Temporal Relationship in Recovery of Muscular Pain and Functional Variables in an Experimental Muscular Pain Model in Hamstrings

Temporal Relationship in Recovery of Muscular Pain, Functional Variables and Normal Gait Pattern in an Experimental Muscular Pain Model in Hamstrings

Basal measurements are taken in relation to the study variables. Immediately subjects perform eccentric exercise on right hamstrings to develop delayed onset muscle soreness (DOMS).

Measurements of the study variables are taken in the same conditions 48, 96 and 168 hours after the exercise to study the evolution of the variables while recovering from DOMS.

Study Overview

• Status: Completed
• Conditions: Pain, Muscle

Detailed Description

Basal measurements are taken in relation to the study variables.

The variables are:

• pressure pain thresholds
• electromyography values
• static and dynamic plantar pressure measurement
• active knee extensibility
• maximal strength of knee flexors
• thermography
• scales of pain perception

Immediately subjects perform eccentric exercise on right hamstrings to develop DOMS (delay onset muscle soreness).

Measurements of the study variables are taken in the same conditions 48, 96 and 168 hours after the exercise to study the evolution of the variables while recovering from DOMS.

• Study Type: Observational
• Enrollment (Actual): 24

Contacts and Locations

Study Locations

• Spain
  • Zaragoza
    • Villanueva De Gállego, Zaragoza, Spain, 50830
      • Universidad San Jorge

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

• Sampling Method: Non-Probability Sample

Study Population

Non sedentary healthy men

Description

Inclusion Criteria:

• not sedentary subject (IPAQ scale > 600 MET)
• healthy subjects, without pain nor injury at the moment

Exclusion Criteria:

• subjects with acute or chronic pain on every spot of pelvis or lower limbs at the momento or for the last 3 months;
• subjects with history of severe injury in the hamstrings muscles;
• presence of serious illness;
• presence of pathologies in relation to chronic pain (as fibromyalgia, migraine disorders, non specific and chronic lumbar pain);
• not commitment for continuity in the study program;

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in spatio temporal parameters of gait	Changes in spatio temporal parameters of gait over a treadmill will be measurement using an optical measurement system consisting of a transmitting and receiving bar (OptoGait System).	Baseline, 48 hours, 96 hours, 1 week

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in Pressure Pain Thresholds	Changes in pressure pain thresholds (PPT) will be determined with pressure algometry bilaterally over the leg and shoulder. PPT is defined as the exact time point where the pressure is first being perceived at painful.	Baseline, 48 hours, 96 hours, 1 week
Changes in active knee extension test	Changes in range of motion (°; degrees) will be assessed in both sides using the active knee extension (AKE) test. AKE test: subject is lying prone with hip and knee flexed at 90°. Then, maximal knee extension is performed.	Baseline, 48 hours, 96 hours, 1 week
Changes in knee-flexors maximal isometric muscle strength	Changes in knee-flexors maximal isometric strength (Newton) will be assessed by using a hand-held dynamometer.	Baseline, 48 hours, 96 hours, 1 week
Electromyography (EMG) measurement during the tests	Electromyography values will be taken from hamstrings during the performance of gait analysis and dynamometry	Baseline, 48 hours, 96 hours, 1 week
Changes in thermography on hamstrings areas	A thermography image will be taken every day of assessment. Changes in colour pixels will be analysed to determine temperature changes.	Baseline, 48 hours, 96 hours, 1 week
Changes in static and dynamic plantar pressure measurement	Changes in static and dynamic plantar pressure measurement will be performed in every session by using a pressure platform.	Baseline, 48 hours, 96 hours, 1 week
Changes in subjective perception of pain and impairment: Two questionnaire (Modified 7-item Likert Scales)	Two questionnaires (Modified 7-item Likert Scales) are filled up by the subject to show subjective perception of pain related to movement along the recovery period. Scale of pain intensity, from 0 (no pain) to 6 (higher pain intensity). Scale of functional impairment, from 0 (no impairment) to 6 (higher impairment).	48 hours, 96 hours, 1 week

Collaborators and Investigators

• Sponsor: Universidad San Jorge
• Investigators: Study Director: Víctor Doménech, MSc, Universidad San Jorge

Study record dates

Study Major Dates

• Study Start (Actual): October 15, 2018
• Primary Completion (Actual): August 31, 2019
• Study Completion (Actual): August 31, 2019

Study Registration Dates

• First Submitted: May 6, 2019
• First Submitted That Met QC Criteria: May 7, 2019
• First Posted (Actual): May 8, 2019

Study Record Updates

• Last Update Posted (Actual): November 10, 2020
• Last Update Submitted That Met QC Criteria: November 9, 2020
• Last Verified: November 1, 2020

More Information

Terms related to this study

• Keywords: Healthy subjects; Electromyography; Gait analysis; Pressure pain thresholds; DOMS; Maximal strength; Plantar pressure measurement; Active Knee Extension test
• Additional Relevant MeSH Terms: Nervous System Diseases; Pain; Neurologic Manifestations; Musculoskeletal Diseases; Muscular Diseases; Neuromuscular Diseases; Musculoskeletal Pain; Myalgia
• Other Study ID Numbers: PI18/208

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: We don't plan to share data collected

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No