Clinical Trials Sponsored by Rex Bionics Plc

Total 51 results

Rex Bionics Plc
Generic Devices Consulting, Inc.

Completed

Safety and Feasibility Evaluation of Robot Assisted Physiotherapy Exercises With REX (RAPPER II)

Spinal Cord Injury

Australia, United Kingdom, New Zealand
East Kent Hospitals University NHS Foundation Trust
Rex Bionics

Completed

Rex Robot Assisted Rehabilitation to Enhance Balance and Mobility for People With Multiple Sclerosis, Clinical and Biomarker Study - RAPPER IV (RAPPER IV)

Multiple Sclerosis

United Kingdom
Bionic Sight LLC

Recruiting

BS01 in Patients With Retinitis Pigmentosa

Retinitis Pigmentosa

United States
Redx Pharma Plc

Completed

A Study to Assess Efficacy of RXC004 +/- Nivolumab in Ring Finger Protein 43 (RNF43) or R-spondin (RSPO) Aberrated, Metastatic, Microsatellite Stable, Colorectal Cancer After Progression on Standard of Care (SOC)

Colorectal Cancer

Spain, Korea, Republic of, United Kingdom, United States
Redx Pharma Plc

Active, not recruiting

Study to Evaluate the Safety and Tolerability of RXC004 in Advanced Malignancies

Cancer | Solid Tumor

United Kingdom
Redx Pharma Plc
Merck Sharp & Dohme LLC

Completed

A Study to Assess RXC004 Efficacy in Advanced Solid Tumours After Progression on Standard of Care (SoC) Therapy (PORCUPINE2) (KEYNOTE-E86)

Advanced Solid Tumours

United Kingdom, Australia
Redx Pharma Plc
Simbec Research

Completed

A 3-part Study to Evaluate Safety, Tolerability, Food Effect and Drug-drug Interactions of RXC007 in Healthy Volunteers

Liver Diseases | Fibrosis | Kidney Diseases | Inflammation | Idiopathic Pulmonary Fibrosis | Non-alcoholic Steatohepatitis

United Kingdom
Bioniche Pharma USA LLC

Completed

Bioequivalence Study of Azacitidine for Injection in Myelodysplastic Syndrome (MDS) Patients

Myelodysplastic Syndrome

United States, France
Redx Pharma Plc
Simbec Research

Recruiting

Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of RXC007 in Idiopathic Pulmonary Fibrosis

Fibrosis | IPF

Italy, Spain, United States, Belgium, United Kingdom, Austria, Czechia, Poland, Switzerland
Wex Pharmaceuticals Inc.
Premier Research Group plc

Terminated

The Purpose of This Study is to Determine if Tetrodotoxin (TTX) is Effective in the Treatment of Pain Resulting From Chemotherapy Treatment (TTX-CINP-201)

Pain | Neuropathic Pain | Peripheral Neuropathy

United States
Queen's University
Biogenics Research Chamber, LLC

Completed

Comparability and Standardization of Controlled Allergen Challenge Facilities

Allergic Rhinitis

Canada, United States
Red Nucleus Enterprise Solutions, LLC

Recruiting

NSAA NON-Interventional Study Protocol

Duchenne Muscular Dystrophy

United States
Jonsson Comprehensive Cancer Center
Faxitron bioptics, LLC

Completed

SCOUT Reflector for Tagging Lymph Nodes for Targeted Removal in Patients With Breast Cancer

Stage I Breast Cancer AJCC v7 | Stage IA Breast Cancer AJCC v7 | Stage IB Breast Cancer AJCC v7 | Stage II Breast Cancer AJCC v6 and v7 | Stage IIA Breast Cancer AJCC v6 and v7 | Stage IIB Breast Cancer AJCC v6 and v7 | Stage III Breast Cancer AJCC v7 | Stage IIIA Breast Cancer AJCC v7 | Stage IIIB... and other conditions

United States
QBiotics Group Limited
Merck Sharp & Dohme LLC

Terminated

A Trial of Tigilanol Tiglate in Combination With Pembrolizumab in Stage IIIB to IV M1c-melanoma

Melanoma

Australia
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Safety and Efficacy of Mipomersen (ISIS 301012) As Add-on Therapy in High Risk Hypercholesterolemic Patients

Hypercholesterolemia | Coronary Heart Disease

United States
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Single Doses of Mipomersen in Japanese Healthy Volunteers

Healthy Volunteer

Germany
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Dose-escalating Safety Study of ISIS 301012 in Homozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy

Hypercholesterolemia, Familial

United States, Netherlands
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration

Metabolic Diseases | Congenital Abnormalities | Infant, Newborn, Diseases | Genetic Diseases, Inborn | Dyslipidemias | Metabolism, Inborn Errors | Lipid Metabolism Disorders | Hypercholesterolemia | Hyperlipidemias | Lipid Metabolism, Inborn Errors | Hypobetalipoproteinemias | Hypolipoproteinemias | Hypolipopro... and other conditions

Netherlands
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Safety and Efficacy of Mipomersen in Patients With Severe Hypercholesterolemia on a Maximally Tolerated Lipid-Lowering Regimen and Who Are Not on Apheresis

Hypercholesterolemia | Coronary Heart Disease

South Africa, Germany, United States, United Kingdom, Canada, Czech Republic
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia

Metabolic Diseases | Congenital Abnormalities | Infant, Newborn, Diseases | Genetic Diseases, Inborn | Dyslipidemias | Metabolism, Inborn Errors | Lipid Metabolism Disorders | Hypercholesterolemia | Hyperlipidemias | Hyperlipoproteinemias | Lipid Metabolism, Inborn Errors | Hyperlipoproteinemia Type II | Metabolic... and other conditions

United States
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Study to Assess the Effects of Mipomersen on Lipid and Lipoprotein Metabolism in Healthy Subjects

Healthy Volunteer

United States
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Study of ISIS 301012 (Mipomersen) in Heterozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy

Hypercholesterolemia, Familial

United States, Netherlands
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Safety and Efficacy Study of ISIS 301012 (Mipomersen) Administration in High Risk Statin Intolerant Subjects (ASSIST)

Metabolic Diseases | Dyslipidemias | Lipid Metabolism Disorders | Hypercholesterolemia | Hyperlipidemias | Metabolic Disorder

Netherlands
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Efficacy and Safety Study of ISIS 301012 (Mipomersen) as Add-on in Familial Hypercholesterolemic Patients With Coronary Artery Disease (RADICHOL II)

Coronary Artery Disease | Heterozygous Familial Hypercholesterolemia

United States, Canada
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia

Metabolic Diseases | Congenital Abnormalities | Infant, Newborn, Diseases | Genetic Diseases, Inborn | Dyslipidemias | Metabolism, Inborn Errors | Lipid Metabolism Disorders | Hypercholesterolemia | Hyperlipidemias | Hyperlipoproteinemias | Lipid Metabolism, Inborn Errors | Hyperlipoproteinemia Type II | Metabolic... and other conditions

United States, Canada, Brazil, Taiwan, Singapore, South Africa, United Kingdom
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial Hypercholesterolemia (RADICHOL 1)

Metabolic Diseases | Congenital Abnormalities | Infant, Newborn, Diseases | Genetic Diseases, Inborn | Dyslipidemias | Metabolism, Inborn Errors | Lipid Metabolism Disorders | Hypercholesterolemia | Hyperlipidemias | Hyperlipoproteinemias | Lipid Metabolism, Inborn Errors | Hyperlipoproteinemia Type II | Metabolic... and other conditions

United States, Taiwan, Brazil, Canada, South Africa, United Kingdom, Singapore
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

A Study to Determine the Effects of Multiple Doses of Mipomersen (200 mg SC) on the Pharmacodynamics and Pharmacokinetics of Single-dose Warfarin

Healthy

United States
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

A Study to Evaluate 3 Different Dosing Regimens of Mipomersen Administered Via Subcutaneous Injections to Healthy Volunteers

Healthy Volunteer

Canada
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Safety and Tolerability of Varying Load and Dose of ISIS 301012 in People With Elevated LDL-cholesterol Levels

Hypercholesterolemia

Germany
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Effect of Mipomersen on Cardiac Repolarization Conducted in Healthy Subjects

Healthy

United States
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Dose-escalating Safety Study in Subjects on Stable Statin Therapy

Hypercholesterolemia

Netherlands, United States
Chen Wei Ren, MD

Unknown

Effects of Glucagon Like Peptide-1 on No-reflow

Acute ST-segment Elevation Myocardial Infarction

China
Chen Wei Ren, MD

Unknown

Efficacy Study of Glucagonlike Peptide-1 to Treat Reperfusion Injury

Acute Myocardial Infarction

China
Community Medical Foundation for Patient Safety
Red Oak Instruments, LLC

Completed

Acupuncture Outcomes Based Rehabilitation

Pain
The Emmes Company, LLC
Boston Children's Hospital; Ionis Pharmaceuticals, Inc.

Completed

Angelman Syndrome Video Assessment (ASVA) Source Material Study (ASVA SMS)

Angelman Syndrome

United States
Smith, Timothy R., M.D.
Ionis Pharmaceuticals, Inc.; Clinvest Research, LLC

Completed

Efficacy and Safety of IONIS-PKKRx for Preventive Treatment of Chronic Migraine

Chronic Migraine

United States
Spaulding Rehabilitation Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Not yet recruiting

Deploying Digital Prosthetic Interface Technology and Exercise in Dysvascular Amputees

Amputation | Diabete Type 2

United States
EDP Biotech
Paragon Rx Clinical, Inc.; iCura Diagnostics, LLC

Completed

COVID-19 iCura SARS-CoV-2 Ag OTC: Clinical Evaluation

COVID-19 | SARS-CoV-2 Infection

United States
Lantibio
River Plate Biotechnology, Inc.; Rx Development Resources, LLC

Completed

Safety and Efficacy Assessment of Vismed® (Sodium Hyaluronate) for the Treatment of Dry Eye Syndrome

Dry Eye Disease

United States
Carlos III Health Institute
Merck Sharp & Dohme LLC; Red Temática de Investigación Cooperativa en Sida

Unknown

Pregnancy in Women With HIV Infection

HIV Infections | Pregnancy Related
Brigham and Women's Hospital
Chinese PLA General Hospital; Guangdong Provincial People's Hospital; Guangzhou...

Completed

Imputation of PaO2 From SaO2

Acute Respiratory Failure

United States, China
Guoqiang Yu
National Cancer Institute (NCI); Bioptics Technology LLC; Kentucky Small Business...

Recruiting

Loupe-Based Intraoperative Fluorescence Imaging

Glioblastoma Multiforme | Anaplastic Astrocytoma

United States
South East Asia Research Collaboration with Hawaii
Merck Sharp & Dohme LLC; Pfizer; Gilead Sciences; Thai Red Cross AIDS Research... and other collaborators

Recruiting

Antiretroviral Therapy for Acute and Chronic HIV Infection (AAHIV)

Acute HIV Infection | Chronic HIV Infection

Thailand
Shanghai Jiao Tong University School of Medicine
The First Affiliated Hospital of Nanchang University; The Affiliated Hospital... and other collaborators

Recruiting

Clinical Characteristics, Lifestyle and Multi-omics Analysis in Autoimmune Gastritis

Autoimmune Gastritis

China
Wei-Hai Xu
Peking Union Medical College Hospital; Qilu Hospital of Shandong University; Second... and other collaborators

Completed

Stroke Imaging Package Study (SIPS)

Cerebral Small Vessel Diseases | Intracranial Arteriosclerosis | Acute Ischemic Stroke

China
Shanghai Chest Hospital
Shandong University of Traditional Chinese Medicine; Department of Cardiology... and other collaborators

Not yet recruiting

CARTO-Finder Guided Ablation Versus Multiscale Entropy Guided Ablation in Persistent Atrial Fibrillation

Persistent Atrial Fibrillation

China
Yi Yang
Wuzhou Red Cross Hospital; General Hospital of Shenyang Military Region; Chinese... and other collaborators

Recruiting

Stroke Registration of Young Adults in China (REACH)

Ischemic Stroke

China
Tongji Hospital
Shanghai Zhongshan Hospital; Peking University Third Hospital; Huashan Hospital; First Affiliated Hospital Xi'an Jiaotong University and other collaborators

Completed

Quality Control and Evaluation in Standard COPD Management

COPD

China
Peking Union Medical College Hospital
The First Affiliated Hospital with Nanjing Medical University; Peking University... and other collaborators

Recruiting

The Follow-up of Mesh/Native Tissue Complications Study(Part II)

Pelvic Organ Prolapse

China
Peking Union Medical College Hospital
The First Affiliated Hospital with Nanjing Medical University; Peking University... and other collaborators

Recruiting

The Follow-up of Mesh/Native Tissue Complications Study(Part I)

Pelvic Floor

China

Clinical Trials Sponsored by Rex Bionics Plc

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Venezuela

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Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

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