Search clinical trials for: Use of NGF injection as a model of non-inflammatory neuropathic pain in healthy subjects

Total 492907 results

Prof Herta Flor
Heidelberg University

Completed

Cortical Representation of Hyperalgesia Induced by Nerve Growth Factor (LOGIN_NGF)

Healthy Subjects | Non-inflammatory Neuropathic Pain

Germany
Aalborg University

Unknown

Exercise-induced Ischemia and the Influence of Pain Modulation in a Nerve Growth Factor (NGF) Model

Healthy Subjects | Hyperalgesia | Pain Response

Denmark
Aalborg University

Completed

Interaction Between NGF and Acute Exercise-induced Ischemia

Healthy Subjects | Hyperalgesia | Pain Response

Denmark
Aalborg University

Completed

Spread of Muscle Hyperalgesia and Pain in a Low Dose NGF-induced Pain Model

Healthy Subjects | Hyperalgesia

Denmark
Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Not yet recruiting

A Single Dose Escalation Study of HHT201 in Healthy Subjects

Alzheimer Disease

China
JMackem Co., Ltd
Seoul National University Hospital

Recruiting

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Oral Administration of AJH-2947 in Healthy Korean and/or Caucasian Adult Male Subjects

Diabetic Neuropathies | Neuropathic Pain | Post Herpetic Neuralgia

Korea, Republic of
University Hospital, Basel, Switzerland

Recruiting

Boosting Open-Label Placebo Effects in Acute Induced Pain in Healthy Adults (BOLPAP)

Acute Pain

Switzerland
Francesco Bono

Recruiting

BotulInum Toxin Type A for Peripheral Neuropathic Pain in subjEcts With Carpal Tunnel Syndrome (INjECT)

Pain | Carpal Tunnel Syndrome | Neuropathic Pain | Drug Use | Neurogenic Inflammation

Italy
Initiator Pharma

Not yet recruiting

Study to Investigate the Pharmacodynamic Effects of IP2015 in Healthy Male Subjects Using the Intradermal Capsaicin Model

Pain
Cedars-Sinai Medical Center

Recruiting

Development of Effective, Opioid Sparing Techniques for Peri-operative Pain Management of Transgender Patients Undergoing Gender Affirming Surgeries

Gender Dysphoria

United States
Weill Medical College of Cornell University
Genentech, Inc.

Recruiting

Polatuzumab Vedotin in Combination With Chemotherapy in Subjects With Richter's Transformation

Chronic Lymphocytic Leukemia | Richter Syndrome

United States
SWOG Cancer Research Network
National Cancer Institute (NCI)

Active, not recruiting

Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage III Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung Cancer AJCC v8 | Stage IIIC Lung Cancer AJCC v8 | Advanced Lung Non-Small Cell Carcinoma | Recurrent Lung Non-Small Cell Carcinoma

United States
Acasti Pharma Inc.

Active, not recruiting

Single-dose to Evaluate the Pharmacokinetics of GTX-101 and Subcutaneous Injectable Bupivacaine in Healthy Subjects

Postherpetic Neuralgia

Canada
Laboratoires Vivacy

Completed

Effectiveness and Safety of STYLAGE® M LIDOCAINE Versus STYLAGE® M in Filling Nasolabial Folds (MLIDOM)

Aging

France
Johns Hopkins University

Completed

Intra-operative Uterosacral Ligament Bupivacaine Injection During Minimally Invasive Hysterectomy

Pain, Postoperative | Opioid Use

United States
Boston University

Withdrawn

Articaine vs Lidocaine for Pediatric Dental Procedures

Pain, Postoperative | Anesthesia, Dental

United States
NYU Langone Health

Completed

Effects of a Surgical Site Injection on Pain Scores and Narcotic Use After Orthopaedic Trauma Surgery

Pertrochanteric Fracture

United States
H. Lundbeck A/S

Completed

A Single Dose Study of Lu AG09222 in a Headache Model With Healthy Subjects

Healthy

Denmark
University of California, San Francisco

Completed

Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial

Postoperative Pain | Thoracic Diseases | Opioid Use

United States
Pacira Pharmaceuticals, Inc

Terminated

Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section

Pain

United States
Universidad San Jorge

Completed

Temporal Relationship in Recovery of Muscular Pain and Functional Variables in an Experimental Muscular Pain Model in Hamstrings

Pain, Muscle

Spain
Aalborg University

Unknown

The Effect of Experimental Neck Pain in Healthy Participants

Healthy | Neck Pain

Denmark
Wake Forest University
National Institute of General Medical Sciences (NIGMS)

Terminated

Effect of Spinal Ketorolac After Acute Opioid Exposure

Healthy

United States
Biogen

Terminated

Effect of GSK1014802 on Electrical Hyperalgesia and Threshold Tracking in Healthy Subjects

Neuropathic Pain | Pain, Neuropathic
AstraZeneca

Completed

A Study to Assess the Bioavailability and to Compare the Pharmacokinetics of AZD7594 Inhaled Via Monodose Inhaler and Multiple-dose Dry Powder Inhalers (DPI) or Pressurized Metered-dose Inhaler (pMDI) in Healthy Male Subjects

Asthma | Chronic Obstructive Pulmonary Disease (COPD)

United States
Merck Sharp & Dohme LLC

Completed

Concomitant Use of Hepatitis A Vaccine, Inactivated With Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) and Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Given to Healthy Children 15 Months of Age (V251-068)

Hepatitis A Virus
University Hospital, Linkoeping

Completed

Prospective Randomized Trial of Fruits or Nuts Eaten Between Regular Meals in Healthy Subjects

Healthy Subjects

Sweden
IlDong Pharmaceutical Co Ltd

Completed

Study for Comparing The Pharmacokinetics of A Pregabalin Controlled Release Tablet 300mg With Immediate Release Formulation and to Assess the Effect of High Fat Diet in Healthy Male Subjects

Healthy
Thammasat University

Completed

The Efficacy of Periarticular Single Drug Compared With Multimodal Drug Injection in Controlling Pain After TKA (TKA)

Postoperative Pain

Thailand
Pfizer

Completed

Cold Pressor Test is Used in This Study to Assess the Effect of PF-06305591 on Pain Intensity Evoked by Cold in Healthy Male Subjects

Healthy

Belgium
Piramal Enterprises Limited

Terminated

Clinical Trial to Study the Safety Tolerability, Pharmacokinetics, Food Effect & Pharmacodynamics of a New Compound P7435 in Healthy, Overweight and/or Obese Subjects

Healthy, Overweight and/or Obese Subjects

India
Manhattan Eye, Ear & Throat Hospital
Genentech, Inc.

Completed

Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy (FVF4140S)

Polypoidal Choroidal Vasculopathy | Pseudoxanthoma Elasticum | Pathological Myopia | Retinal Angiomatous Proliferation | Coats' Disease | Idiopathic Retinal Telangiectasia | Multi-focal Choroiditis | Rubeosis Iridis | Von Hippel Lindau Disease | BEST VITELLIFORM MACULAR DYSTROPHY, MULTIFOCAL (Disorder)

United States
Medical University of Vienna

Completed

A Randomized, Placebo-controlled Study Investigating the Effects of Moxaverine on Ocular Blood Flow After Oral Administration in Healthy Subjects

Effect of Orally Administrated Moxaverine on Ocular Blood Flow

Austria
Shalvata Mental Health Center

Unknown

Chronic Cannabis Users: A Model for Negative Symptoms in Schizophrenia

Healthy Subjects | Chronic Cannabis Users

Israel
Creabilis SA
Aalborg University Hospital

Completed

A Study to Investigate the Pharmacodynamic Effects of CT327 on Intra-dermal Nerve Growth Factor (NGF) and Evoked Pain Responses, in Healthy Male Volunteers

Neuropathic Pain

Denmark
Fayoum University Hospital

Recruiting

Quality Of Recovery After Pericapsular Nerve Group (PENG) Block For Hip Hemiarthroplasty Under Spinal Anesthesia

Hip Hemiarthroplasty

Egypt
University of Hartford

Not yet recruiting

The Combined Effect of TENS and TaVNS on Pressure and Heat Pain Thresholds in Pain-Free Subjects

Healthy Volunteers

United States
Zhejiang Hanmai Pharmaceutical Technology Co.,...

Not yet recruiting

Multiple-Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of YJ001 for Spray Use in Patients With Diabetic Peripheral Neuropathic Pain

Diabetic Peripheral Neuropathic Pain

United States
Shandong Suncadia Medicine Co., Ltd.

Not yet recruiting

Effect of Verapamil Tablets on the Pharmacokinetic of HRS-1893 Tablets in Healthy Subjects

Obstructive Hypertrophic Cardiomyopathy
Foundation for Orthopaedic Research and Education
Pacira Pharmaceuticals, Inc

Not yet recruiting

Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion

Back Pain | Post Operative Pain | Physical Stress | Narcotic Use | Surgery-Complications

United States
Kristian Kjær Petersen

Recruiting

Exploration of Gait Biomechanics and Pain

Pain | Healthy

Denmark
Icahn School of Medicine at Mount Sinai

Recruiting

Erector Spinae Plane Block With Bupivacaine for Medical Thoracoscopy

Postoperative Pain | Pleural Disease

United States
Shanghai Henlius Biotech

Not yet recruiting

A Randomized, Single Intravenous Dose, Parallel Phase I Clinical Study to Compare the Pharmacokinetic Characteristics, Safety, and Immunogenicity of HLX05 Vs. Erbitux® (Cetuximab) in Healthy Adult Male Chinese Subjects

EGFR Overexpression
Rhode Island Hospital

Not yet recruiting

Ultrasound Guided Serratus Anterior Plane Block in ED Patients With Rib Fractures

Opioid Use | Rib Fractures | Regional Anesthesia | Pain Acute

United States
Kerry O'Rourke
Shriners Hospitals for Children

Not yet recruiting

Liposomal Bupivacaine Use in Alveolar Bone Graft Patients

Cleft Lip and Palate
Xi'an Xintong Pharmaceutical Research Co.,Ltd.

Recruiting

Safety, Tolerability Phase Ia Study of XT1061 in Single and Multiple Doses in Healthy Subjects (XT1061)

Chronic Hepatitis b

China
GEN İlaç ve Sağlık Ürünleri A.Ş.
Sulfateq B.V.

Recruiting

A First-In-Human Study of Single and Multiple Ascending Doses of Oral SUL-238 in Healthy Subjects

Healthy Subjects

Turkey
NeuroBo Pharmaceuticals Inc.

Recruiting

First in Human Study in Subjects With Obesity, But Otherwise Healthy

Obesity

United States
Rhythm Pharmaceuticals, Inc.

Recruiting

A Study of RM-718 in Healthy Subjects and in Patients With HO

Hypothalamic Obesity

United States
Peking University First Hospital

Recruiting

Liposomal vs. Conventional Bupivacaine for Pain Control

Analgesia | Paravertebral Block | Regional Block | Local Anesthetics

China

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