Intratumoral CAN1012(selective TLR7 Agonist) in Subjects with Solid Tumors

A Phase 1, Dose Escalation, Open-Label Study of Intratumoral CAN1012 in Subjects with Unresectable or Metastatic Advanced Solid Tumors

To evaluate CAN1012 when administered by IT injection to subjects with advanced solid tumors who are not candidates for standard therapy.

Study Overview

• Status: Active, not recruiting
• Conditions: Solid Tumor
• Intervention / Treatment: Drug: CAN1012

• Study Type: Interventional
• Enrollment (Actual): 27
• Phase: Phase 1

Contacts and Locations

Study Locations

• China
  • Guangdong
    • Guangzhou, Guangdong, China, 510535
      • Canwell Biotech Limited

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Male or female age >18 years at screening.
2. Metastatic or locally advanced solid tumor that has progressed on, is refractory to, or for which there is no efficacious standard of care therapy.
3. At least one measurable lesion (RECIST 1.1)
4. At least one lesion that can receive intratumor injection multiple times
5. Performance status of 0 or 1 on the ECOG Performance Scale.
6. Life expectancy >12 weeks at Baseline.

7. Demonstrate adequate organ function as defined below. All screening laboratory assessments should be performed within 14 days of treatment initiation and include the following:

   1. Absolute neutrophil count (ANC) >=1.5 × 10^9/L； Platelets >=100 × 10^9/L；Hemoglobin >=9 g/dL;
   2. Measured or calculated creatinine clearance (CrCl) >=60 mL/min;
   3. Total bilirubin ≤1.5 × ULN OR direct bilirubin ≤ULN for subjects with total bilirubin levels > 1.5× ULN； Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 × ULN OR ≤5 × ULN for subjects with liver metastases."
8. Women of childbearing potential must have negative serum pregnancy test within 3 days prior to receiving the first study drug administration.For women of childbearing potential, must be willing to use an adequate method of contraception from 30 days prior to the first study drug administration and 120 days following last day of study drug administration.Male subjects of childbearing potential must be surgically sterile or must agree to use adequate method of contraception during the study and at least 120 days following the last day of study drug administration.
9. Able and willing to provide written informed consent and willing to comply with the study's requirements.

Exclusion Criteria:

1. Have a history of allergies in the past, and known to be allergic to CAN1012 injection or any of its components.
2. Have received TLR7/8 agonists in the past (except for topical dermal medications).
3. A history of another malignancy within the past 3 years that is progressing or requires active treatment. Exceptions include basal cell carcinoma of the skin, squamous cell carcinoma of the skin that has undergone curative therapy, or in situ cervical cancer.

"4. Unstable/inadequate cardiac function defined as follows:

1. New York Heart Association Class 3 or 4 congestive heart failure
2. uncontrolled hypertension
3. acute coronary syndrome within 6 months
4. clinical important cardiac arrhythmia

5. mean corrected QT (QTc) interval corrected for heart rate > 450 msec (m) or > 470 msec (md)." 5. Has known active infection with the human immunodeficiency virus, Hepatitis B(e.g., hepatitis B surface antigen [HBsAg] reactive) or Hepatitis C (e.g., hepatitis C virus [HCV] ribonucleic acid [qualitative] is detected), or active coronavirus disease 2019(COVID-19) infection. Note: Subjects who have been vaccinated against Hepatitis B and who are positive only for the Hepatitis B surface antibody are permitted to participate inthe study.

   6. Participated in a clinical study of an investigational agent within 4 weeks of screening.

   7. Have received chemotherapy, radiotherapy, biological therapy, endocrine therapy, targeted therapy, immunotherapy and other anti-tumor therapy within 4 weeks before the first administration of the research drug [among them, the following provisions are: nitrosourea (such as carmustine, lomustine, etc.) or mitomycin C is within 6 weeks before the first administration of the research drug; Oral fluorouracil, small molecule targeted drugs are 5 half-lives (whichever is longer) for 2 weeks before the first administration of the study drug or the known drug; Traditional Chinese medicines with antitumor indications are within 2 weeks before the first administration of the study drug].

   8. Has an active infection requiring systemic therapy within 4 weeks before the first dose of the drug under study, including but not limited to complications of infection that require hospitalization, bacteremia, severe pneumonia, etc.

   9. Patients with symptoms or who have undergone radiation therapy or surgery within 3 months prior to the first administration of the study (those with brain metastases and instability shall not be included).

   10. Injections of primary or metastatic lesions should be avoided in the central nervous system, thoracic cavity, heart and large blood vessels, liver, lungs, spleen and pancreas.

   11. Unresolved toxicities from prior therapy, defined as having not resolved to Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 (v5.0) Grade 0 or 1, with exception of endocrinopathies from prior therapy, alopecia, and vitiligo.

   12. Treatment with systemic corticosteroids at doses exceeding 10 mg/day prednisone or equivalent.

   13. Uncontrolled concurrent illness 14. Patients with clinically significant lung diseases in the past, including but not limited to interstitial lung disease, pulmonary fibrosis and severe radiation pneumonitis.

   15. A history of coagulopathy resulting in uncontrolled bleeding or other bleeding disorders.

   16. Concomitant or planned use of sensitive substrates of major cytochrome P450 enzymes (see Appendix 4).

   17. Has known psychiatric, substance abuse, or other disorders that would interfere with cooperation with the requirements of the study in the opinion of the investigator.

   18. Persons with a known history of alcohol or drug dependence. 19. Is pregnant or breastfeeding. 20. The investigator believes that the subject is unsuitable for other reasons to participate in this clinical trial.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: CAN1012; CAN1012 intratumoral injection given alone	Drug: CAN1012; CAN1012 IT injection (once every 4 weeks)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Tolerability as determined by assessment of the maximum tolerated dose or maximal assessed dose per protocol of CAN 1012 with cancers.	Tolerability as determined by assessment of the maximum tolerated dose or maximal assessed dose per protocol of CAN 1012 with cancers.	12 months
Recommended Phase 2 Dose (RP2D)	To determine a recommended phase 2 dose of CAN1012 for further development by evaluating number of patients with treatment-related adverse events as assessed by the Common Terminology Criteria for Adverse Events version 5.0 (CTCAE 5.0)	12 months
Maximum Tolerated Dose (MTD)	Determine the maximum tolerated dose by assessing the Incidence of Dose Limiting Toxicities (DLTs), treatment emergent and treatment related adverse events (assessed by CTCAE 5.0).	12 months
PK characterization - Cmax	Maximum observed plasma and tumor concentration of CAN1012 after IT administration.	12 months
PK characterization - tmax	Time to reach maximum plasma and tumor concentration of CAN1012 after IT administration.	12 months
tumor size in injected lesions and non-injected lesions	Changes in tumor size using computed tomography (CT) scan or magnetic resonance imaging (MRI) scan assessment based on Response Evaluation Criteria in Solid Tumors (RECIST) v1.1	12 months
Safety as determined by assessment of dose limiting toxicities per protocol of CAN1012 with cancers.	Safety as determined by assessment of dose limiting toxicities per protocol of CAN1012 with cancers.	12 months

Collaborators and Investigators

• Sponsor: Canwell Biotech Limited

Study record dates

Study Major Dates

• Study Start (Actual): September 9, 2022
• Primary Completion (Estimated): June 30, 2025
• Study Completion (Estimated): June 30, 2025

Study Registration Dates

• First Submitted: October 10, 2022
• First Submitted That Met QC Criteria: October 13, 2022
• First Posted (Actual): October 14, 2022

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: February 12, 2025
• Last Verified: February 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms
• Other Study ID Numbers: KW-CAN1012-101

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No