Search clinical trials for: Targeted Therapeutic Effect

Total 157783 results

Jonsson Comprehensive Cancer Center

Not yet recruiting

A Vaccine (Neoantigen-Targeted ppDC) for the Treatment of H3 G34-mutant Diffuse Hemispheric Glioma

Diffuse Hemispheric Glioma, H3 G34-Mutant

United States
Juno Therapeutics, Inc., a Bristol-Myers Squibb...
Bristol-Myers Squibb Services Unlimited Company

Recruiting

A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases

Systemic Lupus Erythematosus | Systemic Sclerosis | Idiopathic Inflammatory Myopathy

United States, Belgium, France, Spain, Germany, Italy
Rennes University Hospital

Recruiting

Microsampling Approach for Monitoring of Kinase Inhibitor Targeted Therapies (MISTIK)

Blood Concentrations of Nine Anti-cancer Drugs : Axitinib, Olaparib, regorafénib, Cabozantinib, Niraparib, Talazoparib, Palbociclib, Abemaciclib, Tucatinib

France
Chinese University of Hong Kong

Recruiting

The Therapeutic Effect of Targeted Intrinsic Foot Muscles Exercises in Plantar Fasciitis

Pain | Plantar Fasciitis, Chronic

Hong Kong
Stanford University
United States Department of Defense

Recruiting

Umbrella Trial Testing Integrative Subtype Targeted Therapeutics in Estrogen Receptor Positive, HER2-Negative Breast Cancer

Breast Cancer | HER2-negative Breast Cancer | ER Positive Breast Cancer

United States
Second Affiliated Hospital, School of Medicine,...
Carbiogene Therapeutics Co. Ltd.

Recruiting

Novel BCMA-targeted CAR-T Cell Therapy for Multiple Myeloma

Relapsed or Refractory Multiple Myeloma

China
University of Maryland, Baltimore
United States Department of Defense; US Department of Veterans Affairs Cooperative... and other collaborators

Recruiting

Trial of Therapeutic Hypothermia in Patients With ARDS (CHILL)

Respiratory Distress Syndrome, Adult

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery

Hydronephrosis | Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant | Stage III Bladder Urothelial Carcinoma AJCC v6 and v7 | Stage III Renal Pelvis Cancer AJCC v7 | Stage III Ureter Cancer AJCC v7 | Stage III Urethral Cancer AJCC v7 | Stage IV Renal Pelvis Cancer AJCC v7 | Stage IV... and other conditions

United States
Memorial Sloan Kettering Cancer Center
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Active, not recruiting

BCMA Targeted CAR T Cells With or Without Lenalidomide for the Treatment of Multiple Myeloma

Multiple Myeloma

United States
Cairo University

Completed

Macular Perfusion Changes After Anti-VEGF Versus Targeted Retinal Photocoagulation in Proliferative Diabetic Retinopathy (PROPER)

Diabetic Retinopathy | Proliferative Diabetic Retinopathy | Vascular Endothelial Growth Factor Overexpression

Egypt
University of Colorado, Denver
Pfizer; Criterium, Inc.; Cascadian Therapeutics Inc.

Completed

Tucatinib, Palbociclib and Letrozole in Metastatic Hormone Receptor Positive and HER2-positive Breast Cancer

Breast Cancer

United States
National Cancer Institute (NCI)

Completed

MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations

Advanced Malignant Solid Neoplasm

United States
National Cancer Institute (NCI)

Completed

Mesothelin-Targeted Immunotoxin LMB-100 in Combination With Tofacitinib in Persons With Previously Treated Pancreatic Adenocarcinoma, Cholangiocarcinoma and Other Mesothelin Expressing Solid Tumors

Epithelioid Mesothelioma | Cholangiocarcinoma, Extrahepatic | Neoplasms With Mesothelin Expression | Adenocarcinoma, Pancreatic

United States
Allarity Therapeutics
Smerud Medical Research International AS; Lantern Pharma Inc.

Active, not recruiting

Irofulven in AR-targeted and Docetaxel-Pretreated mCRPC Patients With Drug Response Predictor (DRP®)

Metastatic Castration-Resistant Prostate Cancer Patients

Denmark
Ipsen

Terminated

Study to Evaluate the Safety and Preliminary Efficacy of 177Lu-OPS201 in NETs

Neuroendocrine Tumors

United States, Australia, Austria, Canada, Denmark, France, Switzerland, United Kingdom
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Treatment of Relapsed or Chemotherapy Refractory Chronic Lymphocytic Leukemia or Indolent B Cell Lymphoma Using Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19

Leukemia

United States
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Terminated

Targeted T Cells After Neoadjuvant Chemotherapy in Treating Women With Stage II or III Breast Cancer Undergoing Surgery

Breast Cancer

United States
Medicenna Therapeutics, Inc.

Completed

Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma

Glioblastoma | Glioblastoma Multiforme | Grade IV Astrocytoma | Grade IV Glioma

United States
National Cancer Institute (NCI)

Terminated

Marizomib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial, and Spinal Cord Ependymoma

Ependymoma | Anaplastic Ependymoma | Ependymomas

United States
Centre Hospitalier Departemental Vendee
Institut National de la Santé Et de la Recherche Médicale, France; University...

Completed

Impact of Speed Of Rewarming After CaRdiac Arrest and ThErapeutic Hypothermia (ISOCRATE)

Heart Arrest | Cardiac Arrest | Hypothermia

France
University of Utah

Completed

Early Prediction of Therapeutic Response to Targeted Therapy in Stage IIIB/IV or Recurrent Lung Cancer Patients

Cancer | Non Small Cell Lung Cancer

United States
Oslo University Hospital

Completed

Hypothermia After Cardiac Arrest - Effects on Myocardial Function and Inflammatory Response. (IH3)

Inflammatory Response | Hypothermia | Ischemia Reperfusion Injury | Out of Hospital Cardiac Arrest

Norway
University of California, San Diego

Completed

Pharmacologically-augmented Cognitive Therapies (PACTs) for Schizophrenia.

Schizophrenia

United States
National Cancer Institute (NCI)

Completed

Treatment of Castration Resistant Prostate Cancer Using Multi-Targeted Recombinant Ad5 PSA/MUC1/Brachyury Based Immunotherapy Vaccines

Prostatic Neoplasms | Prostatic Cancer

United States
University of Maryland, Baltimore

Withdrawn

Pilot RCT of Therapeutic Hypothermia Plus Neuromuscular Blockade in COVID-19 Patients With ARDS (CHILL-pilot)

Respiratory Distress Syndrome, Adult | Sars-CoV2

United States
Amsterdam UMC, location VUmc
VitrOmics BV

Terminated

Targeted Therapy Selection Based on Tumor Tissue Kinase Activity Profiles for Patients With Advanced Solid Malignancies, an Exploratory Study (TSAP)

Advanced Solid Tumors | Metastasis | Inoperable

Netherlands
Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University; Sun Yat-Sen Memorial Hospital...

Unknown

To Explore the Diversity of Intestinal Flora in Patients With Advanced HCC Combin ed With Anti-PD-1 and Targeted Drug Therapy and the Correlation Between Metabolites and Therapeutic Effect

Advanced Hepatocellular Carcinoma
Celldex Therapeutics

Terminated

A Study of Glembatumumab Vedotin as Monotherapy or in Combination With Immunotherapies in Patients With Advanced Melanoma

Melanoma

United States
Lille Catholic University
Allergan

Unknown

Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis (TOXART)

Joint Diseases | Magnetic Resonance Imaging | Knee | Therapeutics

France
Maastricht University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Completed

Peppermint Oil for the Treatment of Irritable Bowel Syndrome: Optimizing Therapeutic Strategies Using Targeted Delivery (PERSUADE)

Irritable Bowel Syndrome | Colonic Diseases, Functional | Abdominal Pain

Netherlands
Shahid Beheshti University of Medical Sciences

Unknown

Comparison of Therapeutic Effects Between Intravitreal Injection of Bevacizumab With Intravitreal Injection of Bevacizumab and Targeted Laser Photocoagulation of Non Perfused Areas of Retina in Patients With Acute Retinal Vein Occlusion (bevacizumab)

Retinal Vein Occlusion With Macular Edema

Iran, Islamic Republic of
Chinese University of Hong Kong

Completed

Can Targeted Elimination of B-cell Depletion Therapy and/or Combination Therapy on Systemic Lupus Erythematosus

Systemic Lupus Erythematosus

China
INSYS Therapeutics Inc

Completed

Histologic Effect/Safety of Pre/Post-Operative IL13-PE38QQR in Recurrent Resectable Supratentorial Malignant Glioma Patients

Glioblastoma Multiforme | Malignant Glioma | Anaplastic Astrocytoma | Mixed Oligoastrocytoma | Malignant Astrocytoma

United States
Assiut University

Recruiting

Investigating Microparticle Levels In Filtered Packed Red Blood Cell Units

Packed Red Cells Causing Adverse Effects in Therapeutic Use

Egypt
Muhammad Haroon Anwar
Pakistan Institute of Medical Sciences

Not yet recruiting

Perfusion Index as a Predictor of Hypotension Following Sub-arachnoid Block Among Patients Undergoing Lower Segment Caesarean Section

Hypotension | Spinal Anesthetics Causing Adverse Effects in Therapeutic Use | Hypotension on Induction

Pakistan
Cumhuriyet University

Recruiting

The Effect of Therapeutic Touch at Birth on Pain, Birth Duration, Traumatic Birth Perception and Anxiety

Pregnancy | Vaginal Delivery

Turkey
Dilek GÜRÇAYIR

Recruiting

The Effect of Therapeutic Touch Applied During Knee Replacement Surgery on Anxiety, Vital Signs and Comfort Level

Intraoperative Complications

Turkey
University of Pecs
Gyirmót Sport & Wellness Hotel

Not yet recruiting

Therapeutic Effect of the Natural Mineral Water of the Well B-308 OKK in Győr (Gyirmót) on Knee Osteoarthrosis

Knee Osteoarthritis

Hungary
Stanford University
American Heart Association

Not yet recruiting

Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries (MVP-ANOCA)

Angina Pectoris | Microvascular Angina | Vasospastic Angina | Myocardial Bridge of Coronary Artery

United States
Biohaven Therapeutics Ltd.

Not yet recruiting

A Study to Determine if BHV-7000 is Effective and Safe in Adults With Idiopathic Generalized Epilepsy With Generalized Tonic-clonic Seizures (SHINE)

Generalized Epilepsy

United States
Boston Medical Group

Recruiting

Effectiveness of Pelvic Floor Therapy for the Management of Erectile Dysfunction and Premature Ejaculation.

Erectile Dysfunction | Premature Ejaculation | Pelvic Floor; Weak | Premature (Early) Ejaculation

Colombia
Neurona Therapeutics

Not yet recruiting

Effect of NRTX-1001, a Cellular Therapy Product, for the Treatment of Refractory Bilateral TLE

Epilepsy, Temporal Lobe
Hospital Universitario 12 de Octubre

Not yet recruiting

Registry of Patients in Shock Treated With Vasopressin

Shock | Vasopressor Adverse Reaction | Vasopressin Causing Adverse Effects in Therapeutic Use | Vasopressin Deficiency

Spain
Istanbul University - Cerrahpasa (IUC)

Not yet recruiting

The Effect of Therapeutic Play on Anxiety and Fear Levels in Children With Diabetes

Type1diabetes | Anxiety State | Therapeutic Play | Fear State
VA Office of Research and Development

Not yet recruiting

Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression

Depression | Chronic Low Back Pain

United States
Umm Al-Qura University

Recruiting

"Comparative Effect of Different Drugs Used to Tr€at Patients in Rheumatoid Arthritis Saudi Database (RASD)"

Rheumatoid Arthritis RA
Axsome Therapeutics, Inc.

Recruiting

SUNOSI® (Solriamfetol) Pregnancy Registry

Obstructive Sleep Apnea | Narcolepsy | Pregnant Women and Their Offspring

United States
Osmaniye Korkut Ata University

Recruiting

The Effect of Foot Reflexology and Therapeutic Touch on Fatigue, Depression and Quality of Sexual Life in Women

Depression

Turkey
Sidney Kimmel Comprehensive Cancer Center at Johns...
Agenus Inc.; Private Philanthropic Funds

Not yet recruiting

KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal Cancer

Colorectal Cancer | Pancreatic Cancer

United States
Universidad de Granada

Not yet recruiting

Effects of Pain Neuroscience Education and Virtual Reality in Patients With Chronic Low Back Pain

Chronic Low-back Pain

Spain

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