Search clinical trials for: High cholesterol, Treatment for high cholesterol, Lowering cholesterol, Lowering high cholesterol, H

Total 492424 results

Amgen

Active, not recruiting

Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke (VESALIUS-CV)

Coronary Heart Disease (CHD)

Canada, France, United States, Spain, United Kingdom, Korea, Republic of, Netherlands, Austria, Australia, Czechia, Taiwan, Finland, Hungary, Italy, Poland, Greece, Germany, Brazil, Latvia, Denmark, Mexico, Russian Federation, Bulgaria and more
Amgen

Completed

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER)

Dyslipidemia

United States, Austria, Belgium, Canada, Denmark, Finland, France, Germany, Italy, Netherlands, Spain, Sweden, United Kingdom, Czechia, Hungary, Taiwan, Colombia, Poland, Russian Federation, Switzerland, Korea, Republic of, Mexico, ... and more
GWT-TUD GmbH

Active, not recruiting

Prospective German Very High Cardiovascular Risk Patients Dyslipidemia Treatment Indication Registry (PERI-DYS)

Dyslipoproteinemias

Germany
Amgen

Completed

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk Open-label Extension (FOURIER OLE)

Dyslipidemia

United States, Poland, Czechia, Hungary, Russian Federation, Ukraine, Slovakia
Amgen

Completed

Monoclonal Antibody Against PCSK9 to Reduce Elevated LDL-C in Subjects Currently Not Receiving Drug Therapy for Easing Lipid Levels-2 (MENDEL-2)

Hyperlipidemia

United States, Denmark, Taiwan, Korea, Republic of, Australia, Belgium, Canada, South Africa, France, Turkey
Amgen

Completed

LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2 (LAPLACE-2)

Hyperlipidemia

United States, Denmark, France, Italy, Czechia, Taiwan, Switzerland, Korea, Republic of, Germany, Hong Kong, Netherlands, Australia, Belgium, Canada, Hungary, South Africa, Russian Federation, Spain, United Kingdom, Sweden, Mexico
Amgen

Completed

Monoclonal Antibody Against PCSK9 to Reduce Elevated Low-density Lipoprotein Cholesterol (LDL-C) in Adults Currently Not Receiving Drug Therapy for Easing Lipid Levels (MENDEL)

Hyperlipidemia

United States, Denmark, Australia, Belgium, Canada
Beijing Anzhen Hospital

Unknown

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With High Risk Coronary Artery Disease (FORWARD) (FORWARD)

Dyslipidemia | High Risk Coronary Artery Disease

China
Amgen

Completed

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-4 (GAUSS-4)

Hypercholesterolemia

Japan
Amgen

Completed

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects -2 (GAUSS-2)

Hyperlipidemia

United States, Denmark, Belgium, Germany, Hong Kong, Netherlands, France, Australia, Canada, South Africa, United Kingdom, Spain, Poland, Switzerland
Amgen

Completed

Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study-2 (RUTHERFORD-2)

Hyperlipidemia

Canada, France, Netherlands, United Kingdom, New Zealand, South Africa, Spain, United States, Australia, Germany, Sweden, Hong Kong, Switzerland, Norway
Amgen

Completed

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-3 (GAUSS-3)

Hyperlipidemia

Canada, Denmark, France, United States, Czechia, New Zealand, Australia, South Africa, Italy, United Kingdom, Netherlands, Germany, Norway
Amgen

Completed

Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects (EBBINGHAUS)

Dyslipidemia

United States, Belgium, Denmark, Finland, France, Italy, Spain, Hungary, Poland, Germany, Czechia, Turkey, United Kingdom, Malaysia, Australia, Hong Kong, New Zealand, Canada, South Africa, Greece, Portugal, Netherlands, Russian Federation and more
Acasti Pharma Inc.
JSS Medical Research Inc.

Completed

Assess the Safety and Efficacy of NKPL66 (CaPre™) in the Treatment of Mild-to-high Hypertriglyceridemia

Hypertriglyceridemia

Canada
Odense University Hospital

Completed

Influence of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment

Myocardial Infarction [C14.907.585.500]

Denmark
McGill University Health Centre/Research Institute...

Completed

High-Density Lipoprotein (HDL) Treatment Study

Genetic Diseases, Inborn | Coronary Arteriosclerosis | Hypoalphalipoproteinemias

Canada
Novartis Pharmaceuticals

Not yet recruiting

VictORION-INCLUSION is a Multicenter, Randomized, Open Label, Study of Inclisiran + Usual Care vs Usual Care Alone in an Inclusive and Underrepresented Population at High Risk for or Diagnosed With ASCVD Within a Pragmatic EHR Framework. (V-INCLUSION)

Atherosclerotic Cardiovascular Disease
Yonsei University

Not yet recruiting

Randomized Comparison of Efficacy and Safety of High-intensity Rosuvastatin/Ezetimibe Combination Versus Treat-to-target Rosuvastatin Monotherapy for Patients With Peripheral Artery or Polyvascular Disease (CARE-PVD Trial)

Peripheral Artery Disease | Polyvascular Disease

Korea, Republic of
University of Roehampton

Recruiting

Efficacy of Cholesterol-lowering L. Plantarum on Cardiometabolic Health Biomarkers in Coeliac Disease Patients (ProCoChoL)

Celiac Disease

Italy, United Kingdom
Amway (China) R&D Center

Recruiting

The Efficacy of Amway Uric Acid Lowering Product on Hyperuricemia

Hyperuricemia

China
Sun Yat-sen University

Recruiting

Effect of IOP Lowering on Progressive HM

High Myopia | Glaucoma, Suspect

China
Novartis Pharmaceuticals

Recruiting

Study Evaluating Effectiveness and Adherence of Inclisiran Plus Standard of Care (SoC) Lipid-lowering Therapy Compared to SoC in ASCVD (VICTORION REAL)

Mixed Dyslipidemia | Primary Hypercholesterolemia

Switzerland, Saudi Arabia, United Arab Emirates, United Kingdom, Austria, Israel, China, Malaysia
University of Colorado, Boulder

Recruiting

Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise

Hypertension | Blood Pressure | Aging | Endothelial Dysfunction

United States
Organisation for Rural Community Development, Bangladesh
Swinburne University of Technology

Recruiting

Lowering Blood Pressure by Changing Lifestyle (LBP)

High Blood Pressure

Bangladesh
Sun Yat-sen University

Recruiting

Effect of Lowering IOP in Glaucoma Suspects With HM (GSHM)

High Myopia | Glaucoma, Suspect

China
The University of Queensland
National Health and Medical Research Council, Australia; Cambridge University... and other collaborators

Recruiting

Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE) (PHOSPHATE)

Kidney Failure, Chronic | Hyperphosphatemia

Canada, United Kingdom, Australia, Brazil, New Zealand
Organon and Co

Completed

A Study to Assess the Cholesterol Lowering Effect of an Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Patients With High Cholesterol and With High Cardiovascular Risk (0653A-809)(COMPLETED)

Hypercholesterolemia
Organon and Co
Merck Shering-Plough JV Study

Completed

A Study to Assess the Cholesterol Lowering Effect of Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Elderly Patients With High Cholesterol at High or Moderately High Risk for Coronary Heart Disease (0653A-128)

Hypercholesterolemia
Novartis Pharmaceuticals

Active, not recruiting

Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD (Lp(a)HORIZON)

Cardiovascular Disease and Lipoprotein(a)

United States, China, Germany, South Africa, Italy, Spain, Belgium, Czechia, Hungary, Japan, Taiwan, Netherlands, Australia, Austria, Canada, France, Israel, Switzerland, United Kingdom, Korea, Republic of, Argentina, Denmark, Greece, Romani... and more
University of Oxford
University of Edinburgh; National Institute for Health Research, United Kingdom and other collaborators

Completed

Lowering Events in Non-proliferative Retinopathy in Scotland (LENS)

Diabetic Retinopathy

United Kingdom
Unity Health Toronto
University of Manitoba; University of British Columbia; Canadian Institutes of... and other collaborators

Completed

The Combined Portfolio Diet and Exercise Study (PortfolioEx)

Cardiovascular Diseases | Metabolic Syndrome | Type 2 Diabetes | Hypercholesterolemia

Canada
Amgen

Terminated

Safety and Efficacy of Evolocumab in Addition to Optimal Stable Background Statin Therapy in Chinese Participants With Primary Hypercholesterolemia and Mixed Dyslipidemia

Mixed Dyslipidemia | Primary Hypercholesterolemia

China
Matthew Feinstein

Completed

High Intensity Lipid Lowering Following Acute Coronary Syndromes for Persons Living With HIV (HILLCLIMBER)

HIV Infection | Coronary Heart Disease

United States
Ukrainian Medical Stomatological Academy

Completed

Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease (EFFORT)

Adverse Effect | Atherosclerosis, Coronary | Insulin Resistance Syndrome

Ukraine
Organon and Co

Completed

Effectiveness of Two Approved Drugs in Lowering High Cholesterol (0733-224)

Hypercholesterolemia
The George Institute
National Health and Medical Research Council, Australia; Takeda; Conselho Nacional... and other collaborators

Completed

Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) (ENCHANTED)

Ischemic Stroke | High Blood Pressure

Australia
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge

Active, not recruiting

Investigating the Lowest Threshold of Vascular Benefits From LDL Cholesterol Lowering in Patients With Stable CV Disease (INTENSITY-HIGH)

Cardiovascular Diseases | Atherosclerosis

United Kingdom
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Study Of The Efficacy Of Atorvastatin For Lowering Cholesterol In High-Risk Patients With High Cholesterol

Dyslipidemias

Belgium
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Study Of The Efficacy Of Atorvastatin In Lowering Cholesterol In Latin American Patients With High Cholesterol (LA ATGOAL)

Dyslipidemias

Brazil, Colombia, Panama, Mexico, Guatemala, Chile, Ecuador, Venezuela
Acasti Pharma Inc.

Completed

A Phase 3 STudy of CaPRe in LOwering Very hiGh TriglYcerides (TRILOGY 2) (TRILOGY 2)

Hypertriglyceridemia

United States, Mexico, Canada
Acasti Pharma Inc.

Completed

A Phase 3 STudy of CaPRe In LOwering Very hiGh TriglYcerides (TRILOGY 1) (TRILOGY 1)

Hypertriglyceridemia

United States
AstraZeneca

Completed

Epanova® for Lowering Very High Triglycerides II (EVOLVE II) (EVOLVEII)

Hypertriglyceridemia

Denmark, United States, Hungary, Netherlands, Russian Federation, Czechia, Canada
Yonsei University

Unknown

RAndomized Comparison of Efficacy and Safety of Lipid-lowerING With Statin Monotherapy Versus Statin/Ezetimibe Combination for High-risk Cardiovascular Diseases (RACING Trial)

Cardiovascular Diseases | Cerebrovascular Disease | Peripheral Atherosclerotic Disease

Korea, Republic of
Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy and Safety of Alirocumab Versus Placebo on Top of Maximally Tolerated Lipid Lowering Therapy in Patients With Hypercholesterolemia Who Have Type 1 or Type 2 Diabetes and Are Treated With Insulin (ODYSSEY DM - Insulin)

Hypercholesterolaemia

Belgium, Spain, Germany, Austria, Italy, United States, France, Netherlands, Switzerland, United Kingdom
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Carotid Plaque Characteristics by MRI in AIM-HIGH (Carotid MRI Substudy)

Coronary Artery Disease | Atherosclerosis | Carotid Artery Diseases

United States, Canada
Seoul National University Bundang Hospital

Completed

Blood Pressure Lowering Effects of Amosartan Regarding Proviso iN Patients With High Blood Pressure

Hypertension
Unity Health Toronto
University of Manitoba; University of British Columbia; Canadian Institutes of... and other collaborators

Withdrawn

Magnetic Resonance Imaging-Portfolio Diet Study #7 (MRIPD#7)

Cardiovascular Diseases | Obesity | Diabetes | Metabolic Syndrome | Hypercholesterolemia

Canada
Unity Health Toronto
University of Manitoba; University of British Columbia; Canadian Institutes of... and other collaborators

Withdrawn

Enhanced Multicenter Dietary Portfolio Study (EDP8)

Cardiovascular Diseases | Type 2 Diabetes | Hypercholesterolemia

Canada
Novartis Pharmaceuticals

Completed

Blood Pressure Lowering of Aliskiren Hydrochlorothiazide (HCTZ) Versus Amlodipine in Stage 2 Hypertension in African Americans (ATLAAST)

Hypertension

United States
AstraZeneca

Completed

Epanova® for Lowering Very High Triglycerides (EVOLVE)

Severe Hypertriglyceridemia

United States, Hungary, India, Russian Federation, Denmark, Ukraine, Netherlands

Search clinical trials for: High cholesterol, Treatment for high cholesterol, Lowering cholesterol, Lowering high cholesterol, H

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Ireland

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations