Search clinical trials for: lipopolysaccharide

Total 90 results

National Jewish Health

Not yet recruiting

Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma (Nasal-LPS)

Asthma | Asthma; Eosinophilic

United States
Hospices Civils de Lyon

Not yet recruiting

Characterisation of TLR4+ Blood Cells in Patients With Solid Cancer (ODYSSEE)

All Types of Solid Cancer

France
Patrick Wagner, MD, FACS
List Biological Laboratories, Inc

Recruiting

Feasibility Study of Intra-Tumoral Lipopolysaccharide Immunotherapy for Intra-Abdominal (LPS)

Abdominal Cancer | Malignancy

United States
Efferon JSC

Recruiting

Selective Lipopolysaccharide Hemosorption in Maternal Sepsis (MINERVA)

Maternal sepsIs

Russian Federation
Efferon JSC
Ligand Research, LLC

Recruiting

Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Sepsis (LASSONEO)

Sepsis | Septic Shock

Russian Federation
Aristotle University Of Thessaloniki

Not yet recruiting

Correlation of P-glycoprotein Polymorphisms With Microbial Metabolites in Patients With Alzheimer's Disease on Medication

Alzheimer Disease

Greece
University of Exeter

Recruiting

Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR

Parkinson Disease | Neurodegenerative Diseases

United Kingdom
Hasanuddin University

Not yet recruiting

Effect of Oryza Sativa l Extract to LPS, ZO-1, and Intestinal Microbiota in Obese Individuals

Obesity

Indonesia
Yale University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Recruiting

Effect of Endotoxin on Alcohol Consumption

Alcohol Use Disorder

United States
Yale University
National Center for Complementary and Integrative Health (NCCIH)

Recruiting

CBD-Microglia PET Study

Healthy | CBD

United States
Centre Hospitalier Universitaire de Besancon

Recruiting

Lipopolysaccharide Metabolism and Identification of Potential Biomarkers Predictive of Graft-versus-host Disease After Allogeneic Stem Cell Transplantation (MetAlloLip)

Hematologic Diseases | Stem Cell Transplantation

France
National Jewish Health

Recruiting

Alveolar Macrophage Programming Following Endotoxin Exposure

ARDS, Human

United States
National Institute of Environmental Health Sciences...

Recruiting

Immune Cell Response to Stimuli

Inflammation

United States
Centro de Investigación en Alimentación y Desarrollo...

Completed

Dietary Intervention to Reduce Metabolic Endotoxemia

Obesity | Endotoxemia | Dietary Habits | Clinical Trial | Intestinal Microbiota

Mexico
Yale University
National Institute on Aging (NIA)

Completed

Peripheral Benzodiazepine Receptors (PBR28) Brain PET Imaging With Lipopolysaccharide Challenge for the Study of Microglia Function in Alzheimer's Disease

Alzheimer Disease

United States
University of North Florida

Completed

Happy Gut Study - Fermented Vegetables and Cardiovascular Biomarkers

Cardiovascular Diseases

United States
National Medical Research Center for Therapy and...
Center for Strategic Planning and Management of Biomedical Health Risks

Completed

Intestinal Microbiota in COPD and Asthma (MicrObAs)

Chronic Respiratory Diseases

Russian Federation
Karaganda Medical University
Ministry of Education and Science, Republic of Kazakhstan

Active, not recruiting

Bacterial Translocation Markers as Predictors of Infectious and Inflammatory Complications in Acute Bowel Obstruction

Systemic Inflammatory Response Syndrome | Colorectal Cancer | Intestinal Obstruction | Post-Op Complication | Colon Tumor

Kazakhstan
Laureate Institute for Brain Research, Inc.

Completed

Lipopolysaccharide (LPS) Challenge in Depression

Major Depressive Disorder

United States
Yale University
National Institute of Mental Health (NIMH)

Active, not recruiting

Imaging the Neuroimmune System in PTSD

Post Traumatic Stress Disorder

United States
Imperial College London
GlaxoSmithKline

Completed

Nasal LPS Challenge in Healthy Volunteers

Healthy

United Kingdom
Janssen Research & Development, LLC

Completed

A Study of Adalimumab on Inflammatory Mediators Following a Systemic Endotoxin Challenge

Healthy

Belgium
Centre Hospitalier Universitaire Dijon

Completed

Clinical Relevance of the Reverse Lipopolysaccharide Transport Pathway in Patients With Acute Peritonitis (LIPS)

Peritonitis

France
University of California, Los Angeles
National Institute of Mental Health (NIMH)

Terminated

Leucine for Depression Study (L-DEP)

Depression

United States
Radboud University Medical Center
UMC Utrecht

Completed

The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells (LPS-BM)

Sepsis, Endotoxemia, Immunosuppression

Netherlands
Yale University

Completed

Neuroimmune Response to Lipopolysaccharide

Healthy

United States
Tungs' Taichung Metroharbour Hospital

Completed

Serum Level of Lipopolysaccharide-binding Protein (LBP) and Atherosclerosis in Hemodialysis Patients

Systemic Inflammatory Response Syndrome

Taiwan
University of Southern Denmark
Odense University Hospital; University of Ghana; Odense Patient Data Explorative... and other collaborators

Completed

POC Strategies to Improve TB Care in Advanced HIV Disease (TBPOC)

Acquired Immunodeficiency Syndrome | Tuberculosis, Pulmonary | Human Immunodeficiency Virus (HIV) | Extrapulmonary Tuberculosis

Ghana
Imperial College London

Completed

Development of Human Nasal Challenge Models With Microbial Constituents and Grass Pollen

Asthma | Latent Tuberculosis | Allergic Rhinitis

United Kingdom
University of California, Los Angeles

Withdrawn

Theophylline for Depression Study (T-DEP)

Depression

United States
Centre for Human Drug Research, Netherlands
Maruho Co., Ltd.

Completed

Intradermal LPS and Antibiotics

Inflammation; Skin

Netherlands
GlaxoSmithKline
Biomedical Advanced Research and Development Authority

Terminated

Effects of GSK2798745 on Alveolar Barrier Disruption in a Segmental Lipopolysaccharide (LPS) Challenge Model

Healthy Volunteers

Germany
Adrenomed AG
Radboud University Medical Center

Completed

Adrecizumab-LPS Study

Healthy Volunteers

Netherlands
Medical University of Vienna

Completed

Vorapaxar in the Human Endotoxemia Model

Healthy Volunteers

Austria
Bernd Jilma

Completed

Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide (LPS_DF)

Endotoxemia | Healthy Volunteers

Austria
University of North Carolina, Chapel Hill
Environmental Protection Agency (EPA)

Completed

Systemic Inflammatory Response to CCRE (Endoscreen)

Healthy

United States
Philip Kern
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Blood Lipopolysaccharide (LPS) Rifaximin Study

Metabolic Syndrome | Insulin Resistance | Obese

United States
GlaxoSmithKline

Completed

Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects

Arthritis, Rheumatoid

United Kingdom
University of Milan
Istituti Clinici di Perfezionamento di Milano

Completed

Lipoprotein Metabolism and Bacterial Lipopolysaccharide in Parkinson's Disease (LiMBaLiP)

Parkinson Disease

Italy
Washington University School of Medicine
Doris Duke Charitable Foundation

Completed

Assessing NOS Uptake With PET Imaging in Lung Inflammation

Lung Inflammation

United States
Karolinska Institutet
The Swedish Research Council; University of California, San Francisco; Swedish... and other collaborators

Completed

Inflammation and Brain Function - Main Study

Sickness Behavior
Karolinska Institutet
The Swedish Research Council; University of California, San Francisco; Swedish... and other collaborators

Completed

Inflammation and Brain Function - Pilot Study

Sickness Behavior
Fraunhofer-Institute of Toxicology and Experimental...
Hannover Medical School

Completed

Development of Novel Non-invasive Inflammometry Following Lipopolysaccharide, Endotoxin (LPS) Challenge in Healthy Volunteers

Healthy

Germany
University of Nottingham

Completed

Effect of Lipopolysaccharide on Skeletal Muscle Functions (LPS)

Sepsis

United Kingdom
University of Ulm

Unknown

CD64 and Antibiotics in Human Sepsis (CD64SEPLDX)

Sepsis | Critical Illness | SIRS | Antibiotic Resistant Infection

Germany
GlaxoSmithKline
Professor Chilvers, University of Cambridge

Completed

Neutrophil Imaging in Healthy Subjects Following Lipopolysaccharide or Saline Challenge and in Subjects With Chronic Obstructive Pulmonary Disease

Pulmonary Disease, Chronic Obstructive

United Kingdom
Robert J Noveck, M.D.
Foundation for the National Institutes of Health

Completed

Dose-Related Inflammatory Effects of Intravenous Endotoxin in Humans

Healthy

United States
Moerae Matrix, Inc.

Unknown

Phase 1a Study in Healthy Smokers to Investigate the Effect With MMI-0100 on Airway Inflammation in Induced Sputum After Challenge With Inhaled Lipopolysaccharide (LPS)

Acute Inflammatory Response to Non-antigenic Stimulus

United Kingdom
Groupe Hospitalier Paris Saint Joseph
Institut Pasteur; Agency for Science, Technology and Research

Completed

Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis (CASPASEs)

Severe Sepsis

France
Radboud University Medical Center

Completed

Effects of Vasopressors on Immune Response

Endotoxemia

Netherlands

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