- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00346008
Studying Genes to Identify Melanoma in Patients in Iceland and Their Family Members
Genetic Epidemiologic Studies of Melanoma in Iceland
RATIONALE: Studying the genes expressed in samples of blood from patients with cancer and their family members may help doctors identify biomarkers related to cancer.
PURPOSE: This clinical trial is studying genes to identify melanoma in patients in Iceland and their family members.
Study Overview
Status
Conditions
Detailed Description
OBJECTIVES:
- Assess the feasibility of Iceland Genomics Corporation (UVS) to identify melanoma in multiple-case families, individuals with multiple tumors, and selected additional family members in Iceland.
- Assess the feasibility of mutation detection using sequencing and HPLC.
- Determine UVS' ability to create datasets with demographic, epidemiologic and molecular data.
OUTLINE: Participants and patients undergo blood collection and complete lifestyle questionnaires. All patients and population-based controls have DNA samples sequenced for MC1R. Demographic and epidemiologic data on all study participants is collected. Sequencing of the major melanoma susceptibility genes CFDKN2A, CDK4, and MC1R is also performed.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
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Reykjavik, Iceland, 105
- Iceland Genomics Corporation
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
DISEASE CHARACTERISTICS:
- Patients diagnosed with melanoma and selected family members are eligible to participate
- Must live in Iceland
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Study Plan
How is the study designed?
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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Feasibility to identify melanoma
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Feasibility to detect mutation
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Ability to create datasets
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Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Study Chair: Alisa Goldstein, PhD, National Cancer Institute (NCI)
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- NBCI-03-033-CM
- NCI-06-C-N026
- CDR0000551606 (Registry Identifier: PDQ (Physician Data Query))
- NBCI-01-087-CM
- 999906026
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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