Clinical Trials Sponsored by Critical Therapeutics

Total 17095 results

Critical Therapeutics

Completed

Assessment of PFT, Safety, and PK of Zileuton Injection in Asthma Patients

Asthma
Critical Therapeutics

Terminated

CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB)

Coronary Disease | Heart Valve Diseases

United States
Critical Therapeutics

Terminated

Zileuton CR vs Placebo in Poorly Controlled Asthma Patients on Moderate Dose ICS

Asthma

United States
Critical Therapeutics

Completed

Safety Study of Zileuton Injection in Patients With Asthma

Asthma

United States
Critical Therapeutics

Unknown

Study of Oral Zileuton in the Treatment of Moderate to Severe Facial Acne Vulgaris

Acne Vulgaris

United States
Emory University
Critical Therapeutics

Completed

Study to Evaluate the Impact of Obesity on Airway Inflammation and Mechanics in Asthmatics (ABI/BALA)

Asthma

United States
Allarity Therapeutics
Amarex Clinical Research

Recruiting

Study to Determine the Maximum Tolerated Dose (MTD) of PARPi 2X-121 Monotherapy and the MTD of Dovitinib in Combination With 2X-121 in Patients With Advanced Solid Tumors

Advanced Solid Tumors

United States
Trevi Therapeutics
Davita Clinical Research

Completed

Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus

Uremic Pruritus
Heptares Therapeutics Limited
Quotient Clinical

Completed

Relative Bioavailability Study in Healthy Subjects to Evaluate the Pharmacokinetics of HTL0009936 After One Dose of Prototype Formulation

Alzheimer's Disease

United Kingdom
TauRx Therapeutics Ltd
Quotient Clinical

Completed

Multiple Dose Study of TRx0037

Alzheimer's Disease
TauRx Therapeutics Ltd
Quotient Clinical

Completed

Comparative Bioavailability in Healthy Elderly Volunteers

Alzheimer's Disease
Allarity Therapeutics
Amarex Clinical Research

Recruiting

Clinical Pre-screening Protocol for Ovarian Cancer

Ovarian Cancer

United States, United Kingdom
Nabriva Therapeutics AG
Quotient Clinical

Completed

A Study to Assess Mass Balance Recovery, Metabolite Profile and Identification of IV and Oral 14C-BC-3781

Healthy

United Kingdom
United Therapeutics
Asian Clinical Trials

Terminated

Study of Intravenous Remodulin in Patients in India With Pulmonary Arterial Hypertension (TRUST-1)

Pulmonary Arterial Hypertension

India
Hoth Therapeutics, Inc.
Worldwide Clinical Trials

Recruiting

Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors (CLEER)

Acneiform Eruption Due to Chemical | Xerosis Cutis | Paronychia

United States
Amytrx Therapeutics, Inc.
Amarex Clinical Research

Completed

Topically Applied AMTX-100 CF for Adult Patients With Mild to Moderate Atopic Dermatitis

Atopic Dermatitis

United States
Edgewise Therapeutics, Inc.
Worldwide Clinical Trials

Completed

A Study to Assess Safety, Tolerability, and PK of EDG-5506 in Healthy Volunteers and Becker Muscular Dystrophy Adults

Becker Muscular Dystrophy | Healthy Volunteer

United States
Aquestive Therapeutics
Covance; inVentiv Health Clinical

Terminated

Riluzole Oral Soluble Film (ROSF) Swallowing Safety in Amyotrophic Lateral Sclerosis (ALS) (ROSF)

Amyotrophic Lateral Sclerosis

United States
Lotus Clinical Research, LLC
CerSci Therapeutics

Unknown

Double-blind, Placebo-control, Study to Evaluate the Safety and Pharmacokinetics of CT-044 HCl, in Healthy Volunteers

Surgery | Pain, Acute | Acute Pain | Neuropathy

United States
Lotus Clinical Research, LLC
CerSci Therapeutics

Completed

Open-label, Crossover, Food Effect Study to Evaluate CT-044 in Healthy Human Volunteers

Surgery | Pain, Acute | Acute Pain | Neuropathy

United States
BioXcel Therapeutics Inc
Worldwide Clinical Trials

Active, not recruiting

Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia and Bipolar Disorder (SERENITY III)

Schizophrenia | Schizoaffective Disorder | Bipolar I Disorder | Bipolar II Disorder | Agitation,Psychomotor | Schizophreniform Disorders

United States
NBE-Therapeutics AG
Cmed Clinical Services

Terminated

NBE-002 in Patients With Advanced Solid Tumors

Triple Negative Breast Cancer | Advanced Solid Tumor | Advanced Cancer

United States
Aquestive Therapeutics
Covance; inVentiv Health Clinical

Completed

Study of Diazepam Buccal Film Administered in the Interictal and in the Ictal-Periictal States to Adults With Epilepsy

Epilepsy

United States
Clarus Therapeutics, Inc.
inVentiv Health Clinical

Completed

Safety and Efficacy Trial of Testosterone Undecanoate

Male Hypogonadism

United States
Nivalis Therapeutics, Inc.
Davita Clinical Research

Completed

A Drug-Drug Interaction Study of N91115 +/- Rifampin in Healthy Adult Subjects

Drug Interaction Potentiation

United States
Ranok Therapeutics (Hangzhou) Co., Ltd.

Recruiting

A Study of RNK05047 in Subjects With Advanced Solid Tumors/Diffuse Large B-cell Lymphoma (CHAMP-1)

Advanced Solid Tumor | DLBCL

United States
Cessation Therapeutics, Inc.
Dr. Vince Clinical Research

Recruiting

Safety, Tolerability, and Pharmacokinetics of CSX-1004

Opioid Use Disorder | Opioid Overdose

United States
selectION Therapeutics GmbH
FGK Clinical Research GmbH

Completed

A First-In-Human Study to Evaluate the Safety, Tolerability, and Efficacy of Si-544 in Adults With Atopic Dermatitis

Atopic Dermatitis

Germany
Allergy Therapeutics
SynteractHCR; Metronomia Clinical Research GMBH

Completed

A Study of Tolerability and Safety of a New Cumulative Dose of Grass MATA MPL (G104)

Seasonal Allergic Rhinitis

United States
Amsterdam Molecular Therapeutics
The Clinical Trial Company

Unknown

Study to Re-assess and Re-confirm Data Previously Recorded About the Incidence and Severity of Acute Abdominal "Pancreatitis" Episodes in Lipoprotein Lipase Deficient (LPLD) Subjects Previously Enrolled on AMT Clinical Studies

Lipoprotein Lipase Deficiency

Canada
Amsterdam Molecular Therapeutics
The Clinical Trial Company

Completed

Efficacy and Safety of Human Lipoprotein Lipase (LPL)[S447X] Expressed by an Adeno-Associated Viral Vector in LPL-deficient Subjects

Familial Lipoprotein Lipase Deficiency

Canada
SHINKEI Therapeutics, Inc
Duke Clinical Research Institute

Not yet recruiting

Study to Assess the Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients With Severe Traumatic Brain Injury (TBI).

Traumatic Brain Injury
BioXcel Therapeutics Inc
Lotus Clinical Research, LLC

Recruiting

Tachyphylaxis, Tolerance, & Withdrawal Post Treatment With Igalmi for Agitation in Schizophrenia or Bipolar Disorder

Schizophrenia | Bipolar Disorder | Schizo Affective Disorder | Agitation,Psychomotor | Schizophreniform Disorders

United States
Allarity Therapeutics
Amarex Clinical Research; Alcedis GmbH

Recruiting

Investigation of 2X-121 in Patients With Advanced Ovarian Cancer Selected by the 2X-121 DRP® (PREDICT 2X-121)

Advanced Ovarian Cancer

United Kingdom, United States
Sollis Therapeutics, Inc.
Lotus Clinical Research, LLC

Completed

Treatment of Pain Associated With Lumbosacral Radiculopathy in Adults (RePRIEVE-CM)

Lumbosacral Radiculopathy

United States
Five Prime Therapeutics, Inc.
Worldwide Clinical Trials

Withdrawn

Study of FP-1039 in Subjects With Endometrial Cancers

Endometrial Cancers With FGFR2 Mutations
selectION Therapeutics GmbH
FGK Clinical Research GmbH

Recruiting

A Study to Evaluate the Safety and Tolerability, and the Efficacy of Si-544 in Adults With Psoriasis Vulgaris or Psoriatic Arthritis

Psoriasis Vulgaris | Psoriatic Arthritis

Germany
Medtronic Neurovascular Clinical Affairs
Micro Therapeutics Inc.

Completed

Study Comparing Onyx and TRUFILL in Brain Arteriovenous Malformations (AVMs)

Brain Arteriovenous Malformations

United States
Flexion Therapeutics, Inc.
Lotus Clinical Research, LLC

Completed

Study to Evaluate the Safety and Tolerability of FX301 in Patients Undergoing Bunionectomy

Pain, Postoperative | Bunion

United States
High Point Clinical Trials Center
Ferox Therapeutics

Terminated

Insulin Tolerance Test Study in Patients With Type 1 Diabetes

Hypoglycemia | Type 1 Diabetes

United States
Raziel Therapeutics Ltd.
Spaulding Clinical Research LLC

Completed

Evaluation of Safety, Efficacy and Thermogenesis-induction of RZL-012 in Overweight and Obese Volunteers

Obesity | Weight Loss | Overweight and Obesity

United States
Akebia Therapeutics
Cyclerion Therapeutics

Completed

A Study to Evaluate the Soluble Guanylate Cyclase (sGC) Stimulator IW-1973 in Diabetic Nephropathy / Diabetic Kidney Disease as Measured by Albuminuria

Type 2 Diabetes Mellitus With Diabetic Nephropathy

United States
Akebia Therapeutics
Cyclerion Therapeutics

Completed

A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (HFpEF) (CAPACITY-HFpEF)

Heart Failure With Preserved Ejection Fraction

United States, Canada
Aminex Therapeutics, Inc.
Iqvia Pty Ltd; Novella Clinical

Withdrawn

Study of Orally-Administered AMXT 1501 Dicaprate in Normal Healthy Volunteers

Neoplasms | Tolerance | Medication Toxicity

United States
Melinta Therapeutics, Inc.
Christchurch Clinical Studies Trust Ltd

Completed

Oritavancin on the Results of Multiple Coagulation Tests in Healthy Volunteers

Healthy Volunteers

New Zealand
GSO Global Clinical Research BV
Karyopharm Therapeutics Inc

Terminated

Phase 1 Trial To Evaluate mFOLFOX6 With Selinexor In Patients With Metastatic Colorectal Cancer (SENTINEL)

Colorectal Neoplasm

Germany, Belgium
GSO Global Clinical Research BV
Karyopharm Therapeutics Inc

Completed

A Phase II Study of Selinexor Plus Cytarabine and Idarubicin in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia (Relapsed/Refractory)

Germany
Enlivex Therapeutics Ltd.
Nordic Bioscience Clinical Development (NBCD)

Recruiting

Study of Intra-articular Allocetra in Knee Osteoarthritis

Osteoarthritis, Knee

Israel
Spero Therapeutics
Clinical Network Services (CNS) Pty Ltd

Completed

A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of SPR206 in Healthy Volunteers

Healthy Volunteers

Australia
Arana Therapeutics Ltd
Trident Clinical Research Pty Ltd

Completed

Dose Optimisation Study of ART621 in Subjects Diagnosed With Rheumatoid Arthritis Taking Methotrexate

Rheumatoid Arthritis

Sri Lanka

Clinical Trials Sponsored by Critical Therapeutics

Sponsors and Collaborators

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