Influence of Laser Irradiation Low Intensity on Reparative Osteogenesis and Angiogenesis Under Transosseous Osteosynthesis

Abstract

Introduction: The use of non-medicinal facilities of correcting processes for various pathological conditions is one of the most urgent problems of modern medicine. The purpose of the work is to study the efficiency of low-intensive of infrared laser irradiation in promoting reparative osteogenesis and angiogenesis during fracture treatment under transosseous osteosynthesis with a qualitative and quantitative morphological analysis. Methods: A tibial fracture was modeled experimentally in rats from control and experimental groups, then repositioning and fixation of fragments performed. The fracture zone of the experimental group animals was exposed to pulsed infrared laser irradiation of low intensity. The animals from control group underwent irradiation simulation. The operated bones were investigated using x-ray, light and electron microscopy, x-ray electron probe microanalysis. Results: The sessions of laser irradiation decreased inflammatory process severity, activated fibrillogenesis and angiogenesis, accelerated the compactization of newly formed bone tissue, and enhanced its maturity degree while primary healing occurred in the fracture. Conclusion: Laser therapy of fracture zone ensures the formation of regenerated bone and fragment union within earlier periods.

Keywords: angiogenesis; fracture; laser irradiation; reparative osteogenesis; transosseous osteosynthesis.

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