Search clinical trials for: pharmacokinetic modelling

Total 12823 results

UMC Utrecht
Dutch Health Care Insurance Board

Completed

Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol.

Rheumatoid Arthritis | Polymyositis | Giant Cell Arteritis | Polymyalgia Rheumatica | Wegener's Granulomatosis

Netherlands
University of Cape Town
World Health Organization; Medical Research Council, South Africa; Global Fund

Completed

A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria

Malaria

Mozambique
University of Cape Town
World Health Organization; Medical Research Council, South Africa

Completed

A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria

Malaria

Mozambique
Committee on Chinese Medicine and Pharmacy

Completed

The Pharmacokinetics Study of Concentrated Herbal Formula and Traditional Herbal Decoctions in Humans

Healthy

China
Hospital Universitario Ramon y Cajal
Novartis; Astellas Pharma Inc

Unknown

Pharmacokinetic Study on the Combination of Everolimus-Tacrolimus

Kidney Diseases

Spain
Acusphere

Completed

Phase 1 Safety and Pharmacokinetic Study of AI-700 in Patients With Diminished DLCO and COPD and/or CHF

Chronic Obstructive Pulmonary Disease | Congestive Heart Failure

United States
IBSA Institut Biochimique SA

Completed

Endometrial Effects of Daily Progesterone s.c. 25 and 50 Mg Aqueous Formulation to Female Healthy Volunteers

Healthy
Astellas Pharma Inc

Completed

A Study to Assess Efficacy, Safety and Pharmacokinetics of a Tacrolimus New Oral Formulation (MR4) in BMT Recipients

Bone Marrow Transplantation | Graft Versus Host Disease | Graft-Versus-Host Disease | Graft-Vs-Host Disease

Japan
DiObex

Completed

A Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Activity of Very Low Dose-Glucagon in Subjects With Type 1 Diabetes Mellitus

Type 1 Diabetes

United States
Centers for Disease Control and Prevention
Malaria Research and Training Center, Bamako, Mali; Liverpool School of Tropical...

Suspended

Chlorproguanil-Dapsone in Pregnant Women

Malaria

Mali
University of Aarhus
Novo Nordisk A/S

Completed

A Comparison of Pharmacodynamics and Pharmacokinetics of Insulin Aspart, Biphasic Insulin Aspart 30, 50 and 70.

Type 1 Diabetes

Denmark
Laboratoires Thea

Completed

Ocular Tolerance, Safety and Ocular Pharmacokinetics After 1 Drop of T1225 0.5, 1.0, 1.5% in 48 Healthy Volunteers

Eye Infections, Bacterial
Laboratoires Thea

Completed

Safety and Ocular Pharmacokinetics After 1 Drop of T1225 0.5, 1 and 1.5% in 48 Healthy Volunteers

Eye Infections, Bacterial

France
Laboratoires Thea

Completed

Ocular Pharmacokinetics After a Single Drop Instillation of T1225 0.5, 1, 1.5% in 91 Healthy Volunteers

Eye Infections, Bacterial
Eli Lilly and Company

Completed

Pharmacokinetic Characterization of Intramuscular Olanzapine Depot

Schizophrenia | Schizoaffective Disorder

Australia, Belgium, Brazil, Croatia, Czech Republic, Mexico, Slovakia, Spain
National Cancer Institute (NCI)

Completed

A Phase I Trial of 5-Fluorouracil Given With 776C85 (GW776) and Low-Dose Leucovorin in Adult Patients With Solid Tumors

Neoplasms | Lymphoma

United States
National Cancer Institute (NCI)

Completed

Capravirine to Treat Children With HIV Infection

HIV Infection

United States
Danish University of Pharmaceutical Sciences

Unknown

Pharmacokinetics and Pharmacodynamics of Buprenorphine in Healthy Volunteers

Healthy Volunteers

Denmark
International Partnership for Microbicides, Inc.

Completed

A Study to Assess the Pharmacokinetics of Dapivirine (TMC120) Vaginal Microbicide Gel

HIV Infections

South Africa
Association Pour La Recherche des Thérapeutiques...

Unknown

Tolerance and Pharmacokinetics With Capecitabine 5 Out of 7 Days Regimen

Breast Neoplasms | Chemotherapy

France
Eyetech Pharmaceuticals
Pfizer

Completed

Study of the Safety, Tolerability and Pharmacokinetics of 1 Mg/Eye and 3 Mg/Eye Pegaptanib Sodium in Patients With Exudative Age-Related Macular Degeneration (AMD)

Age-Related Macular Degeneration
Otsuka Pharmaceutical Development & Commercialization...

Completed

Aripiprazole Pharmacokinetics (PK) and Tolerability Study in Children and Adolescents

Schizophrenia | Mania
Hamamatsu University

Unknown

Pharmacokinetic and Pharmacodynamic Study of S-1 in Patients With Digestive Organ Cancer

Gastric Cancer | Pancreatic Cancer | Esophageal Cancer | Colon Cancer

Japan
Heidelberg University

Unknown

Nicotinic Acid - Pharmacokinetics, Pharmacodynamics, Receptor Expression

Healthy
National Institute of Allergy and Infectious Diseases...

Completed

The Effect of Efavirenz and Nelfinavir on the Blood Levels of Certain Lipid-Lowering Drugs

HIV Infections | Lipodystrophy | HIV Seronegativity

United States
GlaxoSmithKline

Completed

Monotherapy Versus Placebo Over 7 Days-Non-Nucleoside Reverse Transcriptase Inhibitor-Experienced HIV1 Infected Adults

HIV Infections

United States
Technical University of Munich

Completed

The Influence of Injection Rate on EEG Propofol Peak Effect as Measured by Bispectral Index

Healthy | Elective Surgery

Germany
J. Uriach and Company

Completed

Evaluation of Possible Effects on the QT/ QTc Interval of Rupatadine in Healthy Volunteers

Human Experimentation (Human Volunteers)

Spain
China Medical University Hospital

Unknown

Pharmacokinetic Study of Marine Active in Health Men

Hyperuricemia, Anserine, Pharmacokinetic

Taiwan
University Hospital Schleswig-Holstein

Completed

Investigation of the Steady State Pharmacokinetics of Sirolimus, Mycophenolat Mofetil and Fluvastatin After Renal Transplantation

Renal Transplantation
University Hospital Schleswig-Holstein

Completed

Investigation of the Steady State Pharmacokinetics of Tacrolimus, Mycophenolate Mofetil and Fluvastatin After Renal Transplantation

Renal Transplantation
UMC Utrecht
Netherlands: Ministry of Health, Welfare and Sports

Unknown

Processing and Effects of Cannabis

Tachycardia | Hypotension

Netherlands
Heidelberg University

Completed

BlueCQ Bioavailability

Pharmacokinetics | Bioavailability | Methylene Blue | Chloroquine
National Taiwan University Hospital

Unknown

The Pharmacokinetics of Sirolimus When Combined With Cyclosporine or Tacrolimus in Renal Transplant Patients

Kidney Transplantation | Immunosuppression | Transplantation

Taiwan
National Taiwan University Hospital

Unknown

Sirolimus Blood Concentrations on Conversion From Oral Solution to Tablets

Kidney Transplantation | Immunosuppression | Transplantation

Taiwan
Centers for Disease Control and Prevention
US Department of Veterans Affairs

Completed

TBTC Study 25PK: Intensive Pharmacokinetic Study of Three Doses of Rifapentine and 25-Desacetyl Rifapentine

Tuberculosis

United States, Canada
Centers for Disease Control and Prevention
US Department of Veterans Affairs

Completed

TBTC Study 23A: Pharmacokinetics of Intermittent Isoniazid and Rifabutin in HIV-TB

HIV Infections | Tuberculosis

United States, Canada
French National Agency for Research on AIDS and...
Hoffmann-La Roche

Terminated

Evaluation of Therapeutic Drug Monitoring of Protease Inhibitors on Virologic Success and Tolerance of Highly Active Antiretroviral Therapy (HAART)

HIV Infections

France
Sarawak MediChem Pharmaceuticals

Unknown

The Safety and Effectiveness of (+)-Calanolide A in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States
National Center for Research Resources (NCRR)

Completed

Pharmacokinetics of Tacrolimus in Kidney Transplant Recipients: Once Daily Versus Twice Daily Dosing

Kidney Transplantation

United States
Genentech, Inc.

Completed

A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 (rCD4) in Patients With AIDS and AIDS-Related Complex

HIV Infections

United States
Chiron Corporation

Unknown

Safety and Effectiveness of L2-7001 (Interleukin-2) in HIV-Positive Patients Receiving Anti-HIV Therapy

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
Genentech, Inc.

Completed

A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4 Immunoglobulin (rCd4-IgG) Administered by Intravenous Bolus in Patients With AIDS and AIDS Related Complex

HIV Infections

United States
Argus Pharmaceuticals

Completed

Pharmacokinetics of Nystatin LF I.V. in Patients With Acquired Immune Deficiency Syndrome-Related Complex (ARC)

HIV Infections

United States
Glaxo Wellcome

Completed

A Phase I Study to Evaluate the Pharmacokinetics, Safety and Antiviral Effects of Concurrent Administration of Zidovudine (AZT) and 2'3'-Dideoxyinosine (ddI) in Patients With Human Immunodeficiency Virus (HIV)

HIV Infections

United States
Triangle Pharmaceuticals

Unknown

Emtricitabine Given Once A Day With Other Anti-HIV Drugs in Children With HIV

HIV Infections

United States, Argentina, Mexico, Panama, Puerto Rico, South Africa
Roche Global Development

Completed

An Open Label Evaluation of the Safety and Pharmacokinetics of Ganciclovir in Children

HIV Infections | Cytomegalovirus Retinitis

United States
Genentech, Inc.

Completed

Safety, Efficacy, and Pharmacokinetics Study of Tarceva to Treat Advanced Colorectal Cancer

Colorectal Cancer

United States
Hoffmann-La Roche

Completed

A Multiple Dose Crossover Pharmacokinetics Study to Evaluate the Effects of Food on the Absorption of Oral Ganciclovir

HIV Infections | Cytomegalovirus Infections

United States
Hoffmann-La Roche

Completed

A Phase I Pharmacokinetic Study in HIV-Positive Subjects of Oral Ganciclovir and Concomitant Antiretroviral Zidovudine and Didanosine

HIV Infections | Cytomegalovirus Infections

United States

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