Search clinical trials for: Endothelial Cell Dysfunction

Total 59358 results

Emmecell

Active, not recruiting

Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema

Endothelial Dysfunction | Corneal Edema | Fuchs Dystrophy | Corneal Endothelial Dystrophy | Bullous Keratopathy | Pseudophakic Bullous Keratopathy | Corneal Endothelial Dysfunction | Fuchs Endothelial Corneal Dystrophy | Moderate Corneal Endothelial Decompensation

United States
Cliniques universitaires Saint-Luc- Université...
Université Catholique de Louvain

Completed

Effect of a Specific Aquaporin-1 Inhibitor on Vascular Oxidative Stress in Healthy Volunteers (Bacoxy_II)

Cardiovascular Diseases | Endothelial Dysfunction | Oxidative Stress | Bacopaside II | Bacopa Monnieri | Aquaporin 1 | AQP1

Belgium
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Castleman Disease | Lymphangioleiomyomatosis | Digestive System Carcinoma | Malignant Neoplasm | Recurrent Breast Carcinoma | Recurrent Thyroid Gland Carcinoma | Metastatic Urothelial Carcinoma | Malignant Female Reproductive System Neoplasm | Neurofibromatosis Type 2 | Recurrent Adult Soft Tissue Sarcoma and other conditions

United States
National Cancer Institute (NCI)

Active, not recruiting

Ipilimumab With or Without Bevacizumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

Stage IV Cutaneous Melanoma AJCC v6 and v7 | Stage IIIC Cutaneous Melanoma AJCC v7 | Unresectable Melanoma

United States
Gary Van Guilder
Western Colorado University; Auckland University of Technology

Completed

The Dose-response Effects of High Intensity Functional Training on Metabolic Syndrome Risk Factors

Metabolic Syndrome | Insulin Resistance | Endothelial Dysfunction | Atherogenic Dyslipidemia

United States
Poznan University of Physical Education

Completed

Effect of 2000-meter Rowing Test on Parameters of Intestinal Integrity in Elite Rowers During Competitive Phase (Rowers)

Endothelial Dysfunction

Poland
MD Stem Cells

Enrolling by invitation

Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study (ACIST)

Alzheimer Disease | Traumatic Brain Injury | Autism Spectrum Disorder | Lewy Body Disease | Vascular Dementia | Autism | Dementia, Mixed | Alzheimer Dementia | Dementia, Multi-Infarct | Cadasil | Parkinson-Dementia Syndrome | Chronic Traumatic Encephalopathy | Autistic Behavior | Lewy Body Dementia With Behavioral... and other conditions

United States, United Arab Emirates
University Hospital of Limerick
University of Limerick

Terminated

The Role of Unsteady Wall Shears Stress Stimuli on Human Umbilical Vein Endothelial Cells Harvested From Umbilical Cords (HUVEC)

Vascular Diseases

Ireland
Aarhus University Hospital
University of Aarhus

Active, not recruiting

Cognitive Function in Patients Treated for Metastatic Melanoma With Immune Checkpoint Inhibitors

Melanoma | Quality of Life | Inflammation | Fatigue | Cognitive Impairment | Sleep | Depression, Anxiety | Cancer-related Cognitive Impairment | Sickness Behavior

Denmark
Cliniques universitaires Saint-Luc- Université...

Completed

Effect of Oral Intake of Bacopa Monneiri on Vascular Oxidative Stress (Bacoxy_I)

Cardiovascular Diseases | Endothelial Dysfunction | Oxidative Stress | Bacopaside II | Bacopa Monnieri | Aquaporin 1 | AQP1

Belgium
Matthew Neal MD
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE (ACTIV-4A)

Covid19

United States, Spain, Brazil, Italy
Capricor Inc.
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health... and other collaborators

Terminated

Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration (ALLSTAR)

Myocardial Infarction

United States
Roswell Park Cancer Institute

Active, not recruiting

Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer

Acute Myeloid Leukemia | Polycythemia Vera | Myelofibrosis | Chronic Myelomonocytic Leukemia | Waldenstrom Macroglobulinemia | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Secondary Acute Myeloid Leukemia | Sickle Cell Disease | Myelodysplastic Syndrome | Plasma Cell Myeloma | Chronic Granulomatous... and other conditions

United States
Nantes University Hospital
Etablissement Français du Sang

Completed

Impact of the Composition of Packed Red Blood Cell Supernatant on Renal Dysfunction and Posttransfusion Immunomodulation (TRANSNEPHRON)

Renal Failure

France
RTI International
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Enrolling by invitation

Early Check: Expanded Screening in Newborns

Primary Hyperoxaluria Type 3 | Diabetes Mellitus | Hemophilia A | Hemophilia B | Hereditary Fructose Intolerance | Cystic Fibrosis | Factor VII Deficiency | Phenylketonurias | Sickle Cell Disease | Dravet Syndrome | Duchenne Muscular Dystrophy | Prader-Willi Syndrome | Fragile X Syndrome | Chronic Granulomatous Disease and other conditions

United States
Exelixis
Ipsen

Active, not recruiting

A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy

Differentiated Thyroid Cancer

Hong Kong, Italy, United States, Argentina, Australia, Austria, Belgium, Brazil, Canada, Croatia, Czechia, France, Germany, Hungary, Israel, Korea, Republic of, Mexico, Netherlands, Poland, Romania, Russian Federation, Spain, Taiwan, ... and more
National Cancer Institute (NCI)

Active, not recruiting

Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases

Metastatic Lung Non-Small Cell Carcinoma | Stage IV Lung Cancer AJCC v8 | Metastatic Malignant Neoplasm in the Brain

United States
Amgen

Active, not recruiting

AMG 510 Ethnic Sensitivity Study (CodeBreaK 105).

Advanced/Metastatic Solid Tumors With KRAS p.G12C Mutation

Taiwan, Hong Kong
Massachusetts General Hospital
American Cancer Society, Inc.; The Leukemia and Lymphoma Society

Active, not recruiting

Multimodal Sexual Dysfunction Intervention In HCT

Hematologic Diseases | Sexual Dysfunction | Hematopoietic Stem Cell Transplantation

United States
I.M. Sechenov First Moscow State Medical University

Enrolling by invitation

Diagnostics of Coronavirus Disease 2019 Cardiovascular Complications

COVID-19 | Quality of Life | Oxygen Consumption | Diastolic Dysfunction | Endothelial Function | Exercise Tolerance

Russian Federation
Karolinska University Hospital
Karolinska Institutet; The Swedish Research Council; Region Stockholm; Swedish... and other collaborators

Active, not recruiting

Safety and Efficacy of Hyperbaric Oxygen Therapy for Long COVID Syndrome (HOT-LoCO)

COVID-19 | Post COVID-19 Condition | Post-COVID Syndrome | Post COVID-19 Condition, Unspecified | Post COVID Condition | Post-Acute COVID-19 Syndrome

Sweden
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Biomarkers of Renal Dysfunction in Neuroblastoma Survivors

Neuroblastoma Survivors

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Paclitaxel and Bevacizumab With or Without Emactuzumab in Treating Patients With Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Ovarian Endometrioid Adenocarcinoma | Ovarian Seromucinous Carcinoma | Ovarian Undifferentiated Carcinoma | Ovarian Clear Cell Adenocarcinoma | Ovarian Mucinous Adenocarcinoma | Fallopian Tube... and other conditions

United States
National Cancer Institute (NCI)
Celgene Corporation

Active, not recruiting

Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver Dysfunction

Glioma | Hematopoietic and Lymphoid Cell Neoplasm | Lymphoma | Recurrent Head and Neck Carcinoma | Recurrent Lung Carcinoma | Recurrent Renal Cell Carcinoma | Stage III Cutaneous Melanoma AJCC v7 | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Recurrent Pancreatic Carcinoma | Stage III Pancreatic Cancer... and other conditions

United States, Canada
National Cancer Institute (NCI)

Active, not recruiting

Cediranib Maleate and Olaparib Compared to Bevacizumab in Treating Patients With Recurrent Glioblastoma

Recurrent Glioblastoma

United States
OHSU Knight Cancer Institute
Oregon Health and Science University

Terminated

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Primary Myelofibrosis | Anemia | Recurrent Hodgkin Lymphoma | Refractory Hodgkin Lymphoma | Anatomic Stage IV Breast Cancer AJCC v8 | Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Chronic Myelomonocytic Leukemia | Refractory Myelodysplastic... and other conditions

United States
National Cancer Institute (NCI)

Active, not recruiting

TORC1/2 Inhibitor MLN0128 and Bevacizumab in Treating Patients With Recurrent Glioblastoma or Advanced Solid Tumors

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Ovarian Clear Cell Cystadenocarcinoma | Ovarian Endometrioid Adenocarcinoma | Ovarian Serous Cystadenocarcinoma | Endometrial Clear Cell Adenocarcinoma | Endometrial Serous Adenocarcinoma | Recurrent... and other conditions

United States
Hospices Civils de Lyon

Completed

Pilot Study DiaDEP (DiaDEP)

Diabetes Mellitus, Type 1 | Type1diabetes

France
University of Iowa

Completed

Restoring Glycocalyx Thickness in Older Adults to Improve Vascular Function (RESTORE)

Aging | Endothelial Dysfunction | Vascular Stiffness

United States
National Cancer Institute (NCI)

Completed

Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Ovarian Carcinoma | Pancreatic Neuroendocrine Tumor | Unresectable Solid Neoplasm | Fibrolamellar Carcinoma

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Probiotic Yogurt Supplement in Reducing Diarrhea in Patients With Metastatic Kidney Cancer Being Treated With Vascular Endothelial Growth Factor-Tyrosine Kinase Inhibitor

Metastatic Renal Cell Carcinoma | Diarrhea | Stage IV Renal Cell Cancer

United States
M.D. Anderson Cancer Center

Active, not recruiting

Ensartinib, Carboplatin, Pemetrexed and Bevacizumab for the Treatment of Stage IIIC or IV or Recurrent ALK-Positive Non-small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage IIIC Lung Cancer AJCC v8 | Recurrent Lung Non-Small Cell Carcinoma

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Active, not recruiting

Testing Ramipril to Prevent Memory Loss in People With Glioblastoma

Glioblastoma | Chemoradiation | Cognitive Decline | Radiotherapy; Complications

United States, Guam
Massachusetts General Hospital
National Institutes of Health (NIH)

Completed

Inflammation and Cardiovascular Health in Women

Myocardial Infarction | HIV/AIDS

United States
National Cancer Institute (NCI)

Completed

Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma

Brain Stem Glioma | Childhood Spinal Cord Neoplasm | Childhood Cerebral Anaplastic Astrocytoma | Cerebral Astrocytoma | Childhood Cerebellar Anaplastic Astrocytoma

United States, Canada
Queen Mary University of London
Barts & The London NHS Trust

Completed

Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage (NITRATE-TOD)

Hypertension

United Kingdom
Stanford University
National Institutes of Health (NIH)

Active, not recruiting

Serial Ultrasound in Metastatic Renal Cell Carcinoma (mRCC)

Kidney Cancer | Renal Cell Carcinoma | Metastatic Renal Cell Carcinoma

United States
National Cancer Institute (NCI)

Active, not recruiting

Eribulin Mesylate in Treating Patients With Locally Advanced or Metastatic Cancer of the Urothelium and Kidney Dysfunction

Metastatic Urothelial Carcinoma | Stage III Bladder Urothelial Carcinoma AJCC v6 and v7 | Stage IV Bladder Urothelial Carcinoma AJCC v7 | Locally Advanced Urothelial Carcinoma | Recurrent Urothelial Carcinoma | Unresectable Urothelial Carcinoma | Advanced Urothelial Carcinoma

United States
Reata, a wholly owned subsidiary of Biogen
AbbVie

Completed

RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - GUARD

Ocular Inflammation | Ocular Pain | Corneal Endothelial Cell Loss | Cataract Surgery

United States
University of Bologna

Completed

Effect of Apple Polyphenols on Vascular Oxidative Stress and Endothelium Function Study (APP trial_2016)

Endothelial Dysfunction

Italy
The Cleveland Clinic

Completed

Endothelial Function After Cardiac Surgery

Endothelial Dysfunction

United States
Augusta University

Active, not recruiting

Mechanisms for Vascular Dysfunction and Exercise Tolerance in CF (CF-AOX)

Cystic Fibrosis

United States
Roswell Park Cancer Institute
GlaxoSmithKline

Active, not recruiting

Pazopanib Hydrochloride and Bevacizumab in Treating Patients With Previously Untreated Metastatic Kidney Cancer

Clear Cell Renal Cell Carcinoma | Stage IV Renal Cell Cancer

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Cellular Immunotherapy Following Chemotherapy in Treating Patients With Recurrent Non-Hodgkin Lymphomas, Chronic Lymphocytic Leukemia, or B-Cell Prolymphocytic Leukemia

Recurrent Adult Burkitt Lymphoma | Recurrent Mantle Cell Lymphoma | Recurrent Marginal Zone Lymphoma | Recurrent Small Lymphocytic Lymphoma | Recurrent Diffuse Large B-Cell Lymphoma | Post-Transplant Lymphoproliferative Disorder | Recurrent Chronic Lymphocytic Leukemia | Recurrent Follicular Lymphoma and other conditions

United States
Amsterdam University Medical Center

Enrolling by invitation

Cognitive Functioning and Health Related Quality of Life in Retinoblastoma Survivors (RbNeuroQoL)

Retinoblastoma | Neurocognitive Dysfunction | Health-Related Behavior

Netherlands
Shufeng Li

Completed

Mechanism of IL-10 Pathway-mediated Regulatory B Cell Dysfunction in Osteoarthritis

Osteoarthritis | Knee Arthritis

China
Nantes University Hospital

Completed

Endothelial Dysfunction in Reversible Cerebral Vasoconstriction Syndrome (DESS)

Reversible Cerebral Vasoconstriction Syndrome

France
OHSU Knight Cancer Institute
Genentech, Inc.; Oregon Health and Science University

Withdrawn

SMMART Adaptive Clinical Treatment (ACT) Trial

Anatomic Stage III Breast Cancer AJCC v8 | Recurrent Ovarian Carcinoma | Anatomic Stage IV Breast Cancer AJCC v8 | Advanced Malignant Solid Neoplasm | Advanced Pancreatic Carcinoma | Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Recurrent... and other conditions

United States
MIPO Clinic

Completed

Role of Neutrophils and Electro-bioluminescence in the Rehabilitation (RNE)

Nonsmall-cell Lung Cancer

Kazakhstan
St. Jude Children's Research Hospital

Active, not recruiting

Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)

Acute Lymphoblastic Leukemia | Executive Dysfunction | Transcranial Direct Current Stimulation

United States

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