Search clinical trials for: The efficacy and safety of intranasal dexmedetomidine

Total 489375 results

University of Arkansas

Not yet recruiting

Safety & Efficacy of Intranasal Dexmedetomidine, Fentanyl & Midazolam in the Pediatric Emergency Room

Pain | Anxiety | Acute Stress Disorder

United States
Xijing Hospital

Unknown

The Clinical Research of Intranasal Dexmedetomidine Used in Plastic Surgery of Children

The Efficacy and Safety of Intranasal Dexmedetomidine
Chongqing Medical University

Recruiting

Prospective Multicenter Observational Study and Promotion of the Application of Focused Ultrasound in Allergic Rhinitis

Allergic Rhinitis

China
Brigham and Women's Hospital

Not yet recruiting

Pilot Study 1: Efficacy and Safety of Sublingual Dexmedetomidine (BXCL501) for the Treatment of Agitation in the Emergency Department

Schizophrenia | Schizoaffective Disorder | Bipolar Disorder | Agitation | Schizophreniform Disorders
Chemi-Pharm AS

Recruiting

The Efficacy and Safety of BioBlock® Intranasally Administered Virus-Neutralizing Bovine Colostrum Nasal Spray in Preventing of COVID-19 (Coronavirus Disease-19) Infection in Healthy Volunteer Individuals

SARS CoV 2 Infection

Estonia
Advagene Biopharma Co. Ltd.
Gadjah Mada University

Recruiting

Evaluating the Safety and Efficacy of AD17002 Intranasal Spray in Treating Participants With Mild to Moderate COVID-19

COVID-19

Indonesia
King Abdullah International Medical Research Center

Recruiting

Prospective, Randomized, Open Label Controlled Trial To Evaluate The Safety And Efficacy Of Dexmedetomidine Use Beyond 24 Hours Compared With Midazolam In Children Admitted To Pediatric Intensive Care Unit at King Abdullah Specialist Children Hospital- Ministry of National Guard Health Affairs. (PROMISE)

Dexmedetomidine | Withdrawal Symptoms | Midazolam | Failure of Extubation

Saudi Arabia
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients (SEEDS)

Analgesia | Ketamine | Dexmedetomidine | Mechanical Ventilation | Intensive Care Units

China
University of Sao Paulo
Federal University of Paraíba

Recruiting

Efficacy and Safety of Dexmedetomidine in the Analgesic Prophylaxis , in Patients Undergoing Cardiovascular Surgery

Coronary Artery Disease | Pain | Valve Heart Disease | Cardiopathy

Brazil
BioXcel Therapeutics Inc
Cognitive Research Corporation

Recruiting

Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder

Schizophrenia | Bipolar Disorder I | Schizo-Affective Disorder | Schizophreniform; Schizophrenic | Bipolar Disorder II

United States
Second Affiliated Hospital, School of Medicine,...

Recruiting

A Randomized Single-blind Clinical Trial of the Efficacy and Safety of Remimazolam in Painless Bronchoscopy

Sedation | Bronchoscopy

China
Cristcot LLC
Cristcot HCA LLC

Recruiting

Phase 3 Study to Evaluate the Safety and Efficacy of Hydrocortisone Acetate Suppositories

Ulcerative Proctitis

United States, Georgia, Denmark, South Africa, Vietnam, Lebanon, Jordan, Saudi Arabia, Philippines, Poland, France, India, Romania, Bulgaria, Moldova, Republic of, Turkey
Xia Zhang

Recruiting

The Efficacy and Safety of Lower Limb Nerve Blocks in Postoperative Analgesia for the Free Flap Donor Sites

Pain, Post Operative | Elective Reconstructive Surgery

China
Shanghai Pharmaceuticals Holding Co., Ltd

Completed

Study to Evaluate the Efficacy and Safety of SPH3127 In Patients With Mild-moderate Essential Hypertension

Essential Hypertension

China
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression

Depressive Disorder, Treatment-Resistant

United States, China
Janssen Research & Development, LLC

Completed

Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for Suicide

Depressive Disorder, Major

United States, France, Italy, Spain, Hungary, Belgium, Brazil, Bulgaria, Poland
Intravacc B.V.
Novotech (Australia) Pty Limited

Completed

Safety and Efficacy of Intranasal Administration of Avacc 10 Vaccine Against COVID-19 in Healthy Volunteers (ITV2002)

COVID-19

Australia
Tonix Pharmaceuticals, Inc.
Premier

Completed

A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine (PREVENTION)

Chronic Migraine | Chronic Migraine, Headache | Chronic Migraine Without Aura | Aura Migraine

United States
Advagene Biopharma Co. Ltd.

Completed

Evaluating Safety, Tolerability, and Potential Efficacy of Intranasal AD17002 in Adults With Mild to Moderate COVID-19

COVID-19

Taiwan
Optinose US Inc.

Completed

Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis Without the Presence of Nasal Polyps

Chronic Rhinosinusitis

United States, Australia, Poland, New Zealand, Spain, Georgia, United Kingdom, Bulgaria, Czechia, Romania
University Hospital, Basel, Switzerland

Withdrawn

Compare the Efficacy and Safety of Intranasal Esketamine in Chronic Opioid Refractory Pain (IMPORTANCE)

Cancer Pain

Switzerland
Optinose US Inc.

Completed

Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps

Chronic Rhinosinusitis

United States, United Kingdom, Bulgaria, Canada, Georgia, Poland, Russian Federation, Sweden
BioXcel Therapeutics Inc
Cognitive Research Corporation

Terminated

An Efficacy, and Safety Study Of BXCL501 For The Treatment Of Agitation Associated With Dementia

Dementia | Agitation

United States
Pfizer

Completed

Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans

MRI Sedation

United States, Japan
Meissa Vaccines, Inc.
Hvivo

Completed

Human Challenge Study to Evaluate the Efficacy of MV-012-968 Vaccine

RSV Infection

United Kingdom
Takeda

Completed

A Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis (EARNEST)

Pouchitis

United States, Spain, United Kingdom, Canada, Germany, Netherlands, Italy, Belgium, France
UNION therapeutics

Terminated

Safety and Efficacy of Intranasal Administration of Niclosamide (UNI91103) in Adults With Asymptomatic or Mild COVID-19 (PREVENT)

Covid19

Germany
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression (TRANSFORM-3)

Depressive Disorder, Treatment-Resistant

United States, France, Belgium, Spain, Poland, Bulgaria, South Africa, Finland, Brazil, Sweden, United Kingdom, Lithuania
Janssen Research & Development, LLC

Completed

54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide (Aspire II)

Depressive Disorder, Major

United States, Belgium, Canada, Poland, France, Spain, Brazil, Lithuania, Czechia, Austria, Argentina, Turkey
Turn Therapeutics
Gorgas Memorial Institute for Health Studies; Hospital Santo Tomas; Hospital...

Completed

Safety and Efficacy of Intranasal Application of GX-03 as a Treatment and Prevention for COVID-19.

Covid19

Panama
Michigan State University

Completed

Safety and Efficacy of Combining Intranasal Insulin & Acute Exercise

Exercise | Insulin

United States
Pfizer
Maruishi Pharmaceutical

Completed

Clinical Study to Investigate the Efficacy and the Safety of DA-9501 in Sedation During the Surgery With Epidural Anesthesia or Spinal Anesthesia Without Intubation

Sedation

Japan
Ministry of Health, Turkey
Istanbul University; Ankara Training and Research Hospital; Prof. Dr. Cemil Tascıoglu... and other collaborators

Active, not recruiting

Efficacy and Safety of Hydroxychloroquine and Favipiravir in the Treatment of Mild to Moderate COVID-19

COVID-19 | Sars-CoV2

Turkey
Milestone Pharmaceuticals Inc.
Medpace, Inc.

Completed

Efficacy and Safety of Intranasal MSP-2017 (Etripamil) for the Conversion of PSVT to Sinus Rhythm (NODE-1)

Paroxysmal Supraventricular Tachycardia (PSVT)

United States, Canada
Janssen Research & Development, LLC

Completed

54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide (Aspire I)

Depressive Disorder, Major

United States, Korea, Republic of, Malaysia, Taiwan, Bulgaria, Spain, Hungary, Germany, Estonia, South Africa, Slovakia
Janssen Pharmaceutical K.K.

Completed

A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant Depression

Depression

Japan
Perseverance Research Center, LLC
Athena Medical Group

Unknown

Evaluate the Efficacy and Safety of Oral Hydroxychloroquine, Indomethacin and Zithromax in Subjects With Mild Symptoms of COVID-19 (COVID-19)

COVID-19

United States
Cairo University

Unknown

Efficacy and Safety of Anti HCV Drugs in the Treatment of COVID-19

COVID-19
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression (TRANSFORM-2)

Treatment-resistant Depression

United States, Poland, Germany, Spain, Czechia
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression (SYNAPSE)

Treatment Resistant Depressive Disorder

United States, Japan, Belgium
Janssen Research & Development, LLC

Completed

A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for Suicide

Major Depressive Disorder

United States
Jeff C. Huffman, MD
BioXcel Therapeutics Inc

Unknown

Dexmedetomidine Sublingual Film for the Management of Agitation in Delirium: Safety and Preliminary Efficacy

Delirium
Janssen Research & Development, LLC

Completed

A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression (SUSTAIN-2)

Treatment-resistant Depression

United States, Australia, France, United Kingdom, Belgium, Germany, Taiwan, Spain, Argentina, Mexico, Poland, Bulgaria, Malaysia, South Africa, Turkey, Finland, Korea, Republic of, Brazil, Austria, Sweden, Lithuania
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression (TRANSFORM-1)

Treatment-resistant Depression

United States, France, Belgium, Mexico, Canada, Brazil, Estonia, Hungary, Slovakia
Kythera Biopharmaceuticals

Completed

Safety Study of Deoxycholic Acid for the Reduction of Localized Subcutaneous Fat in the Submental Area in Subjects 65 to 75 Years of Age

Efficacy | Safety | Moderate to Severe Convexity of Submental Fat

United States
UCB Biopharma S.P.R.L.

Terminated

Study to Evaluate the Safety and Efficacy of USL261 (Intranasal Midazolam) in Patients With Seizure Clusters (ARTEMIS1)

Epilepsy

United States, Australia, Canada, Germany, Hungary, Israel, Italy, New Zealand, Poland, Spain, Ukraine
Novo Nordisk A/S

Completed

A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide and Insulin Degludec in Subjects With Type 2 Diabetes (DUAL™ II)

Diabetes Mellitus, Type 2 | Diabetes

United States, India, Denmark, Hungary, Slovenia, Switzerland, Bulgaria
Optinose US Inc.

Completed

Study Evaluating the Efficacy and Safety of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi Directional Device in Subjects With Bilateral Nasal Polyposis Followed by an 8-Week Open-Label Extension Phase to Assess Safety

Bilateral Nasal Polyposis

United States, Canada
Novo Nordisk A/S

Completed

A Trial Comparing the Efficacy and Safety of Liraglutide 1.8 mg/Day to Liraglutide 0.9 mg/Day in Japanese Subjects With Type 2 Diabetes Mellitus.

Diabetes Mellitus, Type 2 | Diabetes

Japan
Acerus Pharmaceuticals Corporation

Completed

Safety and Efficacy of Intranasal TBS-1 Treatment of Male Hypogonadism

Male Hypogonadism

United States

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