Search clinical trials for: Somatic mutation

Total 3495 results

AstraZeneca

Completed

Comparison of AZD6244 in Combination With Dacarbazine Versus (vs) Dacarbazine Alone in BRAF Mutation Positive Melanoma Patients

Melanoma

Sweden, United States, Brazil, Czech Republic, France, Spain, United Kingdom, Germany, Norway, Hungary, Netherlands, Switzerland
Hoffmann-La Roche

Terminated

An Observational Study on Long-Term Persistence of Resistant Mutations And Durability of Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Direct Acting Antiviral (DAA)- Containing Regimens

Hepatitis C, Chronic

France, United States, Canada, New Zealand, Spain, Germany, United Kingdom, Australia, Italy, Brazil, Mexico, Slovakia, Poland, Puerto Rico, Austria
National OncoVenture
Hanmi Pharmaceutical Company Limited

Terminated

NOV120101 (Poziotinib) for 1st Line Monotherapy in Patients With Lung Adenocarcinoma

Adenocarcinoma of Lung Stage IV | Adenocarcinoma of Lung Stage IIIB

Korea, Republic of
University of Wisconsin, Madison
National Cancer Institute (NCI)

Unknown

Study of Biomarkers in Tissue Samples From Patients With Breast Cancer

Breast Cancer
Institut National de la Santé Et de la Recherche...

Terminated

PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors (PRECARDIA)

Dilated Cardiomyopathy

France, Denmark, Germany, Italy, Netherlands, Spain, United Kingdom
Health Decisions
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

A Phase I Study to Evaluate the PK and PD of a Single Injection of Levonorgestrel Butanoate for Female Contraception (CCN011)

Contraceptive Usage

United States
Charite University, Berlin, Germany

Unknown

RM-493 Treatment Trial in Proopiomelanocortin (POMC) Deficient Patients

Homozygous or Compound Heterozygous POMC, LEPR or PCSK1 Gene Mutation

Germany
Istituti Ospitalieri di Cremona

Unknown

Olaparib in Locally Advanced ER, PgR and HER2 Negative (Triple Negative) and in Locally Advanced Germline BRCA Mutation-positive Breast Cancer Patients

Breast Cancer | Triple Negative Breast Cancer
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Mutations, Hormone Therapy (HRT) and Venous Thromboembolism

Cardiovascular Diseases | Venous Thromboembolism | Postmenopause
Hoffmann-La Roche

Completed

A Study of Tarceva (Erlotinib) in Patients With Locally Advanced, Metastatic or Recurrent Non-Small Cell Cancer Who Present Epidermal Growth Factor Receptor Mutations

Non-Squamous Non-Small Cell Lung Cancer

Bulgaria
Fudan University

Unknown

Mutation of BRCA1/2 and Other Potential Genes in Triple-negative Breast Cancer

Breast Cancer

China
Hoffmann-La Roche

Completed

A Study of Tarceva (Erlotinib) in First Line in Patients With Locally Advanced or Metastatic Lung Adenocarcinoma With EGFR Mutations

Non-Squamous Non-Small Cell Lung Cancer

Hungary, Latvia, Turkey
Memorial Sloan Kettering Cancer Center

Withdrawn

Clinical Outcomes in Hereditary Cancer

Breast Cancer | Pancreatic Cancer

United States
Irina A Anselm

No longer available

Triheptanoin (UX007) to Treat Citrate Transporter Deficiency

Citrate Transporter Deficiency | SLC13A5 Gene Mutation

United States
Memorial Sloan Kettering Cancer Center

Completed

Phase II Trial to Correlate Radiographic Response Induced By Gefitinib With Mutations in the Protein-Tyrosine Kinase Domain of the EGF Receptor Gene

Lung Cancer | Non-small Cell Lung Cancer | Bronchioloalveolar Cancer

United States
GenoSaber
Sun Yat-sen University; Shanghai Chest Hospital; Shanghai Pulmonary Hospital,...

Unknown

Human EGFR Mutations Quantitative Detection Kit (Real-time Fluorescent PCR Method)

Non Small Cell Lung Cancer | EGFR-TKI Resistant Mutation | EGFR-TKI Sensitizing Mutation
University of Washington
National Cancer Institute (NCI); National Institute of Nursing Research (NINR)

Completed

Group-Based Lifestyle Intervention in Measuring Biomarker Levels in Participants at High Risk for Breast Cancer (DEEM)

Ductal Breast Carcinoma in Situ | BRCA1 Mutation Carrier | BRCA2 Mutation Carrier | Atypical Ductal Breast Hyperplasia | Lobular Breast Carcinoma in Situ | Atypical Lobular Breast Hyperplasia

United States
Paola Queirolo
Istituto Nazionale per lo Studio e la Cura dei Tumori

Completed

Vemurafenib + Fotemustine to Treat Advanced Melanoma Patients With V600BRAF Mutation Recurred While on Vemurafenib (BeyPro1)

Malignant Melanoma Stage IV

Italy
National Cancer Institute (NCI)

Completed

Selumetinib in Cancers With BRAF Mutations

Adult Solid Neoplasm

United States
Baylor Research Institute

Completed

Androgenetic Alopecia in Fabry Disease

Fabry Disease

United States
GenoSaber

Unknown

EGFR Mutation Detection From Advanced NSCLC Patient Tissue and Plasma in EGFR-TKI Treatment

Non-small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
Genentech, Inc.

Completed

Vemurafenib and Panitumumab Combination Therapy in Patients With BRAF V600E Mutated Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

United States
Novartis Pharmaceuticals

Completed

A Study of AMNN107 in the Treatment of Metastatic and/or Inoperable Melanoma Harboring a c-Kit Mutation (TEAM)

Melanoma

United States, Belgium, Germany, Singapore, Italy, Australia, Netherlands, Sweden, Spain, Canada, Switzerland, Argentina, Brazil, China
Washington University School of Medicine

Withdrawn

Ponatinib in the Treatment of FGFR Mutation Positive Recurrent or Persistent Endometrial Carcinoma

Endometrial Neoplasms
Massachusetts General Hospital
Boston Children's Hospital

Unknown

Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia

Congenital Diaphragmatic Hernia

United States
HealthPartners Institute

Completed

Phase I Study of Weekly Topotecan in Combination With Sorafenib in Treatment of Relapsed Small Cell Lung Cancer

Lung Cancer | Small Cell Carcinoma

United States
Institut National de la Santé Et de la Recherche...

Unknown

Susceptibility Genes in Autism Spectrum Disorders

Autism Spectrum Disorders

France
Wayne State University

Completed

Stress and Health Interview for Primary Care Patients With Medically Unexplained Symptoms

Somatoform Disorders

United States
AstraZeneca

Completed

A Non-interventional Study (NIS) Registry for the Epidemiological and Scientific Evaluation of Epidermal Growth Factor Receptor (EGFR) Mutation Status in Patients With Newly Diagnosed Locally Advanced or Metastatic Non Small Cell Lung Cancer (NSCLC) (Stage IIIB/IV Non-small Cell Lung Cancer). (REASON)

Non Small Cell Lung Cancer

Greece
University of Cincinnati
Merck Sharp & Dohme LLC

Completed

Evaluating the Role of Immune Responses in the Emergence of Protease Inhibitor Mutations

Hepatitis C

United States
Memorial Sloan Kettering Cancer Center
Ascenta Therapeutics

Terminated

Erlotinib and AT-101 in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients With Epidermal Growth Factor Receptor (EGFR) Activating Mutations

Lung Cancer

United States
Samsung Medical Center

Withdrawn

Feasibility of Mutational Analysis of Non-Small Cell Lung Cancer (NSCLC) Using Low-volume Lung Aspirates

Lung Cancer

Korea, Republic of
Memorial Sloan Kettering Cancer Center
Genentech, Inc.

Terminated

Vemurafenib (R05185426) in Poor Performance Status Patients With Unresectable Locally Advanced or Metastatic Melanoma Harboring a V600E/K Mutation

Melanoma

United States
Karolinska Institutet

Completed

Cognitive Behavior Therapy for Health Anxiety: A Comparison of Three Forms of Self-help

Illness Anxiety Disorder | Somatic Symptom Disorder | Severe Health Anxiety

Sweden
Mclean Hospital
Brain & Behavior Research Foundation

Completed

Acute Glycine Pharmacodynamic Study

Psychotic Disorders | Schizophrenia

United States
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S0424 - Carcinogens in Lung Tissue From Smokers (Closed to Entry as of 7/15/07) and Non-Smokers With Newly Diagnosed Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer

Lung Cancer

United States
GlaxoSmithKline

Terminated

Brain Metastases In ErbB2-Positive Breast Cancer

Neoplasms, Breast

United States, Spain, Israel, Canada, Germany, Belgium, Austria, Sweden, Greece, France, Italy
Duke University
National Cancer Institute (NCI)

Completed

Genetic Study in Patients Receiving Treatment for Hodgkin's Disease or Childhood Brain Tumor

Lymphoma | Brain and Central Nervous System Tumors

United States
Bristol-Myers Squibb

Completed

Trial of BMS-690514 in Non-Small Cell Lung Cancer Subjects Who Have Been Treated With Gefitinib or Erlotinib and Are Genotypically EGFR Mutation Positive or Who Have Had a Prior Response

Non-Small-Cell Lung Carcinoma

Japan
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Withdrawn

Identifying Early Lung Cancer Cells in Malignant Pleural Effusion Samples From Patients With Primary Lung Cancer

Lung Cancer | Metastatic Cancer

United States
Boehringer Ingelheim

Completed

Trial of Continuous Once Daily Oral Treatment Using BIBW 2992 (Afatinib) Plus Sirolimus (Rapamune®) in Patients With Non-small Cell Lung Cancer Harbouring an EGFR Mutation and/or Disease Progression Following Prior Erlotinib or Gefitinib

Carcinoma, Non-Small-Cell Lung

Spain
Vertex Pharmaceuticals Incorporated

Completed

Study of VX-809 Alone and in Combination With VX-770 in Cystic Fibrosis (CF) Patients Homozygous or Heterozygous for the F508del-CFTR Mutation

Cystic Fibrosis

United States, France, United Kingdom, Germany, Australia, New Zealand, Belgium
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Withdrawn

Lapatinib Resistance in Patients With Breast Cancer

Breast Cancer

United States
National Cancer Institute (NCI)

Completed

MK-2206 and AZD6244 in Patients With Advanced Colorectal Carcinoma

Colorectal Neoplasms

United States
National Cancer Institute (NCI)

Completed

Sirolimus to Treat Cowden Syndrome and Other PTEN Hamartomatous Tumor Syndromes

Hamartoma Syndrome, Multiple | Cowden's Disease

United States
Hoffmann-La Roche

Completed

A Pharmacokinetics Study to Investigate the Effect of Vemurafenib on Digoxin in Patients With BRAFV600 Mutation-Positive Metastatic Melanoma

Malignant Melanoma, Neoplasms

Russian Federation, Korea, Republic of, Israel, South Africa, Belarus
Massachusetts General Hospital
Novartis Pharmaceuticals

Withdrawn

BKM120 in Cancers With PIK3CA Activating Mutations

Breast Cancer | Colorectal Cancer | Lung Cancer | Cholangiocarcinoma | Solid Tumors
Fondazione IRCCS Istituto Nazionale dei Tumori,...
Ministero della Salute, Italy

Unknown

Tailored Beta-catenin Mutational Approach in Extra-abdominal Sporadic Desmoids Tumor Patients

Desmoid-type Fibromatosis

Italy
Vertex Pharmaceuticals Incorporated
Cystic Fibrosis Foundation

Terminated

Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Homozygous for the F508del-CFTR Mutation (DISCOVER)

Cystic Fibrosis

United States
Betta Pharmaceuticals Co., Ltd.

Unknown

First-line Treatment With Icotinib in Elder NSCLC EGFR Mutated Patients

Non-Small Cell Lung Cancer

China

Search clinical trials for: Somatic mutation

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