Search clinical trials for: PIK3CA Mutations

Total 1315 results

Peking University Third Hospital

Unknown

A Clinical Trial of Safety and Efficacy of Fasudil in Subjects With Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis

China
The Christie NHS Foundation Trust

Unknown

Study of DNA Mutations in Predicting the Effect of External-Beam Radiation Therapy in Patients With Early Breast Cancer, Localized Prostate Cancer, or Gynecological Cancer

Sarcoma | Cervical Cancer | Breast Cancer | Ovarian Cancer | Fallopian Tube Cancer | Prostate Cancer | Vulvar Cancer | Endometrial Cancer | Vaginal Cancer | Primary Peritoneal Cavity Cancer

United Kingdom
The University of New South Wales

Completed

Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes

Myelodysplastic Syndromes | Leukemia

United Kingdom
University College London Hospitals

Completed

Carboplatin or Docetaxel in Treating Women With Metastatic Genetic Breast Cancer

Breast Cancer | Hereditary Breast/Ovarian Cancer (brca1, brca2) | brca1 Mutation Carrier | brca2 Mutation Carrier

Australia, Israel, United Kingdom, Spain, Sweden, Portugal
University of Alabama at Birmingham
National Cancer Institute (NCI)

Withdrawn

Celecoxib in Preventing Cancer in Patients at High Risk for Ovarian Epithelial Cancer Who Are Undergoing Prophylactic Oophorectomy

Ovarian Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United States
Leeds Cancer Centre at St. James's University Hospital

Unknown

Identifying Gene Mutations in Patients With Melanoma and in Families With a History of Hereditary Melanoma

Melanoma (Skin) | Hereditary Multiple Melanoma

United Kingdom
Leeds Cancer Centre at St. James's University Hospital

Unknown

Study of Families With Melanoma

Melanoma (Skin)

United Kingdom
Leeds Cancer Centre at St. James's University Hospital

Unknown

Answering Questions About Vitamin D Supplementation and Sun Exposure in Patients Who Have Undergone Surgery for Stage IB, Stage II, or Stage IIIA Melanoma

Melanoma (Skin)

United Kingdom
Cancer Research Centre at Weston Park Hospital

Unknown

Studying Patterns, Causes, and Control of Disease in Patients With Lung Cancer in the North Trent (England) Region

Lung Cancer

United Kingdom
Leeds Cancer Centre at St. James's University Hospital

Completed

Alemtuzumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia in Partial Remission or Complete Remission

Leukemia

United Kingdom
Leeds Cancer Centre at St. James's University Hospital

Unknown

Studying Tumor Tissue Samples From Patients With Melanoma Who Have Undergone Sentinel Lymph Node Biopsy

Melanoma (Skin)

United Kingdom
Medical Research Council

Completed

DNA Analysis of Blood and/or Tissue Samples From Patients With Primary Kidney Cancer Receiving Sorafenib on Clinical Trial MRC-RE05-SORCE

Kidney Cancer

United Kingdom
Istituto Scientifico H. San Raffaele

Unknown

Study of Blood and Tissue Samples in Predicting Response to Second-Line Therapy Using Erlotinib Hydrochloride or Chemotherapy in Patients With Advanced Non-Small Cell Lung Cancer

Lung Cancer

Italy
Cambridge University Hospitals NHS Foundation Trust

Unknown

Neoadjuvant Epirubicin, Cyclophosphamide, and Paclitaxel With or Without Gemcitabine in Treating Women Who Are Undergoing Surgery for Early Breast Cancer

Breast Cancer

United Kingdom
Assistance Publique - Hôpitaux de Paris

Completed

Characterization Phenotypic and Genetic Study of the Intestinal Epithelial Dysplasia or Tufting Enteropathy (TE) (DEI)

Intestinal Epithelial Dysplasia | Tufting Enteropathy

France
TC Erciyes University

Unknown

Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene Mutations in Acromegaly (AIP)

Acromegaly

Turkey
Natera, Inc.

Completed

Clinical Use of Parental Support To Detect Single Gene Mutations

Single Gene Disorders

United States
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Unknown

Studying Genes in Samples From Younger Patients With Acute Lymphoblastic Leukemia

Leukemia
National Cancer Institute (NCI)

Unknown

Biomarkers in Samples From Adult Patients With Acute Myeloid Leukemia Who Failed Existing Standard-of-Care Treatment

Leukemia
Cytonet GmbH & Co. KG
CRS Clinical Research Services Mannheim GmbH

Completed

Study in Healthy Subjects, Patients With Urea Cycle Disorders (UCD) and Carriers of UCD Mutations to Evaluate Urea Cycle Function

Urea Cycle Disorders

Germany
Iceland Genomics Corporation
National Cancer Institute (NCI)

Completed

Studying Genes to Identify Melanoma in Patients in Iceland and Their Family Members

Melanoma (Skin)

Iceland
QLT Inc.

Completed

Safety/Proof of Concept Study of Oral QLT091001 in Subjects With Leber Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP) Due to Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) Mutations

LCA (Leber Congenital Amaurosis) | RP (Retinitis Pigmentosa)

United States, Canada, Germany, Netherlands, United Kingdom
University of Copenhagen
Rhythm Pharmaceuticals, Inc.

Completed

Melanocortin 4 Receptor Mutations and Obesity-associated Diseases (Mc4Obes)

Obesity

Denmark
ArQule, Inc. (a wholly owned subsidiary of Merck...

Completed

Dose Escalation Study of ARQ 736 in Adult Subjects With Advanced Solid Tumors Harboring BRAF and/or NRAS Mutations

Solid Tumor

United States, Italy
Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)

Withdrawn

Biomarkers in Stored Tumor Samples From Younger Patients With Liver Cancer

Liver Cancer
Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)

Completed

DNA Analysis of Tissue Samples From Patients With Head and Neck Cancer

Head and Neck Cancer
Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)

Terminated

Studying Common Genetic Mutations Related to Mucositis in Patients With Multiple Myeloma Receiving High-Dose Melphalan

Mucositis | Multiple Myeloma and Plasma Cell Neoplasm

United States
Università Vita-Salute San Raffaele
IRCCS San Raffaele; Merck Sharp & Dohme LLC

Unknown

GePheRal: Clinical Validation of the Genotypic Diagnosis of Hiv-1 Resistance to Raltegravir by Parallel Analysis of the Genotype and Phenotype Profiles of Resistance

HIV-1 Infected Patients | Fold-change Resistance | Resistance Mutations

Italy
Cukurova University

Completed

MEVALONATE KINASE GENE MUTATIONS AND THEIR CLINICAL CORRELATIONS IN BEHÇET'S DISEASE

Behçet's Disease

Turkey
Samsung Medical Center
AstraZeneca

Unknown

Evaluation of EGFR TKI Resistance Mechanism Using Plasma DNA Analysis

EGFR Mutation Positive Non-small Cell Lung Cancer

Korea, Republic of
Catholic University of the Sacred Heart

Unknown

Study With Trabectedin in BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype Ovarian Cancer (MITO15)

BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype

Italy
AbbVie (prior sponsor, Abbott)

Completed

Kaletra: Therapy With Double Protease Inhibitors

Human Immunodeficiency Virus

Germany
AstraZeneca

Completed

Study of Selumetinib (AZD6244)(ARRY-142886) in Combination With Irinotecan in Previously Treated Patients With Colorec

Colorectal Cancer

United States
Chinese Society of Lung Cancer

Completed

Study of Pemetrexed Versus Gefitinib in Patients With Locally Advanced or Metastatic Non Small Cell Lung Cancer Who Have Previously Received Platinum-Based Chemotherapy Without Epidermal Growth Factor Receptor (EGFR) Mutations

Non Small Cell Lung Cancer

China
Assistance Publique - Hôpitaux de Paris

Completed

Efficacy and Safety Study of Sulfonylureas in Neonatal Diabetes Mellitus (GLIDKIR6-2)

Diabetes Mellitus

France
Spanish Lung Cancer Group
Merck Sharp & Dohme LLC

Terminated

Phase I/II of Oral Vorinostat Combination With Erlotinib in NSCLC Patients With EGFR Mutations With DP After Erlotinib.

Non-small Cell Lung Cancer

Spain
Korea University
GlaxoSmithKline

Completed

Adding Adefovir Dipivoxil Versus Switching to Entecavir in Patients With Lamivudine-resistant Chronic Hepatitis B

Chronic Hepatitis B

Korea, Republic of
Institut National de la Santé Et de la Recherche...

Unknown

Clinical, Molecular and by Neuroimaging of LRRK2 Mutations (LRRK2)

Parkinson's Disease

France
Memorial Sloan Kettering Cancer Center
Memorial Health University Medical Center

Completed

BRCA1 Haploinsufficiency and Gene Expression

BRCA1 Mutations

United States
AstraZeneca

Completed

Observational Study on the Management of Patients With Non Small Cell Lung Cancer Adenocarcinoma (MUTACT)

Non Small Cell Lung Cancer

France
Assistance Publique - Hôpitaux de Paris

Completed

Immunological Consequences of CARD15/NOD2 Mutations in Crohn's Disease (PLAC)

Crohn's Disease

France
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Dasatinib and Vorinostat in Treating Patients With Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia or Acute Lymphoblastic Leukemia

Leukemia

United States
University of Washington

Completed

AMD 3100 for Treatment of Myelokathexis

Neutropenia

United States
Vejle Hospital

Completed

Irinotecan and Panitumumab as 3rd Line Treatment for mCRC Without KRAS Mutations

Metastatic Colorectal Cancer

Denmark
University of North Carolina, Chapel Hill
Elizabeth Glaser Pediatric AIDS Foundation

Completed

Maternal TDF and FTC to Reduce NNRTI Resistance Mutations After Intrapartum NVP (TD-2)

Pregnancy | HIV

Zambia
National Cancer Institute (NCI)

Withdrawn

HLA-B35 Alleles and AIDS

HIV-1 | AIDS

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Completed

Gossypol (AT-101) and Temozolomide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Brain and Central Nervous System Tumors

United States
University of California, Davis
National Cancer Institute (NCI)

Completed

Lapatinib and Vinorelbine in Treating Patients With Advanced Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific

United States
Vejle Hospital

Terminated

Pemetrexed and Gemcitabine for Treatment Resistant Patients With Metastatic Colorectal Cancer and KRAS Mutations (PG)

Metastatic Colorectal Cancer

Denmark
Ionis Pharmaceuticals, Inc.
ALS Association; Muscular Dystrophy Association

Completed

Safety, Tolerability, and Activity Study of ISIS SOD1Rx to Treat Familial Amyotrophic Lateral Sclerosis (ALS) Caused by SOD1 Gene Mutations (SOD-1)

Familial Amyotrophic Lateral Sclerosis

United States

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