Stroke Registration of Young Adults in China (REACH)

This is a multi-center, prospective,continuous registry study. The investigators will include 3000 young adult (18-45 years old) patients with confirmed first-ever acute ischemic stroke in China. The main purpose of this study is to build the study cohort of young ischemic stroke patients in China, and to compare the prognosis and stroke recurrence of young patients with different ischemic stroke subtypes. Secondary objectives are trying to find biomarkers of stroke recurrence.

Study Overview

• Status: Recruiting
• Conditions: Ischemic Stroke
• Intervention / Treatment: Other: Treatment following current guidelines

Detailed Description

Approximately 10%-14% of all ischemic strokes occur in young adults ages 18 to 45 years old. Stroke etiology in this population differs by geographic region and has greater heterogeneity than in older individuals. Ascertain the definite etiologic classification in this young patients might be the key point to prevent the stroke recurrence and reduce the stroke burden. Advances in stroke diagnostic tests, particularly neuroimaging, refinement in classification schema. In this multi-center registry study conducted in China, we determine to explore the difference of prognosis and stroke recurrence of young patients with different ischemic stroke subtypes.

• Study Type: Observational
• Enrollment (Estimated): 3000

Contacts and Locations

• Study Contact: Name: Yi Yang, MD,PhD; Phone Number: +86-18186870008; Email: doctor_yangyi@hotmail.com
• Study Contact Backup: Name: Zhenni Guo, MD; Phone Number: +86-18186872986; Email: zhen1ni2@163.com

Study Locations

• China
  • Jilin
    • Changchun, Jilin, China, 130000
      • Recruiting
      • First Hospital of Jilin University
      • Contact: Yi Yang, MD, PhD; Phone Number: +86-18186870008; Email: doctoryangyi@163.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Young adult patients who had their first-ever ischemic stroke symptoms within 72 hours and visited one of the 22 participating medical centers in People's Republic of China.

Description

Inclusion Criteria:

• Age 18 through 45 years, both genders
• First-ever acute ischemic stroke
• Onset of symptoms within 72 hours of inclusion
• Willing to participate in follow-up visits

Exclusion Criteria:

• Silent stroke
• Failure to give their informed consent

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Young adult stroke patients; Young adult (18-45 years old) patients with confirmed first-ever acute ischemic stroke	Other: Treatment following current guidelines; Treatment following current guidelines

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Stroke recurrence	Percentage of patients with the 1 year new vascular events, defined as any event of the following: Any stroke (ischemic or hemorrhage)	1 year
Post-stroke disability	Modified Rankin Scale score changes (continuous) and dichotomized at percentage with score 0-2 vs. 3-6 at 3-month follow-up.	3 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cardiovascular death	Percentage of patients with the 3-month, 6-month and 1 year cardiovascular death caused by any event of the following: Any stroke (ischemic or hemorrhage), sudden cardiac death, acute myocardial infarction, heart failure, and other cardiovascular death including pulmonary embolism, rupture of aortic aneurysm, cardiovascular interventional therapy, and peripheral arterial disease.	3 months, 6 months and 1 year
Other cardiovascular event	Percentage of patients with the 3-month, 6-month and 1 year other cardiovascular event including non-lethal myocardial infarction, and non fatal heart failure.	3 months, 6 months and 1 year
Other systemic embolism	Percentage of patients with the 3-month, 6-month and 1 year other systemic embolism except for cerebral artery, coronary artery, and pulmonary artery. Such as mesenteric arterial embolism,splenic artery embolization.	3 months, 6 months and 1 year

Collaborators and Investigators

• Sponsor: Yi Yang
• Collaborators: Wuzhou Red Cross Hospital; General Hospital of Shenyang Military Region; Chinese PLA General Hospital; The First Affiliated Hospital of Soochow University; General Hospital of Ningxia Medical University; Shaoxing People's Hospital; Cangzhou Central Hospital; Inner Mongolia People's Hospital; The Affiliated Hospital of Yanbian University; Dezhou People's Hospital; Jiujiang No.1 People's Hospital; Binzhou Medical University; Siping Central People's Hospital; First Affilated Hospital of Jiamusi University; Xuchang Central Hospital; The First Affilated Hospital of the Medical College, Shihezi University; Daqing Oilfieled General Hospital; Heilongjiang Provicial Hospital; Luoyang Central Hospital Affilated to Zhengzhou University; Affilated Hospital of Inner Mongolia University for the Nationalities; Fudan University Pudong Medical Center

Study record dates

Study Major Dates

• Study Start (Actual): November 26, 2017
• Primary Completion (Estimated): December 31, 2024
• Study Completion (Estimated): July 31, 2025

Study Registration Dates

• First Submitted: January 15, 2017
• First Submitted That Met QC Criteria: January 17, 2017
• First Posted (Estimated): January 18, 2017

Study Record Updates

• Last Update Posted (Estimated): March 1, 2024
• Last Update Submitted That Met QC Criteria: February 29, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Keywords: youth; etiology; prognosis; recurrence; biomarkers
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Stroke; Ischemic Stroke
• Other Study ID Numbers: REACH

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO