Search clinical trials for: Surrogate

Total 124 results

CentraCare

Recruiting

Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates for Fluid Responsiveness (PHOENIX)

Fluid Responsiveness

United States
Columbia University
National Institute on Aging (NIA)

Recruiting

Removing Surrogates' Uncertainty to Reduce Fear and Anxiety After Cardiac Events (RESURFACE)

Cardiac Arrest

United States
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
Shandong Cancer Hospital and Institute

Recruiting

IMM2520, a PD-L1 and CD47 Bispecific Antibody in Patients With Advanced Solid Tumors

Breast Cancer | Small Cell Lung Cancer | Colorectal Cancer | Advanced Solid Tumor | Non-small Cell Lung Cancer | Squamous Cell Cancer of Head and Neck

China
Synedgen, Inc.
United States Department of Defense; Medical Technology Enterprise Consortium

Recruiting

Efficacy of SynEx Wound Rinse in Civilian Surrogates of Combat Injury Wounds

Wound Heal

United States
Weill Medical College of Cornell University
National Institute of Nursing Research (NINR)

Recruiting

A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients

Trauma | Critical Care | Psychotherapy | Grief

United States
Diabetes Foundation, India

Not yet recruiting

Vitamin D Supplementation on Surrogate Markers of Atherosclerosis

Atherosclerosis
Kaohsiung Medical University

Not yet recruiting

Dapagliflozin and Renal Surrogate Outcomes in Advanced Chronic Kidney Disease (DAPA-advKD)

Chronic Kidney Diseases
Mahidol University
Thai AIDs society

Recruiting

Efficacy and Safety of Low-Dose Colchicine on Surrogate Markers of Cardiovascular Events in People Living With HIV Receiving Antiretroviral Therapy

HIV Infections | Inflammatory Markers | Colchicine Adverse Reaction

Thailand
Hospices Civils de Lyon

Recruiting

Ultrasound and MRI Measurement of Quadriceps Femoris Muscle in Critically Ill Children (Echo-QF-IRM)

Quadriceps Femoris Measurement as a Surrogate of Muscle Mass Assessment in Critically Ill Children

France
University of Sydney
Northern Care Alliance NHS Foundation Trust; Waitemata District Health Board; Australasian Kidney Trials Network

Recruiting

Better Evidence and Translation for Calciphylaxis (BEAT-Calci)

Calciphylaxis

Australia, New Zealand
University of Pittsburgh
Duke University; National Institute on Aging (NIA); Oregon Health and Science... and other collaborators

Recruiting

Multi-component Family Support Tool Intervention (FST) (FST)

Critical Illness

United States
University of Pittsburgh
Massachusetts General Hospital; National Institute on Aging (NIA)

Recruiting

Integrated Supportive and Palliative Care for Older Adults in the ICU (ProPACC)

Critical Illness

United States
Chinese University of Hong Kong
University of Sydney; Chongqing Medical University; Hong Kong University of Science... and other collaborators

Not yet recruiting

Air Pollution (PM2.5) on Accelerated Atherosclerosis: A Montelukast Interventional Study in Modernizing China

Atherosclerosis, Coronary

Hong Kong
Association for Innovation and Biomedical Research...

Recruiting

10-year Progression of Diabetic Retinopathy: Identification of Signs and Surrogate Outcomes (PROGRESS10)

Diabetic Retinopathy

Portugal
Klinik Hirslanden, Zurich

Recruiting

Intelligent Vacuum Assisted Biopsy Immediately Before Surgery as an Intra- or Pre-Operative Surrogate for Patient Response to Neoadjuvant Chemotherapy for Breast Cancer (VISION I)

Breast Cancer

Switzerland
Indiana University
National Institutes of Health (NIH); National Institute on Aging (NIA); Indiana... and other collaborators

Recruiting

POST Facilitation for Community Dwelling Older Adults (POST-RCT) (POST-RCT)

Depression | Anxiety | Post Traumatic Stress Disorder | Satisfaction

United States
Diabetes Foundation, India

Recruiting

Vitamin D Supplementation on Surrogate Markers of Ageing, Ageing Genes, Glycemic and Metabolic Markers in North India

PreDiabetes | Aging | Vitamin D Supplementation

India
Hôpital Necker-Enfants Malades
Association Mucoviscidose-ABCF2; Vaincre la Mucoviscidose

Recruiting

Surrogate Markers of Response to New Therapies in Cystic Fibrosis Patients (BIO-CFTR)

Cystic Fibrosis

France
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); Memorial Sloan Kettering Cancer Center; Washington... and other collaborators

Active, not recruiting

Improving Outcomes Assessment in Chronic GVHD

Chronic Graft Versus Host Disease

United States
Indiana University
National Institutes of Health (NIH); National Institute on Aging (NIA); Indiana... and other collaborators

Withdrawn

Virtual Communication in the Hospital: Impact on Patients and Surrogates (VCHIPS)

Depression | Anxiety | Communication | Distress, Emotional

United States
Milton S. Hershey Medical Center
National Institute of Nursing Research (NINR)

Completed

Choosing an Effective Healthcare Spokesperson: An Interactive Intervention

Advance Care Planning | Surrogate Decision-making | Healthcare Spokesperson

United States
Milton S. Hershey Medical Center
National Institute of Nursing Research (NINR); Brigham and Women's Hospital

Completed

Preparing Family Caregivers to Make Medical Decisions for Their Loved Ones

Heart Failure | Neoplasms | Lung Diseases | Kidney Diseases

United States
University of Mississippi Medical Center
National Center for Complementary and Integrative Health (NCCIH); University...

Completed

Identification of Surrogate Blood and/or Urine Biomarker for Immulina TM (Trademark) in Normal Humans

Adherence, Patient

United States
Weill Medical College of Cornell University
National Cancer Institute (NCI); Memorial Sloan Kettering Cancer Center; New...

Completed

Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience Among Surrogate Decision-Makers of ICU Patients (EMPOWER)

Critical Illness | Communication Disabilities

United States
The University of Hong Kong

Enrolling by invitation

Preparing Surrogates of Dementia Patients Through an Advance Care Planning Intervention

Dementia

Hong Kong
Ralf J. Jox

Completed

Promoting Self-determination for Institutionalized Older People Without Decision-making Capacity: Advance Care Planning by Proxy (PROSPECT)

Advanced Dementia | Loss of Medical Decision Making Capacity

Switzerland
National Institutes of Health Clinical Center (CC)

Completed

Focus Groups to Determine Surrogates Views Regarding Patient Preference Predictors

Normal Physiology

United States
University of Bern
University of Zurich; Swiss National Science Foundation; University of Lausanne; University of Geneva, Switzerland and other collaborators

Completed

ESTxENDS Trial: MN Substudy - Micronuclei in Buccal Epithelium, a Surrogate Measure of Future Cancer Risk, Induced by Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig) (ESTxENDS)

Smoking Cessation | Micronuclei

Switzerland
University of Gdansk
Principal Investigator: Karolina Lutkiewicz, PhD; Sub-Investigator: Łucja Bieleninik... and other collaborators

Completed

General Attitudes Towards Surrogacy in Poland

Surrogate Mothers

Poland
Aalborg University

Completed

Characterization of Bovine Adrenal Medulla as a New Surrogate Model of Non-histaminergic Itch

Itch

Denmark
Janssen-Cilag Ltd.

Terminated

Effect of Guselkumab on Cardiovascular Risk Surrogate Markers in Participants With Moderate to Severe Plaque Psoriasis (G-CARE)

Psoriasis

Italy, Germany, Greece
State University of New York at Buffalo

Completed

Using a Nurse-Led Communication Strategy for Surrogates in the Intensive Care Unit

Communication Research

United States
Institut Bergonié
Institut du Cancer de Montpellier - Val d'Aurelle; UNICANCER

Active, not recruiting

Survival Endpoints for Treatment Evaluation in Subjects Treated for Metastatic Breast Cancer: Contribution of Real-life Databases

Cancer

France
University Hospitals Cleveland Medical Center

Completed

Pilot Evaluation of FAMCOPE-ICU (Family Coping and Emotion Regulation Tool in the ICU)

Coping Skills | Emotion Regulation

United States
Laval University
McGill University; Institut de Recherches Cliniques de Montreal

Completed

Insulin Omission Surrogate (iOS) (iOS)

Type 1 Diabetes

Canada
University of Utah

Completed

Home-based HIIT to Improve CRC Survivorship: Feasibility and Relationship With Novel Surrogate Biomarkers of CRC Recurrence

Colorectal Neoplasms | Colorectal Cancer | Rectal Cancer | Rectal Neoplasms | Colonic Neoplasms | Colonic Cancer | Colorectal Carcinoma

United States
Matthias Haenggi

Completed

Resuscitation Registry - Surrogate Markers of Outcome After Cardiac Arrest (CPR)

Cardiac Arrest

Switzerland
National Institutes of Health Clinical Center (CC)

Completed

Characteristics and Outcomes of a Capacity-to-Consent Assessment Service

Cognitive Dysfunction

United States
University of Colorado, Denver
National Heart, Lung, and Blood Institute (NHLBI); Emergency Medicine Foundation

Completed

A Novel Patient Decision Aid for Surrogate Decision Makers of Comatose Survivors of Cardiac Arrest

Cardiac Arrest With Successful Resuscitation

United States
Chulalongkorn University
National Vaccine Institute, Thailand; Chula Vaccine Research Center (ChulaVRC)... and other collaborators

Completed

ChulaCov19 Vaccine in Healthy Adults

COVID-19 Vaccine | Safety Issues

Thailand
Certmedica International GmbH
University Hospital, Bonn

Completed

Influence of Polyglucosamine L112 on Serum Surrogate Markers of Cholesterol Absorption

Cholesterol Lowering

Germany
Maureen Lyon
National Institute of Nursing Research (NINR); St. Jude Children's Research... and other collaborators

Completed

Building Evidence for Effective Palliative/End of Life Care for Teens With Cancer (FACE-TC)

Cancer

United States
University Hospital Heidelberg
German Cancer Research Center; University Hospital Dresden

Terminated

Evaluation of Measurable Residual Disease in Patients With Acute Myeloid Leukemia as Surrogate Endpoint for Survival (PERDAM)

Leukemia, Myeloid, Acute

Germany
Institut Bergonié
Institut National de la Santé Et de la Recherche Médicale, France

Completed

Immune-checkpoint Inhibitors and Surrogate Endpoints in Cancer Trials (SURROGATE-ICI) (SURROGATE-ICI)

Cancer Treated With Immune-checkpoint Inhibitors

France
Case Western Reserve University
National Institute of Nursing Research (NINR); National Institutes of Health...

Completed

Decision Support Among Surrogate Decision Makers of the Chronically Critically Ill (INVOLVE) (INVOLVE)

Critical Illness

United States
Aalborg University

Completed

Characterization of BAM8-22 as a New Surrogate Model of Non-histaminergic Itch

Itch

Denmark
University of Wisconsin, Madison
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Testing Doxazosin to Treat Stress Mechanisms in Alcoholism

Alcoholism

United States
Soonchunhyang University Hospital

Completed

Surrogate Quality Indicators for Adenoma Detection Rate (ADR)

Colon Adenoma

Korea, Republic of
University of Pennsylvania

Completed

Use of Nudges To Enhance Enrollment in Critical Care Research

Critical Illness

United States
Institut Bergonié
National Cancer Institute, France; Institut du Cancer de Montpellier - Val... and other collaborators

Completed

Variability of Definitions for Survival Endpoints and Surrogate Properties for OS in Sarcoma Trials: a Meta-analysis (DATECAN-2)

Cancer

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