- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03621631
Effect of Tai Chi Exercise on Mechanical Joint Loading in Knee Osteoarthritis
February 13, 2023 updated by: Edward Via Virginia College of Osteopathic Medicine
Real Time Biofeedback Tai Chi Training for Knee Osteoarthritis: A Feasibility Study
This project is designed to identify the biomechanical mechanisms of Tai Chi (TC) exercise and test a novel optimized TC intervention by modifying newly identified mechanisms for those with knee osteoarthritis (OA) and to assess the changes in mechanical load with the intervention.
It combines unique real time torque biofeedback approach, and uses external knee adduction moment (EKAM) as modulation target tailored to TC intervention in this population.
The potential benefit from this project is to provide biomechanical insights of TC and this novel TC approach may produce meaningful changes of mechanical load in these patients who can learn and practice safely during this intervention.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Detailed Description
Disabilities that arise from typical impairments of knee osteoarthritis (OA) include decreased muscle strength, reduced range of motion, and decreased aerobic cardiovascular function.
A large number of individuals with knee OA experience disability and require rehabilitation.
Traditional TC intervention has been a promising therapeutic intervention in knee OA, but the efficacy of TC as a knee OA intervention has proven inconclusive presumably because individuals with knee OA perform different TC components (steps) with widely varying mechanical knee joint loads.
This variation could be a confounding factor in the way in which TC affects knee OA.
Therefore, a feasibility study is proposed here to quantify external knee adduction moment (EKAM) response to the different TC steps, and then determine if it is feasible to use biofeedback of torque acting on the knee to modify some TC steps so as to reduce the EKAM they produce.
Those TC steps whose EKAM can be easily reduced below mean EKAM during walking and those already below that level will constitute an optimized form of TC for knee OA; the remainder will be discarded.
A phase 1 randomized controlled trial will be conducted to compare the optimized TC intervention to traditional TC training in reducing EKAM.
The proposed research represents the first study to identify the biomechanical mechanisms of TC and to target EKAM by using a real-time biofeedback approach to manipulate EKAM during TC performance.
Study Type
Interventional
Enrollment (Anticipated)
60
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Texas
-
San Antonio, Texas, United States, 78258
- Recruiting
- UT Health San Antonio, Rehabilitation Biomechanics Lab
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
40 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- OA participants will be diagnosed based on the American College of Rheumatology classification criteria.
- Knee pain average level > 3 cm on a 10 cm visual analog scale,
- Kellgren / Lawrence scale of 2-3 on radiographs.
- Pain/tenderness over the medial region or lateral region of the knee on physical examination.
- The participants will have 40 years of age or older and have no TCC experience prior this study.
Exclusion Criteria:
- a history of lower extremity joint replacement
- intra-articular knee injection (steroid, hyaluronic acid) within the previous 6 months
- systemic rheumatoid arthritic condition affecting the knee clinically or radiographically,
- report of any of the following health problems (heart condition, chest pain during periods of activity or rest)
- currently seeking or receiving physical therapy for knee OA,
- having a medical condition precluding the participant from undergoing physical activity or biomechanical gait analysis.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: optimized Tai Chi intervention
|
Optimized Tai Chi intervention
Other Names:
|
Active Comparator: traditional Tai Chi intervention
|
Traditional Tai Chi intervention
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
change from baseline knee joint mechanical load at 4 weeks
Time Frame: baseline and 4 weeks
|
knee joint mechanical load will be measured by using high speed cameras and force plates to estimate external knee adduction moment (EKAM)
|
baseline and 4 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
August 27, 2018
Primary Completion (Anticipated)
July 31, 2023
Study Completion (Anticipated)
September 1, 2023
Study Registration Dates
First Submitted
July 31, 2018
First Submitted That Met QC Criteria
August 3, 2018
First Posted (Actual)
August 8, 2018
Study Record Updates
Last Update Posted (Actual)
February 15, 2023
Last Update Submitted That Met QC Criteria
February 13, 2023
Last Verified
February 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2016-050
- 1K23AT009568-01A1 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
YES
IPD Plan Description
De-identified individual participant data for all primary outcome measure will be made available
IPD Sharing Time Frame
Data will be available within 6 month of study completion
IPD Sharing Access Criteria
Data access requests will be reviewed by an external independent review panel.
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
- ICF
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Knee Osteoarthritis
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LifeBridge HealthMicroPort Orthopedics Inc.; Rubin Institute for Advanced OrthopedicsRecruitingKnee Osteoarthritis | Osteoarthritis, Knee | Knee Pain Chronic | Arthropathy of Knee Joint | Knee Disease | Osteoarthritis Knees Both | Osteoarthritis Knee Left | Osteoarthritis Knee RightUnited States
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University Hospital, Clermont-FerrandSanofiCompletedKnee Osteoarthritis (Knee OA)France
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Joseph E. BroylesCompletedDegenerative Lesion of Articular Cartilage of Knee | Degeneration; Articular Cartilage, Knee | Unilateral Primary Osteoarthritis of Knee | Osteoarthritis Knee
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Jiangsu XinChen-Techfields Pharma Co., LTD.Completed
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The Hong Kong Polytechnic UniversityCompleted
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