Recurrent Hepatocellular Carcinoma

United States
University of Liege
KU Leuven; Maastricht University Medical Center

Completed

Allogeneic HCT With HLA-matched Donors : a Phase II Randomized Study Comparing 2 Nonmyeloablative Conditionings

Hematological Malignancies

Belgium, Netherlands
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Completed

Radiation Therapy in Treating Patients With Extensive Stage Small Cell Lung Cancer

Lung Cancer

United States, Canada, Israel
UBP Greater China (Shanghai) Co., Ltd

Not yet recruiting

Evaluating Safety and Efficacy of Repeat Doses of UB-621in Adult Patients With Recurrent Genital Herpes

Recurrent Genital Herpes

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