Search clinical trials for: Prothrombin Complex Concentrate

Total 4686 results

Baxalta now part of Shire
Baxalta Innovations GmbH, now part of Shire

Completed

FEIBA Reconstitution Volume Reduction and Faster Infusion Study (FEIBA STAR)

Hemophilia A or B With Inhibitors

Croatia, North Macedonia, Ukraine
Rush University Medical Center
Advocate Health Care

Completed

Fixed-dose Activated Versus Variable-dose Inactivated Prothrombin Complex Concentrate for Warfarin-associated Major Bleed

Hemorrhage
CSL Behring

Completed

Observational Study of Prophylaxis and Treatment of Acute Perioperative Bleeding With Beriplex® P/N (Probe Study)

Coagulation Protein Disorders | Perioperative Care | Blood Loss, Surgical

United Kingdom
Tulane University School of Medicine

Completed

Efficacy Study of Activated Prothrombin Complex for Prevention of Bleeds in Hemophilia A With Inhibitors (ProFEIBA)

Hemophilia A With Inhibitors

United States
CSL Behring

Completed

Prothrombin Complex Concentrate for Anticoagulant Reversal

Acquired Coagulation Factor Deficiency

Austria, Germany, Hungary, Israel, Lithuania, Netherlands, Poland, Switzerland
Medical University of Vienna

Recruiting

Coagulation in Cirrhosis (COUCH)

Liver Cirrhosis

Austria
Konkuk University Medical Center

Not yet recruiting

Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery

Prostate Cancer | Hip Osteoarthritis | Knee Disease | Spine, Open
IRCCS Policlinico S. Donato

Terminated

ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery (ZEPLAST-PED)

Bleeding | Surgery--Complications | Congenital Heart Disease | Transfusion-Related Acute Lung Injury | Cardiac Defect | Fibrinogenopenia; Acquired | Transfusion-Associated Circulatory Overload

Italy
Mayo Clinic

Withdrawn

FEIBA to Optimize Postcardiopulmonary Bypass Hemostasis in Pediatric Cardiac Patients

Cardiac Disease
Konkuk University Medical Center

Not yet recruiting

Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Cardiac Surgery

Cardiac Valve Disease
Brigham and Women's Hospital
CSL Behring

Recruiting

Assessment of Coagulation Factor Levels in Left Ventricular Device (LVAD )Patients Following Temporary Warfarin Reversal With Four Factor Prothrombin Complex Concentrate (4F-PCC) (KVAD)

Anticoagulation | Anticoagulation Reversal

United States
Octapharma

Completed

Use of Prothrombin Complex Concentrate in Patients Admitted in Emergency Care Units for Severe Bleeding While Receiving Oral Anticoagulants

Emergency Care for Severe Bleeding While on Anticoagulants

France
Konkuk University Medical Center

Not yet recruiting

Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Liver Transplantation Surgery

Liver Diseases
Oregon Health and Science University

Active, not recruiting

Prehospital Kcentra for Hemorrhagic Shock

Trauma Injury

United States
University Health Network, Toronto

Unknown

Factor Replacement in Surgery (FARES)

Bleeding in Cardiac Surgery

Canada
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

Evaluation of the Efficacy of Early Bunching of a FF-PCC in Patients With Severe Traumatic Hemorrhage

Trauma
University Medical Center Groningen
Boehringer Ingelheim; CSL Behring

Unknown

Reversal of Dabigatran With Prothrombin Complex Concentrate

Drug Action Reversal

Netherlands
Fondation Ophtalmologique Adolphe de Rothschild

Recruiting

CPP Versus PFC to Correct Coagulation Disorders in Adult Neurosurgical Patients (CLOT-CRANE)

Intracranial Hemorrhages

France
HealthPartners Institute

Completed

Fixed Versus Variable Dosing of 4-factor Prothrombin Complex Concentrate for Emergent Warfarin Reversal (kcentra)

Hemorrhage | Acute Bleeding on Long-Term Anticoagulation Therapy | Significant Bleeding in Patients With a Coagulopathy (Prolonged Thrombin Time) | Urgent Reversal of Vitamin K Antagonist (VKA) Anticoagulation

United States
Janssen Research & Development, LLC

Completed

A Study to Evaluate Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of JNJ-64179375 in Healthy Male Subjects

Healthy

Belgium
Medical University Innsbruck

Terminated

RETIC Trial: Reversal of Trauma Induced Coagulopathy Using Coagulation Factor Concentrates or Fresh Frozen Plasma

Major Trauma

Austria
Bellal A. Joseph, MD, FACS

Unknown

REPlaCE- Randomized Trial Evaluating the Use of Prothrombin Complex concEntrate to Improve Survival in Patients With Traumatic Coagulopathy (REPLaCE)

Hemorrhage | Coagulopathy
Chinese Academy of Medical Sciences, Fuwai Hospital
Peking Union Medical College Hospital; Guizhou Provincial People's Hospital; Beijing... and other collaborators

Not yet recruiting

Efficacy of Prothrombin Complex Concentrate Reducing Perioperative Blood Loss in Cardiac Surgery

Cardiac Surgical Procedures
Heidelberg University

Completed

International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage (INCH)

Intracranial Hemorrhages

Germany
Kathirvel Subramaniam
University of Maryland, Baltimore; CSL Behring

Recruiting

Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation (OPSTAHT)

Heart Failure，Congestive | Heart Disease End Stage

United States
Mayo Clinic
CSL Behring

Completed

PCC vs. FFP for Post Cardiopulmonary Bypass Coagulopathy and Bleeding

Bleeding | Blood Loss, Surgical | Cardiovascular Surgical Procedures | Prothrombin Complex Concentrates | Fresh Frozen Plasma

United States
CSL Behring
Kaiser Permanente

Completed

An Observational Cohort Study to Investigate the Risk of Thromboembolic Events in Patients Receiving Kcentra® or Plasma to Reverse Vitamin K Antagonist (VKA) Therapy in the Setting of Acute Major Bleeding

Hemorrhage

United States
CSL Behring

Completed

Study of a Prothrombin Complex Concentrate for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Japanese Subjects

Acute Major Bleeding | Reversal of Coagulopathy

Japan
Queen Mary University of London
British Heart Foundation

Completed

Trial of PCC Versus FFP in Patients Undergoing Heart Surgery (PROPHESY)

Bleeding | Surgery | Transfusion

United Kingdom
University of Utah

Withdrawn

FFP Versus PCC in Intracranial Hemorrhage

Intracranial Hemorrhage, Traumatic | Intracranial Hemorrhage, Spontaneous

United States
Octapharma

Completed

Study of Octaplex (Human Prothrombin Complex Concentrate) and Fresh Frozen Plasma in Patients Under Vitamin K Therapy Antagonist Needing Urgent Surgery or Invasive Procedures

Reversal of Anticoagulant Treatment

United States
Baxalta now part of Shire

Completed

Efficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant Reversal

Prothrombin Complex Factor Deficiency

Hungary, Austria
Angel Augusto Perez Calatayud
Grupo Mexicano para el Estudio de la Medicina Intensiva

Completed

Patient Blood Management for Massive Obstetric Hemorrhage

Post Partum Hemorrhage | Transfusion Related Complication | Fibrinogenolysis; Hemorrhage | Fibrinogen; Deficiency, Acquired | Massive Hemorrhage

Mexico
Emory University
Octapharma

Recruiting

Treatment of Hemophilia A Patients With FVIII Inhibitors (MOTIVATE)

Hemophilia A

United States, Germany
University of Utah
Sheila B. Terry Memorial Research Fund

Terminated

Factor VII, Prothrombin Complex Concentrate, and Fresh Frozen Plasma in Warfarin-Related Intracranial Hemorrhage

Intracranial Hemorrhage
Emory University
Children's Research Oversight Committee Funds

Completed

Thrombin Generation in Neonatal Plasma After Cardiopulmonary Bypass

Cardiopulmonary Bypass

United States
Thomas Jefferson University
Bristol-Myers Squibb; CSL Behring

Completed

Reversibility of Apixaban Anticoagulation With the Four Factor Prothrombin Complex Concentrate Kcentra (4PAR)

Thrombosis

United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Reversal of the Anticoagulant Effects of Milvexian by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Participants

Healthy

Netherlands
CSL Behring

Recruiting

Evaluation of BE1116 in Patients With Traumatic Injury and Acute Major Bleeding to Improve Survival ( TAP Study )

Traumatic Injury

United States, United Kingdom, Australia
University of California, San Diego

Recruiting

Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis (BMAC)

Osteo Arthritis Knee

United States
IRCCS Policlinico S. Donato
CSL Behring

Completed

The ZEro PLASma Trial (ZEPLAST): Avoidance of Fresh Frozen Plasma in Cardiac Surgery (ZEPLAST)

Heart Disease

Italy
Octapharma

Completed

Study of Octaplex, a Four-factor Prothrombin Complex Concentrate (4F-PCC) and Beriplex® P/N (Kcentra) for the Reversal of Vitamin K Antagonist (VKA) Induced Anticoagulation in Patients Needing Urgent Surgery With Significant Bleeding Risk.

Significant Bleeding Risk

Russian Federation, United States, Romania, Ukraine, Belarus, Bulgaria, Georgia, Germany, Moldova, Republic of, Poland, Spain
Sheba Medical Center

Completed

Combination Therapy of Low Doses of rFVIIa and FEIBA for Severe Hemophilia A Patients With an Inhibitor to Factor VIII

Hemophilia A
University of Sao Paulo General Hospital

Completed

Strategy of Transfusion in Trauma Patients - STATA Trial (STATA)

Wounds and Injuries

Brazil
Hospital for Special Surgery, New York
Emory University; Arthritis Foundation

Not yet recruiting

Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction

Anterior Cruciate Ligament Injuries | Bone Marrow Aspirate Concentrate | ACL Injury | Post-Traumatic Osteoarthritis of Knee

United States
University of L'Aquila
TRIB s.r.l.

Completed

Treatment of Inherited Factor VII Deficiency (STER)

Factor VII Deficiency

Italy
University of Exeter

Completed

Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

Healthy
University Hospital, Grenoble

Completed

Early Administration of Prothrombin Concentrate Complex in Patients With Acute Hemorrhage Following Severe Trauma (PROCOAG)

Shock, Hemorrhagic

France
University of Limerick
Marigot Ltd.; Enterprise Ireland

Completed

Bioavailability of Plant Protein Amino Acids

Bioavailability of Amino Acids Following Oral Ingestion of Plant-Based Proteins in Young, Healthy Men

Ireland
Bulent Ecevit University

Completed

Concentrated Growth Factor in the Treatment of Gingival Recessions

Gingival Recession

Search clinical trials for: Prothrombin Complex Concentrate

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