Search clinical trials for: Failed at least one line of standard therapy

Total 482715 results

Immatics Biotechnologies GmbH

Completed

IMA901 in Patients Receiving Sunitinib for Advanced/Metastatic Renal Cell Carcinoma

Metastatic Renal Cell Carcinoma

United States, France, Romania, United Kingdom, Italy, Russian Federation, Poland, Germany, Hungary, Netherlands, Norway
University of Pennsylvania

Completed

Autologous Redirected RNA Meso-CIR T Cells

Malignant Pleural Mesothelioma

United States
Forest Laboratories

Terminated

Comparative Study of Ceftazidime-Avibactam Versus Standard of Care as Therapy in Febrile Neutropenic Adults With Cancer

Neoplasms | Febrile Neutropenia

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Four Versus Six Cycles of Cyclophosphamide/Doxorubicin or Paclitaxel in Adjuvant Breast Cancer

Breast Cancer

United States, South Africa
SciClone Pharmaceuticals

Unknown

First Line Bio-immunotherapy With Thymosin Alpha 1 in Patients With Sensitizing EGFR Mutation Positive Non Small Cell Lung Cancer Who Are Taking Standard of Care Therapy

EGFR Mutation Positive Non Small Cell Lung Cancer

Italy
PD Dr. med. Wolfgang Schuette
Eli Lilly and Company; Roche Pharma AG

Completed

Efficacy Study of Avastin® With Pemetrexed +/- Carboplatin to Treat Elderly Patients With Non-small Cell Lung Cancer (65plus)

Non-squamous Non-small Cell Lung Cancer

Germany
Cancer Trials Ireland

Completed

Customized Headrest or Standard Headrest in Holding Patients Still While Undergoing Radiation Therapy for Head and Neck Cancer

Head and Neck Cancer

Ireland
Oncozyme Pharma Inc.

Completed

An Exploratory Study of OCZ103-OS in Combination With Standard of Care in Stage IV Non-Small Cell Lung Cancer (NSCLC) Patients

Non-small Cell Lung Cancer

Poland
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors

Kidney Cancer

United States, Canada, Puerto Rico, Australia, Netherlands, New Zealand, Switzerland
Novartis Pharmaceuticals

Completed

Effect of Zoledronic Acid as Anti-Cancer Treatment in Metastatic Breast Cancer Patients (MACS1295)

First or Second Line HER2-negative Breast Cancer | Metastatic Disease Without Bone Metastasis

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

Sarcoma

United States, Canada, Puerto Rico, Australia, Netherlands, New Zealand, Switzerland
Favrille

Suspended

GM-CSF With or Without Vaccine Therapy After Combination Chemotherapy and Rituximab as First-Line Therapy in Treating Patients With Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma

Lymphoma

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia

Leukemia

United States, Australia, Canada
New Mexico Cancer Care Alliance

Terminated

Comparison of Standard of Care or Treatment on Protocol

Stomach Cancer | Esophageal Cancer | Ovarian Cancer | Lung Cancer | Bladder Cancer | Skin Cancer | Uterine Cancer

United States
Cancer Research Campaign Clinical Trials Centre

Unknown

Hyperthermia and Mitomycin C, Bacillus Calmette-Guerin, or Standard Therapy as Second-Line Therapy in Treating Patients With Recurrent Bladder Cancer

Bladder Cancer

United Kingdom
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI); Eastern Cooperative Oncology Group; Southwest... and other collaborators

Completed

Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors

Testicular Germ Cell Tumor | Extragonadal Germ Cell Tumor | Childhood Germ Cell Tumor

United States, Puerto Rico, Australia, Peru
Janssen-Cilag International NV

Completed

Expanded Access Protocol (EAP) to Provide Bortezomib to Patients With Multiple Myeloma Who Have Received at Least 2 Previous Lines of Therapy and Are Refractory to or Have Relapsed After Their Last Therapy for Multiple Myeloma

Multiple Myeloma
Gynecologic Oncology Group
National Cancer Institute (NCI)

Terminated

Vaccine Therapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer

Ovarian Cancer

United States, Canada
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer

Pain | Head and Neck Cancer

United States
National Cancer Institute (NCI)
Children's Cancer Group

Completed

Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor

Sarcoma | Neutropenia

United States, Puerto Rico, Canada, Switzerland, Australia
Eli Lilly and Company

Completed

Docetaxel or Pemetrexed With or Without Cetuximab in Patients With Recurrent or Progressive Non-Small Cell Lung Cancer

Non Small Cell Lung Cancer

United States, Canada
Samsung Medical Center

Completed

Second-line Therapy Versus Supportive Care for Pretreated Advanced Gastric Cancer

Advanced Gastric Cancer

Korea, Republic of
Assistance Publique - Hôpitaux de Paris

Terminated

Light Constraint Induced Therapy Experiment (LICITE)

Stroke

France
National Taiwan University Hospital

Completed

The Efficacy of Sequential Therapy as Second Line Therapy for Refractory Helicobacter Pylori Infection - A Pilot Study

H. Pylori Infection

Taiwan
University of Arizona
Janssen Pharmaceutica N.V., Belgium; Southern Arizona VA Health Care System

Completed

Role of Pain Modulation in GERD Patients Who Failed Standard Dose Proton Pump Inhibitors (PPI)

Gastroesophageal Reflux Disease

United States
Gruppo Oncologico Italiano di Ricerca Clinica

Recruiting

AGNOSTIC THERAPY IN A PHASE II SINGLE-ARM STUDY IN FIRST-LINE TREATMENT OF DURVALUMAB IN ASSOCIATION WITH CARBOPLATIN OR CISPLATIN AND ETOPOSIDE IN PATIENTS AFFECTED BY EXTENSIVE STAGE - EXTRAPULMONARY SMALL CELL CARCINOMA (DURVASCC)

Extrapulmonary Small Cell Carcinoma

Italy
Riphah International University

Not yet recruiting

Adapted Physical Activities in Hemiplegic Cerebral Palsy

Hemiplegic Cerebral Palsy

Pakistan
University Health Network, Toronto
Academic Medical Organization of Southwestern Ontario; York University; Toronto...

Not yet recruiting

Online Psychology Program for Chronic Pain After Surgery (ADOPT-TPS)

Pain, Acute | Pain, Chronic | Post-surgical Pain | Post-Surgical Pain, Chronic

Canada
Guangdong Provincial People's Hospital

Not yet recruiting

Randomized Study of ABC-14 Regimen Compared With "3+7" Standard Induction Therapy or AB-14 for ND AML

Acute Myeloid Leukemia

China
University Health Network, Toronto

Not yet recruiting

A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment (ABLATE)

Locally Advanced Pancreatic Adenocarcinoma
Ohio State University Comprehensive Cancer Center

Recruiting

Evaluating the Impact of a Virtually Supervised Exercise Intervention and Group Counseling on Inflammation and the Microbiome of Smokers at High Risk for Lung Cancer, BE FIT Trial

Lung Carcinoma

United States
Indonesia University

Recruiting

The Role of Thread Embedding Acupuncture for Pain and Quality of Life in Endometriosis Patients

Endometriosis-related Pain

Indonesia
Anhui Provincial Cancer Hospital
Hutchison Medipharma Limited

Recruiting

Surufatinib Combined With Carboplatin/Paclitaxel and Surufatinib Combined With Olaparib as First-line and Maintenance Therapy for Newly Diagnosed High-risk Ovarian Cancer

Ovarian Cancer

China
Baylor Research Institute
National Institute on Disability, Independent Living, and Rehabilitation...

Recruiting

Early Robotic Gait Training After Stroke (ERA Stroke)

Stroke

United States
Boston Medical Group

Recruiting

Effectiveness and Safety of TENS Therapy for Premature Ejaculation (TENSPE2)

Premature Ejaculation | TEN | Sex Disorder

Mexico
University of Southern California
National Cancer Institute (NCI)

Not yet recruiting

Access to Genetic Testing in Underserved Patients With Cancer

Malignant Solid Neoplasm | Breast Carcinoma | Metastatic Prostate Carcinoma | Ovarian Carcinoma | Triple-Negative Breast Carcinoma | Male Breast Carcinoma | Pancreatic Exocrine Neoplasm | Stage IVB Prostate Cancer American Joint Committee on Cancer v8

United States
Emory University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Not yet recruiting

Automated Insulin Delivery for Inpatients With Dysglycemia (AIDING)

Type 1 Diabetes | Type 2 Diabetes

United States
University of Cologne
AstraZeneca

Not yet recruiting

Maintenance Durvalumab (MEDI4736) and Olaparib (AZD2281) After Standard 1st Line Treatment (Carboplatin/Cisplatin, Etoposide, Durvalumab) in HRD Positive Extensive Disease (ED) Small-cell Lung Cancer (SCLC) (GUIDANCE)

Small Cell Lung Carcinoma
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Not yet recruiting

A Phase II Study of SSGJ-707 Combination Therapy in Advanced NSCLC Patients

First-line Advanced NSCLC Patients

China
Celgene
Bristol-Myers Squibb

Recruiting

A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation (KarMMa-9)

Multiple Myeloma

Austria, United States, Spain, Australia, Japan, France, Israel, Italy, Canada, Greece, Belgium, Norway, Romania, Czechia, Denmark, Germany, Korea, Republic of, United Kingdom, Poland
Janjira Petsuksiri
Mahidol University

Not yet recruiting

Orbital Radiotherapy in Grave's Ophthalmopathy 1 Week vs 2 Weeks (OraGO-1 Trial)

Thyroid Associated Ophthalmopathy

Thailand
Ohio State University Comprehensive Cancer Center

Not yet recruiting

Ketogenic Dietary Intervention to Improve Response to Immunotherapy in Patients With Metastatic Melanoma and Metastatic Kidney Cancer

Metastatic Renal Cell Carcinoma | Metastatic Cutaneous Melanoma | Stage IV Renal Cell Cancer AJCC v8 | Clinical Stage IV Cutaneous Melanoma AJCC v8

United States
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Not yet recruiting

Immunosensitized Radiotherapy Combined With Evoximab (AK112) and Chemotherapy Neoadjuvant Therapy for Stage II-III Non-small Cell Lung Cancer

Stereotactic Radiotherapy; Evoximab (AK112); New Adjuvant Therapy for Non-small Cell Lung Cancer
Kyverna Therapeutics

Not yet recruiting

A Study of Anti-CD19 CAR T-Cell Therapy, in Subjects With Refractory Primary and Secondary Progressive Multiple Sclerosis

Multiple Sclerosis | Multiple Sclerosis, Secondary Progressive | Multiple Sclerosis, Primary Progressive
Mayo Clinic

Recruiting

Remote Cognitive Assessment Battery and Wearable Device Monitoring Platform While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy

Malignant Brain Neoplasm

United States
Brno University Hospital

Not yet recruiting

The Influence of Blood Sampling Technique on the Total Amount of Blood Collected for Laboratory Testing Critically Ill Pediatric Patients (PEDPBM)

Iatrogenic Anaemia

Czechia
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI)

Not yet recruiting

Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps

Colorectal Carcinoma

United States
Instituto de Investigación Hospital Universitario...

Recruiting

Optimization of Atopic Dermatitis Treatment That Requires Second-line Systemic Therapy Through Predictive Models

Atopic Dermatitis

Spain
Alnylam Pharmaceuticals

Recruiting

Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy

Hereditary Amyloidosis, Transthyretin-Related | Asymptomatic Carrier State

France
Bristol-Myers Squibb

Recruiting

Transgene Assay Testing Service of Tumor Samples From Patients Who Received a Bristol-Myers Squibb Manufactured Gene Modified Cell Therapy and Have a Qualifying Secondary Malignancy

Multiple Myeloma | Non-Hodgkin Lymphoma | Chronic Lymphocytic Leukaemia

Belgium

Search clinical trials for: Failed at least one line of standard therapy

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