Search clinical trials for: Target engagement

Total 5275 results

NeuroSense Therapeutics Ltd.

Recruiting

A Phase 2, Randomized, Prospective Double-Blind, Single-Center, Placebo-controlled Study to Evaluate Safety, Tolerability, Target Engagement, and Efficacy of PrimeC in Patients With Mild to Moderate Alzheimer's Disease. (RoAD)

Alzheimer Disease

Israel
Homerton University Hospital NHS Foundation Trust

Recruiting

Fathers and Partners in Family Integrated Care Study (TARGET)

Premature Birth | Mental Health Wellness 1

United Kingdom
Matthew Southward
National Institute of Mental Health (NIMH)

Recruiting

A Precision Medicine Approach to Target Engagement for Emotion Regulation

Depression | Obsessive-Compulsive Disorder | Anxiety | Borderline Personality Disorder | Posttraumatic Stress Disorder | Eating Disorders | Emotional Regulation

United States
Oregon Health and Science University
Alzheimer's Association

Recruiting

Safety and Target Engagement of Centella Asiatica in Cognitive Impairment

Mild Cognitive Impairment | Alzheimer's Disease

United States
University of Maryland, Baltimore
University of California, Los Angeles; Stanley Medical Research Institute

Recruiting

Luteolin for the Treatment of People With Schizophrenia

Schizophrenia | Schizoaffective Disorder

United States
Eisai Inc.

Recruiting

A Study to Assess Safety and Target Engagement of E2814 in Participants With Mild to Moderate Cognitive Impairment Due to Dominantly Inherited Alzheimer's Disease

Alzheimer Disease

United States, United Kingdom
Amgen

Recruiting

Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

Prostate Cancer

Japan, United States, Korea, Republic of, Taiwan, Australia, Spain, Germany, Switzerland, Portugal, China
Stanford University
National Institute of Mental Health (NIMH)

Recruiting

Target Engagement of a Novel Dissonance-Based Treatment for DSM-5 Eating Disorders

Eating Disorder

United States
Oakland University
National Institute on Minority Health and Health Disparities (NIMHD); National...

Active, not recruiting

Colorectal Cancer Screening Intervention Study

Colorectal Cancer

United States
New York State Psychiatric Institute
National Institute of Mental Health (NIMH)

Withdrawn

Multimodal Assessment of Cannabinoid Target Engagement in Adults With Obsessive-Compulsive Disorder

Obsessive-Compulsive Disorder

United States
Baylor College of Medicine
Brown University; University of Iowa; University of Texas

Completed

Targeting HIV Retention and Improved Viral Load Through Engagement ('THRIVE')

Depression | Anxiety | Human Immunodeficiency Virus

United States
GlaxoSmithKline

Completed

A Safety, Tolerability, Pharmacokinetics (PK) and Target Engagement (TE) Study of GSK3858279 in Healthy Participants and Evaluation of the Efficacy of Repeat Doses in Participants With Osteoarthritis (OA)

Pain, Inflammatory

United Kingdom, Germany, Poland
University of California, Los Angeles
National Institute of Mental Health (NIMH)

Active, not recruiting

Target Engagement and Response to Oxytocin

Schizophrenia

United States
University of Iowa
Michael J. Fox Foundation for Parkinson's Research

Active, not recruiting

Target Engagement of Terazosin in Healthy Adults

Healthy

United States
New York State Psychiatric Institute
National Institute of Mental Health (NIMH)

Active, not recruiting

Glutamatergic Mechanisms of Psychosis and Target Engagement (SA1)

Healthy

United States
GlaxoSmithKline

Completed

Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK3858279 in Healthy Caucasian, Chinese and Japanese Participants

Pain

Australia
Institut de Recherches Internationales Servier
ADIR, a Servier Group company

Completed

Vascular Function and Biomarker Assessments in Healthy Volunteers and in Patients With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

Germany
University of California, Davis
National Institute of Mental Health (NIMH)

Terminated

Reducing Duration of Untreated Psychosis Through Rapid Identification and Engagement (DUP)

Psychotic Disorders

United States
University of Michigan

Completed

Crossover Target Engagement Study of Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease (Project #3 - Experiment 3 [UdallP3E3]) (UdallP3E3)

Parkinson's Disease

United States
VA Greater Los Angeles Healthcare System

Completed

Target Engagement of the Early Auditory Processing Network by Transcranial Direct Current Stimulation (tDCS)

Schizophrenia
Utrecht University
Research institute Brainclinics

Completed

Neuro-Cardiac-Guided Transcranial Magnetic Stimulation: Replication and Dose-response.

Major Depressive Disorder

Netherlands
University of California, Los Angeles

Completed

Target Engagement for Oxytocin: Dose Ranging Study (R21Dose)

Schizophrenia Spectrum
VHsquared Ltd.

Completed

Open-label V565 Target Engagement Study

Ulcerative Colitis

United Kingdom
New York State Psychiatric Institute
National Institute of Mental Health (NIMH)

Completed

Biomarker Assessment of Glutamatergic Target Engagement

Healthy Controls

United States
Bristol-Myers Squibb

Completed

Study to Evaluate the Safety, Pharmacokinetics and Target Engagement of BMS-986142 in Healthy Subjects

Healthy Adult

United States
Bristol-Myers Squibb

Completed

A Single and Multiple Ascending Dose Study to Evaluate the Safety, Pharmacokinetics, and Target Engagement of BMS-986147 in Healthy Subjects

Healthy

United States
Hua Zhu

Not yet recruiting

Research on Early Diagnosis and Clinical Transformation of Nuclide Probe Based on Bioorthogonal-gastric Cancer Mucin Target Visualization

Solid Tumor

China
Osamu Ukimura

Recruiting

Targeted Microwave Tissue Coagulation for Prostate Cancer (MicroPro2)

Prostate Cancer

Japan
Institute of Automation, Chinese Academy of Sciences

Recruiting

Study of VEGF-A Targeting NIR-II Fluorescence Endoscopy in the Gastrointestinal Tract

Dysplasia | Gastrointestinal Polyp | Gastrointestinal Carcinoma

China
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical...

Recruiting

Low-potassium Content Vegetables in Chronic Kidney Disease (LPV in CKD)

the Recommended Target of Daily Vegetables Intake | Risk of Hyperkalemia

Taiwan
Duke University

Not yet recruiting

Hospital-to Home Care Care Transition Interventions (H2H-CTI) Children/Youth With Special Health Care Needs (CYSHCN) (H2H-CYSHCN)

Pediatrics | Health Care | Comparative Effectiveness | Transitional Care | Family Engagement
Essen Biotech

Not yet recruiting

Sequential CAR-T Cells Targeting BCMA/CD19 in Patients With Relapsed/ Refractory Autoimmune Diseases (BAH247)

Autoimmune Diseases | Systemic Lupus Erythematosus | Sjogren's Syndrome | Systemic Lupus Erythematosus Acute

China
National Cancer Institute (NCI)

Not yet recruiting

Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapy

Pheochromocytoma | Somatostatin Receptor Positive | Paragangliomas | Gastrointestinal Neuroendocrine Tumors

United States
Imperial College London

Recruiting

Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment (DATATDM)

Pharmacokinetics | Drug-Related Side Effects and Adverse Reactions | Infections, Bacterial | Drug Monitoring

United Kingdom
Eye & ENT Hospital of Fudan University
The Eye Hospital of Wenzhou Medical University

Not yet recruiting

Targeting NUDT21 siRNA Drugs for Patients With Refractory Retinoblastoma

Retinoblastoma | Refractory
Stanford University
American Heart Association

Not yet recruiting

Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries (MVP-ANOCA)

Angina Pectoris | Microvascular Angina | Vasospastic Angina | Myocardial Bridge of Coronary Artery

United States
Cadence Neuroscience

Not yet recruiting

Biomarker Targeted Stimulation for Epileptiform Events (BTSEE)

Epilepsy
Beijing Cancer Prevention & Treatment Society
Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Recruiting

A Prospective, Multicenter, Non-interventional, Real-world Study to Characterize Changes in Molecular Markers After Three Weeks of Targeted Therapy With Oxitinib in EGFRm NSCLC (pre-FLAME)

Non Small Cell Lung Cancer

China
Hospital Italiano de Buenos Aires

Not yet recruiting

Mortality of MBL-producing Enterobacteriaceae Bacteremias With the Combined Use of Ceftazidime-avibactam and Aztreonam vs. Other Active Antibiotics. A Multicenter Target Trial Emulation.

Bacteremia
Institute of Liver and Biliary Sciences, India
Institute of Liver and Biliary Sciences

Recruiting

Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.

Liver Transplant Recipients

India
University Hospital Padova

Not yet recruiting

Can Needle Size Improve Cancer Detection Rate of Transperineal MRI Target Prostate Biopsy Without Affecting Side Effects? (TARGET)

Prostate Cancer Diagnosis
Essen Biotech

Not yet recruiting

Sequential CAR-T Cells Targeting CD33/CD123 in Patients With Acute Myelocytic Leukemia AML (BAH244)

Acute Myeloid Leukemia | AML | AML, Adult | AML, Adult Recurrent

China
Umm Al-Qura University

Recruiting

"Comparative Effect of Different Drugs Used to Tr€at Patients in Rheumatoid Arthritis Saudi Database (RASD)"

Rheumatoid Arthritis RA
Philip Combiths
National Institute on Deafness and Other Communication Disorders (NIDCD)

Not yet recruiting

Treatment Targets in Spanish and English Bilingual Speech Intervention

Speech Sound Disorder
PersonGen BioTherapeutics (Suzhou) Co., Ltd.

Not yet recruiting

Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases

Rheumatoid Arthritis | Systemic Lupus Erythematosus | Systemic Sclerosis | Immune Thrombocytopenia | Sjogren's Syndrome | Idiopathic Inflammatory Myopathies | Primary Biliary Cholangitis
IRCCS Ospedale San Raffaele

Not yet recruiting

Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies

Rare Diseases | Corneal Neovascularization | Limbal Stem Cell Deficiency | Aniridia | Neurotrophic Keratopathy | Ocular Cicatricial Pemphigoid | Ocular Graft-versus-host Disease | EEC Syndrome
Ainsworth Institute of Pain Management
Saluda Medical Pty Ltd

Recruiting

Targeting the Conus Medullaris With ECAP-Controlled Closed-Loop SCS for Treatment of Chronic Pelvic Pain: HOPE Trial

Pudendal Neuralgia | Chronic Pelvic Pain

United States
Nova Scotia Health Authority
Queen Elizabeth II Health Sciences Centre

Not yet recruiting

Evaluation of a Brief Intervention to Improve Engagement in Early Intervention Services for Psychosis

Psychotic Disorders | Engagement, Patient | Psychiatric Hospitalization

Canada
Jules Bordet Institute
RayzeBio, Inc.

Not yet recruiting

A Phase I Study to Assess the Tolerability of 225Ac-DOTATATE in Patients With Refractory and Relapsing Multiple Myeloma Expressing Somatostatin Receptors (AcTRESS)

Multiple Myeloma in Relapse | Multiple Myeloma, Refractory | Multiple Myeloma Progression

Belgium
University of Texas, El Paso
National Institute on Minority Health and Health Disparities (NIMHD)

Recruiting

Evidence-based Intervention to Improve Walking Engagement in El Paso, Texas

Physical Activity | Activity Trackers

United States

Search clinical trials for: Target engagement

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