Search clinical trials for: substance

Total 15165 results

Bayer
Regeneron Pharmaceuticals

Not yet recruiting

A Study to Learn More About How Well 8 Milligram Aflibercept Works and How Safe it is in Chinese Participants With Diabetic Macular Edema (PHOTONiC)

Diabetic Macular Edema
Shanghai Zhongshan Hospital

Not yet recruiting

PD-1/PD-L1 Inhibitors and Anti-angiogenic Therapy Combined With/Without TACE/HAIC in Patients With BCLC B/C Hepatocellular Carcinoma Beyond Up-to-7

Hepatocellular Carcinoma
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Not yet recruiting

M9466 as Single Agent or in Combination With Tuvusertib in Advanced Solid Tumors (DDRiver 501)

Advanced Solid Tumor

United States, Germany
Peking University Cancer Hospital & Institute

Recruiting

RC48 Treatment for Platinum Sensitive Recurrent Ovarian Cancer With HER2 Expression

Fallopian Tube Carcinoma | Ovarian Carcinoma | Primary Peritoneal Carcinoma

China
Ontario Clinical Oncology Group (OCOG)
Pfizer

Not yet recruiting

Outpatient and Intermittent Dosing of Elranatamab in Relapsed/Refractory Multiple Myeloma (EMBRACE)

Refractory Multiple Myeloma

Canada
University of Washington
National Institute on Alcohol Abuse and Alcoholism (NIAAA); National Institutes...

Not yet recruiting

Developing and Testing an Online Intervention for Alcohol and Cannabis Misuse and Healthy Relationship Skills Among Young Adult Couples

Alcohol Drinking | Cannabis Use | Couples
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Not yet recruiting

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics (COSMIC)

Melanoma | Non-Hodgkin Lymphoma | Breast Carcinoma | Lung Non-Small Cell Carcinoma | Colorectal Carcinoma
Ilona Myllyniemi
University of Cambridge

Not yet recruiting

Tracking Mood: The Effects of Daily Mood Tracking VAS on Alcohol Consumption in Adult Heavy Drinkers

Alcohol Drinking | Alcohol Dependence | Alcohol Use Disorder | Alcohol Abuse | Alcohol Intoxication
VA Palo Alto Health Care System
National Institute on Alcohol Abuse and Alcoholism (NIAAA); Stanford University

Not yet recruiting

Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder

Drinking Behavior | Alcoholism | Alcohol Use Disorder | Alcohol Abuse | Drinking Problem

United States
Howard University
National Institute on Drug Abuse (NIDA); University of Miami; University of Illinois... and other collaborators

Not yet recruiting

Integrating MOUD in African American Community Settings (Better Together)

Opioid Use Disorder

United States
Peter MacCallum Cancer Centre, Australia
AbbVie

Not yet recruiting

MRD-Directed Consolidation With Epcor-only or Epcor-R2 Post Anti-CD19 CAR TCell Therapy for Large B-Cell Lymphoma (EpLCART)

Relapsed/Refractory Large B-cell Lymphoma

Australia
Zhangfa Song

Not yet recruiting

Chemotherapy Plus Bevacizumab and Anti-PD-1 Followed by Induction Therapy of Chemotherapy Plus Bevacizumab

Metastatic Colorectal Cancer | MSS

China
University of Houston
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Recruiting

A Mobile Intervention for Black Individuals Who Engage in Hazardous Drinking

Anxiety | Alcohol Abuse

United States
The National Center on Addiction and Substance...

Not yet recruiting

Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID)

Substance Use Disorders | Internalizing Disorders
Kite, A Gilead Company
Arcellx, Inc.

Not yet recruiting

A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma (iMMagine-3)

Multiple Myeloma
University of Florence
Azienda Ospedaliera Città della Salute e della Scienza di Torino; University... and other collaborators

Recruiting

Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients (STAR)

Migraine | Chronic Migraine | Migraine Without Aura | Migraine With Aura

Italy
IRCCS Ospedale San Raffaele

Not yet recruiting

Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies

Rare Diseases | Corneal Neovascularization | Limbal Stem Cell Deficiency | Aniridia | Neurotrophic Keratopathy | Ocular Cicatricial Pemphigoid | Ocular Graft-versus-host Disease | EEC Syndrome
Yale University
ViiV Healthcare

Not yet recruiting

Pharmacist-led Intervention for Injectable HIV Treatment for Women With Health-related Social Needs

Hiv

United States
Vall d'Hebron Institute of Oncology

Not yet recruiting

Combination Therapy for BRAF-V600E Metastatic CRCm (BRAVE)

Metastatic Colorectal Cancer
Ruyao Liu

Not yet recruiting

Functional Response Characteristics of Brain Under Swallowing Task Paradigm

Dysphagia | Swallowing Disorder | Swallowing Substances

China
University of Michigan
National Institute on Drug Abuse (NIDA)

Not yet recruiting

Testing an Arts-based Program to Reduce Nurse Stigma Towards Perinatal Substance Use

Nurse's Role | Stigma, Social | Implicit Bias
University of Florence
Azienda Ospedaliera Città della Salute e della Scienza di Torino; University... and other collaborators

Recruiting

Effectiveness and Tolerability of Eptinezumab (TACHIS)

Migraine | Chronic Migraine | Migraine Without Aura | Migraine With Aura

Italy
University Hospital, Antwerp
Universiteit Antwerpen; AZ Jan Palfijn Gent

Not yet recruiting

Diagnosing Drug Allergy: the T is the Key (TAT)

Amoxicillin Allergy
The First Affiliated Hospital of Soochow University

Not yet recruiting

Treatment of High-risk Newly Diagnosed Multiple Myeloma With Minimal Residual Disease Detection

Multiple Myeloma | Newly Diagnosed | MRD | High Risk
Cancer Institute and Hospital, Chinese Academy...

Not yet recruiting

Chidamide Combined With Sintilimab and Bevacizumab for the First-line Treatment of Advanced Liver Cancer

Liver Cancer
University of Florence
Azienda Ospedaliera Città della Salute e della Scienza di Torino; University... and other collaborators

Recruiting

RimegepAnt effectIvenesS and tolErability as Migraine Preventive Treatment (RAISE)

Migraine | Chronic Migraine | Migraine Without Aura | Migraine With Aura

Italy
Oregon Health and Science University

Not yet recruiting

DBS TaT in Peer-assisted Telemedicine for Hepatitis C

Hepatitis C
University of New Mexico

Not yet recruiting

Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose

Opioid Overdose | Opiate Overdose

United States
Massachusetts General Hospital
National Institute of Allergy and Infectious Diseases (NIAID)

Not yet recruiting

Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing (DACAT)

Drug Hypersensitivity | Drug-Induced Anaphylaxis | Antibiotic Allergy | Drug Allergy | Beta Lactam Adverse Reaction | Cephalosporin Allergy | Cephalosporin Reaction

United States
AstraZeneca
Parexel

Recruiting

Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).

Opioid Use Disorder

United States
European Organisation for Research and Treatment...

Not yet recruiting

Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Women With Early Breast Cancer; A Pragmatic Randomized Controlled Trial

Musculoskeletal Pain | Drug-Related Side Effects and Adverse Reactions | Breast Cancer Stage I | Breast Cancer Stage II | Breast Cancer Stage III | HER2-negative Breast Cancer | ER+ Breast Cancer
University of Iowa

Not yet recruiting

Psilocybin vs Ketamine for Alcohol Use Disorder (Psi vs Ket)

Alcohol Dependence | Alcohol Use Disorder | Alcohol Abuse
Washington D.C. Veterans Affairs Medical Center

Recruiting

Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula (LIFU_TUD)

Tobacco Use Disorder

United States
Tianjin Medical University Cancer Institute and...

Not yet recruiting

A Prospective, Single-arm, Multicenter Phase II Clinical Study of HAIC in Combination With Adebrelimab and Bevacizumab for Potentially Resectable Hepatocellular Carcinoma

Hepatocellular Carcinoma | Adebrelimab

China
University of Windsor
Centre for Addiction and Mental Health

Recruiting

The Pocket Skills Adjunct Project

Depression | Anxiety | Substance Use Disorders | Alcohol Use Disorder

Canada
Maastricht University Medical Center
Gilead Sciences

Not yet recruiting

Sacituzumab Govitecan and Bevacizumab for NSCLC Brain Metastases

NSCLC Stage IV | Brain Metastases, Adult

Netherlands
Hospital Universitari Vall d'Hebron Research Institute
Universitat Pompeu Fabra; IDIAPJgol

Recruiting

Study of the Drivers of Late Diagnosis of Alcohol Related Diseases, Alone or in Combination With Metabolic Dysfunconal Associated Fatty Liver Disease, Implementation and Evaluation of Itnerventions to Reduce Its Burden. (StopALD)

Alcohol Use Disorder | Alcohol-related Liver Disease | Metabolic and Alcohol Related/Associated Liver Disease | Metabolic Disfunction Associated Steatotic Liver Disease

Spain
Beijing Tiantan Hospital
Boston Children's Hospital; Tsinghua University; Institute of Biotechnology,...

Not yet recruiting

Mechanism and Application of DBS in the Treatment of PD

Parkinson's Disease and Parkinsonism
The University of Hong Kong

Not yet recruiting

A Training Program of Drug Allergy for Healthcare Professionals

Drug Allergy

Hong Kong
VA Office of Research and Development

Not yet recruiting

Non-invasive Vagal Nerve Stimulation as Novel Treatment to Improve Functional Outcomes in Veterans With Alcohol Use Disorder

Alcohol Use Disorder

United States
Regeneron Pharmaceuticals

Not yet recruiting

An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World Setting (SPECTRUM-US)

Visual Impairment | Diabetic Macular Edema (DME) | Neovascular Age-related Macular Degeneration (nAMD) | Wet Age-related Macular Degeneration (AMD)
Celgene
Bristol-Myers Squibb

Recruiting

A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation (KarMMa-9)

Multiple Myeloma

Austria, United States, Spain, Australia, Japan, France, Israel, Italy, Canada, Greece, Belgium, Norway, Romania, Czechia, Denmark, Germany, Korea, Republic of, United Kingdom, Poland
Aelis Farma
National Institute on Drug Abuse (NIDA)

Not yet recruiting

Drug-Drug Interaction Between THC and AEF0117 (DDI)

Cannabis Abuse
Medical University of South Carolina
National Institute on Drug Abuse (NIDA)

Not yet recruiting

A Brief Intervention for Cannabis Use

Cannabis Use Disorder
Massachusetts General Hospital
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Not yet recruiting

12-Step Facilitation/MET/CBT (InTEGRA) vs. MET/CBT for Youth With Alcohol and Other Drug Use Disorder (InTEGRA)

Alcohol Use Disorder | Cannabis Use Disorder

United States
University of Kent
Kent Community Health NHS Foundation Trust; NHS Kent and Medway

Recruiting

DE-eSCALation of Opioids Post-surgical dischargE (DESCALE)

Opioid Dependence

United Kingdom
Zhejiang Cancer Hospital

Recruiting

Sequential AG and mFOLFOX Combined With Serplulimab Injection and Bevacizumab Injection in Untreated Advanced Pancreatic Cancer

Non-Resectable Pancreas Carcinoma

China
National Cancer Institute (NCI)

Not yet recruiting

Testing the Addition of ASTX660 (Tolinapant) to the Usual Chemotherapy Treatment (Paclitaxel With or Without Bevacizumab) in Patients With Recurrent Ovarian Cancer

Recurrent Ovarian High Grade Serous Adenocarcinoma | Recurrent Platinum-Resistant Ovarian Carcinoma | Recurrent Fallopian Tube Clear Cell Adenocarcinoma | Recurrent Fallopian Tube Undifferentiated Carcinoma | Recurrent Ovarian Clear Cell Adenocarcinoma | Recurrent Ovarian Undifferentiated Carcinoma and other conditions
University of California, San Diego

Recruiting

The Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome

Complex Regional Pain Syndrome

United States
University of Utah
Rutgers University

Not yet recruiting

Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits

Substance-Related Disorders | Mental Disorders | Chemically-Induced Disorders | Pain | Neurologic Manifestations | Chronic Pain | Opioid-Related Disorders | Narcotic-Related Disorders | Prescription Opioid Misuse

United States

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