Search clinical trials for: Human immune challenge

Total 77682 results

Centre for Human Drug Research, Netherlands

Recruiting

Deep Phenotyping of Cutaneous Lupus Erythematosus

Cutaneous Lupus Erythematosus

Netherlands
Ifakara Health Institute
University of Oxford

Not yet recruiting

In-vivo Transmission Model in Semi-immune Adults

Controlled Human Malaria Infection | Malaria Transmission | Induced Blood Stage Malaria Infection | Malaria Challenge

Tanzania
University of Oxford

Recruiting

KLH Challenge to Explore the Human Immune Response

Immune Response

United Kingdom
Wake Forest University Health Sciences
National Institute on Aging (NIA); Health Resources and Services Administration...

Recruiting

Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older

HIV | Aging

United States
USDA, Western Human Nutrition Research Center

Recruiting

Postprandial Monocyte Study (PPMS)

Inflammation | Nutrition | Immune System

United States
Dalhousie University
National Institute of Allergy and Infectious Diseases (NIAID); Vanderbilt University... and other collaborators

Recruiting

Establishing a Controlled Human Infection Model of Bordetella Pertussis

Pertussis

Canada
GlaxoSmithKline

Completed

Efficacy and Safety of GSK3923868 Inhalation Powder, During Experimental Human Rhinovirus Infection in Participants With Mild Asthma

Pulmonary Disease, Chronic Obstructive

United Kingdom
University of Oxford
Sanaria Inc.; KEMRI-Wellcome Trust Collaborative Research Program; Kenya Medical...

Active, not recruiting

Controlled Human Malaria Infection Transmission Model - Phase A (CHMI-TransMod)

Malaria,Falciparum

Kenya
National Cancer Institute (NCI)

Completed

Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia | Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

United States
Imperial College London

Completed

Development of Human Nasal Challenge Models With Microbial Constituents and Grass Pollen

Asthma | Latent Tuberculosis | Allergic Rhinitis

United Kingdom
National Institute of Allergy and Infectious Diseases...

Completed

Mucosal and Systemic Immunity After Viral Challenge of Healthy Volunteers Vaccinated With Inactivated Influenza Vaccine Via the Intranasal Versus Intramuscular Route

Influenza

United States
University of Southampton
University Hospital Southampton NHS Foundation Trust

Completed

Defining the Immune Response to Nasopharyngeal Colonisation by the Commensal Neisseria Lactamica (Lac-7)

Meningitis, Bacterial

United Kingdom
Centers for Disease Control and Prevention
University of Pennsylvania; Botswana Ministry of Health

Completed

Evaluating Accuracy, Impact, and Operational Challenges of GeneXpert Use for TB Case Finding Among HIV-infected Persons (XPRES)

Tuberculosis | Human Immunodeficiency Virus

Botswana
GlaxoSmithKline

Completed

Evaluation of Antibody Persistence and Immune Memory Against the Hepatitis B Antigen in Previously Vaccinated Children

Hepatitis B

Slovakia
GlaxoSmithKline

Completed

Evaluation of Antibody Persistence & Immune Memory in Subjects Vaccinated During Adolescence With Twinrix™

Hepatitis B | Hepatitis A

Belgium, Czechia
GlaxoSmithKline

Completed

Evaluation of Immune Memory to Twinrix or Comparator by Challenge Dose Administration 4 Years After Primary Vaccination

Hepatitis B | Hepatitis A

Belgium, Czechia
GlaxoSmithKline

Completed

Hepatitis B Antibody Persistence and Immune Response to Hepatitis B Vaccine Challenge in Previously Vaccinated Children

Hepatitis B

Germany
Uniformed Services University of the Health Sciences
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Immune Responses After Human Subject Challenge With Sand Fly Bites

Healthy

United States
GlaxoSmithKline

Completed

Immune Response to Hepatitis B Vaccine Challenge Dose in Subjects Who Received a Primary Neonatal Hepatitis B Vaccine.

Hepatitis B

Thailand
GlaxoSmithKline

Completed

Persistence of Hepatitis B Antibody Levels & Immune Response to a Hepatitis B Vaccine Challenge

Hepatitis B

Germany
Immune Targeting Systems Ltd

Completed

Safety, Tolerability, Efficacy and Immunogenicity of an Influenza A Vaccine (FP-01.1) in Healthy Volunteers Following Virus Challenge

Influenza A

United Kingdom
University of Oxford
Sanaria Inc.; KEMRI-Wellcome Trust Collaborative Research Program; University... and other collaborators

Unknown

Controlled Human Malaria Infection in Semi-Immune Kenyan Adults. (CHMI-SIKA) (CHMI-SIKA)

Malaria

Kenya
Sanaria Inc.
Barcelona Centre for International Health Research

Completed

Optimization of Controlled Human Malarial Infection by Injection of P. Falciparum Sporozoites in Non-Immune Adults

Malaria

Spain
Sanaria Inc.
Institute of Tropical Medicine, University of Tuebingen

Completed

Controlled Human Malarial Infection by Intravenous Injection of Plasmodium Falciparum Sporozoites in Non-Immune Adults

Malaria

Germany
NHS Greater Glasgow and Clyde
University of Glasgow

Unknown

Impact of Immune Challenge on Triple Network Connectivity in Humans

Major Depression
National Institute of Allergy and Infectious Diseases...
Asthma and Allergic Diseases Cooperative Research Centers

Terminated

Human Rhinovirus Infection and Airway Remodeling Mediators

Asthma

Canada
Hvivo

Completed

Discovering New Treatments for Asthma and COPD. A New Human Rhinvovirus for Human Challenge

Rhinovirus
Immune Targeting Systems Ltd

Completed

Safety and Reactogenicity of a H1N1 Influenza Challenge Virus in Healthy Volunteers

Influenza A

Belgium
University of North Carolina, Chapel Hill
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Study of Dust Mite Inhalation in Humans

Allergy | Mild Asthma

United States
Fraunhofer-Institute of Toxicology and Experimental...

Completed

Characterization of Aerosol Generation and Transport in the Human Lung

Asthma
St George's, University of London
University of British Columbia; Bill and Melinda Gates Foundation; Wellcome Trust and other collaborators

Completed

Human Innate Immune Responses To Mycobacterial Aerodigestive Tract Infection (UBC-INNATE01)

Bacterial Infections

United Kingdom
Oxagen Ltd

Completed

OC000459 Dose Finding Study in Hay Fever Sufferers.

Allergic Rhinitis

Austria
Belgian Research on AIDS and HIV Consortium

Not yet recruiting

Use of Long-Acting Injectable Cabotegravir/Rilpivirine for the Treatment of HIV in Belgium

Human Immunodeficiency Virus
Centre Hospitalier Universitaire de Nice

Not yet recruiting

Descriptive Analysis of Changes in Hepatitis B Markers in People Living With HIV on Injectable Therapy.

Hepatitis B | Hiv Infection

France
Istituto Clinico Humanitas
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Recruiting

Role of the Maternal Microbiota on the Immune Response and Metabolism During Hypertensive Disorders (MATER)

Preeclampsia

Italy
Assistance Publique - Hôpitaux de Paris
Institut Pasteur

Recruiting

Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations (SPLEENVIVO)

Splenectomy

France
Kite, A Gilead Company
Arcellx, Inc.

Not yet recruiting

A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma (iMMagine-3)

Multiple Myeloma
IRCCS Ospedale San Raffaele

Not yet recruiting

Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies

Rare Diseases | Corneal Neovascularization | Limbal Stem Cell Deficiency | Aniridia | Neurotrophic Keratopathy | Ocular Cicatricial Pemphigoid | Ocular Graft-versus-host Disease | EEC Syndrome
McMaster University

Not yet recruiting

Measurements of Inflammation Induced by Allergen Inhalation Challenge in Mild Allergic Asthma (MATT)

Mild Asthma

Canada
University College Dublin
St Vincent's University Hospital, Ireland; Mater Misericordiae University Hospital and other collaborators

Recruiting

The All Ireland Infectious Diseases Cohort Project (AIID)

Infectious Disease

Ireland
Massachusetts General Hospital
National Institute of Allergy and Infectious Diseases (NIAID)

Not yet recruiting

Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing (DACAT)

Drug Hypersensitivity | Drug-Induced Anaphylaxis | Antibiotic Allergy | Drug Allergy | Beta Lactam Adverse Reaction | Cephalosporin Allergy | Cephalosporin Reaction

United States
Johns Hopkins University
National Institutes of Health (NIH); Desmond Tutu HIV Foundation

Not yet recruiting

Universal Test and Connect for HIV Service Delivery in South Africa (UTC-SA)

Human Immunodeficiency Virus | Emergency Department | Pre-Exposure Prophylaxis | South Africa
Kyverna Therapeutics

Not yet recruiting

A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Systemic Sclerosis

Systemic Sclerosis | Systemic Sclerosis - Diffuse Cutaneous | Systemic Sclerosis - 2013 ACR/EULAR Classification Criteria
Celgene
Bristol-Myers Squibb

Recruiting

A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation (KarMMa-9)

Multiple Myeloma

Austria, United States, Spain, Australia, Japan, France, Israel, Italy, Canada, Greece, Belgium, Norway, Romania, Czechia, Denmark, Germany, Korea, Republic of, United Kingdom, Poland
Chinese PLA General Hospital

Not yet recruiting

Chidamide+Decitabine Plus Anti-PD-1 Antibody in PD-1 Inhibitor Failed Patients With Classical Hodgkin Lymphoma.

PD-1 Inhibitor Failed Patients With Classical Hodgkin Lymphoma
Humanitas Clinical and Research Center
European Society of Intensive Care Medicine

Not yet recruiting

Fluid Challenge in Intensive Care The FENICE II Study (FENICE II)

Critical Illness | Septic Shock

Italy
University of Kansas Medical Center

Not yet recruiting

Dry Needling in Multiple Sclerosis

Multiple Sclerosis | Spasticity

United States
Natural Resources Institute Finland
Tampere University

Recruiting

Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis (BIWE)

Microbial Colonization | Atopic Dermatitis | Immune System and Related Disorders | Nature, Human

Finland
Natural Resources Institute Finland
Tampere University

Recruiting

Nationwide Research on the Rewilding of Kindergarten Yards (Vahvistu)

Allergy | Cognitive Change | Microbial Colonization | Asthma in Children | Atopic Dermatitis | Respiratory Infection | Nature, Human

Finland
GlaxoSmithKline

Recruiting

A Study to Find and Confirm the Dose and Assess Safety, Reactogenicity and Immune Response of a Vaccine Against Pandemic H5N1 Influenza Virus in Healthy Younger and Older Adults

Influenza, Human

United States

Search clinical trials for: Human immune challenge

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