Search clinical trials for: pralsetinib (BLU-667)

Total 1703 results

Hoffmann-La Roche

Completed

Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors (ARROW)

Neoplasms | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Neoplasms, Glandular and Epithelial | Endocrine System Diseases | Gastrointestinal Neoplasms | Neoplasms, Germ Cell and Embryonal | Head and Neck Neoplasms | Carcinoma, Non-Small-Cell Lung | Respiratory Tract... and other conditions

France, Spain, United States, Korea, Republic of, United Kingdom, Taiwan, China, Belgium, Singapore, Netherlands, Germany, Italy, Hong Kong
Blueprint Medicines Corporation

Approved for marketing

Pre-Approval Access Program (PAAP) for Pralsetinib (BLU-667) in Patients With Unresectable or Metastatic NSCLC or MTC

Non-Small Cell Lung Cancer | Medullary Thyroid Cancer
Thomas Jefferson University
Apollo Health Systems

Completed

Research Study of Treatment for Winter Depression With Different Colors of Light

Seasonal Affective Disorder

United States
Northwestern University
T-Cellerate LLC

Completed

Blue Light Phototherapy

Psoriasis Vulgaris | Grover's Disease

United States
Columbia University
National Institute on Aging (NIA)

Active, not recruiting

The SleepWell Study - Chronotherapeutic Intervention to Improve Sleep Following ACS

Insomnia | Sleep Disturbance | Acute Coronary Syndrome

United States
Hoffmann-La Roche

Active, not recruiting

A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) (AcceleRET-Lung)

Neoplasms | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Neoplasms, Germ Cell and Embryonal | Head and Neck Neoplasms | Carcinoma, Non-Small-Cell Lung | Bronchial Diseases | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Neoplasms, Nerve... and other conditions

Italy, Korea, Republic of, Australia, Spain, Argentina, Belgium, Brazil, France, Portugal, United Kingdom, United States, Japan, Mexico, Poland, Norway, Costa Rica, Switzerland, Netherlands, Germany, Sweden, Turkey, Ireland, Panama
Shanghai Ninth People's Hospital Affiliated to...

Not yet recruiting

Effect of Fixture Thread Depth on Accuracy of Immediate Implant Placement Using Dynamic Navigation

Tooth Loss | Partial-edentulism
Fontem US LLC

Active, not recruiting

Nicotine Uptake and Abuse Liability Assessments of 5 Blu Disposable Electronic Cigarettes in Comparison to a Combustible Cigarette

Healthy Volunteers

United States
Affiliated Hospital to Academy of Military Medical...

Unknown

Linked Color Imaging/Magnifying Blue Laser Imaging vs. White Light for Adenomas and Serrated Lesions in Proximal Colon

Colon Cancer

China
DUSA Pharmaceuticals, Inc.

Completed

Controlled Study of the Occurrence of Actinic Keratosis on the Face After Cryotherapy + Aminolevulinic Acid (ALA) Photodynamic Therapy

Actinic Keratosis

United States
Peter MacCallum Cancer Centre, Australia
Endocyte; Movember Foundation; Medical Research Future Fund; E.J. Whitten Foundation...

Active, not recruiting

Dosimetry, Safety and Potential Benefit of 177Lu-PSMA-617 Prior to Prostatectomy (LuTectomy)

Prostatic Neoplasms

Australia
Medical Dermatology Specialists
DUSA Pharmaceuticals, Inc.

Completed

DUSA: Cyclic PDT for the Prevention of AK & NMSC in Solid Organ Transplant Recipients

Actinic Keratosis | Skin Cancer | Non-melanoma Skin Cancer | Sun Damaged Skin

United States
Bellus Health Inc. - a GSK company

Recruiting

Assessment of the Pharmacokinetics of BLU-5937 Extended Release Prototypes and a BLU-5937 Immediate Release Reference Formulation

Healthy | Cough

United Kingdom
Nova Southeastern University

Terminated

Safety and Preliminary Efficacy of Combination Therapy for the Treatment of Acne Vulgaris

Acne Vulgaris | Acne

United States
Northwestern University

Active, not recruiting

Photodynamic Therapy Incubation Times for Actinic Keratosis

Actinic Keratoses

United States
Vadim S Koshkin
Eli Lilly and Company; Prostate Cancer Foundation

Active, not recruiting

Abemaciclib Before 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer (UPLIFT)

Castration-Resistant Prostate Carcinoma | Stage IV Prostate Cancer AJCC v8 | Stage IVA Prostate Cancer AJCC v8 | Stage IVB Prostate Cancer AJCC v8 | Metastatic Castration-resistant Prostate Cancer | Metastatic Prostate Adenocarcinoma | Metastatic Castration-resistant Prostate Carcinoma

United States
Blueprint Medicines Corporation

Completed

Safety, Tolerability, Pharmacokinetics, and Food Effect of BLU-782 in Healthy Adults

Healthy Volunteers

United States
Valduce Hospital

Completed

BLI (Blue Light Imaging) for the Histological Characterization of Colorectal Polyps

Adenoma Colon

Italy
Imperial College London
University of Southern California; Guy's and St Thomas' NHS Foundation Trust; Ipse... and other collaborators

Terminated

A Study to Assess the Ability of a Novel Endocrine Treatment for Breast Cancer, Irosustat, to Slow Down Cancer Growth (IPET)

Breast Neoplasms

United Kingdom
Imperial College London
Cancer Research UK

Completed

A Study of the Safety and Effectiveness of Irosustat When Added to an AI in ER+ve Locally Advanced or Metastatic Breast Cancer. (IRIS)

Metastatic Breast Cancer | Locally Advanced Breast Cancer

United Kingdom
Hoffmann-La Roche

Withdrawn

A Study of Pralsetinib Versus Standard of Care (SOC) for Treatment of RET-Mutated Medullary Thyroid Cancer (MTC). (AcceleRET-MTC)

Medullary Thyroid Cancer

Spain
Rogers Sciences Inc.

Unknown

A Feasibility Study of a Novel Phototherapy System for the Management of Acute Burns

Burn Wound

United States
The Center for Clinical and Cosmetic Research
Sun Pharmaceutical Industries Limited

Recruiting

Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (isSCC)

Facial Cutaneous Squamous Cell Carcinoma in Situ

United States
Shanghai Jiao Tong University School of Medicine

Unknown

Sequential Intensive Chemotherapy Followed by RIC for Refractory and Relapse ALL

Lymphoblastic Leukemia, Acute, Adult

China
Bellus Health Inc. - a GSK company

Completed

Evaluation of the Pharmacokinetics and Safety of BLU-5937 in Healthy Adult Japanese and Caucasian Subjects

Healthy

United Kingdom
Zimmer Biomet

Terminated

Clinical Outcomes in Patients Treated With SternaLock Blu (SECURE)

Coronary Artery Disease | Heart Valve Diseases | Cardiac Surgical Procedures

United States
Radboud University Medical Center

Completed

Lutetium-177-PSMA-617 in Low Volume Metastatic Prostate Cancer

Prostate Neoplasm

Netherlands
Blueprint Medicines Corporation

Recruiting

(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

Indolent Systemic Mastocytosis | Monoclonal Mast Cell Activation Syndrome

United States, Spain, Australia, France, Netherlands, Switzerland, Norway, United Kingdom, Austria, Belgium, Germany, Italy, Portugal
Blueprint Medicines Corporation

Available

Expanded Access Program for Avapritinib

Solid Tumors
Blueprint Medicines Corporation

Active, not recruiting

Study for Patients Previously Treated in Avapritinib Clinical Trials

Gastrointestinal Stromal Tumors

France
Bellus Health Inc

Completed

Evaluation of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough (SOOTHE)

Refractory Chronic Cough

United States, Germany, Canada, Czechia, Hungary, Poland, United Kingdom
Blueprint Medicines Corporation

Approved for marketing

Early Access Program (EAP) for Avapritinib in Patients With Locally Advanced Unresectable or Metastatic GIST

GIST
Bellus Health Inc. - a GSK company

Recruiting

A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough (CALM-2)

Refractory Chronic Cough

Korea, Republic of, United States, Taiwan, Australia, New Zealand, Czechia, United Kingdom, Germany, Slovakia, India
Blueprint Medicines Corporation

Recruiting

A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling

CNS Tumor | Solid Tumor, Unspecified, Child | Relapsed Solid Neoplasm

United States, Korea, Republic of, United Kingdom, France, Canada, Australia, Austria, Germany, Italy
Bellus Health Inc

Completed

Mass Balance Recovery, Absorption, Metabolism and Excretion of [14C]-BLU-5937

Healthy

United Kingdom
Bellus Health Inc

Terminated

A Dose Escalation Study of BLU-5937 in Unexplained or Refractory Chronic Cough (RELIEF)

Chronic Refractory Cough

United States, United Kingdom
Bellus Health Inc. - a GSK company

Recruiting

A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough (CALM-1)

Refractory Chronic Cough

United States, Canada, Israel, Spain, Belgium, United Kingdom, South Africa, Argentina, Netherlands, Hungary, Colombia, Turkey, Poland, France, India
CStone Pharmaceuticals
Blueprint Medicines Corporation

Completed

A Study of CS3007 in Subjects With Gastrointestinal Stromal Tumor

Gastrointestinal Stromal Tumors

China
Bellus Health Inc

Completed

A Multiple-Dose Study of BLU-5937 in Chronic Pruritus Associated With Atopic Dermatitis (BLUEPRINT)

Atopic Dermatitis | Chronic Pruritus

United States, Canada
Bellus Health Inc

Completed

BLU-5937: First-in-Human, Single and Multiple Doses Escalation, Safety, Tolerability, Pharmacokinetics and Food Effect

Cough

Canada
Novartis Pharmaceuticals

Recruiting

Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

Prostate Cancer

United States
University of California, San Francisco

Completed

Daylight Photodynamic Therapy for Actinic Keratosis

Actinic Keratoses

United States
Shanghai Jiao Tong University School of Medicine

Completed

Flu-Bu-Mel Conditioning Regimen for Myeloid Disease

Relapse Rate After Allo-HSCT

China
Dermatology, Laser & Vein Specialists of the Carolinas

Completed

Bilateral Comparison of Treatment of Facial Actinic Keratoses Using Microneedling and Photodynamic Therapy With Aminolevulinic Acid and Blue Light Versus Photodynamic Therapy With Aminolevulinic Acid and Blue Light Using Two Incubation Times

Actinic Keratoses

United States
University of California, San Francisco
National Cancer Institute (NCI); Prostate Cancer Foundation

Active, not recruiting

177Lu-PSMA-617 and Pembrolizumab in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

Castration-Resistant Prostate Carcinoma | Metastatic Prostate Carcinoma | Prostate Adenocarcinoma | Stage IV Prostate Cancer | Castration Levels of Testosterone | Stage IVA Prostate Cancer | Stage IVB Prostate Cancer

United States
Shanghai Jiao Tong University School of Medicine

Recruiting

Flu-Bu-Mel Based Conditioning Regimen for Patients With Lymphoid Malignancies Undergoing Allo-HSCT

Lymphoid Neoplasm

China
Blueprint Medicines Corporation

Completed

A Phase 1 Study of Fisogatinib (BLU-554) in Patients With Hepatocellular Carcinoma

Hepatocellular Carcinoma (HCC)

China, Korea, Republic of, Taiwan, Hong Kong, United Kingdom, United States, France, Spain, Switzerland, Singapore, Germany, Italy
Imara, Inc.

Withdrawn

Selective PDE9 Inhibition With IMR-687 in Adults With Heart Failure With Preserved Ejection Fraction (SP9In-HFpEF)

Heart Failure With Preserved Ejection Fraction
DUSA Pharmaceuticals, Inc.

Completed

Twelve Month Follow-Up of CP0108

Actinic Keratosis

United States
Presidio Pharmaceuticals, Inc.

Completed

Phase 1 Study of Relative Bioavailability of PPI-668 Tablet and Capsule Formulations

Pharmacokinetic Assessments in Healthy Volunteers

United States

Search clinical trials for: pralsetinib (BLU-667)

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