Search clinical trials for: TLR7 agonist

Total 14261 results

Hoffmann-La Roche

Completed

A Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonist) In Participants With Unresectable Advanced Or Metastatic Hepatocellular Carcinoma, Biliary Tract Cancer, Or Solid Tumors With Hepatic Metastases

Carcinoma, Hepatocellular | Liver Metastases | Biliary Tract Cancer | Secondary Liver Cancer

Korea, Republic of, Denmark, Spain, Taiwan, United States, Hong Kong
National Institute of Allergy and Infectious Diseases...
Gilead Sciences; University of Oxford

Recruiting

Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1

HIV-1-infection

United States, Brazil
Aelix Therapeutics
Gilead Sciences

Completed

Safety, Tolerability and Immunogenicity of MVA.HTI and ChAdOx1.HTI With Vesatolimod in HIV-1 Positive Patients (AELIX-003)

HIV/AIDS

Spain
Global Health Drug Discovery Institute
CMAX Clinical Research Pty Limited; Avance Clinical

Completed

SAD Study of APR002 Investigating the Safety/Tolerability, Pharmacokinetics/Pharmacodynamics in Healthy Subjects

COVID-19

Australia
CanWell Pharma Inc.

Recruiting

Intratumoral CAN1012(Selective TLR7 Agonist) in Subjects With Solid Tumors

Solid Tumor | Cancer Metastatic

United States
GlaxoSmithKline

Completed

Effect of the GSK2245035 on the Allergen-induced Asthmatic Response

Asthma

United Kingdom, Germany
Novartis Pharmaceuticals

Completed

Study to Determine Safety and Dose of NJH395 in Non-breast HER2+ Advanced Cancer

NON-breast HER2+ Malignancies

United States, Italy, Korea, Republic of, Japan
Federico II University

Completed

INF-α Innate Immune Response to Gliadin

Celiac Disease

Italy
Canwell Biotech Limited

Recruiting

Intratumoral CAN1012(Selective TLR7 Agonist) in Subjects With Solid Tumors

Solid Tumor

China
Ascendis Pharma Oncology Division A/S

Recruiting

A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors

Advanced Solid Tumor | Metastatic Solid Tumor | Locally Advanced Solid Tumor | Neoadjuvant Melanoma | Head and Neck Squamous Cell Carcinoma HNSCC | HPV-associated Cancers | Neoadjuvant Cutaneous Squamous Cell Carcinoma (cSCC)

United States, Australia, Spain, Netherlands, Korea, Republic of, Taiwan
Ascendis Pharma Oncology Division A/S

Recruiting

TransCon (TC) TLR7/8 Agonist, TC IL-2 β/γ, Pembrolizumab Prior to Surgery for Advanced Head and Neck Squamous Cell Carcinoma (BelieveIT-201)

Head and Neck Neoplasms

United States, Spain, Georgia, Hungary, Germany, Italy, Taiwan
Washington University School of Medicine

Completed

Biomarkers of Trained Immunity Following MMR Vaccination

Covid19

United States
GlaxoSmithKline

Completed

An Investigation of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2245035 in Healthy Volunteers and Allergic Rhinitics.

Rhinitis, Allergic, Seasonal

Netherlands
Ascendis Pharma Oncology Division A/S

Recruiting

A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or Chemotherapy or TransCon TLR7/8 Agonist in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies (IL Believe)

Advanced Solid Tumor | Metastatic Solid Tumor | Platinum-resistant Ovarian Cancer | Locally Advanced Solid Tumor | Post Anti-PD-1 Melanoma | 2L+ Cervical Cancer | Neoadjuvant Melanoma | Neoadjuvant Non-Small Cell Lung Cancer | Post Anti-PD-(L)1 Non-Small Cell Lung Cancer | Post Anti-PD-(L)1 Small Cell...

United States, Australia, Korea, Republic of
Chinese PLA General Hospital

Unknown

Study of SHR2150 (TLR7 Agonist) in Combination With Chemotherapy Plus PD-1 or CD47 Antibody in Subjects With Unresectable/ Metastatic Solid Tumors

Solid Tumor

China
Hoffmann-La Roche

Active, not recruiting

A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B (Piranga)

Hepatitis B, Chronic

Taiwan, Canada, Korea, Republic of, Thailand, United Kingdom, China, United States, Bulgaria, Spain, New Zealand, Hong Kong, Romania, Chile, France
GlaxoSmithKline
PATH

Completed

A Study to Investigate the Safety and Pharmacodynamics of Repeat Intranasal Administration of the TLR7 Agonist GSK2245035 in Subjects With Respiratory Allergies

Asthma and Rhinitis

Canada
GlaxoSmithKline

Completed

To Investigate the Safety, Pharmacodynamics and Effect on Allergic Reactivity of the Toll-like Receptor 7 (TLR7) Agonist GSK2245035 in Subjects With Respiratory Allergies

Mild Asthma and Allergic Rhinitis

Canada
Nektar Therapeutics

Terminated

A Study of NKTR-262 in Combination With Bempegaldesleukin (NKTR-214) and With Bempegaldesleukin Plus Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumor Malignancies (REVEAL)

Melanoma | Sarcoma | Renal Cell Carcinoma | Colorectal Cancer | Triple Negative Breast Cancer | Head and Neck Squamous Cell Carcinoma | Merkel Cell Carcinoma

United States
Pfizer

Withdrawn

PF-07225570 Alone or in Combination With an Anti-PD-1 Antibody in Recurrent Non-muscle Invasive Bladder Cancer (NMIBC)

Bladder Cancer

Poland, United States
Bolt Biotherapeutics, Inc.
Bristol-Myers Squibb

Active, not recruiting

A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors

HER2-positive Breast Cancer | HER2-positive Colorectal Cancer | HER2-positive Solid Tumors | HER2-positive Gastroesophageal Cancer | HER2-positive Endometrial Cancer

France, United States, Spain, Korea, Republic of, Italy
Brigham and Women's Hospital
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

LIROH - Liraglutide for Obesity in HIV (LIROH)

HIV Infections | Obesity

South Africa
GlaxoSmithKline

Not yet recruiting

A Study to Compare the Relative Potency of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152a to HFA-134a in Mild Asthmatics Aged 18 to 65 Inclusive

Asthma | Mild Asthma
GlaxoSmithKline

Not yet recruiting

A Study to Compare the Pharmacokinetics (PK) of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152A (Test) or HFA-134A (Reference) in Healthy Participants Aged 18 to 55 Inclusive

Asthma | Healthy Participants

Netherlands
M.D. Anderson Cancer Center

Not yet recruiting

Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders

Systemic Sclerosis | Autoimmune Disorders

United States
Massachusetts General Hospital
Patient-Centered Outcomes Research Institute

Not yet recruiting

Sequential Multiple Assignment Randomized Trial for Bipolar Depression (SMART-BD)

Depression | Bipolar I Disorder

United States, Canada
Sir Run Run Shaw Hospital

Recruiting

Hetrombopag for the Thrombocytopenia Induced by Concurrent Chemoradiotherapy

Thrombocytopenia | Radiotherapy Side Effect

China
Washington University School of Medicine

Recruiting

Local Anesthesia for Facial Fractures (LAFF)

Pain Management

United States
University of KwaZulu

Not yet recruiting

Anti-Inflammatory Reliever South Africa (AIRSA001)

Asthma
IRCCS Policlinico S. Matteo
Federico II University; University of Roma La Sapienza

Recruiting

Effect of Fixed Combination Citicoline Homotaurine and Pyrroloquinoline Quinone on Pattern-electroretinogram in Glaucoma

Glaucoma | Neuroprotection

Italy
Henry M. Jackson Foundation for the Advancement...
Uniformed Services University of the Health Sciences; Brooke Army Medical Center

Not yet recruiting

Ketamine for Sedation in Severe Traumatic Brain Injury (Ketamine)

Intracranial Hypertension | Severe Traumatic Brain Injury | Intracranial Hemorrhage, Hypertensive
Ain Shams University

Not yet recruiting

The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.

Intraoperative Bleeding

Egypt
National Cancer Institute (NCI)

Not yet recruiting

Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapy

Pheochromocytoma | Somatostatin Receptor Positive | Paragangliomas | Gastrointestinal Neuroendocrine Tumors

United States
Universidad de Almeria
Leiden University Medical Center; ETH Zurich (Switzerland)

Not yet recruiting

Deciphering a Novel and Unique Brown Adipose Tissue Depot in Women (DEBATE)

Cardiometabolic Diseases

Spain
Celgene

Not yet recruiting

A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma (GOLSEEK-2)

Lymphoma, Follicular

United States, Australia, Brazil, Canada, Chile, France, Germany, Italy, Korea, Republic of, Poland, Spain, Taiwan, United Kingdom
Stanford University
American Heart Association

Not yet recruiting

Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries (MVP-ANOCA)

Angina Pectoris | Microvascular Angina | Vasospastic Angina | Myocardial Bridge of Coronary Artery

United States
Centre Hospitalier Universitaire de Nice

Not yet recruiting

Echocardiographic Measurement of Myocardial Work (MYOLOAD)

Intensive Care Unit Syndrome | Cardiovascular Physiological Phenomena

France
Bostal Drug Delivery Co., Ltd

Not yet recruiting

A Study to Evaluate Safety, Tolerability and pK of Semaglutide ER Injectable Suspension in Healthy, Adult Human Subjects

Diabetes Mellitus, Type 2
AstraZeneca
Premier HealthCare Solutions Inc.

Recruiting

Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care (ANCHOR)

Asthma

United States
Jens D Hove, MD,PHD

Recruiting

Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure (FIT-HF)

Obesity | Weight Loss | Chronic Heart Failure | Heart Failure With Reduced Ejection Fraction

Denmark
Benha University

Recruiting

Articaine Plus Dexmedetomidine in Supraclavicular Block

Post Operative Pain, Acute

Egypt
Yanyan Liu

Recruiting

Linperlisib Combined With Chidamide in Patients With PTCL

Peripheral T-cell Lymphoma

China
Icahn School of Medicine at Mount Sinai

Not yet recruiting

Intrathecal Dexmedetomidine vs Epinephrine

Cesarean Section | Anesthesia, Spinal

United States
Acepodia Biotech, Inc.

Not yet recruiting

ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR)

Metastatic Solid Tumor | Locally Advanced Solid Tumor

United States
Anqing Municipal Hospital

Recruiting

The Effect of Dexmedetomidine and Esketamine Combined Infusion Quality of Sleep Undergoing Modified Radical Mastectomy

Dexmedetomidine Plus Esketamine Affect Postoperative Sleep Quality

China
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Not yet recruiting

Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation

Obesity

United States
Theodor Bilharz Research Institute

Recruiting

The Effects of Different Loading Doses of Dexmedetomidine on The Bispectral Index-Guided Propofol Sedation in Patients Undergoing Advanced Upper Gastrointestinal Endoscopic Procedures: A Randomized Control Study

Procedural Sedation | GIT Endoscopy

Egypt
Fujian Provincial Hospital
Fujian Maternity and Child Health Hospital; Fujian Children's Hospital

Not yet recruiting

Intranasal Dexmedetomidine Versus Oral Midazolam Premedication for Postoperative Negative Behavior Changes in Children

Behavior Problem
Kite, A Gilead Company
Arcellx, Inc.

Not yet recruiting

A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma (iMMagine-3)

Multiple Myeloma
Axsome Therapeutics, Inc.

Recruiting

Elucidating TAAR-1, Dopamine, and Norepinephrine in Binge Eating Disorder Using Solriamfetol (ENGAGE)

Binge-Eating Disorder

United States

Search clinical trials for: TLR7 agonist

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