Attention Modulation of Local and Global Inhibition Mechanisms (MILGattention)

Human behavior is both flexible and adapted to the environmental context through inhibition capabilities; the investigator control the subject's behavior by repressing inappropriate responses and selecting, among several possibilities, those that are appropriate. These mechanisms are not independent of attentional control. Attention acts as a selection filter for the investigator's behavior. This leads us to hypothesize that attention modulates the mechanisms of inhibition. Nevertheless, the different brain structures involved, as well as mechanisms underlying the interaction between inhibition and attention remain largely unknown.

Previous research has suggested that inhibition requires selective attention and, conversely, attentional mechanisms would result in the "deselection", or inhibition, of objects in space or irrelevant actions. Reconciling the literature on attention with the one on inhibition appears fundamental for the understanding of the instance to which the mechanisms of inhibition and the cognitive processes interact. Therefore, the goal of this research project will be to investigate how inhibition mechanisms are implemented in the brain and, in more detail, what determines the type of resulting inhibitory control: spatially localized or global. The investigator will test 3 different patient groups (optic ataxia, hemispatial neglect and attention-deficit hyperactivity disorder) compared to control.

In conclusion, this research project will aim to develop a theoretical model of the interaction between attentional control and inhibition mechanisms in order to improve diagnostic and rehabilitation tools in the future.

Study Overview

• Status: Recruiting
• Conditions: Optical Phenomena
• Intervention / Treatment: Behavioral: experience 1 "The negative priming task"; Behavioral: experience 2 "Stop signal task"; Behavioral: experience 3 "Anti-saccades"

• Study Type: Interventional
• Enrollment (Estimated): 120
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Julie OUERFELLI-ETHIER; Email: julie.ouerfelli-ethier@inserm.fr
• Study Contact Backup: Name: laure PISELLA, PhD; Phone Number: +33 4 72 91 34 05; Email: laure.pisella@inserm.fr

Study Locations

• France
  • Bron, France, 69500
    • Recruiting
    • Centre de Recherche en Neuroscience de Lyon
    • Contact: Julie OUERFELLI-ETHIER; Email: julie.ouerfelli-ethier@inserm.fr
    • Contact: laure PISELLA, PhD; Phone Number: +33 4 72 91 34 05; Email: laure.pisella@inserm.fr
    • Principal Investigator: laure PISELLA, PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 8 years to 75 years (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

Description

All patients and healthy subjects:

Inclusion Criteria:

• male and female, age from 18 to 75 years included
• normal vision or corrected vision
• covered by social security
• signed written informed consent

Exclusion Criteria:

• unable to comply with requirements of the study (neurological, psychiatric, sensory or motor troubles)
• adults under legal protection

Patient with hemispatial neglect:

Inclusion Criteria:

• After a stroke (> 1 month ago), presence of a neurological impairment documented by brain imaging (standard of care) and by clinical symptoms.
• The diagnosis will be dissociated from hemianopia by perimetry. The hemispatial neglect consists of a lack of perception and responsiveness concerning the controlesional visual hemifield.

Patient with optic ataxia:

• After a stroke (> 1 month ago), presence of neurological injury in parietal cortex only, supported by a standard of care cerebral MRI
• Present optic ataxia symptoms (The OA consists of pointing errors with the hand contralateral to the lesion (hand effect) and / or to visual targets presented in the field contralateral to the lesion (field effect)).

Patient (adult and children) with attention-deficit hyperactivity disorder:

• present a diagnosis of ADHD subtype inattention or impulse / hyperactivity as established by a neuropsychologist.
• Children will be between 8 and 18 years old
• Adults will be between 18 and 75 years old.
• Participants will not report any comorbid learning disabilities to ADHD.

For minors:

- Having obtained the written consent of the legal representative(s)

Healthy subjects

Inclusion Criteria:

- no known neurological injury

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Healthy volunteers	Behavioral: experience 1 "The negative priming task"; The targets are presented to the subject on a computer screen. The subject must make an eye or hand movement toward the target and ignore the distracters.; Behavioral: experience 2 "Stop signal task"; The targets are presented to the subject on a computer screen. The subject must make an eye movement towards this target. Sometimes a stop signal will appear and the subject will have to avoid to look at the target; Behavioral: experience 3 "Anti-saccades"; The targets are presented to the subject on a computer screen. The subject must make an eye movement toward this target. Sometimes an instruction will ask the subject to look at the opposite of the target
Experimental: patients with optic ataxia (OA)	Behavioral: experience 1 "The negative priming task"; The targets are presented to the subject on a computer screen. The subject must make an eye or hand movement toward the target and ignore the distracters.; Behavioral: experience 2 "Stop signal task"; The targets are presented to the subject on a computer screen. The subject must make an eye movement towards this target. Sometimes a stop signal will appear and the subject will have to avoid to look at the target; Behavioral: experience 3 "Anti-saccades"; The targets are presented to the subject on a computer screen. The subject must make an eye movement toward this target. Sometimes an instruction will ask the subject to look at the opposite of the target
Experimental: patients with hemispatial neglect	Behavioral: experience 1 "The negative priming task"; The targets are presented to the subject on a computer screen. The subject must make an eye or hand movement toward the target and ignore the distracters.; Behavioral: experience 2 "Stop signal task"; The targets are presented to the subject on a computer screen. The subject must make an eye movement towards this target. Sometimes a stop signal will appear and the subject will have to avoid to look at the target; Behavioral: experience 3 "Anti-saccades"; The targets are presented to the subject on a computer screen. The subject must make an eye movement toward this target. Sometimes an instruction will ask the subject to look at the opposite of the target
Experimental: patients with attention-deficit hyperactivity disorder	Behavioral: experience 1 "The negative priming task"; The targets are presented to the subject on a computer screen. The subject must make an eye or hand movement toward the target and ignore the distracters.; Behavioral: experience 2 "Stop signal task"; The targets are presented to the subject on a computer screen. The subject must make an eye movement towards this target. Sometimes a stop signal will appear and the subject will have to avoid to look at the target; Behavioral: experience 3 "Anti-saccades"; The targets are presented to the subject on a computer screen. The subject must make an eye movement toward this target. Sometimes an instruction will ask the subject to look at the opposite of the target

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
error rate	The investigator calculate the number of right and wrong answers (a correct answer is a saccade carried out when it is necessary and by reaching the target; a false answer is a saccade made at the wrong time and / or not reaching the target) to obtain the error rate.	at the end of the simulation passage, an average of 3 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
reaction time	The investigator measure the time it takes for the subject to respond (perform the eye saccade)	at the end of the simulation passage, an average of 3 years

Collaborators and Investigators

• Sponsor: Hospices Civils de Lyon
• Investigators: Principal Investigator: Laure PISELLA, Centre de recherche de Neurosciences de Lyon (CRNL)

Study record dates

Study Major Dates

• Study Start (Actual): November 26, 2022
• Primary Completion (Estimated): November 26, 2028
• Study Completion (Estimated): November 26, 2028

Study Registration Dates

• First Submitted: February 11, 2020
• First Submitted That Met QC Criteria: February 19, 2020
• First Posted (Actual): February 21, 2020

Study Record Updates

• Last Update Posted (Actual): January 30, 2024
• Last Update Submitted That Met QC Criteria: January 29, 2024
• Last Verified: January 1, 2024

More Information

Terms related to this study

• Keywords: Healthy Volunteers; attention; Perceptual Disorders; inhibition; Attention Deficit Disorder with Hyperactivity; attention-deficit hyperactivity disorder (ADHD)
• Other Study ID Numbers: 69HCL19_0728; 2019-A03055-52 (Other Identifier: ID-RCB)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No