Search clinical trials for: IL-6 blockade

Total 28259 results

Istituto Ortopedico Galeazzi

Completed

Evaluation of IL-6 in Synovial Fluid in Obese and Normal Weight Patients Suffering From Gonarthrosis During PTA (IL6PG)

IL-6 Concentration in the Synovial Fluid of Obese Patients is 100% Higher Than the IL-6 Concentration of the Synovial Fluid in Normal Weight Patients

Italy
First Affiliated Hospital of Guangxi Medical University

Completed

Monitoring of Azathioprine Metabolite Concentrations and Cytokine Levels in Neuromyelitis Optica Spectrum Disorder

NMO Spectrum Disorder | Azathioprine Adverse Reaction

China
Medical University of Vienna
Charite University, Berlin, Germany; University of Alberta; CSL Behring

Completed

A Pilot Trial of Clazakizumab in Late ABMR

Antibody-mediated Rejection

Austria, Germany
Atsushi Kawakami
Gilead Sciences

Recruiting

Efficacy and Safety of Selective JAK 1 Inhibitor Filgotinib in Active Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate (TRANSFORM)

Rheumatoid Arthritis | Biomarker | JAK Inhibitor | Musculoskeletal Ultrasound | IL-6 Inhibitor

Japan
Riphah International University
KRL Hospital, Islamabad

Recruiting

Diagnostic and Prognostic Blood Markers in Non Specific Low Back Pain

Low Back Pain

Pakistan
National Institute of Allergy and Infectious Diseases...
PPD; Rho Federal Systems Division, Inc.; Immune Tolerance Network (ITN)

Completed

Tocilizumab (TCZ) in New-onset Type 1 Diabetes (EXTEND)

Type 1 Diabetes Mellitus | T1DM | T1D | New-onset Type 1 Diabetes Mellitus

United States, Australia
Marc Y.Donath

Completed

Role of Interleukin-1 in the Regulation of Muscle Derived Interleukin-6 During Exercise (MUSIL)

Type 2 Diabetes

Switzerland
Case Western Reserve University

Completed

AIDS 347: IL-6 Blockade in Treated HIV Infection (IL-6)

HIV Infections

United States
Sohag University

Recruiting

Evaluation of Serum Interleukin 6 and 8 in Children With Acute Gastroenteritis

Acute Gastroenteritis | Acute Diarrhea

Egypt
Sohag University

Recruiting

IL6&8 in Malnourished Children With Acute Diarrhea

Acute Gastroenteritis | Severe Acute Malnutrition | Acute Diarrhea

Egypt
University Hospital, Montpellier

Completed

IL-6 as a Biomarker for Personalized Treatment of PR (REMISIX)

Rheumatoid Arthritis

France
Universitas Airlangga
Danone Institute International

Completed

The Effect of Lactoferrin in High Calorie Formula on IL-6 and IL10 in Children With Failure to Thrive and Infection (Interleukin)

Infections | Failure to Thrive

Indonesia
Vanderbilt University Medical Center
American Heart Association

Not yet recruiting

Long COVID Immune Profiling

Long COVID | Autonomic Dysfunction | POTS - Postural Orthostatic Tachycardia Syndrome
Radiation Therapy Oncology Group
National Cancer Institute (NCI)

Completed

Radiation Therapy With or Without Antiandrogen Therapy in Treating Patients With Stage I or Stage II Prostate Cancer

Prostate Cancer

United States, Canada
Nantes University Hospital

Recruiting

Dose-escalation of Siltuximab in Combination With Idarubicin and Cytarabine Chemotherapy in Patients With Acute Myeloblastic Leukaemia (AML) With Poor Prognosis: SILTUXILAM (SILTUXILAM)

Acute Myeloid Leukemia (AML)

France
Avidia

Unknown

Phase 1 Study of Safety and Biological Effects of C326, an Inhibitor of IL-6, in Crohn's Disease

Crohn's Disease

Australia
Nantes University Hospital

Completed

Monocentric Phase 1 Study With Escalation of Doses of Tocilizumab in Combination With Chemotherapy (Idarubicin and Cytarabine) in Patients With Acute Myeloblastic Leukemia (AML) (Tocilam)

Acute Myeloid Leukemia (AML)

France
Biocad

Completed

Study of the Efficacy and Safety of BCD-089 in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis (SOLAR)

Rheumatoid Arthritis

Russian Federation
Toros University

Not yet recruiting

Metabolic Control Adolescents Type 1 Diabetes

13-18 Year | Diagnosed at Least 6 Months Ago | HbA1C> 7.5 | Being Able to Read and Write
NHS Greater Glasgow and Clyde
University of Glasgow; NHS Ayrshire and Arran; Golden Jubilee National Hospital

Not yet recruiting

CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis. (CONDUCT-ICU)

Heart Failure | Sepsis | Septic Shock | Myocarditis

United Kingdom
University of Messina

Completed

Evaluation of Saliva IL-6 Levels and Periodontitis

Periodontal Diseases

Italy
Goethe University

Completed

Cytokines in Papillon-Lefèvre Syndrome

Papillon-Lefevre Disease

Germany
Dr. Soetomo General Hospital

Completed

Neuromuscular Electrical Stimulation in Chronic Heart Failure Patient

Chronic Heart Failure

Indonesia
Centre Hospitalier Universitaire de Nice

Completed

Diagnostic of Spontaneous Bacterial Peritonitis

Spontaneous Bacterial Peritonitis

France
Istituto Ortopedico Galeazzi

Recruiting

Correlation Between Altered Glycometabolic Status and Joint Inflammation in Diabetic Patients With Osteoarthritis Undergoing Knee Arthroplasty (GLICO PG)

To Evaluate a Linear Positive Correlation Between Plasma HbA1c and Synovial IL-6 in Diabetic Patients

Italy
Charite University, Berlin, Germany
German Research Foundation; adexter GmbH

Completed

Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1)

Septicemia

Germany
Ferring Pharmaceuticals

Completed

A Study to Investigate Interleukin-6 (IL-6) and IL-6/Soluble IL-6 Receptor (sIL-6R) Complex Levels in Subjects With Active Inflammatory Bowel Disease

Inflammatory Bowel Disease

Denmark, Sweden
Hadassah Medical Organization
Sheba Medical Center; Wolfson Medical Center

Unknown

The Use of Tocilizumab in the Management of Patients Who Have Severe COVID-19 With Suspected Pulmonary Hyperinflammation

Covid19 Pneumonia

Israel
Centre Leon Berard

Completed

Prospective Study in Patients With Advanced or Metastatic Cancer and SARS-CoV-2 Infection (IMMUNONCOVID)

SARS-CoV-2 (COVID-19) Infection | Advanced or Metastatic Hematological or Solid Tumor

France
Belfast Health and Social Care Trust
Queen's University, Belfast

Completed

Inhibition of Bradykinin in COVID-19 Infection With Icatibant (ICASARS)

SARS CoV 2 Infection

United Kingdom
First Affiliated Hospital, Sun Yat-Sen University
Wuhan University; Guangzhou First People's Hospital; Beijing Chao Yang Hospital; Zhujiang Hospital and other collaborators

Unknown

Efficacy and Safety Study of CA330 Hemoadsorption Device on IL-6 Removal in Septic Patients

Sepsis

China
University Hospital Inselspital, Berne
Eastern Virginia Medical School

Completed

Vaginal Inflammation Markers in Postmenopausal Women With and Without Symptoms of Vaginal Inflammation

Menopause | Vaginal Atrophy

Switzerland
Janssen Research & Development, LLC

Completed

A Study to Compare CNTO 328 (Anti-IL-6 Monoclonal Antibody) and VELCADE-Melphalan-Prednisone (VMP) With VMP Alone in Previously Untreated Multiple Myeloma Patients

Multiple Myeloma

United States, Australia, France, Spain, Israel, India, Romania, Korea, Republic of, Singapore, Russian Federation, Poland
University Hospital Ostrava

Completed

Acute Kidney Injury in Severe Trauma

Acute Kidney Injury

Czechia
Affiliated Hospital of Jiangnan University

Active, not recruiting

Association Between PM2.5 Exposure and Ferroptosis in Seizures Patients

Exposure to Polluted Air

China
Jagiellonian University

Recruiting

Activity of Chronic Inflammation in PCOS

Polycystic Ovary Syndrome

Poland
Lahore General Hospital

Unknown

Tocilizumab in COVID-19 Lahore General Hospital (TC19LGH)

SARS-CoV Infection

Pakistan
Mahidol University
Thai AIDs society

Recruiting

Efficacy and Safety of Low-Dose Colchicine on Surrogate Markers of Cardiovascular Events in People Living With HIV Receiving Antiretroviral Therapy

HIV Infections | Inflammatory Markers | Colchicine Adverse Reaction

Thailand
Universidad Rey Juan Carlos

Completed

The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease.

Periodontitis | Periodontal Diseases

Spain
University of Toronto

Completed

IL-6 in Exercise-Induced Anorexia

Pediatric Obesity | Appetitive Behavior

Canada
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Investigating Cytokine Genes of Stem Cell Donors

Stem Cell Transplantation

United States
Bluejay Diagnostics, Inc.

Recruiting

Symphony IL-6 Reference Range Study

Sepsis

United States
Saiful Anwar Hospital

Completed

Effect Of Curcuma Xanthorrhiza and Vitamin D3 Supplementation in SLE Patients With Hypovitamin D

SLE
Charles University, Czech Republic

Active, not recruiting

ICIS in Burn Patients Compared to Other Inflammatory Markers (ICARUS)

Inflammation | Burns | Infection, Bacterial

Czechia
Université de Sherbrooke

Completed

Pharmacological Activation of Brown Adipose Tissue Metabolism (GB6)

Type 2 Diabetes

Canada
University of Washington
Sanofi

Completed

Effects of IAS in Men With Localized Biochemical Relapsed Prostate Cancer (IAS)

Prostate Cancer

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Hormone Therapy and Ipilimumab in Treating Patients With Advanced Prostate Cancer

Prostate Adenocarcinoma | Prostate Carcinoma | Recurrent Prostate Carcinoma | Stage III Prostate Cancer | Stage IV Prostate Cancer

United States
National Institute of Allergy and Infectious Diseases...

Completed

Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants

Candidiasis

United States
Osijek University Hospital

Recruiting

Perioperative Adiponectin and Postoperative Inflammatory Response After Major Abdominal Surgery (ADIPOS)

Systemic Inflammatory Response Syndrome | Postoperative Complications | Surgery | Obesity, Abdominal

Croatia
University of Alabama at Birmingham

Recruiting

Chronic Widespread Pain in HIV: Novel Mechanisms and Therapeutics

Chronic Widespread Pain

United States

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