Search clinical trials for: MDR TB

Total 3593 results

Ain Shams University

Recruiting

Alpha-lipoic Acid in Diabetic Nephropathy

Type 1 Diabetes

Egypt
Bill & Melinda Gates Medical Research Institute
Global Alliance for TB Drug Development; Janssen Pharmaceutica; Otsuka Pharmaceutical...

Recruiting

Efficacy and Safety Evaluation of Two to Four Months of Treatment With the Combination Regimens of DBOS and PBOS in Adults With Pulmonary Tuberculosis

Pulmonary Tuberculosis

Philippines, South Africa
Desmond Tutu TB Centre
University of Stellenbosch; UNITAID; Chiang Mai University

Recruiting

Pharmacokinetics and Safety of DolutegravIr in Neonate (PETITE-DTG)

Hiv

South Africa
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Study of a Single Dose of Pretomanid Added to an Optimized Background Regimen in Children With Rifampicin-Resistant Tuberculosis

Tuberculosis | Rifampicin Resistant Tuberculosis

Brazil, India, South Africa, Tanzania, Thailand
Shanghai Pulmonary Hospital, Shanghai, China
Huashan Hospital; Shanghai Public Health Clinical Center; No.85 Hospital, Changning...

Recruiting

A Exploratory Study of Vγ2Vδ2 T Lymphocyte-based Immunotherapy for MDR-TB

Immunotherapy | MDR-TB

China
Asan Medical Center
Samsung Medical Center; Pusan National University Hospital; Chonnam National... and other collaborators

Recruiting

BPaL(M) Regimen for the Treatment of MDR/RR-TB

Multidrug- and Rifampicin-resistant Tuberculosis

Korea, Republic of
Shanghai Pulmonary Hospital, Shanghai, China
Huashan Hospital; Shanghai Public Health Clinical Center; Anhui Chest Hospital; No.85 Hospital, Changning, Shanghai, China and other collaborators

Recruiting

A Study of Ultrashort PRS Regimen V in the Treatment of MDR-TB

MDR-TB

China
Xiangya Hospital of Central South University

Recruiting

Effects of Epalrestat on Peripheral Neuropathy and Central Nervous System in Diabetic Patients

Diabetes

China
Centre for the AIDS Programme of Research in South...
Amsterdam Institute for Global Health and Development; Global Alliance for... and other collaborators

Recruiting

Triage Test for All Oral DR-TB Regimen (TRiAD Study)

Tuberculosis | Drug Resistant Tuberculosis | MDR-TB | XDR-TB

Nigeria, South Africa, Ethiopia
Kafrelsheikh University
Ministry of Health, Saudi Arabia

Not yet recruiting

Utilizing the Crosstalk Among Chicoric Acid, 13-Cis Retinoic Acid(Aerosolized), Minocycline and Vitamin D as a Potent Quadrate Therapy for Treating Patients With Multidrug-resistant TB and Patient With Both Multidrug-resistant TB and COVID-19

Tuberculosis

Egypt, Saudi Arabia
Fundació Institut Germans Trias i Pujol
National Center for Tuberculosis and Lung Disease, Tbilisi, Georgia; Perinatal...

Recruiting

Adjunctive Acetylsalicylic Acid and Ibuprofen for Tuberculosis (SMA-TB)

Tuberculosis, Pulmonary | Tuberculosis Infection | Tuberculosis, MDR

South Africa, Georgia
Huashan Hospital

Not yet recruiting

MDR-TB Close Contacts Tracing in China (TCCT Study)

Multidrug Resistant Tuberculosis

China
Boston University
Harvard Medical School (HMS and HSDM); University of Colorado, Denver; National... and other collaborators

Recruiting

Efficacy and Tolerability of Bedaquiline, Delamanid, Levofloxacin, Linezolid, and Clofazimine to Treat MDR-TB (DRAMATIC)

Tuberculosis, Multidrug-Resistant

Philippines, Vietnam
Huashan Hospital

Not yet recruiting

NGS-Guided(G) Regimens(R) of Anti-tuberculosis(A) Drugs for the Control(C) and Eradication(E) of MDR-TB (GRACE-TB)

Multidrug Resistant Tuberculosis

China
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx MDR-TB)

Tuberculosis, MDR

Haiti, Tanzania, Thailand, Botswana, Brazil, India, Kenya, Peru, Philippines, South Africa, Uganda, Zimbabwe, Vietnam
National Institute of Allergy and Infectious Diseases...
Otsuka Pharmaceutical Development & Commercialization, Inc.

Recruiting

Evaluating the Pharmacokinetics, Safety, and Tolerability of Delamanid in Combination With Optimized Multidrug Background Regimen (OBR) for Multidrug-Resistant Tuberculosis (MDR-TB) in HIV-Infected and HIV-Uninfected Children With MDR-TB

HIV Infections | Tuberculosis

Tanzania, India, South Africa, Botswana
Janssen Research & Development, LLC

Recruiting

Pharmacokinetic Study to Evaluate Anti-mycobacterial Activity of TMC207 in Combination With Background Regimen (BR) of Multidrug Resistant Tuberculosis (MDR-TB) Medications for Treatment of Children/Adolescents Pulmonary MDR-TB

Multidrug-Resistant Tuberculosis

Mozambique, Philippines, Russian Federation, South Africa, Uganda, Ukraine
National Institute of Allergy and Infectious Diseases...

Recruiting

Training Protocol on the Natural History of Tuberculosis

Mycobacterium Infections | Latent Tuberculosis | Tuberculosis | Tuberculosis, Multidrug-Resistant | Extensively Drug-Resistant Tuberculosis

United States
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University of Liverpool; Ministry... and other collaborators

Completed

Economic Evaluation of New MDR TB Regimens (PRACTECAL-EE)

Multi-drug Resistant Tuberculosis | Pulmonary Tuberculoses | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa, Uzbekistan
Research Center Borstel
Ludwig-Maximilians - University of Munich; "Marius Nasta" Pulmonology Institute

Completed

Nosocomial Transmission of MDR-TB in Bucharest, Romania

Tuberculosis, Multidrug-resistant

Romania
Global Alliance for TB Drug Development

Completed

Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult Patients

Tuberculosis | Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Tuberculosis, MDR | Drug-Resistant Tuberculosis

Tanzania, Georgia, Russian Federation, Brazil, Malaysia, Philippines, South Africa, Uganda
Tuberculosis Research Centre, India
International Union Against Tuberculosis and Lung Diseases; Sarvodaya Charitable... and other collaborators

Active, not recruiting

Modified BPaL Regimen for Managing Pre-XDR TB and MDR (TI/NR) TB in India (mBPaL)

Pre-Extensively Drug-Resistant Pulmonary TB | Treatment Intolerant Multidrug-Resistant Pulmonary TB | Non-responsive Multidrug-Resistant Pulmonary TB

India
IUATLD, Inc
Medical Research Council; Institute of Tropical Medicine, Belgium; Liverpool... and other collaborators

Completed

The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB (STREAM)

MDR-TB

Ethiopia, Georgia, India, Moldova, Republic of, Mongolia, South Africa, Uganda
Global Alliance for TB Drug Development

Active, not recruiting

A Trial to Evaluate the Male Reproductive Safety of Pretomanid in Adult Male Participants With Drug Resistant Pulmonary Tuberculosis Volunteers (PaSEM)

Tuberculosis | Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Tuberculosis, MDR | Drug-Resistant Tuberculosis

Georgia, South Africa
Médecins Sans Frontières, France
Harvard Medical School (HMS and HSDM); Institute of Tropical Medicine, Belgium and other collaborators

Completed

Evaluating Newly Approved Drugs for Multidrug-resistant TB (endTB)

Tuberculosis, Multidrug-Resistant | Infection, Bacterial | Pulmonary Tuberculoses

Pakistan, Georgia, India, Kazakhstan, Lesotho, Peru, South Africa
Médecins Sans Frontières, France
Harvard Medical School (HMS and HSDM); Institute of Tropical Medicine, Belgium and other collaborators

Active, not recruiting

Evaluating Newly Approved Drugs in Combination Regimens for Multidrug-Resistant TB With Fluoroquinolone Resistance (endTB-Q) (endTB-Q)

Bacterial Infections | Gram-Positive Bacterial Infections | Tuberculosis | Tuberculosis, Multidrug-Resistant | Pulmonary Tuberculoses | Mycobacterial Infections

Vietnam, Pakistan, India, Kazakhstan, Lesotho, Peru
Global Alliance for TB Drug Development

Completed

Various Doses and Durations of Linezolid Plus Bedaquiline & Pretomanid in Participants With Drug Resistant Tuberculosis (ZeNix)

Tuberculosis | Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Extensively Drug-Resistant Tuberculosis | Tuberculosis, MDR | XDR-TB | Pre-XDR-TB

South Africa, Russian Federation, Georgia, Moldova, Republic of
Johns Hopkins University
National Institute of Allergy and Infectious Diseases (NIAID); National Institutes... and other collaborators

Active, not recruiting

A Nurse Case Management Intervention to Improve MDR-TB/HIV Co-Infection Outcomes

HIV | MDR-TB

South Africa
Boston University
National Institute of Allergy and Infectious Diseases (NIAID); Centers for... and other collaborators

Completed

Efficacy and Safety of Levofloxacin for the Treatment of MDR-TB (Opti-Q)

Tuberculosis, Multidrug-Resistant

South Africa, Peru
Huashan Hospital

Active, not recruiting

Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T) (TB-TRUST)

Multidrug Resistant Tuberculosis

China
Huashan Hospital

Active, not recruiting

Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)-PLUS (TB-TRUSTplus)

Multidrug Resistant Tuberculosis

China
Beijing Chest Hospital

Completed

The Effect of 18-month Regimen Containing 6 Anti-tuberculosis Drugs for Patients With MDR-TB

Multi-drug Resistant Tuberculosis

China
Centre for the AIDS Programme of Research in South...
Columbia University

Completed

Promoting Engagement in the Drug Resistant TB/HIV Care Continuum in South Africa (PRAXIS)

Patient Non-compliance

South Africa
Beijing Chest Hospital

Active, not recruiting

Safety and Effectiveness of Delamanid-containing Regimen for MDR-TB Patients in China

Multidrug Resistant Tuberculosis

China
Archivel Farma S.L.
London School of Hygiene and Tropical Medicine

Terminated

Safety of RUTI® Vaccination in MDR-TB Patients

Tuberculosis, Multidrug Resistant

Ukraine
Scientific Center for Anti-infectious Drugs, Kazakhstan
Phthisiopulmonology Center of Almaty, Kazakhstan; National Scientific Center... and other collaborators

Completed

FS-1 Drug for Treatment of Multiple Drug-resistant Tuberculosis (FS-1)

Tuberculosis, MDR

Kazakhstan, Kyrgyzstan
Assistance Publique - Hôpitaux de Paris

Completed

Bone Resistant Tuberculosis (TboneR)

Bone and Osteoarticular Infection Due to MDR M. Tuberculosis Strains

France
Anne Margarita Dyrhol Riise
University of Oslo; Haukeland University Hospital; Statens Serum Institut

Completed

Therapeutic Vaccination and Immune Modulation - New Treatment Strategies for the MDR Tuberculosis Pandemic (TBCOX2)

Tuberculosis

Norway
Ina-Respond
National Institute of Health Research and Development, Ministry of Health... and other collaborators

Completed

Tuberculosis Research of INA-RESPOND On Drug Resistance (TRIPOD)

Lung Tuberculosis | MDR TB

Indonesia
Otsuka Pharmaceutical Development & Commercialization...

Terminated

Safety and Pharmacokinetics (PK) in Multidrug-Resistant (MDR) Refractive Tuberculosis

Tuberculosis

Latvia, Lithuania
Korea Otsuka Pharmaceutical Co., Ltd.

Completed

Post Marketing Registry to Assess Usage, Safety and Effectiveness of Deltyba Tablets in Korean Patients With MDR-TB

Multi-drug Resistant Tuberculosis

Korea, Republic of
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University College, London; University... and other collaborators

Active, not recruiting

Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s) (TB-PRACTECAL)

Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa, Uzbekistan
Global Alliance for TB Drug Development

Completed

A Phase 3 Study Assessing the Safety and Efficacy of Bedaquiline Plus PA-824 Plus Linezolid in Subjects With Drug Resistant Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa
Otsuka Pharmaceutical Development & Commercialization...

Completed

A 6-Month Safety, Efficacy, and Pharmacokinetic (PK) Trial of Delamanid in Pediatric Participants With Multidrug Resistant Tuberculosis (MDR-TB)

Multidrug Resistant Tuberculosis

Philippines, South Africa
Jan-Willem C Alffenaar
University of Virginia; Kibong'oto Infectious Diseases Hospital

Completed

Saliva and Dried Blood Spot Therapeutic Drug Monitoring for MDR-TB in Tanzania

MDR-TB

Tanzania
Hasanuddin University
Chulalongkorn University

Completed

Artificial Inteligent for Diagnosing Drug-Resistant Tuberculosis

Resistance to Tuberculostatic Drugs | MDR Tuberculosis

Indonesia
Karolinska Institutet
Fudan University; University Medical Center Groningen

Completed

Drug Concentrations in the Treatment of MDR-TB Related to Minimum Inhibitory Concentrations (TDM-MDR-TB)

Tuberculosis, Multidrug Resistant

China
Global Alliance for TB Drug Development

Completed

A Study in Two Panels of Healthy Adult Participants to Assess Single-Dose Immediate-Release and Single-Dose Dispersible Formulations of Pretomanid

Multi-drug Resistant Tuberculosis

United States
Nearmedic Plus LLC

Completed

Safety, Tolerability, Pharmacokinetics and Food Effects Study of PBTZ169

Healthy Subjects

Russian Federation
Janssen Pharmaceutical K.K.

Completed

An Exploratory Study of TMC207 in Japanese Participants With Pulmonary Multi-Drug Resistant Tuberculosis (MDR-TB)

Tuberculosis, Multidrug-Resistant

Japan

Search clinical trials for: MDR TB

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