Search clinical trials for: NLRP3 inhibitor, inflammasome inhibition

Total 1329 results

University Hospital, Essen

Recruiting

Enhancing Radioiodine Incorporation Into Radio Iodine Refractory Thyroid Cancers With MAPK Inhibition (ERRITI)

Metastatic Thyroid Cancer

Germany
Academisch Medisch Centrum - Universiteit van Amsterdam...

Recruiting

Tapestry: Addition of TGF-β and PDL-1 Inhibition to Definitive Chemoradiation in Esophageal Squamous Cell Carcinoma (TAPESTRY)

Neoplasm, Esophageal | Neoplasm, Esophagus | Malignant Esophagus Tumor

Netherlands
University Health Network, Toronto

Recruiting

Incretin and Treatment With Inhibition of Sodium-glucose Cotransporter-2 Combination Insights Into Mechanisms Implicated in Congestive Heart Failure: "NATRIURETIC" Trial (NATRIURETIC)

Type 2 Diabetes Mellitus

Canada
University of Iowa

Recruiting

MMP-9 Inhibition for Recalcitrant Wet AMD

Wet Age-related Macular Degeneration | Exudative Macular Degeneration

United States
Leiden University Medical Center
Takeda; Netherlands Brain Foundation

Recruiting

Complement Inhibition: Attacking the Overshooting Inflammation @Fter Traumatic Brain Injury (CIAO@TBI)

Traumatic Brain Injury | Trauma, Head

Netherlands
Rennes University Hospital

Recruiting

P-glypoprotein Inhibition Effect on the Pharmacokinetics of Two Tacrolimus Formulations: Prolonged and Extended-release (DIPLOID)

Pharmacokinetics

France
Northwell Health
Lupus Research Alliance

Recruiting

Centrally Acting ACE Inhibition in SLE

Systemic Lupus Erythematosus

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...
University Medical Center Groningen; UMC Utrecht; Erasmus Medical Center; Catharina... and other collaborators

Recruiting

TGF-β And PDL-1 Inhibition in Esophageal Squamous Cell Carcinoma Combined With Chemoradiation TheRapY (TAPESTRY)

Carcinoma, Squamous Cell | Oesophageal Cancer

Netherlands
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Recruiting

Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition

Recurrent Head and Neck Squamous Cell Carcinoma | Advanced Head and Neck Squamous Cell Carcinoma | Metastatic Head-and-neck Squamous-cell Carcinoma | Locally Advanced Head and Neck Squamous Cell Carcinoma | Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck | Stage IV Cutaneous...

United States
Medical University of Graz

Recruiting

Is the BAT Inhibition Able to Replace Sting Challenges? (BATIRS)

Vespid Venom Allergy

Austria
Mary Feng, MD
AstraZeneca

Recruiting

Hypofractionated Radiotherapy Followed by Durvalumab With or Without Tremelimumab for Liver Cancer After Progression on PD-1 Inhibition

Advanced Hepatocellular Carcinoma | Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular Carcinoma AJCC v8 | Stage IIIB Hepatocellular Carcinoma...

United States
National Cancer Institute (NCI)

Recruiting

Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma

Thymic Epithelial Tumor | Thymic Cancer | Recurrent Thymoma

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Recruiting

Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer (FASN)

Prostate Cancer | Refractory Cancer | Castration Resistant Prostatic Cancer

United States
Mark Stein
Bristol-Myers Squibb; Exelixis

Recruiting

CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition (Cyto-KIK)

Kidney Cancer | Renal Cell Carcinoma

United States
University of Pennsylvania

Recruiting

Effects of Sitagliptin in Individuals With Genetically Decreased DPP4

Heart Failure | Type2 Diabetes | Genetics Disease

United States
Shanghai Zhongshan Hospital

Recruiting

Efficiency of Methotrexate and Tofacitinib in Mild and Moderate Patients

Takayasu Arteritis | Methotrexate | Inhibition | Treatment

China
Hospices Civils de Lyon

Recruiting

Attention Modulation of Local and Global Inhibition Mechanisms (MILGattention)

Optical Phenomena

France
Jagiellonian University

Not yet recruiting

Cysteinyl Leukotriene Antagonist in Atherosclerosis Inhibition in Patients After Endovascular Treatment Due to Peripheral Arterial Disease (CADET-PAD)

Peripheral Arterial Disease | Peripheral Vascular Diseases | Lower Limb Ischemia | Atherosclerosis of Artery
Medical College of Wisconsin

Recruiting

Inhibition of Oral Tumorigenesis by Antitumor B

Squamous Cell Cancer of the Oral Cavity

United States
National Cheng-Kung University Hospital

Recruiting

Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage

Inflammation | Obesity

Taiwan
British Columbia Cancer Agency
Hoffmann-La Roche

Recruiting

Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity (CAPTIV-8)

Sarcoma | Breast Cancer | Head and Neck Cancer | Gynecologic Cancer | Lung Cancer | Skin Cancer | Gastrointestinal Cancer | Unknown Primary Tumors | Genitourinary Cancer

Canada
University Health Network, Toronto
Sunnybrook Health Sciences Centre; MOUNT SINAI HOSPITAL

Recruiting

DAPAgliflozin Sodium Water glucosE EffecTs in Patients at High Cardiovascular Risk (DAPA-SWEET)

Cardiovascular Risk Factor

Canada
University College, London

Recruiting

Health, Wellbeing and Performance in Law Enforcement Workers

Inflammation | Musculoskeletal Pain | Occupational Stress | Cognitive Change

United Kingdom
Alexion Pharmaceuticals, Inc.

Recruiting

Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)

Generalized Myasthenia Gravis

United States
University of Michigan Rogel Cancer Center
Janssen Scientific Affairs, LLC

Recruiting

A Multi-Center Trial of Androgen Suppression With Abiraterone Acetate, Leuprolide, PARP Inhibition and Stereotactic Body Radiotherapy in Prostate Cancer (ASCLEPIuS)

Prostate Cancer

United States
Royal Marsden NHS Foundation Trust

Recruiting

WaKING: Wnt and checKpoint INhibition in Gastric Cancer

Metastatic Gastric Cancer | Metastatic Esophageal Cancer

United Kingdom
Jacob Moller
Odense University Hospital; Rigshospitalet, Denmark; Danish Heart Foundation

Recruiting

Angiotensin-Neprilysin Inhibition in Diastolic Dysfunction After AMI (ARNiAMI)

Myocardial Infarction | Diastolic Dysfunction

Denmark
Allison O'Neill, MD

Recruiting

Checkpoint Inhibition In Pediatric Hepatocellular Carcinoma

Liver Cancer | Fibrolamellar Carcinoma | Hepatocellular Carcinoma, Childhood | Liver Cancer, Pediatric

United States
Vanderbilt University Medical Center

Recruiting

Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 2

Heart Failure

United States
Washington University School of Medicine
National Institutes of Health (NIH)

Recruiting

RANKL Inhibition and Mammographic Breast Density (TRIDENT)

Dense Breasts

United States
MedPacto, Inc.
AstraZeneca

Not yet recruiting

Vactosertib With Durvalumab in Urothelial Carcinoma Failing Checkpoint Inhibition

Urothelial Carcinoma Recurrent | Advanced Urothelial Carcinoma

United States
University of Alabama at Birmingham

Recruiting

Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders

Movement Disorders

United States
Ribon Therapeutics, Inc.

Recruiting

Phase 1 Study of RBN-2397, an Oral PARP7 Inhibitor, in Patients With Solid Tumors

Solid Tumor, Adult

United States, Spain
Żelazna Medical Centre, LLC

Recruiting

Satisfaction of Patients With the Chosen Method of Inhibition of Lactation

Lactation Suppressed

Poland
National Jewish Health
Augusta University; Cystic Fibrosis Foundation

Recruiting

Sildenafil Exercise: Role of PDE5 Inhibition

Cystic Fibrosis

United States
University of Maryland, Baltimore

Recruiting

The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia (TrypNAC-II)

Schizophrenia | Schizoaffective Disorder | Schizophreniform Disorder

United States
OHSU Knight Cancer Institute
Genentech, Inc.; Oregon Health and Science University; American Association for... and other collaborators

Recruiting

Targeted Pathway Inhibition in Patients With Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Ductal Adenocarcinoma | Locally Advanced Pancreatic Ductal Adenocarcinoma | Unresectable Pancreatic Ductal Adenocarcinoma

United States
Centre Hospitalier Universitaire de Saint Etienne

Recruiting

Lack of Decision-making in Patients With Alzheimer's Disease : Functions Involved and the Daily Consequences (MAPdP)

Alzheimer Disease

France
Washington University School of Medicine
Tesaro, Inc.

Recruiting

TSR-042 in Addition to Standard of Care Definitive Radiation for Inoperable Endometrial Cancer

Endometrial Cancer | Cancer of the Endometrium

United States
University Hospital, Toulouse

Recruiting

Improvement of Knowledge About the Arthrogenic Muscle Inhibition in the Aftermath of Knee Trauma. (CAMIK)

Anterior Cruciate Ligament Rupture

France
National Cancer Institute (NCI)

Recruiting

Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma or Biliary Tract Carcinoma

Hepatocellular Carcinoma | Hepatocellular Cancer | Metastatic Hepatocellular Carcinoma

United States
Royal Perth Hospital

Recruiting

Effects of Sodium-glucose Co-transporter-2( SGLT-2 ) Inhibition on Sympathetic Nervous System Activity in Humans (EMPA-SNS)

Obesity | Type 2 Diabetes Mellitus | Metabolic Syndrome

Australia
University of Colorado, Denver
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Recruiting

COMT Inhibition Among Individuals With Comorbid AUD/ADHD

Attention Deficit Hyperactivity Disorder | Alcohol Use Disorder

United States
Wayne State University

Recruiting

Inhibition of α-synuclein Cell-cell Transmission by NMDAR Blocker, Memantine

Parkinson Disease

United States
University of Illinois at Urbana-Champaign
Washington University School of Medicine

Recruiting

Role of Sweetness in Glucose Regulation (STS)

Obesity

United States
Region Skane

Recruiting

Faecal Analyses in Spondyloarthritis Therapy (FAST)

Ankylosing Spondylitis | Spondyloarthropathies

Sweden
Laval University
Canadian Institutes of Health Research (CIHR); AstraZeneca

Recruiting

Olaparib for PAH: a Multicenter Clinical Trial (OPTION)

Pulmonary Arterial Hypertension

Canada
Imperial College London
Novartis Pharmaceuticals

Recruiting

IL-1 Signal Inhibition in Alcoholic Hepatitis (ISAIAH)

Alcoholic Hepatitis

United Kingdom
Institute of Cancer Research, United Kingdom
AstraZeneca

Recruiting

PHOENIX DDR/Anti-PD-L1 Trial: A Pre-surgical Window of Opportunity and Post-surgical Adjuvant Biomarker Study of DNA Damage Response Inhibition and/or Anti-PD-L1 Immunotherapy in Patients With Neoadjuvant Chemotherapy Resistant Residual Triple Negative Breast Cancer (PHOENIX)

Breast Neoplasm

United Kingdom
Stanford University
National Institutes of Health (NIH)

Recruiting

Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

Diaphragm Injury

United States

Search clinical trials for: NLRP3 inhibitor, inflammasome inhibition

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