Search clinical trials for: Worsening Heart Failure

Total 78975 results

River 2 Renal Corp.
International HealthCare, LLC

Not yet recruiting

To Evaluate the Safety, Tolerability and Efficacy of R2R01 Combined With SOC as Compared to SOC Alone in Outpatients With Worsening Heart Failure (WHF)

Heart Failure | Worsening Heart Failure (WHF)

United States
Duke University

Recruiting

Effectiveness of Outpatient Intravenous Diuretic Therapy for Treatment of Worsening Heart Failure (OUTPATIENT-WHF)

Heart Failure

United States
Bayer

Recruiting

A Study to Learn How Well the Drug Vericiguat Works and How Safe it is Under Real World Conditions in Indian Participants After Worsening of a Long-term Heart Condition in Which the Left Side of the Heart Does Not Pump Blood as Well as it Should (Chronic Heart Failure With Reduced Ejection Fraction)

Chronic Heart Failure With Reduced Ejection Fraction | Worsening Heart Failure

India
Eli Lilly and Company

Recruiting

A Study of LY3540378 in Participants With Worsening Chronic Heart Failure With Preserved Ejection Fraction (HFpEF)

Heart Failure | Heart Failure With Preserved Ejection Fraction

Spain, United States, Japan, United Kingdom, Czechia, Hungary, Israel, Brazil, Argentina, Canada, Poland, Turkey
Help Therapeutics
Central South University

Recruiting

Allogeneic iPSC-derived Cardiomyocyte Therapy in Patients With Worsening Ischemic Heart Failure

Chronic Heart Failure | Ischemic Heart Failure

China
Nuwellis, Inc.

Recruiting

Ultrafiltration Versus IV Diuretics in Worsening Heart Failure (REVERSE-HF)

Heart Failure (for Example, Fluid Overload)

United States
Gia Dinh People Hospital
Otsuka Pharmaceutical Vietnam

Recruiting

Tolvaptan add-on Therapy to Overcome Loop Diuretic Resistance in Acute Heart Failure With Renal Dysfunction (DR-AHF)

Acute Heart Failure

Vietnam
University of Parma
Azienda Ospedaliero-Universitaria di Parma; Azienda Unità Sanitaria Locale... and other collaborators

Not yet recruiting

Safety and Efficacy of Early, seQUential Oral dIuretic Nephron blockAde In Acute Heart Failure (SEEQUOIA-AHF)

Acute Heart Failure

Italy
Bayer

Active, not recruiting

Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40% (FINEARTS-HF)

Heart Failure

United States, Spain, Denmark, Korea, Republic of, Taiwan, Australia, Hong Kong, Russian Federation, Israel, Canada, Malaysia, United Kingdom, Latvia, Netherlands, Japan, Brazil, China, Lithuania, Poland, Turkey, Italy, Austria, Bul... and more
Corteria Pharmaceuticals

Completed

Multiparametric Assessment of Cardiac Congestion in Outpatient Worsening Heart Failure (EVOLUTION)

Heart Failure | Heart Decompensation

Armenia, Bosnia and Herzegovina
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of LCZ696 in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction (PARALLEL-HF)

Heart Failure With Reduced Ejection Fraction (HF-rEF)

Japan
Saga University

Active, not recruiting

Program of Angiotensin-Neprilysin Inhibition in Admitted Patients With Worsening Heart Failure (PREMIER)

Heart Failure

Japan
University of Michigan
National Institute on Aging (NIA)

Terminated

A Mobile Application to Promote Self-management and Improve Outcomes in Heart Failure

Heart Failure

United States
Novartis Pharmaceuticals

Completed

Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF)

Heart Failure With Preserved Ejection Fraction (HFpEF)

United States, Canada
Lexicon Pharmaceuticals
Sanofi

Terminated

Effect of Sotagliflozin on Cardiovascular Events in Participants With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial)

Heart Failure | Type 2 Diabetes Mellitus

Belgium, Canada, Israel, Spain, Germany, Argentina, Chile, Hungary, Korea, Republic of, Latvia, Lithuania, Russian Federation, Sweden, Romania, Poland, Brazil, Denmark, United States, Australia, Austria, Czechia, Finland, France, Greece, Ita... and more
Bodyport Inc.
Duke Clinical Research Institute

Active, not recruiting

Surveillance and Alert-based Multiparameter Monitoring to Reduce Worsening Heart Failure Events (SCALE-HF 1)

Heart Failure

United States
University of North Carolina, Chapel Hill
Otsuka America Pharmaceutical

Completed

Tolvaptan For Worsening Outpatient Heart Failure: Role of Copeptin In Identifying Responders (TROUPER)

Congestive Heart Failure

United States
Bayer

Completed

A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution

Chronic Kidney Disease | Worsening Chronic Heart Failure

Germany
University of Pennsylvania
Merck Sharp & Dohme LLC

Completed

Zepatier For Treatment Of Hepatitis C-Negative Patients Who Receive Heart Transplants From Hepatitis C-Positive Donors (HCV) (USHER)

Heart Failure

United States
Bayer

Completed

A Study to Learn How Finerenone (BAY94-8862) Moves Into, Through and Out of the Body, How it Affects the Body, and How Safe it is in Adult Participants With Different Degrees of Reduced Liver Function and in Healthy Participants With Similar Age, Weight and Gender Distribution

Diabetic Nephropathy | Worsening Chronic Heart Failure

Germany
Bayer

Completed

Phase IIb Safety and Efficacy Study of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Moderate Chronic Kidney Disease Alone (ARTS-HF Japan)

Heart Failure

Japan
Bayer

Completed

Phase IIb Safety and Efficacy Study of Different Oral Doses of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Chronic Kidney Disease Alone (ARTS-HF)

Heart Failure

France, Taiwan, United States, Turkey, Spain, Greece, Portugal, Germany, Canada, Austria, Czechia, Denmark, Israel, Korea, Republic of, Poland, South Africa, Sweden, Bulgaria, Italy, Finland, Hungary, Lithuania, Netherlands, Australia, ...
Lexicon Pharmaceuticals
Sanofi

Terminated

Safety, Tolerability and Pharmacodynamic Activity of Sotagliflozin in Hemodynamically Stable Participants With Worsening Heart Failure

Cardiac Failure Aggravated

United States, Canada, Netherlands
Bayer

Completed

Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure With Reduced Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-REDUCED)

Heart Failure

Belgium, France, Switzerland, United States, Spain, Greece, Japan, Singapore, Austria, Germany, Korea, Republic of, Poland, Denmark, Israel, Netherlands, Taiwan, Bulgaria, Canada, Sweden, Czechia, Australia, Italy, Hungary, United Kingdom
Bayer

Completed

Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure and Preserved Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-PRESERVED)

Heart Failure

Belgium, France, Spain, Greece, Portugal, Japan, United States, Singapore, Austria, Germany, Korea, Republic of, Poland, Australia, Israel, Netherlands, Switzerland, Taiwan, Bulgaria, Canada, Czechia, Denmark, Hungary, Italy, Sweden, United...
Chronolife

Unknown

International Multi-center Study to Validate an Early Warning Algorithm for Worsening Heart Failure (VESTA)

Chronic Heart Failure
AstraZeneca

Completed

Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure (DAPA-HF)

Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)

United States, Canada, Denmark, United Kingdom, Czechia, Vietnam, Germany, Brazil, India, China, Japan, Taiwan, Netherlands, Bulgaria, Slovakia, Hungary, Poland, Russian Federation, Argentina, Sweden
Biotronik SE & Co. KG

Completed

Selection of Potential Predictors of Worsening Heart Failure (BioDetectHFIV)

Heart Failure

Spain, Italy
Pro-Cardiaco Hospital
Universidade Federal Fluminense; Hospital Universitário Antonio Pedro; Diagnósticos...

Terminated

Accuracy of Urinary NGAL in Predicting CardioRenal Syndrome in Acute Heart Failure at Emergency - CYNDERELA-HF Study (CYNDERELA-HF)

Cardiorenal Syndrome

Brazil
Niguarda Hospital
Associazione Nazionale Medici Cardiologi Ospedalieri

Terminated

REWORD-HF REverse WOrsening Renal Function in Decompensated Heart Failure (REWORD-HF)

Acute Decompensated Heart Failure

Italy
Cardiovascular Clinical Science Foundation

Completed

Randomized, Double-Blind, Placebo Controlled Study of the Short Term Clinical Effects of Tolvaptan in Patients Hospitalized for Worsening Heart Failure With Challenging Volume Management (Secret of CHF)

Heart Failure

United States
Larissa University Hospital

Terminated

Dopamine in Acute Decompensated Heart Failure II (DAD-HF II)

Acute Decompensated Heart Failure

United States, Greece
Scios, Inc.

Completed

A Study of Short-Term Outcomes and Economic Impact For Patients With Worsening Congestive Heart Failure When Natrecor (Nesiritide) is Added to Standard-Care Therapy, Compared to Administration of Placebo With Standard-Care Therapy

Cardiomyopathies | Heart Failure, Congestive | Dyspnea, Paroxysma
Scios, Inc.

Completed

FUSION I Assesses Safety and Tolerability of Two Doses of NATRECOR (Nesiritide) Administered to Patients With Worsening Congestive (Decompensated) Heart Failure Who Are Concurrently Receiving Their Usual Cardiac Medications and Are at High Risk for Hospitalization.

Heart Failure, Congestive
Scios, Inc.

Completed

A Safety Study Comparing Natrecor (Nesiritide) Versus Dobutamine Therapy for Worsening Congestive Heart Failure

Heart Failure, Congestive
Scios, Inc.

Completed

A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure.

Symptomatic Decompensated Congestive Heart Failure | Congestive Heart Failure in Acute Coronary Syndrome
Scios, Inc.

Completed

A Study of Two Doses of Intravenous NATRECOR hBNP (Nesiritide) in Patients With Worsening Congestive Heart Failure Who Have Difficulty Breathing at Rest

Heart Failure, Congestive | Heart Decompensation
Scios, Inc.

Completed

A Study to Develop Additional Safety and Clinical Experience With NATRECOR hBNP (Nesiritide) in the Treatment of Patients With Worsening Congestive Heart Failure Who Require Inpatient Intravenous Therapy With Medications That Influence the Tone and Caliber of Blood Vessels

Heart Failure, Congestive | Heart Decompensation
Solvay Pharmaceuticals

Terminated

Safety and Efficacy Study to Evaluate the Effect of SLV320 on Renal Function in Patients With Worsening Heart Failure

Acute Decompensated Heart Failure; Renal Dysfunction

United States, Canada, Chile, Denmark, France, Germany, Italy, Poland, Romania, Russian Federation, Ukraine
Larissa University Hospital

Unknown

Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial (DAD-HF)

Acute Heart Failure

Greece
University Hospital Hradec Kralove

Unknown

Congestive Heart Failure: Causes of Sudden Worsening

Congestive Heart Failure

Czech Republic
Assistance Publique - Hôpitaux de Paris

Completed

Beta-Blocker Continuation Versus Interruption in Heart Failure Worsening (BConvinced)

Heart Failure, Congestive

France
NovaCardia, Inc.
Merck Sharp & Dohme LLC

Completed

Placebo-Controlled Randomized Study of KW-3902 for Subjects Hospitalized With Worsening Renal Function and Heart Failure Requiring IV Therapy (REACH UP)

Heart Failure, Congestive
sigma-tau i.f.r. S.p.A.
MDS Pharma Services

Completed

A Phase II Trial to Assess Hemodynamic Effects of Istaroxime in Pts With Worsening HF and Reduced LV Systolic Function (HORIZON-HF)

Heart Failure
University of Leicester

Recruiting

A Holistic Patient-centred Intervention to Improve Outcomes of Older People Living With Frailty and Chronic Heart Failure (FIT-HF)

Frailty | Chronic Heart Failure

United Kingdom
Ceryx Medical Australia
Avania

Not yet recruiting

Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEF (RSA-PACE)

Heart Failure With Reduced Ejection Fraction

New Zealand
AstraZeneca
Parexel

Recruiting

A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral AZD0233 Compared With Placebo in Healthy Adult Participants.

Dilated Cardiomyopathy

United States
University of Giessen
Deutsche Luft und Raumfahrt

Not yet recruiting

Perioperative Interdisciplinary, Intersectoral Process Optimization in Heart Failure (PeriOP-CARE HF)

Heart Failure

Germany
Chongqing Medical University

Recruiting

Effect of Bilirubin on Prognosis in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction | Prognathism

China
NuvoAir Medical PC
Optum, Inc.

Not yet recruiting

The COPD CARE Study: Evaluating the Impact of a Virtual-First COPD Service on Major Cardiac and Respiratory Events

COPD | COPD Exacerbation | Cardio/Pulm: Heart Failure

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