Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

Effect of 8 weeks of cherry concentrate supplementation on cognitive function and brain perfusion in healthy older adults

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Dietary supplement: Cherry concentrate; Dietary supplement: Placebo concentrate

Detailed Description

The investigators will perform a double blind, randomised controlled study to determine whether cherry polyphenols improve peripheral vascular function and cerebral perfusion resulting in improved task related brain activation and cognitive function. 30 healthy elderly men and women 60-85y years will be recruited to complete 8-week supplementation with MC concentrate or an isoenergetic cherry placebo concentrate. Participants will be pair matched for age, sex, and cognitive function (Adenbrooke's Cognitive Examination III, ACE-III) and then randomised using a sealed envelope system to receive either placebo or cherry.

• Study Type: Interventional
• Enrollment (Actual): 30
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 60 years to 80 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• physically inactive consuming 5 or less portions of fruit per day Addenbrookes cognitive examination III score >88

Exclusion Criteria:

• physically active consuming more than 5 portions of fruit per day Addenbrookes cognitive examination III score <88 Contraindications for MRI

Study Plan

How is the study designed?

Design Details

• Primary Purpose: BASIC_SCIENCE
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: TRIPLE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
ACTIVE_COMPARATOR: Cherry concentrate; 8 weeks supplementation with montmorency cherry concentrate	Dietary supplement: Cherry concentrate
PLACEBO_COMPARATOR: Placebo concentrate; 8 weeks supplementation with placebo isoenergetic cherry concentrate	Dietary supplement: Placebo concentrate

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Brain perfusion	Arterial spin labelling using MRI, measure will be reported as ml/min	Change from baseline to 8 weeks supplementation

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cognitive function	Battery of cognitive function tasks assessing executive function, global cognitive function score will be reported	Change from baseline to 8 weeks supplementation
Brain activation (fMRI)	fMRI using a hippocampal biased task	Change from baseline to 8 weeks supplementation
Plasma nitrite concentration	Plasma sample analysed via chemiluminescence technique	Change from baseline to 8 weeks supplementation

Collaborators and Investigators

• Sponsor: University of Exeter
• Investigators: Principal Investigator: Joanna L Bowtell, PhD, University of Exeter

Study record dates

Study Major Dates

• Study Start: January 1, 2016
• Primary Completion (ACTUAL): May 1, 2016
• Study Completion (ACTUAL): December 1, 2016

Study Registration Dates

• First Submitted: December 2, 2016
• First Submitted That Met QC Criteria: May 23, 2018
• First Posted (ACTUAL): June 6, 2018

Study Record Updates

• Last Update Posted (ACTUAL): June 26, 2018
• Last Update Submitted That Met QC Criteria: June 21, 2018
• Last Verified: June 1, 2018

More Information

Terms related to this study

• Other Study ID Numbers: 115229/02

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO