Search clinical trials for: BLU 667

Total 108133 results

ChemomAb Ltd.

Completed

The Study of Multiple Doses of CM-101 in Male and Female NAFLD (Nonalcoholic Fatty Liver Disease) and NAFLD/NASH (Nonalcoholic Steatohepatitis) Subjects

Nonalcoholic Fatty Liver Disease

Israel
UCB Pharma

Completed

Transdermal Rotigotine User Surveillance Study (TRUST)

Idiopathic Parkinson Disease

Czechia, Denmark, Germany, Greece, Italy, Mexico, Romania, Slovakia, Spain, Switzerland
Hoffmann-La Roche

Completed

Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors (ARROW)

Neoplasms | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Neoplasms, Glandular and Epithelial | Endocrine System Diseases | Gastrointestinal Neoplasms | Neoplasms, Germ Cell and Embryonal | Head and Neck Neoplasms | Carcinoma, Non-Small-Cell Lung | Respiratory Tract... and other conditions

France, Spain, United States, Korea, Republic of, United Kingdom, Taiwan, China, Belgium, Singapore, Netherlands, Germany, Italy, Hong Kong
Imperial College London
University of Southern California; Guy's and St Thomas' NHS Foundation Trust; Ipse... and other collaborators

Terminated

A Study to Assess the Ability of a Novel Endocrine Treatment for Breast Cancer, Irosustat, to Slow Down Cancer Growth (IPET)

Breast Neoplasms

United Kingdom
Imperial College London
Cancer Research UK

Completed

A Study of the Safety and Effectiveness of Irosustat When Added to an AI in ER+ve Locally Advanced or Metastatic Breast Cancer. (IRIS)

Metastatic Breast Cancer | Locally Advanced Breast Cancer

United Kingdom
Merck Sharp & Dohme LLC

Active, not recruiting

Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)

Hodgkin Lymphoma

United States, Brazil, Colombia, Czechia, France, Germany, Greece, Guatemala, Italy, Korea, Republic of, Mexico, Netherlands, Slovakia, South Africa, Spain, United Kingdom
Blueprint Medicines Corporation

Approved for marketing

Pre-Approval Access Program (PAAP) for Pralsetinib (BLU-667) in Patients With Unresectable or Metastatic NSCLC or MTC

Non-Small Cell Lung Cancer | Medullary Thyroid Cancer
Lightpoint Medical Limited
King's College London; Guy's and St Thomas' NHS Foundation Trust

Unknown

The Breast Surgery EnLight and LightPath Imaging System Study

Breast Neoplasms

United Kingdom
Aretaieion University Hospital

Completed

Preoperative Infusion of Levosimendan in Patients Undergoing Cardiac Surgery

Cardiac Surgery | Cardiac Disease | Cardiac Failure | Inotropes | Ejection Fraction

Greece
Fresenius Medical Care North America

Completed

Bioequivalence Study Comparing Calcium Acetate Oral Solution Versus Calcium Acetate Gelcaps in Healthy Volunteers

Hyperphosphatemia

United States
Chulalongkorn University

Completed

Effect of Banana Blossom on Breast Milk Volume in Mothers of Preterm Newborns

Preterm Birth | Postpartum Women

Thailand
Aga Khan University
Emory University; Centers for Disease Control and Prevention

Completed

Group B Streptococcus Colonization in Mother-newborn Dyads and Association With Serotype-specific Capsular Antibodies in Karachi, Pakistan. (GBS)

Group B Streptococcus (GBS) Colonization

Pakistan
AbbVie

Completed

Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Adults With Moderate to Severe Endometriosis-Associated Pain

Endometriosis
Oslo University Hospital
Universitaire Ziekenhuizen KU Leuven; Rigshospitalet, Denmark; Tampere University... and other collaborators

Terminated

Does Pulse-triggered VNS Autostimulation Increase VNS Efficacy (ERAS)

Epilepsy

Norway
Northwell Health

Completed

Comparing Voiding Trials After Midurethral Sling for Stress Incontinence

Stress Urinary Incontinence | Cystocele | Urethral Hypermobility

United States
AstraZeneca

Completed

Safety and Efficacy Study Comparing ABT-143 to Simvastatin in Subjects With Elevated Levels of Low Density Lipoprotein Cholesterol ("Bad Cholesterol") and Triglycerides

Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia

United States
Istanbul Saglik Bilimleri University

Completed

Evaluation of the Role of Neurodegeneration in Schizophrenia

Schizophrenia

Turkey
Thomas Jefferson University
Patient-Centered Outcomes Research Institute

Completed

Concept Mapping as a Scalable Method for Identifying Patient-Important Outcomes (VOICe)

Concept Mapping Versus Interviews

United States
The Cleveland Clinic

Completed

Standard Medication Reconciliation Protocol in the Primary Care Office-based Setting

Medication Reconciliation Between Patients' Self Report and Electronic Medical Record List

United States
Takeda

Completed

A Study of Icatibant (TAK-667) in Japanese Children and Teenagers With Acute Attacks of Hereditary Angioedema

Hereditary Angioedema

Japan
Blueprint Medicines Corporation
Analysis Group, Inc.

Enrolling by invitation

External Control, Observational, Retrospective Study Comparing Pralsetinib to Best Available Therapy in Patients With RET-Fusion Positive NSCLC

Neoplasms | Respiratory Tract Diseases | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Carcinoma | Neoplasms, Germ Cell and Embryonal | Head and Neck Neoplasms | Carcinoma, Non-Small-Cell Lung | Bronchial Diseases | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Neoplasms... and other conditions

United States, France, Switzerland
National Taipei University of Nursing and Health...
Cheng-Hsin General Hospital

Completed

The Efficacy of Decision Support E-book for Prostate Biopsy Decision Making

Prostate-Specific Antigen

Taiwan
Peking Union Medical College

Completed

A Study of Prevention and Treatment of Postmenopausal Osteoporosis in Chinese Women

Osteoporosis
Takeda

Recruiting

A Survey of Icatibant in Pediatric Participants With Hereditary Angioedema

Hereditary Angioedema (HAE)

Japan
Seoul National University Bundang Hospital
Seoul St. Mary's Hospital; Asan Medical Center; Seoul National University Hospital and other collaborators

Recruiting

Optimal Duration of Dual Antiplatelet Therapy After Stent-assisted Coiling

Endovascular Procedures | Aneurysm Cerebral

Korea, Republic of
Academisch Medisch Centrum - Universiteit van Amsterdam...
Radboud University Medical Center; Universitaire Ziekenhuizen KU Leuven; University... and other collaborators

Recruiting

Prevention of Post-TIPS Hepatic Encephalopathy by Administration of Rifaximin and Lactulose (PEARL)

Liver Diseases | Hepatic Encephalopathy | Portal Hypertension | Cirrhosis, Liver | Pathological Processes

Netherlands, Belgium
HAL Allergy

Completed

PURETHAL® Mites Dose Range Finding Study in Patients With Persistent Allergic Rhinitis/Rhinoconjunctivitis

Allergic Rhinitis | Allergic Rhinoconjunctivitis

Belgium, Germany, Austria, Netherlands, Spain
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

Detection of Pathogen and Antibiotic Resistance Genes by Targeted Next-Generation Sequencing in ICU Patients.

Infections | Critical Illness | Diagnosis
Sebahattin Celik MD

Recruiting

Artificial Intelligence and Cancer Staging in Upper Gastrointestinal Malignancies

Gastrointestinal Cancer

Turkey
Medipol University

Completed

The Effect of Robot-assisted Walking Training on Hemiplegic Individuals

Hemiplegia | Gait, Hemiplegic | Motor Function | Balance; Distorted

Turkey
Takeda

Recruiting

A Study in Adults With Hereditary Angioedema (HAE) Who Currently Receive Icatibant at Home

Hereditary Angioedema (HAE)

United Kingdom
Connecticut Children's Medical Center
UConn Health

Completed

Genetic Influences of Albuterol Response In Children With Bronchiolitis

Bronchiolitis

United States
Hoffmann-La Roche

Active, not recruiting

A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) (AcceleRET-Lung)

Neoplasms | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Neoplasms, Germ Cell and Embryonal | Head and Neck Neoplasms | Carcinoma, Non-Small-Cell Lung | Bronchial Diseases | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Neoplasms, Nerve... and other conditions

Italy, Korea, Republic of, Australia, Spain, Argentina, Belgium, Brazil, France, Portugal, United Kingdom, United States, Japan, Mexico, Poland, Norway, Costa Rica, Switzerland, Netherlands, Germany, Sweden, Turkey, Ireland, Panama
Novartis Vaccines

Completed

Safety and Immunogenicity of Trivalent Subunit Inactivated Flu Vaccine Administered to Healthy Children and Adolescents 3 to 17 Years of Age

Seasonal Influenza

Colombia, Mexico, Panama, Philippines
UCB Biopharma SRL

Completed

A Study With a Initial Treatment Period Followed by a Randomized-withdrawal Period to Evaluate the Efficacy and Safety of Bimekizumab in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis (BE READY)

Psoriatic Arthritis | Moderate to Severe Chronic Plaque Psoriasis | Chronic Plaque Psoriasis

United States, Australia, Canada, Germany, Hungary, Korea, Republic of, Poland, Russian Federation, United Kingdom
Celgene

Completed

Efficacy and Safety Study of Lenalidomide Plus R-CHOP Chemotherapy Versus Placebo Plus R-CHOP Chemotherapy in Untreated ABC Type Diffuse Large B-cell Lymphoma (ROBUST)

Lymphoma, Large B-Cell, Diffuse

United States, Australia, Belgium, Canada, China, Czechia, France, Ireland, Israel, Italy, Japan, Korea, Republic of, Netherlands, New Zealand, Portugal, Puerto Rico, Russian Federation, Spain, Switzerland, Taiwan, Turkey
Novartis Vaccines

Completed

Safety, Tolerability, and Immunogenicity of the Adjuvanted Trivalent Subunit Influenza Vaccine and the Non-Adjuvanted Trivalent Subunit Influenza Vaccine Compared to the Non-Adjuvanted Trivalent Split Influenza Vaccine in Children 6 to < 72 Months of Age

Influenza Disease

Argentina, Australia, Chile, Philippines, South Africa
UCB Biopharma SRL

Terminated

Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy

Drug-Resistant Epilepsy | Focal-Onset Seizures

United States, Australia, Belgium, Bosnia and Herzegovina, Bulgaria, Canada, Croatia, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Japan, Lithuania, Mexico, Poland, Romania, Serbia, Slovakia, Spain, Turk... and more
UCB Biopharma S.P.R.L.

Completed

Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy (ARISE)

Focal-Onset Seizures | Drug-resistant Epilepsy

United States, Australia, Belgium, Bulgaria, Canada, Czechia, France, Germany, Hungary, Italy, Japan, Lithuania, Mexico, Poland, Portugal, Slovakia, Spain, Turkey, United Kingdom
Novartis Vaccines

Completed

Safety and Immunogenicity of MF59C.1 Adjuvanted Trivalent Subunit Influenza Vaccine in Elderly Subjects

Influenza

United States, Colombia, Panama, Philippines
UCB Biopharma SRL

Completed

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis (BE BRIGHT)

Moderate to Severe Chronic Plaque Psoriasis | Chronic Plaque Psoriasis

United States, Australia, Belgium, Canada, Germany, Hungary, Italy, Japan, Korea, Republic of, Poland, Russian Federation, Taiwan, United Kingdom
Celgene

Recruiting

A Placebo-Controlled Study of Oral Ozanimod as Maintenance Therapy for Moderately to Severely Active Crohn's Disease

Crohn Disease

United States, Argentina, Australia, Belgium, Bosnia and Herzegovina, Bulgaria, Canada, Croatia, Czechia, Denmark, Finland, France, Germany, Ireland, Israel, Italy, Korea, Republic of, Latvia, Mexico, Moldova, Republic of, Poland, Romani... and more
Celgene

Recruiting

An Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease

Crohn Disease

United States, Argentina, Australia, Belgium, Bosnia and Herzegovina, Bulgaria, Canada, Chile, Croatia, Czechia, Denmark, Finland, France, Germany, Ireland, Israel, Italy, Korea, Republic of, Latvia, Mexico, Moldova, Republic of, ... and more
Boehringer Ingelheim

Completed

Telmisartan 80mg+Hydrochlorothiazide (HCTZ) 25 mg in Hypertension: an Observational Study

Hypertension

France
Boehringer Ingelheim

Completed

TELMA - Observational Study in Daily Medical Practice of the Effectiveness of Telmisartan for Treatment of Hypertension in Patients With and Without Confirmed Albuminuria in Belgium

Hypertension

Belgium
Boehringer Ingelheim

Completed

Post-Marketing Surveillance of Prazaxa® on the Long-term Use in Patients With Nonvalvular Atrial Fibrillation

Atrial Fibrillation

Japan
Boehringer Ingelheim

Completed

Dabigatran Etexilate for Stroke Prevention in Patients With Atrial Fibrillation and Mild to Moderate Renal Impairment

Atrial Fibrillation

Germany
Celgene

Terminated

A Study to Evaluate the Efficacy and Safety of CC-90001 in Subjects With Idiopathic Pulmonary Fibrosis

Pathologic Processes | Fibrosis | Respiratory Tract Diseases | Lung Diseases | Idiopathic Pulmonary Fibrosis | Lung Diseases, Interstitial | Idiopathic Interstitial Pneumonias

United States, Australia, Colombia, United Kingdom, Russian Federation, Brazil, Germany, Canada, Greece, Romania, Taiwan, Turkey, Ukraine
Kerecis Ltd.

Not yet recruiting

Kerecis Real World Registry

Surgical Wound | Diabetic Foot Ulcer | Venous Leg Ulcer | Pressure Ulcer | Wounds | Soft Tissue Reinforcement
China-Japan Friendship Hospital

Recruiting

Cardiovascular-Renal Adverse Prognosis Assessment System for Coronary Heart Disease With Chronic Kidney Disease Based on Metabolomics (CRUISE-MET)

Chronic Kidney Diseases | Lipid Metabolism Disorders | Coronary Heart Disease

China

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