Search clinical trials for: acquired resistance

Total 10763 results

Tianjin Medical University Cancer Institute and...

Recruiting

Osimertinib Plus Dalpiciclib in Patients With EGFR-mutant, CDK4/6 Pathway Aberrant, Advanced Non-small Cell Lung Cancer Following Acquired Resistance to Third-generation EGFR TKI: a Phase II Trial

Non-small Cell Lung Cancer | EGFR Activating Mutation | EGFR-TKI Resistant Mutation | Cell Cycle Deregulation

China
University of Sao Paulo General Hospital

Not yet recruiting

Isolated Resistance Training and Neuromuscular Electrical Stimulation in Patients With Femoral Intra Aortic Balloon Pump.

Heart Failure | Physical Therapy | Neuromuscular Electrical Stimulation

Brazil
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR)

Not yet recruiting

Integrated Clinical Decision Support for Empiric Antibiotic Selection in Sepsis (IDEAS-CRXO)

Sepsis | Bacterial Infections | Community-Acquired Infections | Hospital Infection
Octapharma

Not yet recruiting

Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

Acquired Antithrombin Deficiency
Assistance Publique - Hôpitaux de Paris

Recruiting

Customized Antibiotic Treatment Duration Among Hospitalized Patients With Moderately Severe Community-Acquired Pneumonia (CAT-CAP)

Community-Acquired Pneumonia

France
Pneumonia Research Network on Genetic Resistance...
Charite University, Berlin, Germany; University of Leipzig; Jena University Hospital

Recruiting

Study of Progression of Community Acquired Pneumonia in the Hospital in Patients With More Severe Preexisting Diseases and Immunosuppression (PROGRESSCOMORB)

Pneumonia | Sepsis | Shock, Septic

Germany
Assiut University

Not yet recruiting

Correlation Between Antibiotic Resistance and Incidence of Sepsis in Community Acquired Pneumonia

Sepsis | Antibiotic Resistance | Community-acquired Pneumonia
Rwanda Biomedical Centre
Institute of Tropical Medicine; World Health Organization

Recruiting

Preventing Acquired Resistance: Strengthen TB Treatment by Adding Amikacin in the First Treatment Week of Multidrug-resistant Tuberculosis (Stake)

Tuberculosis, Multidrug-Resistant

Rwanda
Yonsei University

Not yet recruiting

An Open-label, Phase 2trial of Sotorasib in KRAS G12C-mutant Non-small-cell Lung Cancer(NSCLC) Patients and a Translational Study to Find Acquired Resistance Mechanism to Sotorasib (breakthrough)

Non Small Cell Lung Cancer

Korea, Republic of
Gamaleya Research Institute of Epidemiology and...
MSD Pharmaceuticals LLC

Not yet recruiting

HIV A6 Genome In ART Unsuccessful Patients On DOR (HIV-A6-DOR)

Virus-HIV
Black Diamond Therapeutics, Inc.

Recruiting

Phase 1/2 Study of BDTX-1535 in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations

Non-Small Cell Lung Cancer | NSCLC | Metastatic Lung Cancer | Metastatic Lung Non-Small Cell Carcinoma | EGF-R Positive Non-Small Cell Lung Cancer | Advanced Lung Carcinoma | EGFR-TKI Resistant Mutation | Advanced Non-Small Cell Squamous Lung Cancer | Epidermal Growth Factor Receptor C797S | Epidermal...

United States
University Hospital, Basel, Switzerland
Swiss National Science Foundation

Recruiting

NCCR AntiResist:: New Approaches to Combat Antibiotic-resistant Bacteria (AntiResist)

Antimicrobial Resistance (AMR)

Switzerland
Hospital Universitari de Bellvitge
Hospital Clinic of Barcelona; Carlos III Health Institute; Public Health Agency...

Recruiting

The Impact of Air Pollution on the Consumption of Antimicrobials in the General Population (ONAIR)

Air Pollution | Community-acquired Pneumonia | Drug Resistance, Microbial

Spain
Sunnybrook Health Sciences Centre

Recruiting

Determinants of Acquired Endocrine Resistance in Metastatic Breast Cancer: A Pilot Study (ENDO-RESIST)

Metastatic Breast Cancer

Canada
Scandion Oncology A/S
TFS Trial Form Support

Recruiting

A Phase 2 Trial of SCO-101 in Combination With FOLFIRI for Patients With Metastatic Colorectal Cancer (mCRC) With Acquired Resistance to FOLFIRI

Metastatic Colorectal Cancer

Denmark, Spain, Germany
UMC Utrecht
National University Hospital, Singapore; Berry Consultants; University of Pittsburgh... and other collaborators

Recruiting

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (REMAP-CAP)

Community-acquired Pneumonia, Influenza, COVID-19

United Kingdom, United States, Canada, Australia, Netherlands, Croatia, Germany, Belgium, New Zealand, Ireland, Spain, Japan, Hungary, Colombia, India, Nepal, Pakistan, Portugal, Romania, Saudi Arabia
National Cancer Institute (NCI)

Completed

Local Ablative Therapy for Treatment of Oligoprogressive, EGFR-Mutated, Non-Small Cell Lung Cancer After Treatment With Osimertinib

Lung Neoplasms | Lung Adenocarcinoma

United States
National Institute of Allergy and Infectious Diseases...

Completed

Study of People With HIV Infection Who Have High Viral Loads Despite Combination Antiretroviral Therapy

Human Immunodeficiency Virus | Acquired Immune Deficiency Syndrome Virus | Acquired Immunodeficiency Syndrome Virus | AIDS Virus | Human Immunodeficiency Viruses

United States
Memorial Sloan Kettering Cancer Center
GlaxoSmithKline

Completed

A Phase 1/2 Trial of Trametinib and Erlotinib in Patients With EGFR-Mutant Lung Adenocarcinomas and Acquired Resistance to Erlotinib

Lung Cancer | Lung Cancer Metastatic | Lung Adenocarcinoma | Lung Cancer Stage IV | Recurrent Lung Adenocarcinoma | Recurrent Lung Cancer

United States
Meir Medical Center

Completed

Increasing Insulin Resistance as a Predictor of Impending Bacteremia

Acquired ICU Bacteremia

Israel
University of Cologne

Completed

EGF816 and Trametinib in Patients With Non-small Cell Lung Cancer Harboring Activating EGFR Mutations (EATON)

Bronchial Neoplasms

Spain, Germany
Walter Reed Army Institute of Research (WRAIR)
US Military HIV Research Program; Kenya Medical Research Institute

Completed

Clinic-based ART Diagnostic Evaluation (CLADE)

Acquired Immunodeficiency Syndrome | HIV Infection | RNA Virus Infections | Virus Diseases

Kenya
Swiss Tropical & Public Health Institute
University Hospital, Basel, Switzerland; University of Basel; Ifakara Health... and other collaborators

Completed

Genotype-Informed Versus Empiric Management of VirEmia (GIVE MOVE)

HIV-1-infection

Lesotho, Tanzania
Prism Health North Texas
Merck Sharp & Dohme LLC

Withdrawn

Doravirine and Weight Gain in Antiretroviral Naive (DAWN)

Obesity | Metabolic Syndrome | Body Weight Changes | Human Immunodeficiency Virus | Fasting | Minority Health | ART | BMD

United States
Elizabeth Glaser Pediatric AIDS Foundation
Janssen, LP

Active, not recruiting

Characteristics and Outcomes of Patients Who Received Etravirine and/or Darunavir (NewHorizon)

HIV/AIDS

Cameroon, Kenya, Lesotho, Swaziland, Uganda
Methodist Health System

Completed

Identifying Risk Factors for Gram-negative Resistance for HAP/VAP in the Intensive Care Unit

Hospital-acquired Pneumonia | Ventilator-associated Pneumonia

United States
First Affiliated Hospital of Zhejiang University

Terminated

Osimertinib Combined With Anlotinib in EGFR T790M Mutated NSCLC Patients With Progression on Osimertinib Treatment

Non Small Cell Lung Cancer

China
Centre Hospitalier Intercommunal Creteil

Terminated

Objectives and Measures Dimensions Nasal Resistance of Preterm and Term (MODERN) (MODERN)

Nose Deformities, Acquired

France
National Institute of Allergy and Infectious Diseases...

Terminated

2-5 Intermittent Caloric Restriction in HIV (2-5toWIN)

Metabolic Syndrome | Human Immunodeficiency Virus

United States
Pneumonia Research Network on Genetic Resistance...
Charite University, Berlin, Germany; German Federal Ministry of Education and... and other collaborators

Completed

Study of Progression of Community Acquired Pneumonia in the Hospital (PROGRESS)

Pneumonia | Sepsis | Shock, Septic

Austria, Germany
University Hospital, Lille

Completed

ICU-acquired Colonization and Infection Related to MDR in Immunocompromised Patients (CIMDREA)

Critical Care | Immunocompromised Host

France
SPP Pharmaclon Ltd.

Completed

Study of Ingaron's Effect on Efficacy and Resistance to Antibiotics in Community-acquired Pneumonia

Community-acquired Pneumonia

Russian Federation
UMC Utrecht
ZonMw: The Netherlands Organisation for Health Research and Development; Wits... and other collaborators

Completed

The Intensified Treatment Monitoring Strategy to Prevent Accumulation of Drug Resistance (ITREMA) Trial (ITREMA)

HIV/AIDS

South Africa
Medical Center Alkmaar

Completed

Quantitative Polymerase Chain Reaction for Improved Detection of Pneumococci in CAP "CAPTAIN" (CAPTAIN)

Pneumonia, Pneumococcal | Community-acquired Pneumonia

Netherlands
National Institute of Allergy and Infectious Diseases...

Completed

Antiviral Activity of and Resistance to Lamivudine in Combination With Zidovudine, Stavudine, or Didanosine

HIV Infections

United States, Puerto Rico
National Institute of Allergy and Infectious Diseases...

Completed

A Study to Evaluate the Effects of Azithromycin on MAC Disease Prevention in HIV-Positive Patients

HIV Infections | Mycobacterium Avium-intracellulare Infection

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Prospective Study of Multidrug Resistance and a Pilot Study of the Safety of and Clinical and Microbiologic Response to Levofloxacin in Combination With Other Antimycobacterial Drugs for Treatment of Multidrug-Resistant Pulmonary Tuberculosis (MDRTB) in HIV-Infected Patients.

HIV Infections | Tuberculosis

United States
Daiichi Sankyo, Inc.
Daiichi Sankyo UK Ltd.

Terminated

A Study of DS-2248 in Participants With Advanced Solid Tumors

Non-small Cell Lung Carcinoma | Solid Tumors

United States
Outcome Rea
Institut National de la Santé Et de la Recherche Médicale, France; European... and other collaborators

Completed

Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care (EurobactII)

Sepsis | Bacteremia | Hospital Acquired Condition | Resistance Bacterial

Australia, France
Memorial Sloan Kettering Cancer Center

Completed

Molecular Determinants of Acquired Clinical Resistance to Crizotinib in Non-small Cell Lung Cancer Harboring a Translocation or Inversion Event Involving the ALK Gene Locus

Lung Cancer

United States
ViiV Healthcare
GlaxoSmithKline

Completed

Dolutegravir Expanded Access Study (DEAP)

HIV Infections | Infection, Human Immunodeficiency Virus

France, Germany, United States, Canada, Belgium, Austria, Brazil, Italy, Poland
SCARE (Study group for carbapenem resistance)
European Society of Intensive Care Medicine

Unknown

Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care in Turkey

Sepsis | Bacteremia | Hospital Acquired Condition
National Institute of Allergy and Infectious Diseases...

Completed

Innate and Acquired Resistance to Plasmodium Falciparum Malaria in Mali

Malaria

Mali
National Institute of Allergy and Infectious Diseases...

Completed

Relationship of Viral Resistance Development to CD4 Monitoring Alone or With Viral Load Monitoring

Acquired Immunodeficiency Syndrome | Resistance

Uganda
Shanghai Chest Hospital

Completed

Analysis of Re-biopsy Specimens in Advanced NSCLC With Acquired Resistance of EGFR-TKI Targeted Therapy

Lung Cancer

China
Shanghai Children's Medical Center
Shanghai Children's Hospital; The First Affiliated Hospital of Guangzhou Medical... and other collaborators

Unknown

Mycoplasma Infection Rate and Macrolides Resistance in Children With Acute Respiratory Tract Infection

Respiratory Tract Infections
East Carolina University
Imperial College London; Volcano Corporation

Completed

Correlation Study of Imaging Data Acquired During CABG With Data Acquired in the Cath Lab (PERSEUS)

Coronary Artery Disease

United States
Guangdong Association of Clinical Trials
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Unknown

Anlotinib Hydrochloride Combined With EGFR-Tyrosine Kinase Inhibitor (TKI) in Treating Advanced NSCLC Patients With Acquired Resistance to EGFR-TKI

NSCLC

China
State University of Maringá

Completed

Resistance Training in People Living With HIV/AIDS

HIV/AIDS

Brazil
Astellas Pharma Global Development, Inc.

Terminated

A Study of ASP2215 in Combination With Erlotinib in Subjects With Epidermal Growth Factor Receptor (EGFR) Activating Mutation-Positive (EGFRm+) Advanced Non-Small-Cell Lung Cancer (NSCLC) Who Have Acquired Resistance to an EGFR Tyrosine Kinase Inhibitor (TKI)

Non-Small-Cell Lung Cancer

Japan

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