Search clinical trials for: Symptomatic, left ventricular outflow tract gradient

Total 110349 results

Fatebenefratelli Hospital
Federico II University; Federal University of Rio Grande do Sul; Royal Brompton... and other collaborators

Recruiting

Stress Echo 2020 - The International Stress Echo Study (SE2020)

Coronary Artery Disease | Heart Failure | Aortic Valve Disease | Pulmonary Arterial Hypertension | Tetralogy of Fallot | Hypertrophic Cardiomyopathy | Athletes Heart

Italy
Bristol-Myers Squibb

Active, not recruiting

A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

Hypertrophic Cardiomyopathy | Non-obstructive Hypertrophic Cardiomyopathy | Obstructive Hypertrophic Cardiomyopathy

Denmark, United States, Belgium, Czechia, France, Germany, Israel, Italy, Netherlands, Poland, Portugal, Spain, United Kingdom
Bristol-Myers Squibb

Completed

Extension Study of Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Previously Enrolled in PIONEER (PIONEER-OLE)

Hypertrophic Cardiomyopathy

United States
Mayo Clinic

Withdrawn

Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy | Cardiomyopathy, Hypertrophic | Hypertrophic Obstructive Cardiomyopathy
MyoKardia, Inc.

Completed

Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy (EXPLORER-HCM)

Obstructive Hypertrophic Cardiomyopathy

United States, France, Germany, Czechia, Spain, Belgium, Denmark, Portugal, Netherlands, Israel, Poland, United Kingdom, Italy
Lisa Gundestrup

Not yet recruiting

Aortic Stenosis Associated Left Ventricular Remodeling - An Investigation of Genetic and Gender Specific Differences in 170 Patients Undergoing Aortic Valve Replacement Surgery (SALVAGE)

Aortic Valve Stenosis
Avicenna Military Hospital

Recruiting

Is Mitral Velocity Time-integral a Marker of Preload-responsiveness in Patients With Acute Circulatory Failure?

Preload-responsiveness

Morocco
St. Antonius Hospital

Recruiting

Reverse Remodeling After PTSMA in Severe But Asymptomatic LVOT Obstruction (RASTA)

HOCM, Hypertrophic Obstructive Cardiomyopathy | LVOTO - Left Ventricular Outflow Tract Obstruction | Remodeling, Ventricular

Netherlands
Laval University
University Hospital, Brest

Recruiting

Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)

Aortic Valve Stenosis

United States, France, Austria, Belgium, Canada, Germany
Aarhus University Hospital Skejby

Completed

Pressure Gradient vs. Flow Relationships in Patients With Symptomatic Valvular Aortic Stenosis (PREFLOW)

Aortic Valve Stenosis

Denmark
Bristol-Myers Squibb

Completed

A Study to Evaluate the Effects of Mavacamten in Healthy Participants

Healthy Participants

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Mitral Valve Failure

United States
University of Michigan
National Institutes of Health (NIH)

Active, not recruiting

Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period (T-NOX)

Tetralogy of Fallot | Cardiopulmonary Bypass | Hypoplastic Left Heart Syndrome | Transposition of the Great Arteries | Double Outlet Right Ventricle, Subpulmonary VSD | Pulmonary Atresia With Ventricular Septal Defect | Truncus Arteriosus | Total Anomalous Pulmonary Venous Return | Double Outlet Right...

United States
University Hospital, Motol

Completed

Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy

Czechia
Rennes University Hospital

Terminated

Randomized Study for the Optimal Treatment of Symptomatic Patients With Low Gradient Severe Aortic Valve Stenosis and Preserved Left Ventricular Ejection Fraction (ROTAS)

Aortic Valve Stenosis

France, Belgium
Ruiqin xie

Completed

Comparison of Cardiac Function Between Left Bundle Branch Pacing and Right Ventricular Outflow Tract Septal Pacing in Pacemaker-dependent Patients

Slow Arrhythmia; Left Bundle Branch Pacing; Cardiac Function

China
Texas Cardiac Arrhythmia Research Foundation

Suspended

Half-normal Saline in Idiopathic Left Ventricular Outflow Tract Arrhythmias Ablation

Ventricular Arrythmia

United States
University Hospital, Bordeaux
Amicus Therapeutics; Fédération Française de Cardiologie; Fondation Bordeaux...

Completed

Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies (HCM-Vein)

Endothelial Dysfunction | Hypertrophic Cardiomyopathy

France
MyoKardia, Inc.

Completed

A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction (PIONEER-HCM)

Cardiomyopathy, Hypertrophic Obstructive | Left Ventricular Outflow Tract Obstruction

United States
Centre Hospitalier Universitaire de Nīmes

Completed

Assessment of Agreement Between Two Measurement Methods of Left Ventricular Outflow Tract (LVOT) Velocity Time Integral (VTI) (AUTO-VTI)

Acute Circulatory Failure

France
Washington University School of Medicine

Terminated

Aortic Stenosis and PhosphodiEsterase Type 5 iNhibition (ASPEN): A Pilot Study (ASPEN)

Aortic Stenosis | LV Remodeling, Hypertrophy

United States
Washington University School of Medicine

Terminated

Aortic Stenosis and PhosphodiEsterase iNhibition With Aortic Valve Replacement (ASPEN-AVR): A Pilot Study (ASPEN-AVR)

Aortic Stenosis

United States
Umeå University

Completed

Volume-challenge in Morbid Obesity

Anomaly; Venous Return

Sweden
Universitair Ziekenhuis Brussel

Recruiting

Pharmacokinetics of Inhaled Levosimendan (Symbiov)

Left Ventricular Dysfunction

Belgium
Steen Hvitfeldt Poulsen

Recruiting

Dobutamine Stress Echocardiography in LF/LG Aortic Stenosis and Wild-type Transthyretin Amyloid Cardiomyopathy (DobAttrAS)

Aortic Stenosis | Transthyretin Amyloid Cardiomyopathy

Denmark
Second Affiliated Hospital of Wenzhou Medical University

Recruiting

"Right Ventricular Outflow Tract Posterior Septum Pacing" in Predicting Ventricular Outflow Tract Ventricular Tachycardia Origin

Ventricular Outflow Tract Ventricular Arrhythmias | Radio Frequency Catheter Ablation

China
University of Zurich
ETH Zurich

Recruiting

Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA and MINOCA-mimics (COPE-CMR)

Non ST Elevation Myocardial Infarction | Myocarditis Acute | Takotsubo Cardiomyopathy | Spontaneous Coronary Artery Dissection | Myocardial Infarction With Non-Obstructive Coronary Artery

Switzerland
Zoll Medical Corporation

Recruiting

Central Sleep Apnea Prevalence and Impact on Cognitive Function in Patients With Heart Failure With Reduced or Mildly Reduced Left Ventricular Ejection Fraction (COG01)

Heart Failure | Central Sleep Apnea

Poland
Avicenna Military Hospital

Recruiting

Plethysmographic Perfusion Index and Fluid Responsiveness (PPI-FR)

Fluid Responsiveness

Morocco
National Heart, Lung, and Blood Institute (NHLBI)

Not yet recruiting

NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study

Aortic Valve Stenosis | Hypertrophic Cardiomyopathy | Mitral Valve Disease | Left Ventricular Septal Hypertrophy

United States
National Taiwan University Hospital
Shin Kong Wu Ho-Su Memorial Hospital

Not yet recruiting

Empagliflozin in Heart Failure With Reduced Ejection Fraction and End Stage Renal Disease (EMPA-RRED)

Heart Failure With Reduced Ejection Fraction | End Stage Renal Disease on Dialysis
Fifth Affiliated Hospital, Sun Yat-Sen University

Recruiting

Early Evaluation of Left Ventricular Systolic Function Impairment in Patients With Chronic Kidney Disease by Multimodal Ultrasonography

Chronic Kidney Diseases | Left Ventricular Systolic Dysfunction

China
Puzzle Medical Devices Inc.

Not yet recruiting

Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic Resistance

Heart Failure | Acute Decompensated Heart Failure | Heart Failure With Reduced Ejection Fraction | Heart Failure, Congestive | Heart Failure With Preserved Ejection Fraction | Cardiorenal Syndrome | Diuretic Resistance

Australia
University Hospital, Strasbourg, France

Recruiting

Dietary Sodium Intake in Children on Chronic Dialysis (PeDialysis)

Chronic Dialysis in Children

France
University Hospital, Geneva
Stanislas Abrard; Noble Stéphane

Recruiting

Perioperative Hemodynamic and Microcirculatory Physiological Study During TAVI (TAVI)

Aortic Valve Stenosis

Switzerland
University Hospital of Ferrara

Recruiting

Analysis of Calcium Score of Severe Aortic Stenosis in Patients With and Without Cardiac Amyloidosis (CAUSATIVE Study) (CAUSATIVE)

Aortic Stenosis, Severe | Amyloidosis Cardiac

Italy
China National Center for Cardiovascular Diseases
Shanghai Children's Medical Center; Chinese Academy of Medical Sciences, Fuwai... and other collaborators

Recruiting

Study of Innovative Drug Strategies in Improving Left Ventricular Function After Mitral Repair

Congenital Mitral Insufficiency

China
Xiang Wei
Fudan University; Guangdong Provincial People's Hospital; Beijing Anzhen Hospital and other collaborators

Recruiting

Transapical Beating-Heart Septal Myectomy in Patient With Hypertrophic Obstructive Cardiomyopathy: a Multi-Center Study

Hypertrophic Obstructive Cardiomyopathy

China
University Medical Centre Ljubljana

Not yet recruiting

Conventional Versus Left Bundle Branch Pacing in TAVI

Heart Failure | Aortic Valve Stenosis | Pacemaker-Induced Cardiomyopathy | Transcatheter Aortic Valve Implantation

Slovenia
Venus MedTech (HangZhou) Inc.
TheraGenesis GmbH of Oppenheim, Germany; IQVIA MedTech BV of Antwerp, Belgium

Not yet recruiting

Observational Study of Venus P-Valve (Registry)

Right Ventricular Outflow Tract Dysfunction
Universitas Padjadjaran
National Research and Innovation Agency of Indonesia; Prodia Diacro Laboratories...

Recruiting

Effectiveness and Safety of Quinine Sulfate as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia ( DEAL-COVID19 ) (DEAL-COVID19)

COVID-19

Indonesia
Imperial College London
Royal Brompton & Harefield NHS Foundation Trust; St George's, University of... and other collaborators

Recruiting

Low QRS Voltages in Young Healthy Individuals and Athletes

Dilated Cardiomyopathy | Sudden Cardiac Death | Sudden Cardiac Death Due to Cardiac Arrhythmia | Sudden Cardiac Arrest | Arrhythmogenic Right Ventricular Cardiomyopathy | Arrhythmogenic Left Ventricular Cardiomyopathy

United Kingdom
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Prophylactic Frequent Premature Ventricular complexeS sUPPression on Left ventriculaR Function impairmEnt in aSymptomatic patientS (SUPPRESS)

Ventricular Dysfunction, Left | Premature Ventricular Contractions
Centro Cardiologico Monzino

Recruiting

Effects of Dapagliflozin on Cardiorespiratory Parameters in Heart Failure

Heart Failure | Sleep Apnea | Heart Failure With Reduced Ejection Fraction | Cardiopulmonary Exercise Test | Left Ventricle Remodeling

Italy
Assiut University

Not yet recruiting

PCO2 Gab Marker of Tissue Adequacy of Cardiac Output in Shock State

Shock
Medical University of Warsaw
Institute of Cardiology, Warsaw, Poland; Medical University of Lodz; Medical... and other collaborators

Recruiting

Polish Transcatheter Transfemoral Mitral Valve-in-Valve Implantation (Mitral ViV) Registry

Heart Failure | Mitral Insufficiency | Mitral Stenosis | Mitral Stenosis With Insufficiency | Bioprosthesis Failure

Poland
Valentina Puentmann
Bayer; Alcedis GmbH

Recruiting

Myocardial Protection in Patients With Post-acute Inflammatory Cardiac Involvement Due to COVID-19 (MYOFLAME-19)

Microvascular Angina | Left Ventricular Dysfunction | Vascular Inflammation | Exercise Intolerance | Remodeling, Left Ventricle | Remodeling, Vascular | COVID-19 Associated Cardiac Involvement

Germany, Austria
Main Line Health
Medtronic; Sharpe-Strumia Research Foundation

Recruiting

Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)

Aortic Valve Stenosis | Complete Heart Block | High Degree Second Degree Atrioventricular Block | Pacemaker-Induced Cardiomyopathy

United States
PECA Labs

Recruiting

MASA Valve Early Feasibility Study (MVEFS)

Transposition of Great Vessels | Pulmonary Atresia | Pulmonary Stenosis | Tetrology of Fallot | Truncus Arteriosus | Ross Procedure

United States
Queen Silvia Children's Hospital, Gothenburg, Sweden
Sahlgrenska University Hospital, Sweden; Swedish Heart Lung Foundation

Recruiting

Effect of Fetal Aortic Valvuloplasty on Outcomes (FASSprosp)

Aortic Valve Stenosis | Congenital Heart Disease | Hypoplastic Left Heart Syndrome | Fetal Cardiac Disorder

United States, Austria, Canada, Finland, Germany, Poland, Spain, Sweden

Search clinical trials for: Symptomatic, left ventricular outflow tract gradient

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