Search clinical trials for: Matched Unrelated Allogeneic Stem Cell Transplantation

Total 63566 results

Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Phase III Study Comparing GVHD Prophylaxis With ATG-thymoglobulin to ATLG-grafalon in Elderly Patients With Acute Myeloid Leukemia or Myelodysplasic Syndrome and Receiving an Allogeneic Hematopoietic Stem Cell Transplantation With a 10/10 HLA Matched Unrelated Donor (OPTISAGE)

GVHD
National Institute of Allergy and Infectious Diseases...

Recruiting

Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists

Chronic Granulomatous Disease

United States
Orca Biosystems, Inc.

Recruiting

Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies (Orca-T)

Acute Myeloid Leukemia | Acute Leukemia | Myelodysplastic Syndrome | Acute Lymphoid Leukemia | Therapy-Related Myelodysplastic Syndrome | Mixed Phenotype Acute Leukemia | Undifferentiated Leukemia

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Recruiting

Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904)

Congenital Amegakaryocytic Thrombocytopenia | Paroxysmal Nocturnal Hemoglobinuria | Shwachman-Diamond Syndrome | Bone Marrow Failure Syndrome | Congenital Pure Red Cell Aplasia | Hereditary Sideroblastic Anemia | Hematologic Neoplasm With Germline GATA2 Mutation | Hematologic Neoplasm With Germline... and other conditions

United States
Universitätsklinikum Hamburg-Eppendorf
Clinical Trial Center North (CTC North GmbH & Co. KG); DKMS Stiftung Leben...

Recruiting

Matched Unrelated vs. Haploidentical Donor for Allogeneic Stem Cell Transplantation in Patients With Acute Leukemia

Myelodysplastic Syndromes | Acute Myeloid Leukemia in Remission | Acute Lymphoblastic Leukemia in Remission

Germany, Spain, Italy, Austria, Czechia, Finland, Russian Federation
Orca Biosystems, Inc.

Recruiting

Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Chronic Myeloid Leukemia | Acute Leukemia | Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) | Acute Lymphoid Leukemia

United States
National Institute of Allergy and Infectious Diseases...

Enrolling by invitation

Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and Sirolimus

Severe Combined Immune Deficiency (SCID)

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Active, not recruiting

Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD

Lymphoblastic Lymphoma | Childhood Acute Myeloid Leukemia in Remission | Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Myelodysplastic Syndrome With Excess Blasts | Childhood Acute Lymphoblastic Leukemia in Remission | Recurrent Childhood Acute Lymphoblastic Leukemia | Recurrent... and other conditions

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

AlloHCT From Matched Unrelated Donors in Pts w/ Advanced Hematologic Malignancies & Disorders

Lymphoma | Myelodysplastic Syndromes | Leukemia

United States
Grupo Cooperativo de Estudio y Tratamiento de las...

Completed

Risk-adapted Therapy for Primary Acute Myeloid Leukemia

Leukemia, Myeloid, Acute

Spain
Karolinska Institutet
Medical University of Vienna; Oslo University Hospital; Sahlgrenska University... and other collaborators

Terminated

Randomized Clinical Study Assessing Haplo vs. URD in AML

Acute Myeloid Leukemia

Canada, Austria, Sweden, Russian Federation, Norway
Sidney Kimmel Cancer Center at Thomas Jefferson...

Completed

A Research Study of Bone Marrow Transplantation From Unrelated or Partially Matched Related Donors

Hematological Malignancies

United States
Universitätsklinikum Hamburg-Eppendorf

Completed

Matched Unrelated Donor Stem Cell Transplantation (MUD-SCT) After Dose-reduced Conditioning for Patients With Multiple Myeloma and Relapse After Autologous SCT

Multiple Myeloma

Germany
Stanford University

Completed

Stem Cell Transplant From Matched Unrelated or Partially Matched Related Donors

Blood Cancer | Blood and Marrow Transplant (BMT)

United States
National Cancer Institute (NCI)

Completed

A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation From Related or Matched Unrelated Donors in Pediatric Patients With Solid Tumors and Leukemias

Lymphoma | Leukemia

United States
Memorial Sloan Kettering Cancer Center

Terminated

GVHD Prophylaxis With Post Transplant Cyclophosphamide for Patients With Renal Insufficiency Undergoing a Conventional 8/8 HLA-matched Related or Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplant

Leukemia | Non-Hodgkin's Lymphoma | Myelodysplastic Syndrome

United States
University of Alabama at Birmingham

Terminated

Non-Myeloablative Allogeneic HSCT From HLA Matched Related or Unrelated Donors for the Treatment of Low Grade B Cell Malignancies

Multiple Myeloma | Mantle Cell Lymphoma | Non Hodgkin's Lymphoma | CLL / SLL | Waldenstroms

United States
Beth Israel Deaconess Medical Center
Bayer

Completed

Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders

Multiple Myeloma | Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | AML | Myelodysplastic Syndrome | Aplastic Anemia | Myeloproliferative Disorder | CLL | ALL

United States
University of California, San Francisco

Completed

Non-Myeloablative Allogeneic Stem Cell Transplantation With Matched Unrelated Donors for Treatment of Hematologic Malignancies, Renal Cell Carcinoma, and Aplastic Anemia

Follicular Lymphoma | Renal Cell Carcinoma | Acute Myeloid Leukemia | Multiple Myeloma | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Chronic Myeloid Leukemia | Aplastic Anemia | Myelodysplasia | NHL | Myeloproliferative Diseases

United States
Grupo Cooperativo de Estudio y Tratamiento de las...

Completed

Risk Adapted Treatment for Primary Acute Myeloid Leukemia (AML)

Leukemia, Myelocytic, Acute

Spain
Neovii Biotech
University Medical Center Freiburg

Completed

Acute Graft-Versus-Host Disease (aGvHD) Prophylaxis With ATG-Fresenius in Matched Unrelated Donor-Stem Cell Transplantation (MUD-SCT)

Graft vs Host Disease

Germany
University of Liege

Completed

Nonmyeloablative Stem Cell Transplantation With CD8-depleted or Unmanipulated Peripheral Blood Stem Cells (PBSC)

Hematologic Malignancies

Belgium
St. Jude Children's Research Hospital

Completed

Stem Cell Transplantation for Patients With Hematologic Malignancies

Juvenile Myelomonocytic Leukemia | Non-Hodgkin Lymphoma | Chronic Myeloid Leukemia | Myelodysplastic Syndrome | Acute Lymphoblastic Leukemias | Acute Myelocytic Leukemia | Hemoglobinuria, Paroxysmal

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

Acute Myeloid Leukemia | Hodgkin Lymphoma | Myelofibrosis | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Hematopoietic and Lymphoid System Neoplasm | Myeloproliferative Neoplasm | Chronic Myeloid Leukemia, BCR-ABL1 Positive

United States
Boston Children's Hospital
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health... and other collaborators

Recruiting

A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202) (TransIT)

Severe Aplastic Anemia

United States
Children's Oncology Group

Recruiting

Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome | Mixed Phenotype Acute Leukemia

United States, Australia, Canada
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Comparison of Allogeneic Matched Related Haematopoietic Stem Cell Transplantation After a Reduced Intensity Conditioning Regimen With Standard of Care in Adolescents and Adults With Severe Sickle Cell Disease (DREPA-RIC)

Sickle Cell Disease
Hospital Israelita Albert Einstein

Recruiting

Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological Malignancies

Graft Versus Host Disease | Infection Viral | Bone Marrow Transplant Complications | Engraft Failure | Immunologic Suppression

Brazil
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

HLA 10/10 Matched Unrelated Donor vs Haploidentical Allogenic Hematopoietic Stem Cell Transplantation (MacHaploMud)

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Acute Lymphoblastic Leukemia | Myeloproliferative Syndromes
Samuel Strober
California Institute for Regenerative Medicine (CIRM)

Recruiting

Inducing Graft Tolerance in HLA Haplotype Matched Related and 3 Ag Matched Unrelated Living Donor Kidney Transplantation (CIRM)

Immune Tolerance

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Institutes of Health (NIH)

Recruiting

Comparison of Triple GVHD Prophylaxis Regimens for Nonmyeloablative or Reduced Intensity Conditioning Unrelated Mobilized Blood Cell Transplantation

Diffuse Large B-Cell Lymphoma | Acute Myeloid Leukemia | Recurrent Hodgkin Lymphoma | Acute Lymphoblastic Leukemia | Mantle Cell Lymphoma | Chronic Lymphocytic Leukemia | Myelodysplastic Syndrome | Recurrent Small Lymphocytic Lymphoma | Blastic Plasmacytoid Dendritic Cell Neoplasm | Prolymphocytic Leukemia and other conditions

United States
National Cancer Institute (NCI)

Recruiting

Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

Multiple Myeloma | Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | Acute Leukemia | Myelodysplastic Syndrome

United States
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease

Chronic Granulomatous Disease Transplant

United States
Emory University
Bristol-Myers Squibb; Thrasher Research Fund; Sickle Cell Transplant Advocacy... and other collaborators

Active, not recruiting

Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant (ASCENT)

Graft Versus Host Disease

United States
Children's Hospital of Philadelphia

Completed

CHP 834 Unrelated and Partially Matched Related Donor Peripheral Stem Cell Transportation for T and B Cell Depletion (CliniMACs)

Immunodeficiencies

United States
University of Alabama at Birmingham
Miltenyi Biotec, Inc.

Active, not recruiting

Standardization of CD3+ T Cell Dose for Patients Receiving Allogeneic Peripheral Blood Stem Cell Transplantation From Matched Related Donors

Hematopoietic Stem Cell Transplantation

United States
Universitair Ziekenhuis Brussel

Completed

Unrelated Umbilical Cord Blood Transplantation With Coinfusion of Mesenchymal Stem Cells

Allogeneic Stem Cell Transplantation

Belgium
Memorial Sloan Kettering Cancer Center

Completed

Haploidentical (Half-matched) Related Donor Stem Cell Transplantation Using Killer Immunoglobulin-like Receptors in Addition to Normal Selection Factors to Determine the Best Donor

Hematologic Malignancy

United States
Paul Szabolcs

Enrolling by invitation

Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases (BOLT+BMT)

Chronic Granulomatous Disease (CGD) | Wiskott-Aldrich Syndrome | Severe Chronic Neutropenia | Severe Combined Immunodeficiency (SCID) | Immunodeficiency With Predominant T-cell Defect, Unspecified | Hyper IgE Syndromes | Hyper IgM Deficiencies | Mendelian Susceptibility to Mycobacterial Disease | Common...

United States
Michael Pulsipher, MD

Active, not recruiting

Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia

Severe Aplastic Anemia

United States
Milton S. Hershey Medical Center

Terminated

Clofarabine Pre-conditioning Followed by Stem Cell Transplant for Non-remission AML

Acute Myeloid Leukemia

United States
European Society for Blood and Marrow Transplantation

Completed

Stem Cell Translpantation in Multiple Myeloma

Multiple Myeloma

Austria, Denmark, Germany, Finland, Canada, Sweden, Norway, France, Italy, United Kingdom, Turkey
Nanfang Hospital, Southern Medical University
Zhujiang Hospital

Completed

Risk Stratification-directed Therapy for AML With t(8;21) /AML1-ETO+

Acute Myeloid Leukemia | Risk Stratification
Columbia University

Active, not recruiting

Stem Cell Transplant in Sickle Cell Disease and Thalassemia

Sickle Cell Disease | Beta Thalassemia

United States
Gruppo Italiano Trapianto di Midollo Osseo

Completed

Post Transplant High-Dose Cy as GvHD Prophylaxis in 1 HLA Mismatched Unrelated HSCT for Myeloid Malignancies (GITMO-PHYLOS)

Myeloid Malignancies

Italy
Gruppo Italiano Trapianto di Midollo Osseo

Completed

A Phase II Study on Allogeneic Stem Cell Transplantation in Patients With Active Acute Leukemia (Gandalf-01)

Acute Leukemia

Italy
Scripps Health

Completed

Unrelated Donor Stem Cell Transplantation

Myelodysplastic Syndromes | Multiple Myeloma | Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | Small Lymphocytic Lymphoma | Paroxysmal Nocturnal Hemoglobinuria | Severe Aplastic Anemia | Myeloproliferative... and other conditions

United States
Joanne Kurtzberg, MD
Duke University; Miltenyi Biotec, Inc.

Available

Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants

Hematologic Malignancies | Immune Deficiencies | Inborn Errors of Metabolism Disorders

United States
University of Liege

Terminated

Donor Regulatory T Cells Infusion in Patients With Chronic Graft-versus-host Disease (GVHD)

Chronic Graft-Versus-Host Disease | Acute Graft-Versus-Host Disease | Steroid Refractory Graft-Versus-Host Disease

Belgium
Bristol-Myers Squibb

Completed

A Study to Assess 7/8 HLA-matched Hematopoietic Stem Cell Transplantation Participants Treated With or Without Abatacept in Combination With a Calcineurin Inhibitor and Methotrexate

Stem Cell Transplantation

United States

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