Search clinical trials for: centrally acting analgesic

Total 28446 results

Tris Pharma, Inc.

Completed

Painful Diabetic Polyneuropathy Trial With a New Centrally Acting Analgesic

Diabetic Polyneuropathy

Germany, United Kingdom
Grünenthal GmbH

Completed

Comparison of Increasing Doses of Tapentadol Versus a Combination of Tapentadol and Pregabalin

Low Back Pain | Neuropathic Pain

Austria, Belgium, Denmark, Germany, Netherlands, Poland, Spain
Grünenthal GmbH

Completed

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking Either WHO Step I or Step II Analgesics or no Regular Analgesic

Osteoarthritis | Chronic Pain

Germany, United Kingdom, France, Poland, Spain
Grünenthal GmbH

Terminated

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability.

Osteoarthritis | Chronic Pain

Germany, United Kingdom, Spain, Australia, Denmark, Poland
Grünenthal GmbH
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Completed

A Study to Evaluate the Efficacy and Safety of CG5503 Prolonged Release (PR) in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee

Pain | Knee Osteoarthritis

Austria, Croatia, Germany, Hungary, Italy, Latvia, Netherlands, Poland, Portugal, Romania, Slovakia, Spain, United Kingdom
Grünenthal GmbH

Completed

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics

Low Back Pain | Chronic Pain

Austria, Germany, United Kingdom, Croatia, France, Italy, Poland, Spain, Switzerland
Grünenthal GmbH

Terminated

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking WHO Step III Analgesics But Showing a Lack of Tolerability

Pain | Low Back Pain | Chronic Pain | Neuropathic Pain | Nociceptive Pain

Belgium, Czechia, France, Germany, Netherlands, Poland, Spain, Switzerland
St George's, University of London
Rosetrees Trust

Completed

Pain Management in Osteoarthritis Using the Centrally Acting Analgesics Duloxetine and Pregabalin (DUPRO)

Hand Osteoarthritis

United Kingdom
Grünenthal GmbH

Terminated

Multiple Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations

Healthy

Germany
Grünenthal GmbH

Terminated

Single Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations (Protocol ID 297307)

Healthy

Germany
Grünenthal GmbH

Terminated

Multiple Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations (Protocol ID: 855509)

Healthy

Germany
Grünenthal GmbH

Terminated

Single Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations

Healthy

Germany
University of Bordeaux

Recruiting

Introduction of Long Acting Buprenorphine in France (OBAP)

Addiction Opiate

France
Université Catholique de Louvain
Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Not yet recruiting

QSPainRelief-STRAT (QSPR-STRAT)

Chronic Pain | Analgesia | Adverse Drug Event | Drug Interaction
PATH
London School of Hygiene and Tropical Medicine; Monash University; University... and other collaborators

Not yet recruiting

Assessing the Acceptability, Feasibility, Effectiveness and Cost-effectiveness of LADB

Opioid Dependence
Honglan Zhu

Recruiting

The Study on the Therapeutic Effect and Mechanism of Transcutaneous Acupoint Electrical Stimulation in Female

Dysmenorrhea

China
University of Maryland, Baltimore

Not yet recruiting

Anchoring Sequential Intermittent Long Acting Antimicrobials With Medication for Opioid Use Disorder (MOUD) for Invasive Infections Related to Opioid Use (AIM-STOP)

Bacteremia | Substance Use Disorders | Septic Arthritis | Infection, Soft Tissue | Osteomyelitis Acute
Assistance Publique - Hôpitaux de Paris
Ministry of Health, France; W.L.Gore & Associates; Abbott; Centre Hospitalier St... and other collaborators

Not yet recruiting

PFO Closure, Oral Anticoagulants or Antiplatelet Therapy After PFO-associated Stroke in Patients Aged 60 to 80 Years (CLOSE-2)

Patent Foramen Ovale | Cryptogenic Ischemic Stroke

France
Go Medical Industries Pty Ltd
National Institute on Drug Abuse (NIDA); Columbia University; University at Buffalo and other collaborators

Not yet recruiting

Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent Persons (GM0020)

Opioid Use Disorder
Barts & The London NHS Trust
Boston Scientific Corporation

Not yet recruiting

Evaluating the Effect of Spinal Cord Stimulation Frequency on Fast-Acting Sub-perception Therapy (FAST) for Chronic Pain (CHRONOS)

Neuropathic Low Back Pain

United Kingdom
Johns Hopkins University
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Recruiting

A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain (SKOAP)

Knee Osteoarthritis

United States
Northwell Health
Lupus Research Alliance

Recruiting

Centrally Acting ACE Inhibition in SLE

Systemic Lupus Erythematosus

United States
NYU Langone Health
National Institute on Drug Abuse (NIDA)

Recruiting

Long-acting Buprenorphine vs. Naltrexone Opioid Treatments in CJS-involved Adults

Opioid-use Disorder

United States
Lahey Clinic

Recruiting

Randomized Controlled Trial for Ankle Fracture Pain Control

Ankle Fractures

United States
Kirby Institute
National Health and Medical Research Council, Australia

Recruiting

ETHOS ENGAGE: Enhancing Treatment of Hepatitis C in Opioid Substitution Settings (ETHOS II)

Hepatitis C

Australia
Friends Research Institute, Inc.
National Institute on Drug Abuse (NIDA)

Recruiting

Long-acting Naltrexone for Pre-release Prisoners

Opiate Addiction

United States
University Hospital, Lille

Recruiting

Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease (KETAPAL)

Depression

France
Asbjørn Mohr Drewes
Odense University Hospital; Karolinska University Hospital; Hvidovre University... and other collaborators

Active, not recruiting

Effects of a Peripherally Acting µ-opioid Receptor Antagonist on Recurrent Acute Pancreatitis

Pancreatitis, Acute

Denmark, Sweden
Jewish General Hospital

Active, not recruiting

Long-acting Parasternal Blocks for Analgesia After Cardiac Surgery

Coronary Artery Bypass Graft Surgery

Canada
Yale University
Food and Drug Administration (FDA)

Completed

Variation in Opioid Prescribing and Use for Acute Pain in Diverse Populations

Opioid Use | Opioid Prescribing

United States
ViiV Healthcare

Completed

Study to Evaluate Pharmacokinetic (PK), Safety and Tolerability of Cabotegravir (CAB) 400 Milligrams Per Milliliter (mg/mL) Formulation in Healthy Adult Participants

HIV Infections

United States, New Zealand
Mapi Pharma Ltd.

Completed

A Study to Asses Efficacy, Safety and Tolerability of Monthly Long-acting IM Injection of GA Depot in Subjects With RMS

Multiple Sclerosis, Relapsing-Remitting

United States, Belarus, Bosnia and Herzegovina, Bulgaria, Estonia, Georgia, Israel, Moldova, Republic of, Russian Federation, Ukraine
Asbjørn Mohr Drewes
Odense University Hospital; Hvidovre University Hospital; University Hospital...

Completed

Effects of Peripherally Acting µ-opioid Receptor Antagonists on Acute Pancreatitis

Acute Pancreatitis

Denmark
Our Lady of the Lake Hospital
Louisiana State University Health Sciences Center in New Orleans

Completed

The Utility of Long-acting Local Anesthetic Agents in Reducing Post-operative Opioid Requirements Following Rhinoplasty

Pain, Postoperative | Local Anesthetic

United States
Lars Tanum
Oslo University Hospital; Haukeland University Hospital; The Hospital of Vestfold and other collaborators

Completed

Long Acting Naltrexone for Opioid Addiction: Focus on Sustained Abstinence and Recovery (NaltRec)

Opioid-use Disorder

Norway
University of Washington
National Institute on Drug Abuse (NIDA)

Active, not recruiting

Hepatitis C Pharmacy-based Strategy for Injectors (HepPSI)

Hepatitis C

United States
Go Medical Industries Pty Ltd
National Institute on Drug Abuse (NIDA); Columbia University; New York State... and other collaborators

Completed

The O'Neil Long Acting Naltrexone Implant (OLANI) Pharmacokinetic (PK)/Safety Study in Healthy Volunteers

Opioid Use Disorder

United States
CMC Ambroise Paré

Completed

Axillary Block in Association With Analgesic Truncal Blocks at the Elbow for Wrist Surgery. (BAXASSO)

Wrist Fracture

France
Boston Children's Hospital
Praxair Distribution, Inc.

Withdrawn

Nitrous Oxide for Pain Management During IUD Insertion in Nulliparous Adolescent Women

Analgesia | Adolescent Health | Contraceptive Devices | Long-Acting Reversible Contraception | Gynecology

United States
Wake Forest University Health Sciences

Withdrawn

Long Acting Buprenorphine Injection Compared to Sublingual Buprenorphine/Naloxone Films

Opioid Use
Kyowa Kirin Pharmaceutical Development Ltd
Apices Soluciones S.L.

Completed

Real World Observational Study of Naloxegol for Patients With Cancer Pain Diagnosed With OIC. (NACASY)

Opioid Induced Constipation

Netherlands, Sweden, Finland, Denmark, Spain, France, Germany, Greece, Italy, United Kingdom
Ain Shams University

Completed

Dexmedetomidine Versus Propofol for Sedation in Stereotactic Brain Biopsy

Adverse Effects in the Therapeutic Use of Other and Unspecified Agents Primarily Acting on the Respiratory System
Shionogi

Terminated

A Study of Naldemedine in Participants Undergoing Surgeries That Include a Bowel Resection or Bowel Transection

Postoperative Gastrointestinal Dysfunction

United States
University of Dundee
Burnet Institute; Public Health Wales

Completed

Reaching mEthadone Users Attending Community pHarmacies With HCV (REACH HCV)

Hepatitis C

Australia, United Kingdom
Albert Einstein College of Medicine
Merck Sharp & Dohme LLC; AiCure

Completed

Smartphone Based aDOT Treatment With Fixed-Dose Elbasvir and Grazoprevir in PWIDs

Hepatitis C | Medication Adherence

United States
Durect

Completed

Trial of Extended Release Bupivacaine for Pain Relief After Surgery (PERSIST)

Post Operative Pain

United States
Universitätsklinikum Hamburg-Eppendorf
Bristol-Myers Squibb

Completed

Interferon-free Antiviral Treatment of Chronic Hepatitis C Virus Infection Among Opioid-substituted Patients (INFO)

Hepatitis C, Chronic | Opioid-Related Disorders

Germany
Prisma Health-Upstate
Johns Hopkins University; Massachusetts General Hospital; Montefiore Medical... and other collaborators

Completed

Patient-Centered Models of HCV Care for People Who Inject Drugs (HERO)

Hepatitis C | Medication Adherence

United States
Imperial College London
Aristotle University Of Thessaloniki

Completed

Anti-hypertensive Medication Dosing Regimen in Effective Blood Pressure Control (HARMONY)

Hypertension

Greece, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
King's College Hospital NHS Trust; Cambridge University Hospitals NHS Foundation... and other collaborators

Completed

The REPOSE (Relative Effectiveness of Pumps Over MDI and Structured Education) Trial (REPOSE)

Type 1 Diabetes

United Kingdom

Search clinical trials for: centrally acting analgesic

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